Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. by Rogerio M Castilho, Cristiane H Squarize, Kantima Leelahavanichkul, Yi Zheng, Thomas Bugge, J Silvio Gutkind

“…Recent studies have revealed that the small GTPase Rac1, which regulates cell migration and nuclear gene expression, is required for hair follicle stem function but not for the normal homeostasis of the interfollicular skin.…”
Get full text

Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function by Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu

“…Given the known effectiveness of delaying MCI progression in preventing AD, the genes related to ribosomal function might emerge as biomarkers for early diagnosis.…”
Get full text

HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1 by Keita Tanigaki, Tsukasa Tamamori, Naoko Sasaki, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Atsuo Amano, Michiya Matsusaki, Hiroki Takeuchi, Masae Kuboniwa

“…In the present study, the effects of HAX1 on gingival barrier function were investigated.ResultsExaminations of immortalized human gingival epithelial (IHGE) cells showed HAX1 localization in mitochondria. …”
Get full text

GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…Conclusions GPD2 gene (cg03230175) methylation resulted in reduced gene expression levels, inhibited mitochondrial energy metabolism, decreased ROS levels, and affected P2Y12 gene expression through the NF-κB pathway, ultimately leading to inhibition of coagulation function. …”
Get full text

Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4. by Jonathan Berrout, Mykola Mamenko, Oleg L Zaika, Lihe Chen, Wenzheng Zhang, Oleh Pochynyuk, Roger G O'Neil

“…It is concluded that SK3 is functionally expressed in the distal nephron and collecting ducts where induction of TRPV4-mediated Ca2+ influx, leading to elevated intracellular Ca2+ levels, activates this high Ca2+-affinity K+ channel. …”
Get full text

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. by Anand K Ganesan, Hsiang Ho, Brian Bodemann, Sean Petersen, Jayavani Aruri, Shiney Koshy, Zachary Richardson, Lu Q Le, Tatiana Krasieva, Michael G Roth, Pat Farmer, Michael A White

“…Isolation of molecular machinery known to support autophagosome biosynthesis from this screen, together with in vitro and in vivo validation, exposed a close functional relationship between melanogenesis and autophagy. …”
Get full text

Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression. by Mahmoud El Maassarani, Alice Barbarin, Gaëlle Fromont, Ouafae Kaissi, Margot Lebbe, Brigitte Vannier, Ahmed Moussa, Paule Séité

“…The nuclear localization of ErbB3 has been reported in various cancer tissues and cell lines but the nuclear functions and the putative correlation with tumour progression and resistance to therapy remain unclear. …”
Get full text

Calpain2-mediated downregulation of apoptosis-inducing factors impairs mitochondrial function in noise-induced spiral ganglion neuron degeneration by Ding Zhong-Jia, Wang Ren-Feng, Mi Wen-Juan, Wang Yin, Zha Ding-Jun

“…Calpain 2 regulated decreased expression of AIF may relieve the low function of mitochondrion in SGN after noise.…”
Get full text

Assessment of serum parameters caused by the outbreak of mycoplasma pneumoniae pneumonia in children after COVID-19 by Fangye Zhou, Sen Yang, Wenchang Zhang, Min Huang

“…All of the blood samples were tested for coagulation function, procalcitonin, serum protein and glucose among MPP group and control group. …”
Get full text

Sentence Structure Analysis in Patients with Ischemic Stroke by Janice L. Hinkle, Rudolf Cymorr Kirby P. Martinez

“…Conventional content analysis revealed an overarching pattern articulated in two ways: (1) Awareness of recent space and time and remote memories of people and place (2) Expression of the self as person. Conclusions. This secondary analysis provides normative data and a rich description of cognitive function in a group of individuals describing the DSS at baseline and again at 3 years after stroke but the sample was too small to be able to provide a simple metric of cognitive function. …”
Get full text

Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species by Mohamad K. Hammoud, Celina Meena, Raimund Dietze, Nathalie Hoffmann, Witold Szymanski, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller

“…Conclusion Our findings highlight significant AA-induced alterations in the signaling network that regulates NK cell activity. As low expression of several NK cell receptors correlates with shorter OC patient survival, these findings suggest a functional linkage between AA, NK cell dysfunction and OC progression.…”
Get full text

Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis by Mostafa D. Mostafa, Maggie E. Amer, Magda A. ElKomy, Azza I. Othman, Mohamed A. El‑Missiry

“…TQ-treated obese rats showed improved thickening of the pyramidal cell layer in the hippocampus and improved cognitive function and memory impairments. Molecular docking analysis indicated that TQ exhibited a marked affinity for inhibiting binding sites of tau and amyloid-β proteins. …”
Get full text

Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis by Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue, Lin Cai

“…Cholecystokinin 2 receptor (CCK2R) mediated the protective effect of gastrin since the CCK2R blocker CI988 attenuated the gastrin-mediated angiogenesis and cardiac function protection. Conclusion Our data revealed that gastrin promoted angiogenesis and improved cardiac function in post-MI mice, highlighting its potential as a therapeutic target candidate.…”
Get full text

Molecular mechanisms of inflammation in the pathogenesis of respiratory disorders in patients with pulmonary tuberculosis by M. Ye. Dyakova, N. B. Serebryanaya, L. D. Kiryukhina, D. S. Esmedlyaeva, P. K. Yablonskiy

Get full text

Identification and Functional Characterization of P159L Mutation in in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5) by Eun Ky Kim, Ji Seon Lee, Hae Il Cheong, Sung Soo Chung, Soo Heon Kwak, Kyong Soo Park

“…Mutation in HNF1B, the hepatocyte nuclear factor-1β (HNF-1β) gene, results in maturity-onset diabetes of the young (MODY) 5, which is characterized by gradual impairment of insulin secretion. However, the functional role of HNF-1β in insulin secretion and glucose metabolism is not fully understood. …”
Get full text

Functional Bacterial Cellulose-Based MXene (Ti3C2Tx) Electronic-Skin Patch for Accelerated Healing and Monitoring by Saliha Nur lIhan, Bahar Akyuz Yilmaz, Fatih Ciftci

Get full text

Functional Involvement of Melatonin and Its Receptors in Reproductive Regulation of the Marine Teleost, Large Yellow Croaker (<i>Larimichthys crocea</i>) by Xudong Liang, Jixiu Wang, Baoyi Huang, Haojie Yuan, Yucheng Ren, Chenqian Wu, Tianming Wang, Jingwen Yang

Get full text

Overexpression of miR-192 Inhibits In Vitro Porcine Embryo Development by Inducing Oxidative Stress Damage and Impairing Mitochondrial Function by Fan He, Mingguo Li, Fan Chen, Rong Zhou, Mengfan Qi, Binbin Fu, Huapeng Zhang, Qingchun Li, Yanzhen Bi, Tao Huang

“…This impairment leads to imbalances in the oxidative–reductive system and abnormalities in mitochondrial function during the 4-cell stage, resulting in the significant accumulation of ROS, notable decreases in the expression of antioxidant enzymes CAT and SOD1 mRNA, reduction in mitochondrial membrane potential, and induction of apoptosis in pig blastocysts. …”
Get full text

KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension by Yinzhen Chen, Mingfu Chen, Ridong Zhou, Jichang Zheng, Gongxin Yang, Meiyu Chen, Jing Tu, Hongming Lin, Hu Zhao, Chen Lin, Xiaobin Chen

“…Conclusion 2,2,2 Trichloroethanol activates KCNK2, elevates MMP 2/9, and improves uterine arterial endothelial function, while PlGF synergizes with KCNK2 signaling to potentiate these effects. …”
Get full text

Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila by Malene L Urbanus, Andrew T Quaile, Peter J Stogios, Mariya Morar, Chitong Rao, Rosa Di Leo, Elena Evdokimova, Mandy Lam, Christina Oatway, Marianne E Cuff, Jerzy Osipiuk, Karolina Michalska, Boguslaw P Nocek, Mikko Taipale, Alexei Savchenko, Alexander W Ensminger

“…Backed by a few notable examples of effector–effector regulation in L. pneumophila, we sought to define the extent of this phenomenon through a systematic analysis of effector–effector functional interaction. We used Saccharomyces cerevisiae, an established proxy for the eukaryotic host, to query > 108,000 pairwise genetic interactions between two compatible expression libraries of ~330 L. pneumophila‐translocated substrates. …”
Get full text