An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. by Changchun Chen, Eisuke Itakura, Katherine P Weber, Ramanujan S Hegde, Mario de Bono

“…Thus, UfSP2 proteins have protease- and Ufm1-independent functions in GPCR biogenesis.…”
Get full text

Rapid Alterations in Perirenal Adipose Tissue Transcriptomic Networks with Cessation of Voluntary Running. by Gregory N Ruegsegger, Joseph M Company, Ryan G Toedebusch, Christian K Roberts, Michael D Roberts, Frank W Booth

“…In wheel locked rats, IPA revealed enrichment of transcripts for the following functions: extracellular matrix, macrophage infiltration, immunity, and pro-inflammatory. …”
Get full text

GPR139 agonist and antagonist differentially regulate retrieval and consolidation of fear memory in the zebrafish by Nisa Roy, Satoshi Ogawa, Sachiko Tsuda, Ishwar S. Parhar

“…These results suggest that the GPR139 antagonist did not block the inhibitory action of the GPR139 agonist in the decision-making process during the fear-retrieval phase; however, solitarily, it functions in governing the fear consolidation process via activation of the ventral habenula neurons in zebrafish.…”
Get full text

Data-driven prediction and design of bZIP coiled-coil interactions. by Vladimir Potapov, Jenifer B Kaplan, Amy E Keating

“…In this work, we used a large quantitative set of 4,549 bZIP coiled-coil interactions to develop a predictive model that exploits knowledge of structurally conserved residue-residue interactions in the coiled-coil motif. Our model, which expresses interaction energies as a sum of interpretable residue-pair and triplet terms, achieves a correlation with experimental binding free energies of R = 0.68 and significantly out-performs other scoring functions. …”
Get full text

Individualized Assessment and Therapeutic Intervention for Mental Health of American Postmodern Novelists by Ningxia Qu

“…Psychological counseling relies more on external forces to correct cognition and adjust psychology, while music therapy intervention, as a nonsemantic art, can arouse inner functions and mobilize the self-healing potential of American postmodern novel creators. …”
Get full text

Resolvin E1 Inhibits Substance P-Induced Potentiation of TRPV1 in Primary Sensory Neurons by Youn Yi Jo, Ji Yeon Lee, Chul-Kyu Park

“…The neuropeptide substance P (SP) is expressed in primary sensory neurons and is commonly regarded as a “pain” neurotransmitter. …”
Get full text

Integrated Transcriptomic and Metabolic Analyses Highlight Key Pathways Involved in the Somatic Embryogenesis of <i>Picea mongolica</i> by Jinling Dai, Shengli Zhang, Yu’e Bai

“…Numerous differentially expressed genes (DEGs) were found, especially in pathways linked to ribosomal functions, flavonoid biosynthesis, and the metabolism of starch and sucrose. …”
Get full text

PERFORMANCE ANALYSIS FOR DIRECTION-FINDING CIRCULAR ANTENNA ARRAY by Svyatoslav V. Ballandovich, Grigory A. Kostikov, Liubov M. Liubina, Mikhail I. Sugak

“…The solution to the coupled integral equations is obtained using the Galerkin method with piecewise sinusoidal current distribution and with an arbitrary number of basis functions for eight- and four-element circular antenna array. …”
Get full text

Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming by Cosetta Ciliberti, Zbigniew Lazar, Kacper Szymański, Evgeniya Yuzbasheva, Tigran Yuzbashev, Ivan Laptev, Luigi Palmieri, Isabella Pisano, Gennaro Agrimi

“…For the first time, complete gene set of the itaconate biosynthetic pathways from both fungal species were functionally expressed and compared in a yeast system with a similar genetic background. …”
Get full text

Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment by Kin Man Au, Siqing Li, Tian Zhang, Andrew Z. Wang

“…Results Human CA-9-targeted multifunctionalized immunotherapy NPs (MINPs) functionalized with anti-CA-9, anti-4-1BB, and anti-CD27 antibodies outperformed hCA-9-targeted bifunctionalized immunotherapy NPs (BINPs), non-targeted BINPs, and the combination of free antibodies in activating mouse CD8+ T cells and NK cells to kill hCA-9-expressing RCC cells in vitro. …”
Get full text

IMPROVEMENT OF THE SYSTEM OF MANDATORY PENSION INSURANCE IN THE RUSSIAN FEDERATION: DEVELOPMENT OF THE ATYPICAL IN SOCIAL SECURITY by PLESHAKOVA I.N.

