Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization by Zixian Xu, Xin Fang, Shan Wang, Jiabei Mu, Qixian Gai, Yantong Chen, Zheyi Sun, Jiemei Zhai

“…Functionally, TSCC-derived exosomes promoted the polarization of M0 macrophages towards the M2 phenotype. …”
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Smartphone language features may help identify adverse post-traumatic neuropsychiatric sequelae and their trajectories by Lisa Vizer, Jennifer Pierce, Yinyao Ji, Meredith A. Bucher, Mochuan Liu, Lyle Ungar, Salvatore Giorgi, Zhaopeng Xing, Stacey L. House, Francesca L. Beaudoin, Jennifer S. Stevens, Thomas C. Neylan, Gari D. Clifford, Tanja Jovanovic, Sarah D. Linnstaedt, Donglin Zeng, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Brian J. O’Neil, Paulina Sergot, Leon D. Sanchez, Steven E. Bruce, Steven E. Harte, Ronald C. Kessler, Karestan C. Koenen, Samuel A. McLean, Xinming An

“…Language features derived from usual smartphone use can convey important information about health, functioning, and recovery following a traumatic event. …”
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Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics by Jingjing Meng, Xiangqi Zhang, Danfeng Xiang, Hanlu Liang, Shuai Zhao, Lingyan Xu, Jiao Yang, JunJun Chen, Jingxian Zhang, Yonglong Han

“…Abstract Aim Huachansu injection (HCSI) shows effective medicinal functions against osteosarcoma. This study aimed to reveal the underlying mechanisms of HCSI against osteosarcoma by integrating metabolomics, network pharmacology and bioinformatics. …”
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Co-Inhibition of tGLI1 and GP130 Using FDA-Approved Ketoconazole and Bazedoxifene Is Synergistic Against the Growth and Metastasis of HER2-Enriched and Triple-Negative Breast Cance... by Sara Manore, Chuling Zhuang, Mariana K. Najjar, Grace L. Wong, Shivani Bindal, Kounosuke Watabe, Jiayuh Lin, Hui-Wen Lo

“…Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and activator of transcription 3 (STAT3), have been reported to be frequently co-expressed in HER2-enriched breast cancer and triple-negative breast cancer (TNBC), undergo protein-protein interactions for gene regulation and activation, and functionally cooperate to promote breast CSCs. …”
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Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-r... by Adhithiya Charli, Yuan-Teng Chang, Jie Luo, Bharathi Palanisamy, Emir Malovic, Zainab Riaz, Cameron Miller, Manikandan Samidurai, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, Anumantha G. Kanthasamy

“…Collectively, our data reveal that PKCδ functions as a Lamin B1 kinase to disassemble the nuclear membrane during mitochondrial stress-induced neuronal death. …”
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The triple-helix model as foundation of innovative entrepreneurial ecosystems by Klaus Bruno Schebesch, Horațiu Florin Șoim, Radu Lucian Blaga

“…Practical implications – Triple-helix based, cooperative agreements should rethink the effective functionality of EESs. City-centered, EESs tend to be most expressive in their projects but also subject to a stronger long tail-effect. …”
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Research on the Stability Prediction and Optimization of CNC Milling Based on Bagging–NSGAⅡ Under the Influence of Multiple Factors by Congying DENG, Qian YOU, Yang ZHAO, Lijun LIN, Guofu YIN

“…Under each position, impact testing is then carried out at the tool tip for different tool-overhang lengths to obtain the corresponding frequency response functions (FRFs). Then, limiting axial cutting depth <italic>a</italic>_plim values are theoretically predicted using the tool-tip FRFs and machining parameters. …”
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Therapy Companion Mobile App for Acceptance and Commitment Therapy Exercises (ACTaide): Therapist and Client Co-Design Study by Serena Thapar, Daniela Quesada, Bärbel Knäuper

“…The research explored stakeholder preferences and feedback on app functionality, design, and features to guide iterative design improvements. …”
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Microglia in the aged brain develop a hypoactive molecular phenotype after surgery by Zhuoran Yin, Anna K. Leonard, Carl M. Porto, Zhongcong Xie, Sebastian Silveira, Deborah J. Culley, Oleg Butovsky, Gregory Crosby

“…However, they can also contribute to neurodegeneration through their pro-inflammatory properties and phagocytic functions. Acute post-operative cognitive deficits have been associated with inflammation, and microglia have been implicated primarily based on morphological changes. …”
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Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key players by Yidong Zhang, Jiawei Zhu, Ke Hu, Jie Qiu, Fuquan Zhang, Fuquan Zhang

