Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor mi... by Sang Hoon Lee, Jonghwa Won, Sora Kim, Wonjun Son, Yangsoon Lee, Yelim Park, Kyeong-Su Park, Hyunseong Youn, Arim Seo, Byungje Sung

“…This study investigated whether ABL112, an Fc-competent bispecific antibody targeting TIGIT and 4-1BB (TIGITx4-1BB), would enhance antitumor activity via Fcγ receptor (FcγR)-mediated macrophage activation and antibody-dependent cell-mediated functions.Methods TIGIT-dependent 4-1BB activation and TIGIT-blocking activity were assessed using reporter Jurkat T cell lines expressing 4-1BB and TIGIT, respectively. …”
Get full text

المفعولات غير الصريحة في العربية بين القبول والرفض دراسة نحوية دلالية by صبرى عبد الفتاح إبراهيم عبد القوى

“…The result of this was that their orientations diversified, their opinions differed, and their visions differed ; Therefore, it must be wondered about how the two sides dealt with the indirect objects And about the sources of agreement and the difference between them in this is an disclosure of the role of time in the faces of the disagreement between the earlier and the later grammarians, and the study strives to deny the existence of non-explicit expressions from a semantic point of view in order to establish an approved and non-indicative form of its functions. …”
Get full text

Analysis and Case Study of Internal Forces in Nut Column Transmission System of Shiplifts by WANG Di, LIAO Le-kang, JIN Liao

“…To describe axial load transmission at the interface with complex contact mechanics, exponential distribution functions were introduced. The model integrated elastic foundation beam theory with fundamental mechanics of materials, enabling the derivation of closed-form expressions for deflection, internal forces (bending moments and shear forces), and stresses (normal and shear) in both the nut column and adjustment beam. …”
Get full text

Autophagy protein Atg7 is essential for maintaining malaria parasite cellular homeostasis and organelle biogenesis by Akancha Mishra, Suryansh Rajput, Pratik Narain Srivastava, H. Shabeer Ali, Satish Mishra

“…Overall, this study establishes the essential functions of Atg7 in Plasmodium blood and liver stages, and highlights its role in maintaining the parasite’s cellular homeostasis and organelle biogenesis.IMPORTANCEThe malaria life cycle involves two hosts, mosquitoes and vertebrates. …”
Get full text

Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation by M. Sambucci, F. Laudisi, F. Novelli, E. Bennici, M. M. Rosado, C. Pioli

“…PARP-1 regulates cell functions in many types of immune cells, including dendritic cells, macrophages, and T and B lymphocytes. …”
Get full text

Correlation Between the Load-Bearing Capacity, Fire Resistance, and the Price of Glued Laminated Timber by Jurko Zovkić, Zlata Dolaček-Alduk, Ivica Guljaš

“…The correlation of the load limit state capacity proof with the corresponding fire resistance functions makes it possible, for any stress state case, to obtain the optimal price for timber material as their intersection point.…”
Get full text

Molecular evolution of gustatory receptors in the Anopheles gambiae complex by Zachary R. Popkin-Hall, Michel A. Slotman

“…As the vast majority of Grs have unknown functions and much is still unknown about the role of Grs in these species, a more complete interpretation of our data necessitates further characterization of these genes.…”
Get full text

Bioinformatic prediction, annotation and experimental validation of conserved microRNAs in Lactuca sativa Linn by Shehnaz Shair Qambrani, Muhammad Naeem Shahwani, Iftekhar Ahmed Baloch, Shahjahan Shabir Ahmed Rana, Asma Abro

“…The presence of three precursor miRNA clusters suggested coordinated regulatory functions. The identification of conserved miRNAs and their associated protein targets opens avenues for understanding the molecular mechanisms underlying regulatory processes in this economically significant leafy vegetable and the knowledge gained from this research lays the groundwork for potential applications in modulating miRNAs to control desired features in lettuce, thereby contributing to the improvement of this essential crop.…”
Get full text

A Peptide Antagonist of the ErbB1 Receptor Inhibits Receptor Activation, Tumor Cell Growth and Migration In Vitro and Xenograft Tumor Growth In Vivo by Ruodan Xu, Gro Klitgaard Povlsen, Vladislav Soroka, Elisabeth Bock, Vladimir Berezin

“…Inherbin3 binds to the extracellular domains of all four ErbB receptors, with the lowest peptide binding affinity for ErbB4. Inherbin3 functions as an antagonist of epidermal growth factor (EGF)-ErbB1 signaling. …”
Get full text

Linguistic Representation of Women in Balochi Proverbial Discourse: A Feminist Critical Discourse Analysis by Sher Jan Mirza, Munir Khan, Shabnum Sayyed Hussain, Ghulab Mirza