“…Problems are identified not only in the functioning of the compulsory pension insurance system, but also in the low level of formation of pension savings by insured citizens. …”
Get full text

Data Mining–Based Model for Computer-Aided Diagnosis of Autism and Gelotophobia: Mixed Methods Deep Learning Approach by Mohamed Eldawansy, Hazem El Bakry, Samaa M Shohieb

“…This comorbidity can significantly impair the quality of life, particularly in adolescents with high-functioning ASD, where the prevalence reaches 41.98%. …”
Get full text

CircRNA-miRNA-mRNA regulatory network in high-altitude hypobaric hypoxia-induced hearing impairment and hearing acclimatization by Danzeng Awang, Kanzi Danzeng, Tianheng Wang, Quzong Deji, Mengting Huang, Hailong Ren, Xinzhu Liu, Binghan Zhao, Lanzi Gongga

“…The DEmRNAs in this network were functionally annotated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses based on Metascape. …”
Get full text

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis by Tingli Liu, Guiting Pu, Liqun Wang, Ziyu Ye, Hong Li, Rui Li, Yanping Li, Xiaola Guo, William C. Cho, Hong Yin, Yadong Zheng, Xuenong Luo

“…Interestingly, its knockdown leads to liver fibrosis resolution, accompanied by a substantial suppression of parasite growth. Gm40262 functions by targeting miR-193b-5p to activate HSCs and stimulate their proliferation in a TGF-β-dependent manner, thereby promoting ECM production by upregulating Col1α1. …”
Get full text

TMT-Based quantitative proteomic analysis reveals age-related changes in eggshell matrix proteins and their correlation with eggshell quality in Xinyang blue-shelled laying hens by Yu Fu, Dan-rong Zhao, Li-bing Gao, Hai-jun Zhang, Jia Feng, Yu-na Min, Guang-hai Qi, Jing Wang

“…These DEPs are associated with functions such as biomineralization, calcium transport, immunity, and proteases and protease inhibitors. …”
Get full text

Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability by Joshua D Garcia, Chenyu Wang, Ryan PD Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George Jr, Roy Ben-Shalom, David H Hackos, Kevin J Bender

“…Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. …”
Get full text

HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome by Thomas Kraemer, Alexander A. Celik, Trevor Huyton, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. …”
Get full text

Effects of Rumen-Protected Methionine on Meat Quality, Fatty Acid Composition, Volatile Flavor Compounds and Transcriptomics of <i>Longissimus lumborum</i> of Yak (<i>Bos grunniens... by Xia Wu, Zizhen Zuo, Jiajia Li, Jianhui Fu, Jincheng Zhong, Hui Wang, Haitao Shi, Yanling Huang, Haibo Wang

“…Gene ontology enrichment analysis revealed significant differentially expressed genes enrichment in biological processes, cellular components, and molecular functions across RPM5, RPM10, and RPM15 groups compared to the CON. …”
Get full text

Localized delivery and retention of hydrogen sulfide causing regional lipid accumulation in mouse adipose tissues in vivo by Richa Verma, Ming Fu, Hassan M. Arif, Guangdong Yang, Ishani Sarkar, Kuljeet Kaur, John B. Matson, Lingyun Wu, Rui Wang

“…This study confirms the feasibility of selectively delivering H2S via injectable hydrogels and their effectiveness in regulating targeted tissue functions. Furthermore, this work deepens our understanding of the role of H2S in obesity development under physiological conditions and offers a practical implementation strategy for H2S-based therapeutic interventions.…”
Get full text

Biological Characteristics of a Novel Bibenzyl Synthase (<i>DoBS1</i>) Gene from <i>Dendrobium officinale</i> Catalyzing Dihydroresveratrol Synthesis by Shao-Guo Zhou, Ke Zhong, Feng-Xia Yan, Fan Tian, Chang-Sha Luo, Hang-Cheng Yu, Zai-Qi Luo, Xi-Min Zhang

“…However, <i>Dendrobium officinale</i> as a traditional herbal medicine is rich in bibenzyl compounds and performs functions such as acting as an antioxidant, inhibiting cancer cell growth, and assisting in neuro-protection. …”
Get full text