Common genetic determinants of intraocular pressure and primary open-angle glaucoma. by Leonieke M E van Koolwijk, Wishal D Ramdas, M Kamran Ikram, Nomdo M Jansonius, Francesca Pasutto, Pirro G Hysi, Stuart Macgregor, Sarah F Janssen, Alex W Hewitt, Ananth C Viswanathan, Jacoline B ten Brink, S Mohsen Hosseini, Najaf Amin, Dominiek D G Despriet, Jacqueline J M Willemse-Assink, Rogier Kramer, Fernando Rivadeneira, Maksim Struchalin, Yurii S Aulchenko, Nicole Weisschuh, Matthias Zenkel, Christian Y Mardin, Eugen Gramer, Ulrich Welge-Lüssen, Grant W Montgomery, Francis Carbonaro, Terri L Young, DCCT/EDIC Research Group, Céline Bellenguez, Peter McGuffin, Paul J Foster, Fotis Topouzis, Paul Mitchell, Jie Jin Wang, Tien Y Wong, Monika A Czudowska, Albert Hofman, Andre G Uitterlinden, Roger C W Wolfs, Paulus T V M de Jong, Ben A Oostra, Andrew D Paterson, Wellcome Trust Case Control Consortium 2, David A Mackey, Arthur A B Bergen, André Reis, Christopher J Hammond, Johannes R Vingerling, Hans G Lemij, Caroline C W Klaver, Cornelia M van Duijn

“…Both genes functionally interact with known glaucoma disease genes. …”
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Identification, Pathogenicity, and Reverse Genetics System Construction of a Pseudorabies Virus Isolate from Pigs in China by Mo Zhou, Haiyang Liang, Nannan Nie, Li Zhang, Rui Zhu, Shinuo Cao, Shanyuan Zhu

“…The developed reverse genetics system provides valuable tools for investigating viral functions, creating genetically modified PRV strains, and advancing the development of safer vaccines. …”
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Development of the Persian Listening in Spatialized Noise Sentence Test: A Preliminary Study by Zahra Hosseini Dastgerdi, Nasrin Gohari, Abbas Yousefi, Nematollah Rouhbakhsh

“…The speech stimuli were convolved with Head-Related Transfer Functions (HRTFs) to generate speech in the presence of spatialized noise. …”
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Inhibitory Effects of Bovine Lactoferricin-Lactoferrampin on Senecavirus A and Foot-and-Mouth Disease Virus with Recombinant Lactobacillus Oral Treatment in Mice by Wenyue Zhao, Senhao Zhang, Ling Sui, Xiaona Wang, Jiaxuan Li, Wen Cui, Yanping Jiang, Xinyuan Qiao, Lijie Tang

“…Studies have shown that lactoferrin peptides can inhibit the replication of various viruses and enhance the body’s immune functions. Based on this, in the present study, we aimed to investigate the effects of bovine lactoferricin-lactoferrampin (LFCA) on replicating FMDV and SVA and to analyze its role in the cellular antioxidant response caused by viral infection; in addition, we fed mice with constructed recombinant <i>Lactobacillus reuteri</i> expressing LFCA. …”
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Integrated proteomics and metabolomics analysis reveals the impact of zinc exposure on hepatopancreas from Litopenaeus vannamei: Insights into the response mechanisms by Xianbin Su, Panhui Cao, Shuang Zhang, Zhi Liang, Jiayuan Zhang, Jieyu Guo, Xiaowen Zhu, Hui Guo

“…The results demonstrated that Zn exposure limited ATP synthesis and metabolism, impaired energy metabolism, interfered with the normal functioning of metabolites, which in turn inhibits the synthesis of DNA, RNA, and proteins, affected the antioxidant system, and disrupted lipid metabolism, leading to disturbances of the intracellular environment. …”
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HCP5 Derived Novel Microprotein Triggers Progression of Gastric Cancer through Regulating Ferroptosis by Qiuhui Li, Guoqing Guo, Yuli Chen, Lu Lu, Hanyang Li, Zihan Zhou, Jiahao Guo, Xiongkang Gan, Yanming Hu, Qiunuo Li, Ming Sun, Xianghua Liu

“…These ORFs potentially encode novel proteins or peptides with crucial roles in various human cancers, yet the translational potential of these lncRNAs and the functions of the protein products remain largely unexplored, especially in gastric cancer (GC). …”
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Explainable AI for Enhancing Efficiency of DL-Based Channel Estimation by Abdul Karim Gizzini, Yahia Medjahdi, Ali J. Ghandour, Laurent Clavier

“…In particular, we derive the analytical expressions of the XAI-CHEST loss functions and the noise threshold fine-tuning optimization problem. …”
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A VAT1-related gene signature predicts radioresistance in gliomas by Xia Shan, Zhiyan Sun, Ruoyu Huang, Kuanyu Wang, Xiaoguang Qiu, Pei Yang

“…The biological processes of positively expressed genes of risk score were functionally involved in inflammatory and immune response. …”
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AKTMD: Attention-KAN-Based Neural Networks for Transportation Mode Detection by Rui Li, Xueyi Song, Yunmei Wu, Xubo Yu, Hua Huang

“…By introducing learnable B-spline functions, KAN can express more abundant feature information with fewer parameters which strengthens the non-linearities modeling and interpretability. …”
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Indecision on the use of artificial intelligence in healthcare—A qualitative study of patient perspectives on trust, responsibility and self-determination using AI-CDSS by Diana Schneider, Wenke Liedtke, Andrea Diana Klausen, Myriam Lipprandt, Florian Funer, Tanja Bratan, Nils B. Heyen, Heike Aichinger, Martin Langanke

