Deciphering the secret codes in N7‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases by Huan Fang, Jing He, Dan Du, Xue Wang, Xinyu Xu, Linping Lu, Yefan Zhou, Yangyang Wen, Fucheng He, Yingxia Li, Hongtao Wen, Mingxia Zhou

“…This review describes the various biological functions of METTL1, summarises recent advances in understanding its pathogenic and disease‐suppressive functions and discusses the underlying molecular mechanisms. …”
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VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation by Baoji Hu, Baoji Hu, Baoji Hu, Chun-Shiang Chung, Chyna Gray, Yaping Chen, Jihong Jiang, Jihong Jiang, Jianrong Guo, Jianrong Guo, Alfred Ayala

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Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats by Nathália Dantas Duarte, Gabriel Mulinari-Santos, Fábio Roberto de Souza Batista, Marcelly Braga Gomes, Naara Gabriela Monteiro, Ana Cláudia Ervolino da Silva, Reinhard Gruber, Paulo Noronha Lisboa-Filho, Pedro Henrique Silva Gomes-Ferreira, Roberta Okamoto

“…Additionally, the gene expression of bone turnover markers was evaluated. As a main result, the functionalization with genistein increased implant removal torque and the peri-implant bone volume in the BOS + GEN group compared to both BOS and BO groups (both <i>p</i> < 0.05). …”
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The Effects of Glucagon‐Like Peptide‐1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review by Victoria J. Old, Melanie J. Davies, Dimitris Papamargaritis, Pratik Choudhary, Emma L. Watson

“…Outcomes of interest were skeletal muscle respiratory function either in the form of measurements of mass, number, content, oxidative capacity/respiratory function, mitochondrial dynamics, mitochondrial biogenesis and mitophagy. …”
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Effects of on-farm hatching versus hatchery hatching on growth performance, gut development, and intestinal health and function in broiler chickens by Muhammad Zeeshan Akram, Ester Arévalo Sureda, Matthias Corion, Luke Comer, Nadia Everaert

“…High-throughput qPCR analyzed 79 ileal genes regarding barrier integrity, immune function, nutrient transporters, gut hormones, metabolism, and oxidation. …”
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Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress by Mihai Spiridon-Bodi, Cristina Ros-Carrero, J. Carlos Igual, Mercè Gomar-Alba

“…Methods The response of Saccharomyces cerevisiae to Calcofluor White was investigated to characterize the regulation and function of Whi7 and Whi5 under cell wall stress. To control their protein levels, we used dose-dependent β-estradiol-induced expression and auxin-induced degron protein fusions. …”
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Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain by Kana Oue, Yosuke Yamawaki, Kazuhisa Ouhara, Eiji Imado, Tetsuya Tamura, Mitsuru Doi, Yoshitaka Shimizu, Mitsuhiro Yoshida, Noriyoshi Mizuno, Norimitsu Morioka, Takashi Kanematsu, Masahiro Irifune, Yukio Ago

“…Objective Both periodontal disease and obesity are risk factors for dementia, but their links to 1brain function remain unclear. In this study, we examined the effects of oral infection with a periodontal pathogen on cognitive function in a mouse model of obesity, focusing on the roles of microglia.Methods To create a mouse model of diet-induced obesity and periodontitis, male C57BL/6 J mice were first fed a high-fat diet containing 60% lipid calories for 18 weeks, beginning at 12 weeks of age, to achieve diet-induced obesity. …”
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Multi-Omics and Functional Insights into Triterpenoid Biosynthesis Pathways in <i>Neopicrorhiza scrophulariiflora</i> (Pennell) D.Y.Hong by Pinhan Zhou, Juan Wang, Chaohui Li, Lesong Li, Luyuan Duan, Weihao Wang, Xirui Liu, Khadija Tehseen Arshad, Yanli Liang, Yan Zhao

“…We functionally characterized eight upstream oxidosqualene cyclases (OSCs) involved in triterpenoid biosynthesis, among which NsOSC2 is a bifunctional enzyme capable of catalyzing the conversion of 2,3-oxidosqualene to <i>β</i>-amyrin and <i>α</i>-amyrin. …”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

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Case Report: Clinical, molecular, and functional characterization of autoimmune lymphoproliferative syndrome—a family study with a multimodal diagnosis by Bruna Cândido Guido, Ricardo Camargo, Caroliny Victoria dos Santos Silva, Anna Carolina Silva Dias, Robéria Mendonça de Pontes, Agenor de Castro Moreira dos Santos Júnior, Raquel Alves Toscano, Fabíola Scancetti Tavares, Alexandre de Albuquerque Antunes, Karina Mescouto de Melo, Karina Mescouto de Melo, Karina Mescouto de Melo

