Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…The particle size distribution and zeta potential were measured, and the nanovaccine was observed by transmission electron microscopy. The functions and properties of the nanovaccine were evaluated via an mRNA-targeted delivery assay and measurement of dendritic cell (DC) and mucosa-associated invariant T (MAIT) cell maturation and activation. …”
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The Main Directions of Improving the Methodology for the Application of Advanced Information and Communication Technologies in the Statistical Activities of the Republic of Uzbekis... by I. E. Zhukovskaya

“…The scientific article presents the main directions of improving the methodology for the application of advanced information and communication technologies in the statistical activities of the Republic of Uzbekistan in the context of the formation of a digital economy, in particular with the aim of achieving maximum reliability and efficiency in collecting and processing statistical data, as well as the openness and quality of information when receiving consolidated indicators for various user requests, an analysis of the functionality of information systems and technologies used in the statistical field was carried out, a methodology for the provision of modern state interactive services to end users was developed on the basis of the implementation of a digital analytical platform, mechanisms for improving the quality of state statistical reporting based on the use of web service technologies were proposed, scientific approaches to the integration of statistical activities with other ministries and departments in the in the context of the digitalization of the economy are expressed.The author concludes that the digital economy changes all spheres of life in modern society, contributes to the formation of a new management paradigm, methods and means based on the strengthening of the role of science as a leading productive force generating more and more new knowledge, leading to new trends in the improvement of managerial processes, solving problems of information compatibility of various software and technological complexes, which, in turn, contributes to the processes of globalization and improvement of the social sphere of the national economy, which are manifested not only in the growth of production indicators, but also in the improvement of the quality of life of the country's population.The article shows that a comprehensive analysis, statistical data on the development of innovative processes in the economy allow us to note that innovations based on the use of the advanced ICT contribute to improving the technical and technological basis of production processes, optimizing management processes, and developing human capital. …”
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Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism by Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski

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Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction by Meijun Liu, Maobin Yu, ZiYang Ma, Zilong Xu, Tao Zhang, Hongsen Zeng, Ze Li, XiYu Dang, Peihai Zhang

“…Additionally, a gene set enrichment analysis (GSEA) was performed to investigate the functions of the key target genes, and the mRNA-miRNA and TF-mRNA regulatory networks were developed to explore the potential regulation of these key genes. …”
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The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Objectives The main objective of this review is to assess evidence about the effects of detention on the mental and physical health and social functioning of asylum seekers. Search methods Relevant literature was identified through electronic searches of bibliographic databases, internet search engines, hand searching of core journals and citation tracking of included studies and relevant reviews. …”
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Regarder au-delà des élections : l’historicité complexe de la participation politique dans la Libye contemporaine by Chiara Loschi, Chiara Pagano

“…To shed light on the current political scenario, we propose here to reconsider the political from below, and namely by looking where only disruptions to the neo-liberal model of functioning democracies have been detected so far - and thus in most manifestations referred to as 'chaos', 'statelessness' or absence of 'political culture'. …”
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Common Neighborhood Energy of the Non-Commuting Graphs and Commuting Graphs Associated with Dihedral and Generalized Quaternion Groups by Hanaa Alashwali, Anwar Saleh

“…We derive explicit formulas for the CN characteristic polynomials and corresponding CN eigenvalues for both the NCM-graph and CM-graph as functions of <i>n</i>. Consequently, we establish closed-form expressions for the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>E</mi><mrow><mi>C</mi><mi>N</mi></mrow></msub></semantics></math></inline-formula> of these graphs, which are parameterized by <i>n</i>. …”
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Targeting iNAMPT and NAD Biosynthesis to Break the Obesity-Associated Liver Cancer Link by Kelly Thornton, Linda Torres, Elisa L. Pedone, Jessica S. Waltenbaugh, Cassandra M. Swanson, Emily Gonzalez, Ramona S. Price

“…Because iNAMPT and cellular energetics, a hallmark of cancer, play an important role in liver cancer progression, it has become a target for cancer therapies focused on inhibiting its functions. The objective of this study was to determine the contribution of NAD biosynthesis in obesity-associated liver cancer progression. …”
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Integrative physiological and transcriptomic analysis provides insights on the molecular basis of ABA-enhanced drought tolerance in pear (Pyrus betulaefolia) by Guo-Ling Guo, An-Ran Luo, Yun-Hui Tan, Rui-Kang Yuan, Ting-Yue Luo, Pan-Pan Ma, Jun-Yu Zhan, Piao Han, Li Liu, Wei Heng, Zhenfeng Ye, Sheng Yang, Bing Jia

“…However, whether and how ABA functions in the drought responses of pear plants is yet explored. …”
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Nonlinear Dynamical Model and Analysis of Emotional Propagation Based on Caputo Derivative by Liang Hong, Lipu Zhang

