Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury by Qi-Hang Zhao, Ya-Ting Zhang, Ke Wen, Qi Ding, Zi-Ying Chen, Dilinuer Tula, Jia-Hui Li, Juan Zhou, Yun-Fei Xiao, Xiao-Hui Guan, Ke-Yu Deng, Ling-Fang Wang, Hong-Bo Xin

“…Nicotinamide adenine dinucleotide (NAD+), functioning as a coenzyme or cofactor, is crucial for both redox and non-redox processes. …”
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System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain—an explorative study by Mika Jönsson, Emmanuel Bäckryd, Stefan Ljunggren, Nina Ottosson, Amaia Jauregi-Miguel, Sara I. Liin, Antonio Checa, Craig E. Wheelock, Bijar Ghafouri

“…These results present a previously unexplored network of integrated alterations of lipoproteins, octadecanoids, and cytokines in patients suffering from NeuP, indicative of deviant immuno-protective functioning across several biological systems including lipid metabolic processes, inflammation, and Kv7.2/7.3 signalling.…”
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ROS-responsive drug delivery system with enhanced anti-angiogenic and anti-inflammatory properties for neovascular age-related macular degeneration therapy by Jiayi Zuo, Yining Pan, Yuanli Wang, Wei Wang, Haojie Zhang, Si Zhang, Youru Wu, Jiangfan Chen, Qingqing Yao

“…Therefore, combinational therapeutics with anti-angiogenic, reactive oxygen species (ROS)-scavenging and anti-inflammatory functions will broaden therapeutic effects and reduce side effects. …”
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Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus Infection by Rui Yu, Yunyun Mao, Kai Li, Yanfang Zhai, Yue Zhang, Shuling Liu, Yuemei Gao, Zhengshan Chen, Yanhong Liu, Ting Fang, Mengsu Zhao, Ruihua Li, Junjie Xu, Wei Chen

“…Human thymosin beta-4 (Tβ4), a 43-residue peptide with an acetylated N-terminus, is widely expressed in human tissues. Tβ4 regulates actin polymerization and functions as an anti-inflammatory molecule and an antioxidant as well as a promoter of wound healing and angiogenesis. …”
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The effect of vitamin D serum levels on the values of C-reactive protein and fecal calprotectin in patients with ulcerative colitis in clinical remission by Krnetić Žarko, Ičin Tijana, Savić Željka, Latinović Bošnjak Olgica, Vračarić Vladimir, Damjanov Dimitrije, Jocić Tatiana, Pejin Radoslav, Janjić Nebojša

“…Vitamin D plays a critical role in digestive calcium absorption and, thanks to its immunomodulatory properties, affects intestinal barrier integrity, gut microbiota, and immune system functionality. The aim of the study was to examine 25-hydroxyvitamin D [25(OH)D] levels in patients with ulcerative colitis (UC) in clinical remission, as well as its effects on the values of fecal calprotectin (FC) and C-reactive protein (CRP). …”
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Examining the relationship between emotion regulation, sleep quality, and anxiety disorder diagnosis by Bryana L. Schantz, Emma R. Toner, Mackenzie L. Brown, Nikki Kaiser, Alan Chen, Samrachana Adhikari, Susanne S. Hoeppner, Eric Bui, Naomi M. Simon, Kristin L. Szuhany

“…For those with better emotion regulation, poor sleep quality and worse daytime functioning due to sleep were important predictors of anxiety diagnosis. …”
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ROS-dependent localization of glycolytic enzymes to mitochondria by Pau B. Esparza-Moltó, Arvind V. Goswami, Süleyman Bozkurt, Christian Münch, Laura E. Newman, Alexandra G. Moyzis, Gladys R. Rojas, Deann Guan, Jeffrey R. Jones, Fred H. Gage, Gerald S. Shadel

“…We speculate that the increased mitochondrial localization of glycolytic enzymes is an adaptive response to mtROS that alters glucose flux toward the antioxidant pentose phosphate pathway, creates distinct regulatory pools of mitochondrial metabolites or new metabolic circuits, and/or provides cytoprotection or other adaptive responses via moonlighting functions unrelated to their enzymatic activity.…”
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Rumex japonicus Houtt. alleviates dextran sulfate sodium-induced colitis by protecting tight junctions in mice by Hee-Young Kim, Hyongjun Jeon, Chang Hwan Bae, Yukyoung Lee, Hyungwoo Kim, Seungtae Kim

“…According to recent studies, plants of the genus Rumex have beneficial functionalities such as anti-microbial, antioxidative, and anti-inflammatory effects. …”
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A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus by Beatriz Moleirinho, Beatriz Moleirinho, Margarida Paulo-Pedro, Margarida Paulo-Pedro, Nicole C. Martins, Nicole C. Martins, Emily Jelagat, Emily Jelagat, Eller Conti, Eller Conti, Tiago R. Velho, Tiago R. Velho, Miguel Abecasis, Rui Anjos, Afonso R. M. Almeida, Afonso R. M. Almeida, Ana E. Sousa, Ana E. Sousa

“…Our flow cytometry approach separates Treg populations with likely distinct functions and facilitates the design of future studies to unravel the complexity of human regulatory T cells.…”
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Coenzyme Q10 protects keratinocytes against oxidation-induced energy stress as revealed by spatiotemporal analysis of cell energetics by Roland Abi Nahed, Ali Hussein, Cécile Cottet-Rousselle, Alexandra Vogelsang, Francesco Aulicino, Imre Berger, Thomas Blatt, Julia M. Weise, Uwe Schlattner

“…We successfully established HaCaT cells stably expressing AMPfret, validated their functionality by inducing energy stress with 2-deoxy-D-glucose, and demonstrated that Q10, together with high glucose conditions in culture, can enhance cellular energetics compared to low glucose controls. …”
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The Problem of the Reliability of Bending Models for Composite Plates of Medium Thickness by Shvabyuk V. I., Rotko S. V., Ribeiro L. F., Kuts N. H., Zakharchuk V. I., Shvabyuk V. V.

