Simulation game-based learning for cognitive apprenticeship development: a focus on processing speed by Patcharabhorn Sounthornwiboon, Khwanying Sriprasertpap, Prachyanun Nilsook

“…Future implications include expanding SGBL with AR/VR and multiplayer functions to enhance engagement and applicability.…”
Get full text

The QDπ dataset, training data for drug-like molecules and biopolymer fragments and their interactions by Jinzhe Zeng, Timothy J. Giese, Andreas W. Götz, Darrin M. York

“…The QDπ dataset enables creation of flexible target loss functions for neural network training relevant to drug discovery, including information-dense data sets of relative conformational energies and barriers, intermolecular interactions, tautomers and relative protonation energies of drug-like compounds and biomolecular fragments. …”
Get full text

Play in Children with Autism – Parents and Professionals’ Perception by Jovana Đokić, Mirjana Đorđević, Nenad Glumbić, Aleksandra Đurić-Zdravković

“…It helps them better understand the world around them, express their emotions, refine motor skills, and develop essential life skills. …”
Get full text

Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer by Harrison J. Boka, Rebekah M. Engel, Christine Georges, Paul J. McMurrick, Helen E. Abud

“…In response, recent analyzes, including those utilizing whole genome sequencing, transcriptional profiling, and single-cell analyses, have demonstrated that key molecular differences exist between disease sites, with differentially expressed genes spanning a diverse range of cellular functions. …”
Get full text

Temperature Proxies as a Solution to Biased Sampling of Lake Methane Emissions by Joachim Jansen, Brett F. Thornton, Martin Wik, Sally MacIntyre, Patrick M. Crill

“…Temperature proxies based on Arrhenius functions that closely fit measured fluxes (R2 ≥ 0.93) enable gap filling the colder months of the ice‐free season and reduce sampling bias. …”
Get full text

Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice by Anindya Ghosh, Isabelle Chénier, Yat Hei Leung, Abel K. Oppong, Marie-Line Peyot, S. R. Murthy Madiraju, Irina Al-Khairi, Jehad Abubaker, Fahd Al-Mulla, Marc Prentki, Mohamed Abu-Farha

“…Summary: Angiopoietin-like protein 8 (Angptl8), expressed in the liver and adipocytes, forms a complex with Angptl3 or Angptl4, which regulates lipoprotein lipase and triglyceride metabolism. …”
Get full text

Proteomic Analysis of <i>Listeria monocytogenes</i> Subjected to Pulsed Magnetic Field by Di Chen, Jingya Qian, Shuhao Huo, Feng Wang, Haile Ma, Shan Liu

“…The disruption of cellular functions and metabolic pathways may contribute to the death of <i>L. monocytogenes</i> under PMF treatment. …”
Get full text

Cathelicidins Limit Intracellular <i>Neospora caninum</i>-Infection in Macrophages by Franco Fiorani, Priyoshi Lahiri, Rodrigo Puentes, Peter John Bradley, Dadin Prando Moore, Eduardo Ruben Cobo

“…Cathelicidins are host defense peptides known for their antimicrobial and immunomodulatory functions, but their role in <i>N. caninum</i> infections remains elusive. …”
Get full text

Conformal leptogenesis in composite Higgs models by Kaustubh Agashe, Peizhi Du, Majid Ekhterachian, Chee Sheng Fong, Sungwoo Hong, Luca Vecchi

“…This exotic mechanism, which we call Conformal Leptogenesis, admits a reliable description in terms of a set of “Boltzmann equations” whose coefficients can be expressed in terms of correlation functions of the CFT. …”
Get full text

Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke by Laetitia Thieren, Henri S. Zanker, Jeanne Droux, Urvashi Dalvi, Matthias T. Wyss, Rebecca Waag, Pierre-Luc Germain, Lukas M. von Ziegler, Zoe J. Looser, Ladina Hösli, Luca Ravotto, E. Dale Abel, Johannes Bohacek, Susanne Wegener, L. Felipe Barros, Mohamad El Amki, Bruno Weber, Aiman S. Saab

“…Sensorimotor and memory functions remain intact in male GLUT1 cKO mice, indicating that GLUT1 loss does not impair behavior. …”
Get full text

The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease by Paula Peruzzi Elia, Yolanda Faia M. Tolentino, Claudio Bernardazzi, Heitor Siffert Pereira de Souza

“…These innate immunity receptors exhibit complementary biological functions, with evidence for pathways overlapping. …”
Get full text

