Small heat shock protein B8: from cell functions to its involvement in diseases and potential therapeutic applications by Marta Chierichetti, Riccardo Cristofani, Valeria Crippa, Veronica Ferrari, Marta Cozzi, Elena Casarotto, Paola Pramaggiore, Laura Cornaggia, Guglielmo Patelli, Ali Mohamed, Margherita Piccolella, Mariarita Galbiati, Paola Rusmini, Barbara Tedesco, Angelo Poletti

“…Heat shock protein family B (small) member 8 (HSPB8) is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins. …”
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A functional genomics approach identifies candidate effectors from the aphid species Myzus persicae (green peach aphid). by Jorunn I B Bos, David Prince, Marco Pitino, Massimo E Maffei, Joe Win, Saskia A Hogenhout

“…We exploited publicly available aphid salivary gland expressed sequence tags (ESTs) to apply a functional genomics approach for identification of candidate effectors from Myzus persicae (green peach aphid), based on common features of plant pathogen effectors. …”
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Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…Nonetheless, they are of particular interest for the treatment of glioblastoma, which is an aggressive form of brain cancer with few effective therapeutic options, due to their ability to cross the highly selective blood-brain barrier.Methods Here, we use our pooled screening platform, CARPOOL, to expedite the discovery of CARs with antitumor functions necessary for solid tumor efficacy. We performed selections in primary human T cells expressing a library of 1.3×106 third generation CARs targeting IL-13Rα2, a cancer testis antigen commonly expressed in glioblastoma. …”
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Effect of ultra-disperse powder оf zirconate-titanate lead on morphological and functional status of kidney studied experimentally by N. M. Shevtsova, V. V. Novitsky, Ye. A. Stepovaya, S. V. Nizkodubova

“…The presented results are indicative of moderately expressed toxic effect of UDP of circonate-titanate lead on morphological and functional status of rat's kidney, been subjected to its inhalation influence.…”
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Generation and Functional Characteristics of CRISPR/Cas9-Edited <i>PtrPHOTs</i> Triple-Gene Mutants in Poplar by Hongtao Yao, Jiyao Cheng, Yuning Jing, Siran Zhu, Chong Wang, Yuxiang Cheng

“…In this study, the PHOT gene family was identified in <i>Populus trichocarpa</i>, and it included three members, <i>PtrPHOT1</i>, <i>PtrPHOT2.1</i>, and <i>PtrPHOT2.2</i>, all of which were highly expressed in mature leaves. Using CRISPR/Cas9 gene editing technology, triple-gene mutations in the <i>PtrPHOT1/2.1/2.2</i> (<i>PtrPHOTs</i>) were generated, providing initial insights into the functions of PHOTs in trees. …”
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A New Extended Jacobi Elliptic Function Expansion Method and Its Application to the Generalized Shallow Water Wave Equation by Yafeng Xiao, Haili Xue, Hongqing Zhang

“…With the aid of symbolic computation, a new extended Jacobi elliptic function expansion method is presented by means of a new ansatz, in which periodic solutions of nonlinear evolution equations, which can be expressed as a finite Laurent series of some 12 Jacobi elliptic functions, are very effective to uniformly construct more new exact periodic solutions in terms of Jacobi elliptic function solutions of nonlinear partial differential equations. …”
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Liver Functional Evaluation Using Gadoxetic Acid Versus the Gold Standard Hepatobiliary Scintigraphy in Patients with Bile Duct Diseases by M. A. Shorikov, O. N. Sergeeva, A. V. Kashkadaeva, S. G. Averinova, M. G. Lapteva, D. Yu. Frantsev, A. N. Polyakov, N. E. Kudashkin, A. P. Alekhin, E. A. Moroz, E. R. Virshke, B. I. Dolgushin

“…After MR volumetry, the functional volumes of the left and right liver lobes were also defined as the area under the MRCA accumulation curve, which was multiplied by the lobe volume and expressed as a percentage of the similarly calculated function of the entire liver. …”
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A Lattice Boltzmann BGK Model with an Amending Function for Two-Dimensional Second-Order Nonlinear Partial Differential Equations by Xiaohua Bi, Junbo Lei, Demei Li, Lindong Lai, Huilin Lai, Zhipeng Liu

“…Explicit analytical expressions for these distribution functions are presented. …”
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Mathematical analysis of soliton solutions in space-time fractional Klein-Gordon model with generalized exponential rational function method by Rasel Islam, M. Abul Kawser, M. Sohel Rana, M. Nurul Islam

“…The novelty of this article is to examine the sufficient, useful in optical fibers, and further general soliton solutions of the nonlinear KG model using the generalized exponential rational function method (GERFM), which do not exist in the recent literature. …”
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Novel function of single-target regulator NorR involved in swarming motility and biofilm formation revealed in Vibrio alginolyticus by Tongxian Chen, Xiaoling Zhou, Ruonan Feng, Shuhao Shi, Xiyu Chen, Bingqi Wei, Zhong Hu, Tao Peng

