The hematopoietic function, histological characteristics, and transcriptome profiling of Wanxi white geese ovary during nesting and late-laying stages by Chunfang Zhao, Tao Jin, Kefeng Yang, Xinyu Liu, Man Ren, Deyong She, Qianqian Hu, Shenghe Li

“…RNA-Seq was utilized to identify the differentially expressed mRNAs (DEGs) and lncRNAs (DE lncRNAs) in the ovarian tissues associated with nesting in geese during the late-laying and nesting periods. …”
Get full text

C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis by Renan Pereira de Lima, Ang Li, Ankit Gilani, Alfonso Rubio-Navarro, Charles D. Warren, Isabella Y. Kong, Jacob B. Geri, James C. Lo

“…Conclusions: These findings indicate that C3aR1 expression on β cells is necessary to maintain optimal β cell function and preserve β cell mass in T2D.…”
Get full text

ExermiR‐129‐3p Enhances Muscle Function by Improving Mitochondrial Activity Through PARP1 Inhibition by Yeo Jin Shin, Jae Won Yang, Heeyeon Jeong, Joyeong Kim, Bora Lee, Ji‐Won Kim, Seung‐Min Lee, Ju Yeon Kwak, Young Hoon Son, Kap Jung Kim, Yong Ryoul Yang, Chuna Kim, Ki‐Sun Kwon, Kwang‐Pyo Lee

“…However, not all patients are capable of engaging in exercise to maintain muscle function, which underscores the importance of identifying molecular mechanisms of physical training that could lead to the discovery of exercise‐mimicking molecules. …”
Get full text

Transcriptional analysis of maize elite inbred line Jing24 and the function of ZmMAPKKK21 in the response to drought stress by Wen Ren, Zi Shi, Yongxin Zhao, Qian Zhang, Miaoyi Zhou, Chen Cheng, Mengyuan Liu, Bingbing Zhao, Yuhui Guo, Hewei Du, Xiaozeng Yang, Ya Liu

Get full text

RGD-Functionalized Ginsenoside Rg3 Liposomes for Alleviating Oxidative Stress and Choroidal Neovascularization in Age-Related Macular Degeneration by Zhou J, Zhao D, Niu S, Meng W, Chen Z, Li H, Liu Y, Zou L, Li W

Get full text

Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment by Qing Liu, Ye Sun, Baodong He, Haodong Chen, Lijing Wang, Gaojie Wang, Kang Zhang, Ximeng Zhao, Xinzhe Zhang, Dongchao Shen, Xue Zhang, Liying Cui

“…These findings implicate the gain-of-function ANXA11 mutation drives late-onset motor neuron disease by early presymptomatic proteinopathy, progressive neuronal degeneration, neuroinflammation, and autophagic dysfunction.…”
Get full text

Sodium thiosulfate does not affect energy metabolism or organ (dys)function during resuscitation from murine trauma-and-hemorrhage by Maximilian Feth, Mirabel Gracco, Michael Gröger, Melanie Hogg, Sandra Kress, Andrea Hoffmann, Enrico Calzia, Ulrich Wachter, Peter Radermacher, Tamara Merz

“…Mitochondrial function was determined using high-resolution respirometry, and tissue target proteins (nitrotyrosine formation, extravascular albumin accumulation, CSE expression) were analyzed using immunohistochemistry. …”
Get full text

Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation by Reini E N van der Welle, Rebekah Jobling, Christian Burns, Paolo Sanza, Jan A van der Beek, Alfonso Fasano, Lan Chen, Fried J Zwartkruis, Susan Zwakenberg, Edward F Griffin, Corlinda ten Brink, Tineke Veenendaal, Nalan Liv, Conny M A van Ravenswaaij‐Arts, Henny H Lemmink, Rolph Pfundt, Susan Blaser, Carolina Sepulveda, Andres M Lozano, Grace Yoon, Teresa Santiago‐Sim, Cedric S Asensio, Guy A Caldwell, Kim A Caldwell, David Chitayat, Judith Klumperman

“…In a C. elegans model of Parkinson’s disease, co‐expression of VPS41S285P/VPS41R662* abolished the neuroprotective function of VPS41 against α‐synuclein aggregates. …”
Get full text

High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironmentResearch in context by Jiachen Liu, Zhen Shi, Yajian Li, Jie Ma, Jiaying Yao, Zan Yuan, Yuanhao Wang, Chunyuan Yang, Xiao Li, Nianzeng Xing, Yunping Zhu, Jianhong Zhang, Li Wu

“…Furthermore, our study demonstrates that TREM2 and APP function as immune-modulating molecules, with potential therapeutic implications in the context of bladder cancer. …”
Get full text

The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function by Jingjing Wang, Jinlong Qie, Danrong Zhu, Xuemei Zhang, Qingqing Zhang, Yuyu Xu, Yipeng Wang, Kai Mi, Yang Pei, Yang Liu, Guozhong Ji, Xingyin Liu

“…The level of Amyloid-β (Aβ) and brain-derived neurotrophic factor (BDNF) related to neural function showed increased and decreased with aging, respectively. …”
Get full text

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women by Madhuri S. Salker, Nor Haslinda Abd Aziz, Natalia Carman Prodan, Zhiqi Yang, Aditya Kumar Lankapalli, Katrin Lazar, Mohamad Nasir Shafiee, Ersoy Kocak, Ersoy Kocak, Harivignesh Ganesan, Surya Sekhar Pal, Omer Khalid, Norhana Mohd Kasim, Aida Kalok, Norashikin Abdul Fuad, Alfred Lennart Bissinger, Tina Ganzenmueller, Thomas Iftner, Karl Oliver Kagan, Stephan Ossowski, Stephan Ossowski, Nicolas Casadei, Nicolas Casadei, Sara Y. Brucker, Olaf Riess, Olaf Riess, Yogesh Singh, Yogesh Singh, Yogesh Singh, Deutsche COVID-19 OMICS Initiative (DeCOI)