“…Results The interviewees expressed considerable uncertainty regarding the AI-CDSS implementation. …”
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Variants of the human RAD52 gene confer defects in ionizing radiation resistance and homologous recombination repair in budding yeast by Alissa D. Clear, Glenn M. Manthey, Olivia Lewis, Isabelle Y. Lopez, Rossana Rico, Shannon Owens, M. Cristina Negritto, Elise W. Wolf, Jason Xu, Nikola Kenjić, J. Jefferson P. Perry, Aaron W. Adamson, Susan L. Neuhausen, Adam M. Bailis

“…RAD52 is a structurally and functionally conserved component of the DNA double-strand break (DSB) repair apparatus from budding yeast to humans. …”
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Effects of Cooking Treatment on the Changes of Polyphenol and Antioxidant Activity in Sorghum Rice and Its Exploration on the Flavor Enhancement Based on the Multi-omics Technique by Ke LIU, Lei XU, Changyuan WANG, Zhijiang LI, Jingzhi DENG

“…This study provides a theoretical basis for the further research and application of the functionality of sorghum food.…”
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Transcriptome Analysis of the Seed Shattering Mechanism in <i>Psathyrostachys juncea</i> Using Full-Length Transcriptome Sequencing by Yuru Lv, Lan Yun, Xiaodi Jia, Yixin Mu, Zhen Li

“…Seed shattering (SS) functions are a survival mechanism in plants, enabling them to withstand adverse environmental conditions and ensure reproduction. …”
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The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic by Bo Li, Xin Peng, He Li, Fei Chen, Yuxia Chen, Yingqian Zhang, Kai Le

“…Abstract Introduction The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. …”
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Cell Counting and Cell Cycle Analysis of Simple Non-Cultured Endothelial Cell Injection (SNEC-I) Therapy: Characterization for Clinical Translation by Darren S. J. Ting, Gary S. L. Peh, Dawn J. H. Neo, Xiao Yu Ng, Belinda Y. L. Tan, Raymond C. B. Wong, Hon Shing Ong, Jodhbir S. Mehta

“…The translational feasibility and functionality of SNEC-I therapy were examined using an established rabbit model of bullous keratopathy. …”
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Transmembrane-4 L-Six Family Member-1 Is Essential for Embryonic Blood Vessel Development by Chi-Iou Lin, Anne Merley, Hiromi Wada, Jianwei Zheng, Shou-Ching S. Jaminet

“…Transmembrane-4 L-six family member-1 (TM4SF1) is a small cell surface glycoprotein that is highly and selectively expressed on endothelial cell and mesenchymal stem cell surfaces. …”
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Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer by Zige Liu, Xingning Mao, Yuli Xie, Yunkun Yan, Xiang Wang, Junhao Mi, Hao Yuan, Jiange Zhang, Caisheng Huang, Jianxin Chen, Mujia Jili, Shengzhu Huang, Qingyun Zhang, Fubo Wang, Zengnan Mo, Rirong Yang

“…Here, single-cell RNA sequencing of 19 tissue samples from 12 patients—7 MIBC, 3 non-muscle-invasive bladder cancer (NMIBC), and 9 normal tissue samples—identified 13 transcriptionally distinct fibroblast clusters and 10 functionally heterogeneous T-cell subsets. Two interferon (IFN)-responsive fibroblast populations, F-ISG15 (inflammatory CAFs) and F-POSTN (myofibroblastic CAFs), were shown to predominate in the MIBC TME. …”
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Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation by Zhuoqi Li, Mei Tian, Yuanhui Yang, Yuanyuan Wang, Lu Zhang, Fujing Huang, Xiao Wen, Xiaoshu Yin, Xiaoyan Lin, Xiaoyan Lin, Yuan Tian

“…PurposeTo investigate the functions of lung TRM cells in the development and treatment of lung adenocarcinoma (LUAD).MethodsR-language bioinformatics analysis was applied to obtain differentially expressed (DE) lung TRM cell-specific genes and a related prognostic signature, which were further validated using external datasets, immunohistochemical staining images, and biological experiments.ResultsA total of 130 DE lung TRM cell-specific genes were identified, 14 of which were involved in the prognostic signature, including SLC16A3, ARHGAP11A, PTTG1, DTL, GPRIN1, EXO1, GAPDH, TYMS, DAPK2, CCL20, HLA-DQA1, ADAM12, ALOX5AP and OASL. …”
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Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy by Lu Liu, Yuanlai Qiu, Yuying Suo, Siyao Tong, Yiqing Wang, Xi Zhang, Liang Chen, Yue Huang, Huchen Zhou, Hu Zhou, Ze Dong, Cai-Guang Yang

“…The fat mass and obesity-associated protein (FTO) is an RNA demethylase required for catalytic demethylation of N6-methyladenosine (m6A); it is highly expressed and functions as an oncogene in acute myeloid leukemia (AML). …”
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Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice by Ge Yang, Mohammad Massumi, Shahryar Khoshtinat Nikkhoi, Hajar Owji, Mayara Grizotte-Lake, Rick I Cohen, Lazaro Gil Gonzalez, Arash Hatefi

“…To evaluate the functionality of BiKE:E5C1 in vivo, we introduced firefly luciferase-expressing ovarian cancer cells via intraperitoneal injection into hIL-15 and hIL-2 NOG mice, creating a model of ovarian cancer metastasis. …”
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