Effect of Cooling Rate on the Secondary Dendritic Spacing of a Horizontally Solidified 6xxx Series Aluminum Alloy by Luane P. Marques, Suanny Q. Mesquita, André C. Maciel, Rogério B. Costa, Raquel S. França, Otavio L. Rocha, Ivaldo L. Ferreira

“…The experimental relationships for SDAS as functions of TR and local solidification time (tSL) are expressed with the equations: SDAS = constant × (TR)(-1/3) and SDAS = constant × (tSL)(1/3). …”
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Combined analysis of metabolomics and transcriptomics reveals the effects of sugar treatment on postharvest strawberry fruit quality by Zihui Zhang, Riru Tian, Junyi Wan, Yan Wang, He Li

“…These findings elucidate molecular responses to exogenous sugar treatment and offer a foundation for further investigation of gene functions in postharvest fruit quality regulation.…”
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Autoimmunity promotes chronic lymphocytic leukemia progression in an indolent disease model by Lisa Pfeuffer, Viola Siegert, Riccardo Trozzo, Katja Steiger, Roland Rad, Jürgen Ruland, Maike Buchner

“…Abstract Chronic lymphocytic leukemia (CLL) is a heterogeneous B cell malignancy characterized by the accumulation of functionally incompetent B lymphocytes. Despite the availability of highly effective treatments, CLL remains incurable, and the factors contributing to disease progression are not fully understood. …”
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Evaluation of the Diagnostic Ability of Optical Enhancement System in Early Gastric Cancer Demarcation by Misato Nagao, Jun Nishikawa, Ryo Ogawa, Sho Sasaki, Munetaka Nakamura, Junichi Nishimura, Atsushi Goto, Shinichi Hashimoto, Takeshi Okamoto, Masato Suenaga, Yoshihiko Hamamoto, Isao Sakaida

“…Twenty lesions of early gastric cancer were examined by PENTAX endoscopy system with OE-1 and OE-2 functions. The areas of tumor demarcation identified by 12 evaluators (6 novice and 6 experienced) were compared to the corresponding correct areas determined by postoperative histopathology findings. …”
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Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias by Anke Schumann, Ainhoa Martinez-Pizarro, Eva Richard, Christoph Schell, Anna Laura Kössinger, Karina A. Zeyer, Stefan Tholen, Oliver Schilling, Michael Barry, Björn Neubauer, Michael Köttgen, Luciana Hannibal, Lourdes R. Desviat, Ute Spiekerkötter

“…We observed a steep reduction of PGC-1-α, the key mediator modulating mitochondrial functions and a counter actor of mitochondrial fission. …”
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Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics by Tiejun Feng, Fuda Xie, Leo M.Y. Lee, Zhiqiang Lin, Yifan Tu, Yang Lyu, Peiyao Yu, Jialin Wu, Bonan Chen, Ge Zhang, Gary M.K. Tse, Ka Fai To, Wei Kang

“…Abstract Cellular senescence is a double-edged sword in cancer biology, functioning as both a tumor-suppressive mechanism and a driver of malignancy. …”
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Designing a Fully‐Tunable and Versatile TKE‐l Turbulence Parameterization for the Simulation of Stable Boundary Layers by É. Vignon, K. Arjdal, F. Cheruy, M. Coulon‐Decorzens, C. Dehondt, T. Dubos, S. Fromang, F. Hourdin, L. Lange, L. Raillard, G. Rivière, R. Roehrig, A. Sima, A. Spiga, P. Tiengou

“…We follow a heuristic approach for expressing the stability functions and turbulent Prandlt number in order to guarantee the versatility of the scheme and its applicability for planetary atmospheres composed of an ideal and perfect gas such as that of Earth and Mars. …”
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A Novel Approach to Calculate the Range of High-Energy Charged Particles Within a Medium by Ioannis Psychogios, Stylianos Vasileios Kontomaris, Anna Malamou, Andreas Stylianou

“…It provides excellent results for protons with initial energies between 200 MeV and 350 MeV and has the major advantage of being expressed in terms of elementary functions, making its use more straightforward compared to other approaches.…”
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GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery by Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Xavier Saelens, Nico Callewaert

“…The set of optimal artificial VHH N-glycosylation sites identified in this study can serve as a blueprint for targeted glyco-engineering of other VHHs, enabling site-specific functionalization through the rapidly expanding toolbox of synthetic glycobiology.…”
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Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism by Isabel Barón-Mendoza, Luis A. Márquez, Aliesha González-Arenas, Jessica Guzmán-Condado, Vladimir A. Martínez-Rojas, Johaly Anguiano-Buenfil, Montserrat Mejía-Hernández, Jorge Luis Almazán, Leonor Pérez-Martínez, Gustavo Pedraza-Alva, Emilio J. Galván, Angélica Zepeda

