596 Becoming multilingual in thought languages by Colin Hoffman, Mary Bevilacqua, Brian Weaver

“…Objectives/Goals: Understanding cognitive habits and values of individuals or groups, and providing tools to apply them to collaborative, interdisciplinary endeavors to better communicate between different industries, functions, and cultures. Methods/Study Population: Using literary research to establish groupings of common core values in interpersonal communications, applying established 5 patterns of “thought languages” to scale to group communications. …”
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Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells. by Adam G Grieve, Rachel D Daniels, Elena Sanchez-Heras, Matthew J Hayes, Stephen E Moss, Karl Matter, Martin Lowe, Timothy P Levine

“…The effect of OCRL1 in epithelial maturation is seen more strongly in 3-dimensional cultures, where epithelial cells lacking OCRL1 not only fail to form a central lumen, but also do not have the correct intracellular distribution of ZO-1, suggesting that OCRL1 functions early in the maturation of intercellular junctions when cells grow as cysts. …”
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A Discourse Analysis of Radio Call ins In Runyankore-Rukiga. by Niwamanya, Diana

“…By analyzing the structure of these conversations, we identify patterns and functions of discourse markers, such as turn-taking, topic shifts, and signaling agreement or disagreement. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Mechanistically, CD25-biased IL-2cx selectively stimulated expansion and effector functions of tumor-specific CD8+ T cells in a CD25-dependent manner, overcoming Treg cell-mediated suppression. …”
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Integrative analysis of signaling and metabolic pathways, immune infiltration patterns, and machine learning-based diagnostic model construction in major depressive disorder by Lei Tang, Liling Wu, Mengqin Dai, Nian Liu, Lu liu

“…GSVA and immune infiltration results indicate that patients with MDD exhibit differences from normal individuals in various aspects, including biological processes, signaling pathways, metabolic processes, and immune cells. To investigate the functions and biological significance of differentially expressed genes in MDD patients, we performed GO and KEGG enrichment analyses on the differentially expressed genes from five databases (GSE98793, GSE32280, GSE38206, GSE39653, and GSE52790). …”
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MYOCARDIAL PERFUSION ASSESSMENT IN FORECASTING EFFECT OF CORONARY ANGIOPLASTY IN PATIENTS WITH ISCHEMIC CHRONIC HEART FAILURE by A. B. Mironkov, V. V. Chestukhin, F. A. Blyakhman, T. F. Shklyar, E. N. Ostroumov, Е. D. Kotina, S. A. Sakhovsky, E. T. Asoev, B. L. Mironkov

“…Critical size for definition of the favorable forecast of revascularization are 60% and more perfusion defects testifying that in a cardiac muscle the focal cardiosclerosis prevails over the functioning myocardium.…”
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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…We have identified subsets of astrocytes and analyzed their functions. The differentiation trajectory of astrocyte subtypes was explored using Monocle2. …”
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Transcriptome analysis revealed that AcWRKY75 transcription factor reduced the resistance of kiwifruit to Pseudomonas syringae pv. actinidiae by Lixia Ye, Minmin Luo, Yafang Wang, Yafang Wang, Mengqi Yu, Mengqi Yu, Zhi Wang, Fuxi Bai, Xuan Luo, Li Li, Qiong Huang, Jue Peng, Qi Chen, Qinghong Chen, Lei Gao, Lei Zhang

“…Subcellular localization and transcriptional activity analysis confirmed that AcWRKY75 functions as a nucleus-located transcriptional activator. …”
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Trispecific SEED antibodies engineered for neutrophil-mediated cell killing by Veronica Natale, Gergely Heves, Katharina Stadlbauer, Florian Rüker, Vanessa Siegmund, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Stefan Becker, Gordana Wozniak-Knopp

“…The latter is particularly advantageous for bi- and multispecific antibody formats, which are unparalleled in their enhanced selectivity and unique biological functions. We engineered bispecific heterodimeric IgA-based antibodies using the strand-exchanged engineered domain (SEED) technology, which relies on intertwined segments of IgA and IgG in the CH3 domain, and applied mutagenesis to introduce two additional binding sites to enable the interaction of IgA-Fc with the myeloid cell-activating receptor CD89 (FcαR). …”
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Debatable positions of DSM-V and new forms of the organization of the psychiatric help for patients with endogenic mental disorders by A. P. Kotsiubinsky, B. G. Butoma