“…Therefore, to provide guaranteed accuracy of the results, some researchers of these problems have introduced such a concept as “energy consistency” between the functions of representation of the displacement vector components, their number, the order of equations, and the number of boundary conditions. …”
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African swine fever virus modulates the endoplasmic reticulum stress-ATF6-calcium axis to facilitate viral replication by Yanjin Wang, Jiaqi Li, Hongwei Cao, Lian-Feng Li, Jingwen Dai, Mengxiang Cao, Hao Deng, Dailang Zhong, Yuzi Luo, Yongfeng Li, Meilin Li, Dingkun Peng, Zitao Sun, Xiaowei Gao, Assad Moon, Lijie Tang, Yuan Sun, Su Li, Hua-Ji Qiu

“…As intracellular parasitic organisms, viruses have evolved several strategies to modulate ER functions to favor their life cycles. We have previously demonstrated that the differentially expressed genes associated with unfolded protein response (UPR), which represents a response to ER stress, are significantly enriched upon ASFV infection. …”
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Semantic distances of WAIS Similarities word pairs in non-demented adults: An item-level index of semantic memory granularity by Matteo De Marco, Satyam Chauhan, Martina Bocchetta, Annalena Venneri

“…Six hundred sixty-nine non-demented participants completed a neuropsychological battery inclusive of SIM and consolidated tests of semantic memory and executive functioning. Hierarchical linear regressions were designed to test the association between LCH and semantic memory performance after controlling for major confounders. …”
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Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex by Seth R. Batten, Alec E. Hartle, Leonardo S. Barbosa, Beniamino Hadj-Amar, Dan Bang, Natalie Melville, Tom Twomey, Jason P. White, Alexis Torres, Xavier Celaya, Samuel M. McClure, Gene A. Brewer, Terry Lohrenz, Kenneth T. Kishida, Robert W. Bina, Mark R. Witcher, Marina Vannucci, Brooks Casas, Pearl Chiu, Pendleton R. Montague, William M. Howe

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Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis by Yuanzhao Wang, Nana Chen, Bangqiu Zhang, Pingping Zhuang, Bingtao Tan, Changlong Cai, Niancai He, Hao Nie, Songtao Xiang, Chiwei Chen

“…This study aims to identify potential aging-related biomarkers for RS, explore the functions of aging-associated genes, and investigate the immunological microenvironment in RS. …”
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Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells by Yuri M. Poluektov, Olga D. Lopina, Olga D. Lopina, Maria A. Strelkova, Iuliia D. Kuleshova, Alexander A. Makarov, Irina Yu. Petrushanko

“…Hence, alterations of CTS levels in bloodstream significantly affect the functionality of blood cells, contributing to the organism’s adaptive response. …”
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ESTUDIO SOBRE LOS ABSTRACTS DE ARTÍCULOS DE INVESTIGACIÓN INFORMÁTICOS: EVIDENCIALIDAD Y MODALIDAD TEXTUAL by Ivalla Ortega Barrera, Amelia Torres Ramírez

“…In this paper we will analyse two types of characteristic functions: the communicative stamp of the markers which correspond to textual modality, both objective and subjective according to their relationship with the evidential and judgement markers, and the frequency of its use in the genre we are studying.…”
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stGRL: spatial domain identification, denoising, and imputation algorithm for spatial transcriptome data based on multi-task graph contrastive representation learning by Xin Lu, Murong Zhou, Bo Gao, Fang Wang, Shuilin Jin, Qiaoming Liu, Guohua Wang

“…This significantly enhances researchers' understanding of cellular and tissue functions in their spatial context. However, due to current technical limitations, spatial transcriptomics data often exhibit high dropout rates and noise, posing challenges for downstream analysis, like spot clustering, differential gene analysis, and spatial domain identification. …”
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Symptom improvement in a South Asian patient with Parkinson’s disease treated with immediate- and extended-release carbidopa–levodopa: a case report by Gail Reiner, Michael Skipworth

“…As exemplified in this case, greater understanding of non-Caucasian races’ responses to carbidopa–levodopa, extended release, and their combination formulas is needed as is the benefit from subspecialty care within neurology, where the art of medication management is enhanced by experience in movement disorders and where objective tools such as the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale can measure stability, decline, or improvement within each patient pertaining to their activities of daily living, cognitive and motor functions impacted by Parkinson’s disease, as well as monitoring for adverse reactions to medications used for Parkinson’s disease, such as dyskinesias.…”
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Exploring common genomic biomarkers to disclose common drugs for the treatment of colorectal cancer and hepatocellular carcinoma with type-2 diabetes through transcriptomics analys... by Sabkat Mahmud, Alvira Ajadee, Arnob Sarker, Reaz Ahmmed, Tasfia Noor, Md Al Amin Pappu, Md Saiful Islam, Md Nurul Haque Mollah

“…Further analysis of these cGBs with GO-terms and KEGG pathways revealed shared pathogenetic mechanisms of three diseases, including specific biological processes, molecular functions, cellular components and signaling pathways. …”
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