Finding order in measuring disorders: Measurement Uncertainty of Thyroid Function Tests at a tertiary care hospital in Eastern India by Asis Bhattacharya, Kasturi Mukherjee, Arkajit Dasgupta, Debi Mallick, Mousumi Mukhopadhyay

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Discovery of candidate functional non-coding mutations in acute myeloid leukemia using single-cell chromatin accessibility sequencing by Ming Zhu, Jiali Zhu, Zhijuan Zhu, Yiding Yang, Jinxian Dai, Hua Li, Nainong Li, Jialiang Huang

“…Importantly, we pinpoint candidate functional non-coding mutations that associate with alteration of target gene expression in AML. …”
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Enhanced Production and Functional Characterization of Recombinant Equine Chorionic Gonadotropin (rec-eCG) in CHO-DG44 Cells by Munkhzaya Byambaragchaa, Sei Hyen Park, Myung-Hum Park, Myung-Hwa Kang, Kwan-Sik Min

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Gelatin/Cerium-Doped Bioactive Glass Composites for Enhancing Cellular Functions of Human Mesenchymal Stem Cells (hBMSCs) by Andrey Iodchik, Gigliola Lusvardi, Alfonso Zambon, Poh Soo Lee, Hans-Peter Wiesmann, Anne Bernhardt, Vera Hintze

“…Here, novel cerium-doped mesoporous BG microparticles (Ce-MBGs) with different cerium content were included in photocrosslinkable, methacrylated gelatin (GelMA) for promoting cellular functions of human mesenchymal stem cells (hBMSCs). …”
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Establishment of a lupus-prone mouse model of pulmonary arterial hypertension with intermittent hypoxia: functional, biochemical and histological verifications by Dengfeng Wu, Jiangbiao Xiong, Yiping Huang, Yue Yuan, Shunjia Xing, Rui Wu

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Dual functions of silibinin in attenuating aortic dissection via regulating iron homeostasis and endoplasmic reticulum stress against ferroptosis by Zhen Qi, Qiu-Guo Wang, Meng-Xi Huang, Yi-Fan Zeng, Jing-Yu Li, Zhi-Cheng Duan, Ling Tan, Hao Tang

“…SIL treatment enhanced cell viability and mitochondrial function while reducing reactive oxygen species (ROS) generation and mitigating ferroptosis in primary human aortic smooth muscle cells (HASMCs) induced by RSL3 or IKE. …”
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Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study by Zehao Wang, Tianlun Yu, Yuqiao Liu, Yufan Wu, Jingqing Hu, Jingqing Hu

“…BackgroundPalmitoylation, a critical post-translational modification, regulates protein localization and function in cancer. However, its role in glioma progression, immune modulation, and prognosis remains poorly understood.MethodsWe integrated transcriptomic, clinical, and mutation data from multicenter cohorts to analyze 30 palmitoylation-related genes in low-grade gliomas (LGG). …”
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A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells by Yuzhou Gu, Lu Chen, Shuying Chen, Yuhao Wu, Shengjie Hao, Feiyin Sheng, Jiali Yuan, Zhenwei Qin, Di Wu, Yu Han, Zengying Yao, Zhijian Chen, I. Michael Wormstone, Yibo Yu, Junbin Qian, Qiuli Fu, Ke Yao

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Nav1.8 and Chronic Pain: From Laboratory Animals to Clinical Patients by Yu-Feng Xie

“…As a subtype of voltage-gated sodium channel and predominantly expressed in the sensory neurons located in the dorsal root ganglion (DRG), the Nav1.8 channel encoded by the <i>SCN10A</i> gene is found to have different variants in patients suffering chronic pain or insensitivity to pain due to the gain-of-function or loss-of-function of Nav1.8 channels. …”
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Synergistic effect of Agrococcus and Rossellomorea Marisflavi species assisted probiotic functional feed on Vibrio affected Nile tilapia fish by Bhavani Paramashivan, Rajkumar Thamarai, Kalidass Subramaniam, Chinnaperumal Kamaraj, Khalid A. Al-Ghanim, Cittrarsu Vetrivel

“…The main objective of study was to focus on the impact of probiotic functional feed (PFF) on Nile tilapia (Oreochromis niloticus) exposed to challenges from Vibrio harveyi and Vibrio parahaemolyticus. …”
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MAN2B1 in immune system-related diseases, neurodegenerative disorders and cancers: functions beyond α-mannosidosis by Yuwen Han, Yuanshuai Zhou, Jinlin Pan, Minxuan Sun, Jiao Yang

“…Future studies are required to shed more light on the intricate functioning of MAN2B1. To this end, we review the biological functions, expression patterns, enzymatic roles and potential implications of MAN2B1 across various cell types and disease contexts. …”
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Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy by Miren Zuazo, Hugo Arasanz, Gonzalo Fernández‐Hinojal, Maria Jesus García‐Granda, María Gato, Ana Bocanegra, Maite Martínez, Berta Hernández, Lucía Teijeira, Idoia Morilla, Maria Jose Lecumberri, Angela Fernández de Lascoiti, Ruth Vera, Grazyna Kochan, David Escors