“…Two subgroups of tumor infiltrating monocytes with possibly opposite functions might be actively involved in the inflammatory response. …”
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Screening of novel β-carotene hydroxylases for the production of β-cryptoxanthin and zeaxanthin and the impact of enzyme localization and crowding on their production in Yarrowia l... by Mladen Soldat, Tadej Markuš, Vasilka Magdevska, Martin Kavšček, Aleksander Johannes Kruis, Jaka Horvat, Gregor Kosec, Štefan Fujs, Uroš Petrovič

“…An intermediate between β-carotene and zeaxanthin, β-cryptoxanthin, is found only in specific fruits and vegetables and has several important functions for human health. The low concentration of β-cryptoxanthin in these sources results in low extraction yields, making biotechnological production a promising alternative for achieving higher yields. …”
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Genetic model of motor neuron disease in B6SJL-Tg mice: new data on the dynamics of motor symptoms and immunohistochemical manifestations of the neurodegenerative process by А. V. Stavrovskaya, D. N. Voronkov, E. A. Artyomova, B. V. Belugin, М. М. Shmarov, N. G. Yamshchikova, А. S. Gushchina, А. S. Olshansky, B. S. Naroditskiy, S. N. Illarioshkin

“…Aim of study. To assess motor functions, dynamics of survival, and morphological changes in the spinal cord of transgenic B6SJL-Tg (SOD1*G93A) mice. …”
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Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets by Xiang Y, Huang G, Luo C, Jiang J, Zhang T, Zeng Q, Zhou F, Du D

“…Exploring potential biological functions and immune cell infiltration abundance through GO/KEGG enrichment analysis and Immune infiltration analysis. …”
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NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria by Mateusz Szczerba, Akshaya Ganesh, María Luisa Gil-Marqués, Volker Briken, Marcia B. Goldberg

“…In conclusion, we show that NLRP11 functions in the non-canonical caspase-4/caspase-5 inflammasome activation pathway and the canonical NLRP3 inflammasome pathway and that NLRP11 is required for full recognition of mycobacteria by each of these pathways. …”
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Clinical and genetic characteristics of type 7 distal arthrogryposis caused by a pathogenic variant in the <i>MYH8</i> gene by I. V. Sharkova, S. S. Nikitin, T. V. Markova, A. E. Voskanyan, E. A. Melnik, O. A. Shchagina, E. L. Dadali

“…Almost all products of these genes are expressed in the structures of the neuromuscular system, which makes it possible to classify distal arthrogryposis as a neuromuscular disease. …”
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Pragmastilistic Analysis of Migration Discourse (Based on Speeches by British Politicians) by V. N. Matveeva, N. V. Stepanova

“…Similar tactics are also relevant in the framework of pro-migration rhetoric, namely, when comparing the local elite and the visiting population, which performs all the work necessary for the functioning of society. In most cases the main stylistic technique for tactics actualization is antithesis (or the convergence of antithesis and epithet). …”
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Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1 by Ran An, Fang Liu, Niuniu Dai, Fangmin Li, Xingyun Liu, Haijian Cai, Lijian Chen, Jian Du

“…Results The interaction between TgCDPK3 and Arginase-1 is functionally correlated and leads to a reduction in Arginase-1 activity, ultimately, contributing to the M1-biased phenotype of the host macrophages, which is related to restraining the proliferation of parasites. …”
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Assessment of public awareness and willingness to establish a forensic DNA and odontology national database in Egypt: a cross-sectional study by Asmaa Mohammad Moawad, Fatma Mohamed Hassan, Eman D. El Desouky, Youssef Mohsen Ashmawy, Ebtehal Mohammed, Noha E. Ibrahim, Howaida Saeed Mohammed, Basma kamal Ibrahim

“…Additionally, 89.8% agreed that Egypt should have a national DNA database, and 70.5% expressed willingness to submit their genetic profiles. …”
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Strength development and microstructural characterization of eco-cement paste with high-volume fly ash by Lanh Si Ho, Le Van Quang, Dan-Thuy Van-Pham, Trong-Phuoc Huynh

“…There are strong correlations expressed by exponential functions between drying shrinkage and curing period with a high coefficient of determination for all pastes. …”
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Stimulator of Interferon Genes (STING)-Type I Interferon Signaling: Bridging Immunity and Pain by Ti-Chuan Chiu, Yu-Yu Li, Chia-Hung Yu, Kuo-Chuan Hung, Chin-Chen Chu, Ping-Hsun Feng, Ping-Heng Tan

“…Interferons (IFNs) are cytokines with diverse functions, possessing antiviral, antiproliferative, and immunomodulatory effects. …”
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