“…To address these limitations, we propose a coupled framework that integrates Caputo fractional derivatives with hyperbolic tangent–based interaction functions. The fractional-order term quantifies power-law memory decay in affective states, while the nonlinear component regulates connection strength through emotional difference thresholds. …”
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Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophreniaResearch in context by Siobhan K. Lock, Djenifer B. Kappel, Michael J. Owen, James T.R. Walters, Michael C. O'Donovan, Antonio F. Pardiñas, Sophie E. Legge

“…Interpretation: Our results confirm the importance of taking account of medication history (and particularly antipsychotic type and dose) in assessing potential correlates of cognitive impairment or poor functioning in patients with schizophrenia. We also highlight the potential for pharmacogenomic variation to be a useful tool to help guide drug prescription, although these findings require further validation. …”
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Impact of multi-strain probiotics supplementation on growth, immune responses and physiological traits in backyard poultry of Andaman and Nicobar Islands, India by Neha Halder, Neha Halder, Siddhartha Narayan Joardar, Jai Sunder, Arun Kumar De, Debasis Bhattacharya, Ahmed Abd El Wahed, Rea Maja Kobialka, Madathiparambil Gopalakrishnan Madanan, Samiran Mondal

“…In short, multi-strain probiotics supplementation showed its potential as an overall growth promoter in terms of improved growth performance, favorable physiological functions, enhanced immunomodulatory effects and better intestinal morphology in a widely reared backyard poultry breed of Andaman and Nicobar Islands, India, hence can be nominated as a potential alternative to commercial antibiotics at ground level.…”
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Assessment of Biodegradation Mechanisms of Ceftiofur Sodium by <i>Escherichia</i> sp. CS-1 and Insights from Transcriptomic Analysis by Meng-Yang Yan, Cai-Hong Zhao, Jie Wu, Adil Mohammad, Yi-Tao Li, Liang-Bo Liu, Yi-Bo Cao, Xing-Mei Deng, Jia Guo, Hui Zhang, Hong-Su He, Zhi-Hua Sun

“…Furthermore, the differentially expressed genes (DEGs) of <i>E. coli</i> CS-1 were functionally annotated using a combination of genomics and bioinformatics approaches. …”
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Regulatory roles of an sRNA derived from the 5´ UTR and sequence internal to lapA in Pseudomonas aeruginosa PAO1 by Xiaojuan Tan, Jingjing Xiao, Qianqian Liu, Ting Yang, Dandan Feng, Ruyi Zheng, Liping Luo, Xi Cheng, Dongsheng Du, Minghui Li, Jinwei Zhou, Guoping Zhu

“…However, some of these novel sRNAs have been functionally characterized. In this study, a previously uncharacterized sRNA, LapS, in P. aeruginosa PAO1 was identified as a novel sRNA. …”
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Introduction by Verena Balz

“… Since the 1980s, planning approaches in European regions shifted as a result of increasing attention to spatial patterns of interaction and movement on regional levels of scale, and alongside “a relative decline of the role of the state, a growing involvement of nongovernmental actors in a range of state functions, the emergence of new forms of multi-agency partnerships and more flexible forms of networking at various spatial scales” (Davoudi, 2008, p.63). …”
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Regulatory culture and architectural project by Mario Losasso

“…The evolution of normative culture has shifted from a system of objective regulations, aimed at defining characteristics and functions of specific building objects to rationalise what exists, to more flexible regulations that are predominantly suggestions for performance. …”
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Ovidius moralizatus by Pierre Bersuire: target audience, exegetical and ideological context by Ludmilla Evdokimova

“…In my opinion, this term is appropriate in the analysis of various medieval texts including those that have evident pragmatic and communicative functions. It points to the link between the author’s intentions and the initial circle of readers; thus, it allows us to contrast the primary reception of the work with its later interpretations. …”
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A Study on the Consistency and Efficiency of Student Performance Evaluation Methods: A Mathematical Framework and Comparative Simulation Results by Cecilia Leal-Ramírez, Héctor Alonso Echavarría-Heras, Enrique Villa-Diharce, Horacio Haro-Avalos

“…Methods: We propose a scheme aimed at identifying inconsistencies in student evaluation related to the mathematical framework of the used grading method. To explain the functioning of our construct, we provide mathematical representation of conventional grading methods, including summative assessments, rubrics, and the Systematic Task-Based Assessment Method (STBAM) that we have recently developed, which incorporates both traditional and fuzzy logic-based grading modules. …”
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Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…The CAR-T cells expanded (148.4 ± 29 fold; n=7) in serum free media with very high viability (87.8 ± 2.2%; n=7) on day 12. The antitumor functions of CD19 CAR T cells as gauged against percentage lysis of NALM6 cells at a 1:1 ratio is 27.68 ± 6.87% drawing up to the release criteria. …”
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Development and Comparison of Interrupt-Based and Analog-to-Digital Converter Algorithms for Seed Counting in Precision Planters by A. Ghaffarnezhad, H. Navid, H. Karimi

“…IntroductionImproving field operations through precise spot planting rates depends on the accurate functioning of seed flow sensors within the working rows. …”
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