“…It further critically examines the sociocultural mechanisms that normalize such gendered hierarchies within these proverbial expressions. By analyzing the discursive practices embedded in Balochi proverbs, this research elucidates the ways in which language functions as a medium for reinforcing asymmetrical power relations. …”
Get full text

The bird’s-eye perspective: how do district health managers experience the impact of family physicians within the South African district health system? A qualitative study by Klaus B Von Pressentin, Robert J Mash, L Baldwin-Ragaven, R P G Botha, I Govender, W J Steinberg

“…Results: A number of benefits of FPs to the health system in South Africa were confirmed, including: their ability to enhance the functionality of the local health system by increasing access to a more comprehensive and coordinated health service, and by improving clinical services delivered through clinical care, capacitating the local health team and facilitating clinical governance activities. …”
Get full text

Measurement properties of the polish version of the nursing home survey on patient safety culture by Jakub Świtalski, Anna Augustynowicz

“…Abstract Background Measuring patient safety culture should be a fundamental component in the functioning of long-term care facilities. Several tools have been developed for this purpose, including the Nursing Home Survey on Patient Safety Culture (NHSOPSC), which was created and validated in the USA. …”
Get full text

Enhancing chemical reaction search through contrastive representation learning and human-in-the-loop by Youngchun Kwon, Hyunjeong Jeon, Joonhyuk Choi, Youn-Suk Choi, Seokho Kang

“…Scientific contribution This study seeks to enhance the search functionality of chemical reaction databases by drawing inspiration from recommender systems. …”
Get full text

Genesis of the structure of legal relations by I. M. Pohribnyi

“…First of all, procedural legal relations are characterized by the diversity and multiplicity of the composition of subjects, which are divided into, on the one hand, a group directly interested in the results of the legal process, that is, those whose interests are protected, the realization of subjective rights or powers, the fulfillment of legal obligations the whole arsenal of procedural methods, means and techniques helps to avoid or endure legal responsibility, and on the other hand, a group of leading subjects who perform their functions in “other people’s” interests, for the purposes of the case under consideration. …”
Get full text

Single-cell transcriptome atlas reveals mitophagy dynamics in acute chemical injury model and the role of MSCs transplantation by Sang Luo, Fang Wu, Xiaojun Yang

“…Abstract Background and purpose Mitochondrial autophagy, also referred to as mitophagy, clears damaged mitochondria and has dual functions in disease development and liver homeostasis in response to liver pathologies. …”
Get full text

Modern approaches to cataract surgery based on wavefront analysis by E.M. Titarenko, O.V. Shilovskikh, D.I. Ivanov, A.N. Ul’yanov

“…The study of aberrations of the human eye makes it possible to give an objective and quantitative assessment of the optical functions of the eye, which expands the possibilities for diagnosis and for the formation of surgical approaches for initial lens opacities in patients with high visual acuity.…”
Get full text

Crosstalk between miRNAs, high mobility group box-1 and complement system in epilepsy: relevance of response to valproic acid by Dalia Kamal Mostafa, Dina Elsayed Gaber, Passanite S. Hassaan, Fatma I. Dwedar, Abeer E. Dief, Mona Hassan Fathelbab

“…Abstract Background Epileptogenesis is a complex alteration of brain functions with subsequent development of seizures. …”
Get full text

Mutation- and Transcription-Driven Omic Burden of Daptomycin/Dalbavancin-R and Glycopeptide-RS Fitness Costs in High-Risk MRSA: A Nexus in Antimicrobial Resistance Mechanisms—Genom... by Eleonora Chines, Gaia Vertillo Aluisio, Maria Lina Mezzatesta, Maria Santagati, Viviana Cafiso

“…Results: Moderate impact nsSNPs were identified in EGs related to vital cellular functions and VGs. Comparative EG transcriptomics revealed differential expressions and key dysregulations—via asRNAs—prevalently affecting the protein synthesis and cell-envelope EG clusters, as well as the VG cluster. …”
Get full text

Intervention of machine learning in bladder cancer research using multi-omics datasets: systematic review on biomarker identification by Blessy Kiruba, P. S. Athul Narayan, Badhari Raj, S. Rohieth Raj, Sam George Mathew, Sudhakaran Sajitha Lulu, Vino Sundararajan

“…Integrated models combining computational techniques with large multi-omics datasets have gained significant attention, enabling the identification of significant BC biomarkers that include genes coding for diverse cellular functions, differentially expressed genes, proteins, and metabolites. …”
Get full text

Mucosal Vaccines against Bacterial and Viral Pathogens by A. N. Suvorov, Т. A. Kramskaya, T. V. Gupalova, Yu. A. Desheva, G. F. Leontieva

“…The mucosal membranes of the human body play a crucial role in the development, maintenance, and regulation of barrier functions and immune homeostasis, representing an integral component of the overall immune system. …”
Get full text