IgM+IgD− B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells by Ameera M. Bukhari, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Katherine L. Knight

“…IgM+IgD− cells isolated from both tonsil and appendix lack plasma cell and B1 cell markers, and approximately 50% express the memory marker CD27. Functionally, GALT IgM+IgD− cells spontaneously secrete IgM, and class-switch to IgA in response to both T-dependent and T-independent stimulation ex-vivo. …”
Get full text

Synthesis and Biological Evaluation of Herceptin-Conjugated Liposomes Loaded with Lipocalin-2 siRNA for the Treatment of Inflammatory Breast Cancer by Marienid Flores-Colón, Mariela Rivera-Serrano, Esther A. Peterson-Peguero, Pablo E. Vivas-Rivera, Fatima Valiyeva, Pablo E. Vivas-Mejía

“…<b>Results:</b> Dynamic light scattering confirmed the liposome size distribution, which was 66.7 nm for the Herceptin-conjugated liposome versus 43.0 nm in a non-functionalized liposome. Here, we report efficient internalization of this formulation into HER2+ IBC cells, reducing LCN2 levels by 30% and disrupting tumor emboli formation. …”
Get full text

164 An algebra assessment and primer for future clinical and translational scientists entering training by Angie Mae Rodday, Vincent Costello, David M Kent, Joshua T Cohen

“…Results/Anticipated Results: We developed a 20-item quantitative assessment covering properties of operators; identity elements and inverses; simplification of arithmetic and algebraic expressions; solving algebraic equations; functions; equations of a line; and exponents/logarithms. …”
Get full text

A qualitative study on the impact of bleeding disorders on the daily life of Dutch women by Tessa C. M. van Gastel, Lorynn Teela, Manon E. L. Degenaar-Dujardin, Vicky Lehmann, Marjolein Peters, Karin Fijnvandraat, Lotte Haverman

“…Focus groups or semi-structured interviews about the themes (1) healthcare, (2) social functioning, (3) work and education, and (4) sexuality and intimacy were conducted in person or online, based on women’s preference. …”
Get full text

Insights and implications for transcriptomic analysis of heat stress-induced intestinal inflammation in pigs by Zhichao Yu, Yanhong Yong, Xiaoxi Liu, Xingbin Ma, A. M. Abd El-Aty, Leling Li, Ziyuan Zhong, Xingyi Ye, Xianghong Ju

“…GO annotation and KEGG pathway analyses were subsequently performed to determine the functions of the DEGs and DELs. The results revealed 57, 212, and 54 DEGs and 87, 79, and 55 DELs in the CON/H01, CON/H07, and CON/H14 groups, respectively. …”
Get full text

Reuse of bottom sediment from reservoirs to cropland is a promising agroecological practice that must be rationalized by Cécile Gomez, Julien Amelin, Guillaume Coulouma, Juliette Gaab, Subramanian Dharumarajan, Jean Riotte, Muddu Sekhar, Laurent Ruiz

“…First, our results disprove our hypothesis as we found a wide diversity of (i) application rates ranging from light soil amendment to creation of anthropogenic soils, and costs, which were not explained by the distance between reservoirs and fields neither by the field size, suggesting that there is no consensus among farmers on the optimal dose, and (ii) opinions on the impact of sediments on soil functions with the majority citing an improvement in the physical and/or chemical properties of the soil, suggesting that there is no consensus on the sediment impact on soil. …”
Get full text

Adipose tissue-associated Krt23+fibroblasts contribute to immune microenvironment disorders in mouse adipose tissue during the development of obesity by Zhimin Lu, Ling Ding, Sen Zhang, Xing Jiang, Wen Ma, Youhan Liu, Xuewen Tian, Qinglu Wang

“…In-depth analysis unveiled the functions of the adipose AT-associated Krt23+fibroblast (ATAKF) cell subtype and refined the crosstalk hypothesis concerning ATAKFs, macrophages, and neutrophils. …”
Get full text

Pascal ve Sağduyunun Çağrısı: İnanmanın Rasyonelliği/Pascal and the Call of Common Sense: The Rationality of Belief by Bayram Çınar

“…While the argument in question does not constitute definitive proof of God's existence, it functions as a mechanism that motivates individuals toward belief. …”
Get full text

Identification of serum exosome proteins in systemic sclerosis with interstitial lung disease by aptamer proteomics by Sonsoles Piera-Velazquez, Simon T. Dillon, Xuesong Gu, Towia A. Libermann, Sergio A. Jimenez

“…Most of the differentially increased proteins converged around enhanced inflammatory responses, immune cell activation, cell death, and abnormal vascular functions and several of them displayed a highly significant correlation with the CO Diffusion Capacity Levels. …”
Get full text

Focusing on scRNA-seq-Derived T Cell-Associated Genes to Identify Prognostic Signature and Immune Microenvironment Status in Low-Grade Glioma by Jiayu Wen, Qiaoyi Huang, Jiuxiu Yao, Wei Wei, Zehui Li, Huiqin Zhang, Surui Chang, Hui Pei, Yu Cao, Hao Li