“…One of them could become a complex «a round-the-clock hospital (with the open doors) - a day time hospital» which, in turn, can exist within the limits of the Mental Health Center functioning in structure of V. M. Bekhterev Psychoneurological Institute, where patients at a stage of preillness could address, being observed in the further, in case of need, and at the other stages of mental disorders. …”
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Mutual Synchronization of Antiferromagnetic Spintronic Oscillators by A. Yu. Mitrofanova, A. R. Safin, O. V. Kravchenko, S. A. Nikitov

“…A system of Kuramoto equation for the phases of partial oscillators under the influence of the inertial term and phase shift was obtained. Expressions describing the locking and synchronization band as functions of the system parameters (bias currents and sizes) were derived. …”
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On the non-parametric changepoint detection of flow regimes in cyclone Amphan by Venkat Shesu Reddem, Venkata Jampana, Ravichandran Muthalagu, Venkateswara Rao Bekkam, Pattabhi Rama Rao Eluri, Srinivasa Kumar Tummala

“…The segmentations can considerably simplify the parametrization schemes when expressed as linear functions. Moreover, the usefulness of non-parametric automatic detection of data segments of similar statistical properties shall be more apparent when dealing with relatively long time series data.…”
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High Sensitivity L‐Cysteine Indium Telluriselenide Quantum Dot‐Inspired Aptasensor for Interferon Gamma TB Biomarker by Kaylin Cleo Januarie, Usisipho Feleni, Candice Cupido, Nelia Abraham Sanga, Rachel Fanelwa Ajayi, Emmanuel Iheanyichukwu Iwuoha, Marlon Oranzie, Jaymi Leigh January, Zandile Dennis Leve

“…The sensor system consists of gold disc electrode surface that was modified with novel L‐cysteine‐functionalized indium telluriselenide quantum dots (L‐cysteine‐InTeSe QD). …”
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IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro by Yiping Lu, Fangwei Liu, Chao Li, Ying Chen, Dong Weng, Jie Chen

“…Our findings demonstrated that B10 could affect Th responses by the release of IL-10, enhancing Treg functions and converting Teff into Treg.…”
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The anticancer thiosemicarbazone triapine exerts immune-enhancing activities via immunogenic cell death induction and FAS upregulation by Bianca Stiller, Alessia Stefanelli, Hemma Schueffl, Marlene Mathuber, Nadiya Skorokhyd, Judith Gufler, Christine Pirker, Martin Holcmann, Rostyslav Panchuk, Maria Sibilia, Doris Marko, Walter Berger, Christian R. Kowol, Sonja Hager, Petra Heffeter

“…Noteworthy, while radiotherapy induces an immune-activating cell death, so called immunogenic cell death (ICD), cisplatin possesses immunomodulatory and ICD-enhancing functions. Interestingly, although there are several indications that suggest that Triapine could also enhance the immune recognition of cancer cells, no investigations in this direction have been reported so far. …”
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Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum by Qian Xiu, Xiaoru Yin, Yuanyuan Chen, Ziyang Zhang, Yushuai Mao, Tianshi Wang, Jie Zhang, Mingguo Zhou, Yabing Duan

“…These findings indicate that the deficiencies in FgDHODHII are functionally equivalent to complete inhibition of its activity by quinofumelin. …”
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<i>Trypanosoma cruzi</i>: Genomic Diversity and Structure by Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Núria Gironès, Manuel Fresno

“…Trans-sialidases are the most prevalent genes in the genome with a key role in the infection process, while mucins and MASPs are also significant glycosylated proteins expressed on the parasite surface, essential for its biological functions, as host–parasite interaction, host cell invasion or protection against the host immune system, in both insect and mammalian stages. …”
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Increased Levels of Soluble ST2 in Patients with Active Newly Diagnosed ANCA-Associated Vasculitis by Z. Hladinova, Z. Hruskova, B. Svobodova, K. Malickova, V. Lanska, P. Konopásek, E. Jancova, R. Rysava, C. L. Edelstein, V. Tesar

“…ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. …”
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Utilizing an Enhanced YOLOv8 Model for Fishery Detection by Hanyu Jiang, Jiacheng Zhong, Fuyu Ma, Cheng Wang, Ruiwen Yi

“…Additionally, we introduced the Channel Aggregation Efficient Downsampling Block (CAEDB) for more efficient upsampling and to improve the network’s expressive power and information flow through channel aggregation functionality. …”
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Exploring the roles of ncRNAs in prostate cancer via the PI3K/AKT/mTOR signaling pathway by Rongwang Guo, Liji Shi, Yonghui Chen, Canling Lin, Weihua Yin

“…In this paper, we summarize the types of ncRNAs that are associated with the PAM pathway in PCa cells as well as the functions and clinical roles of these ncRNAs in PCa. …”
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