“…Several gene pathways associated with cytotoxic function, interferon signalling type I & II, and pro- and anti-inflammatory functions in NK and CD8+ cytotoxic T cells were attenuated in recovered pregnant patients compared with healthy pregnancies. …”
Get full text

Maximizing Tax Revenue for Profit-Maximizing Monopolist with the CES Production Function and Linear Demand as a Stackelberg Game Problem by Zrinka Lukač, Krunoslav Puljić, Vedran Kojić

“…Since the solution for a general case with an arbitrary degree of homogeneity cannot be determined explicitly, analytical expressions for the tax revenue function, profit function, optimal tax rates, and optimal input levels are derived for scenarios with degrees of homogeneity set to values 0.5 for decreasing and 1 for constant returns to scale. …”
Get full text

Effects of two different variants in the MAGT1 gene on B cell subsets, platelet function, and cell glycome composition by Lucía del Pino Molina, Elena Monzón Manzano, Carla Gianelli, Carla Gianelli, Luz Yadira Bravo Gallego, Luz Yadira Bravo Gallego, Luz Yadira Bravo Gallego, Javier Bujalance Fernández, Paula Acuña, Yolanda Soto Serrano, Keren Reche Yebra, María Bravo García-Morato, María Bravo García-Morato, María Bravo García-Morato, Elena Sánchez Zapardiel, Elena Sánchez Zapardiel, Elena G. Arias-Salgado, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Nora Butta, Eduardo López Granados, Eduardo López Granados, Eduardo López Granados

“…A de novo variant c.97_98 delinsC affecting one member of one family and three members of a second family presented the hemizygous variant c.80``3G>A, p.Trp268Ter, causing a premature stop codon.MethodsWe performed a functional validation of these two variants in the MAGT1 gene and their association with decreased NKG2D expression, uncontrolled EBV viremia, and the development of lymphoma-associated complications in three members of the same family.ResultsWe analyzed the B-cell compartment, we found that the B-cell expansion is driven by immature/transitional (CD5- and CD5+) and naïve B cells. …”
Get full text

Cetylpyridinium chloride disrupts maternal-to-zygotic transition during early embryonic development by impairing mitochondrial function and histone modification by Caiyun Wu, Zhiming Ding, Xuanxi Li, Yan Xu, Huilei Chen, Hongzhen Ruan, Ping Zhou, Zuying Xu, Huifen Xiang

“…Functional enrichment analysis further revealed that DEGs were significantly involved in pathways and processes related to mitochondrial function, ROS, and gene transcription. …”
Get full text

The ERF transcription factor TaERF13-2B functions as a negative regulator of drought tolerance in Arabidopsis and wheat by Yang Yu, Yang Yu, Yang Yu, Conglei Wang, Jianhe Wang, Qingfen Xu, Shuangxing Zhang, Tianqi Song, Guodong Li, Dan Liang, Gang Feng, Gang Feng

“…Ethylene response factors (ERFs) are transcription factors that are essential in modulating drought stress responses in plants such as Arabidopsis and rice. However, the functional role of ERF in wheat drought stress response remains unclear. …”
Get full text

Meijer-G Function With Continued Product and Integer Exponent: Performance of Multi-Aperture UOWC System Over EGG Turbulence by Arvind Kumar, Nikumani Choudhury, Jayendra N. Bandyopadhyay, S. M. Zafaruddin

“…We also approximate the performance of a multi-aperture UOWC system with i.i.d. channels using the single-variate Fox-H function. Using the generalized approach, we present analytical expressions for average bit-error rate (BER) and ergodic capacity for the considered system operating over exponential–generalized gamma (EGG) oceanic turbulence combined with zero-boresight pointing errors. …”
Get full text

Bjorken and threshold asymptotics of a space-like structure function in the 2D U(N) Gross-Neveu model by Yizhuang Liu

“…Hard and non-perturbative scaling functions are naturally generated in their Borel representations with detailed enumerations and explicit expressions provided to all powers. …”
Get full text

‘It’s such a blackbox function’: Norwegian academic librarians’ ambivalent perceptions towards AI use in academic libraries and academia by Idunn Bøyum, Mahmood Khosrowjerdi

Get full text

Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice by Yasuhiro Nemoto, Ryo Morikawa, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Kento Takenaka, Kazuo Ohtsuka, Xigui Chen, Hitoshi Okazawa, Ryuichi Okamoto, Mamoru Watanabe, Ulrich H. von Andrian

“…Functionally, the presentation of intestinal antigens by DNT cells tolerizes antigen-specific naive CD4+ T cells, with this tolerization reversed by conditional ablation of MHC-II in T cells, thereby rendering mutant mice hypersusceptible to intestinal inflammation. …”
Get full text

A sigmoid-function-based method for modeling and bifurcation analysis of power electronics converters with multiple switching-state combinations by Zhihong Yin, Yimin Lu, Xuefei Wei

“…To address these issues, this paper proposes a modeling and bifurcation analysis method based on the sigmoid function. First, a sigmoid function with a large steepness factor is used to accurately fit all discrete switching variables, establishing a model that can uniformly describe all switching-state combinations. …”
Get full text