Targeted macrophage mannose receptor (CD206)-specific protein delivery via engineered extracellular vesicles by Leyla A. Ovchinnikova, Daria Y. Tanygina, Samir S. Dzhelad, Evgeniy G. Evtushenko, Dmitriy V. Bagrov, Alexander G. Gabibov, Yakov A. Lomakin

“…We demonstrated that nanobody-functionalized EVs exhibit enhanced interaction and increased uptake by CD206+ cells compared to non-targeted EVs. …”
Get full text

Single‐Nucleus and Spatial Transcriptome Profiling Delineates the Multicellular Ecosystem in Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy by YeXing Huang, ZeFeng Du, ZhiCheng Lai, DongSheng Wen, LiChang Huang, MinKe He, ZiChao Wu, HuiFang Li, HanYue OuYang, WenChao Wu, Anna Kan, Ming Shi

“…Specifically, intermediate exhausted CD8+ T cells expressing Granzyme‐K and PD‐1 (PD‐1+CD8+ Tex‐int) expanded following HAIC and exhibited a functionally antitumor phenotype. …”
Get full text

Proteomics‐Empowered Microfluidic‐SERS Immunoassay for Identifying and Detecting Biomarkers of Micropapillary Lung Adenocarcinoma by Dechun Zhang, Kaiming Peng, Hui Xu, Yanping Chen, Jing Wang

“…To enable sensitive, multiplex detection of 4 upregulated DEPs, the nanomixing effect is leveraged to enhance target protein‐SERS barcode interactions while minimizing nonspecific binding to antibody‐functionalized gold electrodes. The SERS barcode cocktail allows simultaneous detection of the 4 selected DEPs. …”
Get full text

Free Vibration Analysis of Thick Rectangular and Elliptical Plates with Concentric Cut-Out by Anjibabu Merneedi, Nalluri Mohan Rao, L. Natrayan, L. Yuvaraj, Prabhu Paramasivam

“…The modified Independent Coordinate Coupling Method (ICCM) is validated with FEM package (ANSYS) and applied to know the change in eigenvalues for a plate with cut-out by varying various parameters like aspect ratios, cut-out size, and thickness ratios. Trigonometric functions considered at the boundary level conditions of a simply supported plate should be satisfied. …”
Get full text

An Environmentally-Friendly RNAi Yeast-Attractive Targeted Sugar Bait Turns off the <i>Drosophila suzukii Rbfox1</i> Gene by Keshava Mysore, Jackson Graham, Saisuhas Nelaturi, Teresia M. Njoroge, Majidah Hamid-Adiamoh, Akilah T. M. Stewart, Longhua Sun, Molly Duman-Scheel

“…Laboratory trials demonstrated that the RNAi yeast can be mixed with soda, which functions as SWD attractive targeted sugar bait (ATSB) that can be delivered in a soda bottle feeder. …”
Get full text

Primary headaches and cognitive disorders — pathophysiologically associated and comorbidity conditions. by D. A. Iskra, V. Yu. Lobzin, S. A. Kalygin

“…Primary headaches (migraine, tension-type headache and other primary headaches) cause 3% of all disability cases in adult population, fully decrease possibilities of social functioning. Te phenomenon of the central sensitization is one of the fundamental pathophysiological units of primary headaches. …”
Get full text

On the Flow Behavior in Rotor-Stator System with Superposed Flow by Roger Debuchy, Fadi Abdel Nour, Gérard Bois

“…Thus, two innovative weighting functions are tested, leading to new analytical laws relating the core swirl ratio K to the coefficient of flow rate Cqr introduced by Poncet et al. (2005). …”
Get full text

HTLV-I Basic Leucine Zipper Factor (sHBZ) Actively Associates with Nucleophosmin (B23) in the Nucleolus by Nahid Moghadam, Yong Xiao, Francois Dragon, Benoit Barbeau

“…Our previous study has shown that sHBZ colocalizes and associates with Nucleophosmin/B23, a nucleolar phosphoprotein with multiple functions. In this study, through an optimized nucleolar isolation method, we first confirmed sHBZ’s nucleolar localization via Western blotting in transfected HEK293T cells, chronically HTLV-1-infected T cell lines, and freshly infected HeLa cells. …”
Get full text

Molecular and Physiological Responses of <i>Litopenaeus vannamei</i> to Nitrogen and Phosphorus Stress by Qianqian Zhao, Cun Wei, Jiangling Dou, Yue Sun, Qifan Zeng, Zhenmin Bao

“…Environmental stressors such as nitrogen and phosphorus play a critical role in regulating the growth and physiological functions of <i>Litopenaeus vannamei</i>, a key species in aquaculture. …”
Get full text