“…In most cases, autism is considered idiopathic, involving alterations in numerous genes whose functions are not extensively documented. We evaluated the C58/J mouse strain as an idiopathic model of ASD, emphasizing synaptic transmission as the basis of information processing. …”
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Lactylation‐Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib by Runyu Dong, Yao Fei, Yiren He, Peng Gao, Bo Zhang, Menglin Zhu, Zhixiong Wang, Longfei Wu, Shuai Wu, Xiaoming Wang, Juan Cai, Zhiqiang Chen, Xueliang Zuo

“…Mechanistically, HECTD2 functions as an E3 ubiquitin ligase of KEAP1, which contributes to the degradation of KEAP1 protein. …”
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Design of Ricker Wavelet Neural Networks for Heat and Mass Transport in Magnetohydrodynamic Williamson Nanofluid Boundary-Layer Porous Medium Flow with Multiple Slips by Zeeshan Ikram Butt, Muhammad Asif Zahoor Raja, Iftikhar Ahmad, Muhammad Shoaib, Rajesh Kumar, Syed Ibrar Hussain

“…The solver employs a hybrid approach that combines genetic algorithms, serving as a global search method, with sequential quadratic programming, which functions as a local optimization technique. The heat and mass transportation effects are examined through a stretchable surface with radiation, thermal, and velocity slip effects. …”
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Comprehensive observation of trichome development in Micro-tom tomato by Jiang Chang, Jie Yang, Jianfeng Wang, Shuang Wu

“…With seven morphologically and functionally different types, tomato trichomes are more complex than the unicellular trichomes in Arabidopsis. …”
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer by Haoge Luo, Liping Liu, Xiaoping Liu, Yingdong Xie, Xin Huang, Ming Yang, Chen Shao, Dong Li

“…Mechanistically, nuclear IL-33 primarily functions as a transcriptional co-activator of homologous recombination repair (HRR) genes, whereas the active form of IL-33 can drive the non-homologous end joining (NHEJ) pathway via the canonical IL-33/ST2 axis. …”
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Readability Formulas for Elementary School Texts in Mexican Spanish by Daniel Fajardo-Delgado, Lino Rodriguez-Coayahuitl, María Guadalupe Sánchez-Cervantes, Miguel Ángel Álvarez-Carmona, Ansel Y. Rodríguez-González

“…Readability formulas are mathematical functions that assess the ‘difficulty’ level of a given text. …”
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Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery by Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun

“…Promising nucleic acid drugs have shown the potential to exert precise effects at the molecular level, with different classes of nucleic acids having regulatory functions through varying mechanisms. For the better delivery of nucleic acids, safe and effective viral vectors and non‐viral delivery systems (including liposomes, polymers, etc.) have been intensively explored. …”
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Influence of Scaffold Structure and Biomimetic Properties on Adipose Stem Cell Homing in Personalized Reconstructive Medicine by Doina Ramona Manu, Diana V. Portan, Monica Vuţă, Minodora Dobreanu

“…Human adipose stem cells (ASCs) are multipotent cells expressing mesenchymal stem cell (MSC) markers that are capable of multilineage differentiation and secretion of bioactive factors. …”
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Opioid drug seeking after early-life adversity: a role for delta opioid receptors by Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler

“…We further identify delta opioid receptors (DOR), which mature in the first week of life and thus later than kappa or mu opioid receptors, as a potential mediator of ELA's impacts on reward circuit functions. Accordingly, DOR mRNA in NAc was persistently reduced in adult females with ELA history. …”
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Multivariate statistical analysis of the work stress phenomenon in schoolteachers during the current pandemic context in Chile by Alexis Matheu Pérez, Marcelo Muñoz, Natalia Escobar, Ignacio Irarrazabal Santana, Andrés Loyola Figueroa, Paola Juica Martínez, Macarena Dehnhardt

“…The work overload affects the physical and mental functioning of the teachers, so it can be deduced that, as the days go by and with little improvement in the pandemic, greater mental exhaustion could appear. …”
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INTRODUCTION AND UTILIZATION OF A SOLAR POWERED HYDROPONIC AUTOMATIC NUTRITION SYSTEM (AIROPONIK) AS A SMART AGRICULTURAL SOLUTION FOR HOUSEHOLD-SCALE FARMING IN PANDEREJO VILLAGE... by Muhammad Aldo Setiawan, Rizki Putra Prastio, Saddam Al Fattah Putra, Abdullah Al Masyhur, Muhammad Sandi Saepudin

“…In addition to the functionality of the Airoponik system, its compact, suitcase-style design facilitates easy installation and adjustment of the device in space-constrained environments. …”
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