“…We report a comprehensive clinical, immunophenotypic, molecular, and functional evaluation of nine members of a consanguineous Brazilian family harboring the pathogenic FAS (NM_000043.6:c.748C &gt; T) variant. …”
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Am80‐GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia‐associated infection and mortality by Lin Li, Xiaotian Qi, Weili Sun, Hisham Abdel‐Azim, Siyue Lou, Hong Zhu, Nemani V Prasadarao, Alice Zhou, Hiroyuki Shimada, Koichi Shudo, Yong‐Mi Kim, Sajad Khazal, Qiaojun He, David Warburton, Lingtao Wu

“…Abstract Neutrophils generated by granulocyte colony‐stimulating factor (GCSF) are functionally immature and, consequently, cannot effectively reduce infection and infection‐related mortality in cancer chemotherapy‐induced neutropenia (CCIN). …”
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Functional Characterization of KNOX and BELL Genes in Temperature-Responsive Floral Morphogenesis of Passion Fruit (<i>Passiflora edulis</i>) by Xinni Jiang, Jie Miao, Weifan Zu, Ruohan Zhou, Lexin Zheng, Ying Wei, Chunmei Lai, Rongjuan Qin, Ping Zheng, Xiuqing Wei, Jiahui Xu, Yuan Qin, Xiaoping Niu

“…Yeast two-hybrid assays uncovered functional interactions between <i>PeTALE3</i>/<i>16</i>/<i>18</i>/<i>22</i>/<i>23</i>, highlighting a network governing floral thermoresilience. …”
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Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations by Xiaoyuan Zhong, Robert Mitchell, Christine Billstrand, Emma E. Thompson, Noboru J. Sakabe, Ivy Aneas, Isabella M. Salamone, Jing Gu, Anne I. Sperling, Nathan Schoettler, Marcelo A. Nóbrega, Xin He, Carole Ober

“…Results Heritability enrichment analysis suggested a shared role of immune cells in the development of both AOA and COA while highlighting the distinct contribution of lung structural cells in COA. Functional fine-mapping uncovered 21 and 67 credible sets for AOA and COA, respectively, with only 16% shared between the two. …”
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Ontogeny and function of the intestinal epithelial and innate immune cells during early development of chicks: to explore in ovo immunomodulatory nutrition by Habtamu Ayalew, Changchun Xu, Assefa Adane, Astrid Lissette Barreto Sanchez, Siman Li, Jing Wang, Shugeng Wu, Kai Qiu, Guanghai Qi, Haijun Zhang

“…However, their effectiveness influenced with their developmental and functional stages during pre and post hatch periods of chick. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…Methods To evaluate the regulative roles of CrF‐EVs on lymphatic functions, in vitro assays were performed using human lymphatic endothelial cells (HLECs). …”
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A study on the function of methionine in growth, immunity, antioxidant, endoplasmic reticulum stress and apoptosis of largemouth bass (Micropterus salmoides) by Hualiang Liang, Dongyu Huang, Mingchun Ren, Lu Zhang, Haifeng Mi, Ahmed Mohamed Aboseif, Chunyu Xue, Jiaze Gu

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Unraveling the mechanisms of propofol-induced psychological dependence: a multi-omics approach linked to gut microbiota in hippocampal function by Li Wang, Tangyi Wang, Yadian Lei, Yadian Lei, Yudong Su, Yuxin Lin, Zhijing Wu, Qiong Wu, Qiong Wu, Qiong Wu, Shoude Zhang, Haiyan Wang, Haiyan Wang, Haiyan Wang

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Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation by Yangbai- Lu, Jinfeng- Wu, Xianzhe Li, Xianzhe Li, Qu- Leng, Jian- Tan, Hongxing- Huang, Rui- Zhong, Zhenjie- Chen, Yongxin- Zhang

“…Additionally, in vitro cellular functional experiments, we knocked down SNHG9 that is the most significantly differentially expressed ClncRNA among the three key ClncRNAs. …”
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Oncolytic adeno-immunotherapy improves allogeneic adoptive HER2.CAR-NK function against pancreatic ductal adenocarcinoma by Greyson Biegert, Amanda Rosewell Shaw, Daisuke Morita, Caroline Porter, Ryu Matsumoto, Lisa Jatta, Noah Crooks, Mae Woods, Qizhi Cathy Yao, Robin Parihar, Masataka Suzuki

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Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer by Lijuan Wang, Lidan Hu, Jing Sun, Jianhui Zhao, Siyun Zhou, Lexin Liu, Wei Yu, Yeting Hu, Dan Zhou, Xiangrui Meng, Zhongshang Yuan, Honghe Zhang, Susan Farrington, Maria Timofeeva, Kefeng Ding, Julian Little, Malcolm Dunlop, Evropi Theodoratou, Xue Li

“…Then, functional experiments in (i) CRC cell lines and (ii) tumor xenografts were conducted to examine potential underlying mechanisms involved in colorectal carcinogenesis. …”
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