“…Moreover, we proved that NorR from E. coli had a similar function in controlling motility. NorR overexpression led to increased resistance to oxidative stress and tetracycline. …”
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T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination by Ji-Li Chen, Beibei Wang, Yongxu Lu, Elie Antoun, Olivia Bird, Philip G. Drennan, Zixi Yin, Guihai Liu, Xuan Yao, Maya Pidoux, Adam Bates, Deshni Jayathilaka, Junyuan Wang, Brian Angus, Sally Beer, Alexis Espinosa, J. Kenneth Baillie, Malcolm G. Semple, ISARIC4C Investigators, Timothy Rostron, Craig Waugh, Paul Sopp, Julian C. Knight, James N. Fullerton, Mark Coles, Geoffrey L. Smith, Alexander J. Mentzer, Yanchun Peng, Tao Dong

“…Our data suggest that effective functional profiles of MPXV-specific memory T cells induced by Mpox infection may have an implication on the long-term protective responses to future infection.…”
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ATP dynamics as a predictor of future podocyte structure and function after acute ischemic kidney injury in female mice by Masahiro Takahashi, Shinya Yamamoto, Shigenori Yamamoto, Akihiro Okubo, Yasuaki Nakagawa, Koichiro Kuwahara, Taiji Matsusaka, Shingo Fukuma, Masamichi Yamamoto, Michiyuki Matsuda, Motoko Yanagita

“…In vitro studies suggest that podocytes have high ATP demands to maintain their structure and function, however, analyzing their ATP dynamics in living kidneys has been technically challenging. …”
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The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition by Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, Ting Zhu, Louqian Zhang, Chaofeng Zhang

“…Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in lung fibroblasts and epithelial cells, but its functions in lung homeostasis and diseases remain elusive. …”
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Functional Characterization of <i>PtoWOX1</i> in Regulating Leaf Morphogenesis and Photosynthesis in <i>Populus tomentosa</i> by Feng Tang, Minghui He, Shi Liang, Meng Zhang, Xiaowei Guo, Yuxian Dou, Qin Song, Cunfeng Zhao, Ting Lan

“…These findings clarify the function of <i>PtoWOX1</i> in regulating mid-lateral axis development and leaf margin morphology and provide new insights for the molecular breeding of poplar.…”
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Faecal Metaproteomic Analysis Reveals a Personalized and Stable Functional Microbiome and Limited Effects of a Probiotic Intervention in Adults. by Carolin A Kolmeder, Jarkko Salojärvi, Jarmo Ritari, Mark de Been, Jeroen Raes, Gwen Falony, Sara Vieira-Silva, Riina A Kekkonen, Garry L Corthals, Airi Palva, Anne Salonen, Willem M de Vos

“…A common core of shared microbial protein functions could be identified in all subjects. Furthermore, we observed marked differences in expressed proteins between subjects that resulted in the definition of a stable and personalized microbiome both at the mass-spectrometry-based proteome level and the functional level based on the KEGG pathway analysis. …”
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Comprehensive characterization of the competitive endogenous RNA network revealing its immune-related functions in hepatic ischemia-reperfusion injury. by Lirong Liu, Qi Wang, Shuang Qin, Chang Su, Xin Hai, Zhenkuan Yuan

“…Biological function analysis showed that the HIRI-related ceRNA network contributes to HIRI progression by regulating calcium ion-related regulatory pathways and processes. …”
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Functional and semantic potential of lexemes characterizing eye movements of Sophie Neveu in the novel ‘The Da Vinci Code’ by Dan Brown by D. A. Mukhartova, O. N. Prokhorova, I. V. Chekulai

“…The article deals with the functional features of verbs with the hyperseme look, the hyposemes of which determine their distinctive characteristics and the specifics of their functioning. …”
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CAZyme analysis and functional characterization of a new GH18 chitin hydrolase from Gelidibacter salicanalis PAMC21136 by Lakshan Paudel, Bashu Dev Pardhe, So-Ra Han, Jun Hyuck Lee, Tae-Jin Oh

“…Gelidibacter salicanalis PAMC21136, an Antarctic isolate, was sequenced and functionally annotated. 251 genes were classified into the CAZyme families, which includes the highest number of GH family, highlighting peculiarity towards various macro biopolymers. …”
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Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells by MinYeong Lim, Seonjun Park, Yoon Ha Joo, Sung Eun Kim, Min Hee Ham, TaeSoo Kim, Kihyuck Kwak, Sung Joon Kim, Jung Chan Lee, Sung Ho Park, Hye Young Kim

“…Abstract Group 2 innate lymphoid cells (ILC2s) are central effectors of type 2 immune responses in the lung; however, how mechanical cues regulate their function remains unclear. Here, we identified the mechanosensitive ion channel Piezo1 as a key regulator of ILC2 effector function through translational control. …”
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Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum. by Ashfaq Ghumra, Pongsak Khunrae, Ricardo Ataide, Ahmed Raza, Stephen J Rogerson, Matthew K Higgins, J Alexandra Rowe

“…All antibodies were specific for the R29 parasite strain, and showed no functional activity against five other rosetting strains.…”
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