“…To study the different functions of T cells in LGG, we mapped the single-cell RNA sequencing results of 10 LGG samples to obtain T cell marker genes. …”
Get full text

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice. by Catarina E Hioe, Guangming Li, Xiaomei Liu, Ourania Tsahouridis, Xiuting He, Masaya Funaki, Jéromine Klingler, Alex F Tang, Roya Feyznezhad, Daniel W Heindel, Xiao-Hong Wang, David A Spencer, Guangnan Hu, Namita Satija, Jérémie Prévost, Andrés Finzi, Ann J Hessell, Shixia Wang, Shan Lu, Benjamin K Chen, Susan Zolla-Pazner, Chitra Upadhyay, Raymond Alvarez, Lishan Su

“…These results demonstrate the importance of Fc functions other than ADCC for antibodies without potent neutralizing activity.…”
Get full text

Characteristics of the Autonomic Nervous System State in Patients with Systemic Lupus Erythematosus with the Different Activity Degree According to the Indices of Heart Rate Variab... by Abrahamovych U.

“…Vegetative disorders are a term that unites varieties of origin and manifestations of the violation of vegetative functions of the organism, which are caused by the disorders of their neurogenic regulation. …”
Get full text

Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen by Xiaoqian Ran, Xi Yan, Guanwei Ma, Zhiyuan Liang, Hongbin Zhuang, Xiaoxiao Tang, Xiaolu Chen, Xueshan Cao, Xukun Liu, Yuhan Huang, Yi Wang, Xinglai Zhang, Peng Luo, Liming Shen

Get full text

Quantum <i>κ</i>-Entropy: A Quantum Computational Approach by Demosthenes Ellinas, Giorgio Kaniadakis

“…Second, two novel additional ways of expressing the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>κ</mi></semantics></math></inline-formula>-entropy are further introduced. …”
Get full text

Quand l’écriture entre dans le quotidien : les mots de la mémoire dans les livres de raison (Provence, fin xve-xviiie siècles) by Isabelle Luciani

“…This lexicon is correlated with the functions of memory aids and records (these books of reason could be used as evidence in court), which allows us to question the way words and signs functioned in memory techniques (repetitions, reformulations, mnemonic use of genealogies, reference to historical events, etc.) developed by scribblers often unfamiliar with the learned “arts of memory”. …”
Get full text

Telluride quantum dot-amplified immunosensor for interferon gamma – A TB antigen test biomarker by Sixolile Mini, Kaylin Cleo Januarie, Marlon Oranzie, Candice Cupido, Kefilwe Vanessa Mokwebo, Usisipho Feleni, Emmanuel Iwuoha

“…Interferon-gamma (IFN-γ) is a cytokine (i.e. a microprotein involved in cell signaling and immunomodulation) which is known to be expressed in response to Mycobacterium tuberculosis (Mtb) infections. …”
Get full text

The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network by Yi Wang, Yi Wang, Moran Xu, Xiaoli Zuo, Sheng Wang, Yong Yu, Zhaobing Gao, Zhaobing Gao, Jingbo Qie, Ye Jiang, Fang Huang, Bingqing Xia, Bingqing Xia

“…However, the mechanisms by which MLKL functions in the process of intracerebral hemorrhage (ICH)-induced damage remain unclear.MethodsHere, we explored the correlation between MLKL and pathological damage in ICH patients through histopathological staining and RT-qPCR. …”
Get full text

Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells by Huilong Li, Huilong Li, Haotian Lin, Haotian Lin, Tinghui Fan, Linfei Huang, Li Zhou, Xiaoyu Tian, Ruzhou Zhao, Yanhong Zhang, Xiaopan Yang, Luming Wan, Hui Zhong, Nan Jiang, Congwen Wei, Wei Chen, Wei Chen, Lihua Hou, Lihua Hou

“…Exosomes were purified from the cell supernatant and verified by nanoparticle tracking analysis (NTA), Western blot (WB) analysis and scanning electron microscopy (SEM). Differentially expressed proteins in syncytia-derived exosomes (Syn-Exos) and their functions was analyzed by Proteomic sequencing. …”
Get full text

Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases by Yixin Yang, Qilong Li, Yiwei Zhang, Ning Jiang, Qijun Chen

“…Recent findings highlight the essential role of TLR3 in parasitic infections by detecting nucleic acids from damaged cells to activate dendritic and natural killer cells. TLR3 also functions with other receptors, such as TLR2 and TLR4, to enhance cytokine production and improve parasite clearance. …”
Get full text

Young Adults Journey with Digital Fitness Tools-A Qualitative Study on Use of Fitness Tracking Device [version 1; peer review: 2 approved] by Vishweshwara Bhat, Mukesh Kumar Sinha, Nihala N, Rachel Edna Lobo, Asees Kaur Gulati, Vaishali K, Neha Bora

“…Nonusers had issues with the functionality of the device (ease of use, battery, notifications, apps hang) and were also aware of all the health benefits of using wearables. …”
Get full text