“…CD8 immunity only recovered in patients with functional CD4 immunity. T‐cell proliferative dysfunctionality could be reverted by PD‐1/LAG‐3 co‐blockade. …”
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Melatonin enhances everolimus efficacy in breast cancer by suppressing mTOR pathway activation and promoting apoptosis and mitochondrial function by Şeyma Demirkesen, Yakup İriağaç, Erdoğan Selçuk Şeber, Cenk Aral

“…Cell viability, apoptosis, autophagy activation, and mitochondrial function were evaluated using established techniques. …”
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STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells by Sascha Kahlfuss, Ulrike Kaufmann, Axel R Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi‐Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B Stathopulos, Cori Feist, Scott B Cameron, Stuart E Turvey, Stefan Feske

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Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. by Julio E Molineros, Amit K Maiti, Celi Sun, Loren L Looger, Shizhong Han, Xana Kim-Howard, Stuart Glenn, Adam Adler, Jennifer A Kelly, Timothy B Niewold, Gary S Gilkeson, Elizabeth E Brown, Graciela S Alarcón, Jeffrey C Edberg, Michelle Petri, Rosalind Ramsey-Goldman, John D Reveille, Luis M Vilá, Barry I Freedman, Betty P Tsao, Lindsey A Criswell, Chaim O Jacob, Jason H Moore, Timothy J Vyse, Carl L Langefeld, Joel M Guthridge, Patrick M Gaffney, Kathy L Moser, R Hal Scofield, Marta E Alarcón-Riquelme, BIOLUPUS Network, Scott M Williams, Joan T Merrill, Judith A James, Kenneth M Kaufman, Robert P Kimberly, John B Harley, Swapan K Nath

“…Both missense variants produced dramatic phenotypic changes in apoptosis and inflammation-related gene expression. We experimentally validated function of the intronic SNP by DNA electrophoresis, protein identification, and in vitro protein binding assays. …”
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Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma by Jingru Liu, Jiadi Chen, Shucheng Chen, Yanrong Huang, Kaiming Xu, Danni Cai, Xinai Liao, Ruolan You, Xiaolin Xu, Xiaoting Wang, Diyu Hou, Shuxia Zhang, Fuwen Yang, Huifang Huang

“…Therefore, this study aimed to elucidate frequency and functional characteristics of circulating MAIT cells in DLBCL patients. …”
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Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment by Fangxu Sun, Huafeng Wang, Jing Wu, Imran H. Quraishi, Yalan Zhang, Maysam Pedram, Benbo Gao, Elizabeth A. Jonas, Viet Nguyen, Sijia Wu, Omar S. Mabrouk, Paymaan Jafar-nejad, Leonard K. Kaczmarek

“…The potassium sodium-activated channel subtype T member 1 (<i>KCNT1</i>) gene encodes the Slack channel K_Na1.1, which is expressed in neurons throughout the brain. Gain-of-function variants in <i>KCNT1</i> are associated with a spectrum of epilepsy syndromes, and mice carrying those variants exhibit a robust phenotype similar to that observed in patients. …”
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Effects of different negative pressure cupping interventions on inflammatory response and motor function recovery in delayed onset muscle soreness by Xu Song, Teng Ma, XianYou Cui

“…IntroductionThis study examined the impacts of different negative pressure cupping therapies (NPCT) on pain relief, functional recovery, and inflammatory regulation in delayed onset muscle soreness (DOMS) after high-intensity exercise, with the aim of clarifying the dose-effect relationship.MethodsIn this study, 55 healthy male participants aged 18–25 were selected and divided into 5 groups: the control group (CTR; n = 11) and NPCT groups at different levels (−25 kPa, −35 kPa, −45 kPa, and −55 kPa; n = 11 in each group). …”
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Repetitive magnetic stimulation with iTBS600 induces persistent structural and functional plasticity in mouse organotypic slice cultures by Han Lu, Shreyash Garg, Maximilian Lenz, Andreas Vlachos

“…Background:: Repetitive transcranial magnetic stimulation (rTMS) is well known for its ability to induce synaptic plasticity, yet its impact on structural and functional remodeling within stimulated networks remains unclear. …”
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Functional characterization of the ATOH1 molecular subtype indicates a pro-metastatic role in small cell lung cancer by Alessia Catozzi, Maria Peiris Pagès, Sam Humphrey, Mitchell Revill, Derrick Morgan, Jordan Roebuck, Yitao Chen, Bethan Davies-Williams, Kevin Brennan, A.S. Md. Mukarram Hossain, Vsevolod J. Makeev, Karishma Satia, Pagona P. Sfyri, Melanie Galvin, Darryl Coles, Alice Lallo, Simon P. Pearce, Alastair Kerr, Lynsey Priest, Victoria Foy, Mathew Carter, Rebecca Caeser, Joseph M. Chan, Charles M. Rudin, Fiona Blackhall, Kristopher K. Frese, Caroline Dive, Kathryn L. Simpson

“…Our data validate ATOH1 as a bona fide lineage-defining TF of SCLC with cell survival and pro-metastatic functions. Further investigation exploring ATOH1-driven vulnerabilities for targeted treatment with predictive biomarkers is warranted.…”
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