Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques by Ziyu Wen, Pingchao Li, Yue Yuan, Congcong Wang, Minchao Li, Haohang Wang, Minjuan Shi, Yizi He, Mingting Cui, Ling Chen, Caijun Sun

“…Then, we constructed the recombinant HSV-ΔICP34.5 expressing simian immunodeficiency virus (SIV) env, gag, or the fusion antigen sPD1-SIVgag as a therapeutic vaccine, aiming to achieve a functional cure by simultaneously reactivating viral latency and eliciting antigen-specific immune responses. …”
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Joint Transmit-receive Beam Design of FDA-MIMO Dual-function Radar-communication Systems for Radio-frequency Stealth by Haozheng WU, Chenguang SHI, Jianjiang ZHOU

“…Efficient Radio-Frequency (RF) stealth is crucial for Dual-Function Radar-Communication (DFRC) systems that detect radar stealth and con vert communication transmission. …”
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Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell function by Rafael Rincón, Isabel F. Coira, Antoine Richieu, Fedaa Attana, Muriel Urwyler, Shozeb Haider, Carole Bourquin, Philippe Bertrand, Muriel Cuendet

“…A multiple myeloma cell line containing the non-functional ZnF-UBP domain was then engineered. Although the deacetylase activity of HDAC6 was maintained in these cells, they showed reduced cell growth, impaired aggresome formation, and a dysregulated gene expression profile that was more pronounced than cells entirely deficient in HDAC6. …”
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Molecular mechanism of METTL14-mediated m6A modification regulating microglial function post ischemic stroke by Xiaomin Zhang, Pengyang Du, Bo Bai, Xia Lian, Guofang Xue

“…This study explores the molecular mechanism of METTL14 regulating microglial function post ischemic stroke. A murine model was established by tMCAO. …”
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Using MUC2 mucin producing tumorigenic human goblet-like cells to uncover functional properties of the mucus barrier by Hayley Gorman, France Moreau, Elise Beaupré, Nitin Nitin, Wesley F. Zandberg, Kirk Bergstrom, Paul M. K. Gordon, Antoine Dufour, Kris Chadee

“…These results highlight the importance of regulatory genes for proper mucus production in providing barrier function and homeostasis in the gastrointestinal tract that is markedly affected by metabolic stress and glycosylation prevalent in colonic carcinomas.…”
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Effects of 3D-printed exosome-functionalized brain acellular matrix hydrogel on neuroinflammation in rats following cerebral hemorrhage by Aobo Zhang, Boyu Sun, Chengrui Nan, Lulu Cong, Zongmao Zhao, Liqiang Liu

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Functional analyses revealed Pinus radiata CHLOROPLAST SENSOR KINASE as a key component in UV-B stress and development by Lara García-Campa, Jesús Pascual, Mónica Meijón, Sara Guerrero, David Morales, José M. Álvarez, Luis Valledor

“…In this study, CHLOROPLAST SENSOR KINASE from Pinus radiata (PrCSK), previously identified as a potentially relevant component in UV-B stress response using a systems biology approach, was sequenced and used to generate overexpression and RNAi Arabidopsis thaliana lines to carry out functional validation studies employing phenotypical, physiological, and metabolomic analyses. …”
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PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function by Tongfeng Liu, Shuwen Cheng, Bo Peng, Haojing Zang, Xiaofeng Zhu, Xuetong Wang, Xujie Zhao, Yinmin Gu, Yongbo Pan, Hongbo Hu, Shan Gao

“…However, the underlying function of PD-L2 remains poorly understood. Here, we demonstrate that PD-L2 is majorly expressed in exosomes with surface localization by clear cell renal cell carcinoma (ccRCC) cells. …”
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Identification, cellular localization, and function analysis of a novel toll‐like receptor (PtToll4) in Portunus trituberculatus by Hao Liu, Feng‐Ling Shu, Dan‐Feng Zhang, Fei Yin, Su‐Ming Zhou

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The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget by Faraz Ahmad, Ravi Sudesh, Atheeq Toufeeq Ahmed, Mohanapriya Arumugam, Darin Mansor Mathkor, Shafiul Haque

“…Parenthetically, HOTAIR elicits trans-acting sponging function against multiple micro-RNA species. Oncological research studies have confirmed the pathogenic functions of HOTAIR in multiple cancer types, such as gliomas and proposed it as a pro-oncological lncRNA. …”
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Genome-wide identification, characterization, and functional analysis of the CHX, SOS, and RLK genes in Solanum lycopersicum under salt stress by Amaal Maghraby, Mohamed Alzalaty

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Gene Localization and Functional Validation of <i>GmPDH1</i> in Soybean Against Cyst Nematode Race 4 by Yuehua Dai, Yue Zhang, Chuhui Li, Kun Wan, Yan Chen, Mengen Nie, Haiping Zhang

“…RT-qPCR revealed that <i>GmPDH1</i> expression in HPD roots was upregulated 9 days post-inoculation with SCN4 compared to uninoculated controls. …”
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Functional characterization of SOX5 variant causing Lamb–Shaffer syndrome and literature review of variants in the SOX5 gene by Ping Wang, Hanbing Xie, Xiao Xiao, He Wang, Yan Wang, Shanling Liu

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Multi-omics analysis reveals cancer stemness function and establishes a predictive model for thyroid cancer prognosis and immunotherapy by Zhanrong Feng, Yue Xu, Ying Ding, Xiaoxiao Sun, Qian Zhao, Jingjing Zhu, Qiang Chen, Yang Zhang, Yilai Zhang

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Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation by Tao Shen, Tao Shen, Zhuming Lu, Sisi Yang, Dongxi Zhang, Yongwen Ke, Zhuowen Chen, Jinqiang Wu, Jinqiang Wu, Weidong Wu

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RIS-Assisted Wireless System in the Presence of Direct Channel: Channel Statistics and Performance Analysis by Soumya P. Dash, Debasish Ghose

“…The phases of the reflecting elements of the RIS are selected considering the phases of all the fading channels to maximize the performance of the system. Series-form expressions for the probability density function (p.d.f.) and cumulative distribution function (c.d.f.) are derived for the composite channel of the communication system by considering the RIS channels to follow independent Nakagami-m distributions and the envelope of the direct channel to follow a Rayleigh distribution. …”
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In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimenta... by Diane I. Bitzinger, Michael Gruber, Simon Tümmler, Manuela Malsy, Timo Seyfried, Florian Weber, Andreas Redel, Bernhard M. Graf, York A. Zausig

“…Administration of centrally acting physostigmine in CLP-induced sepsis in rats has protective effects on PMN functions and improves survival times, which may be of interest in clinical practice.…”
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Assessing Functional Conservation Amongst <i>FT</i>- and <i>TFL1</i>-like Genes in Globe Artichoke by Rick Berentsen, María José Domenech, Peter Visser, Francisco Madueño, Vicente Balanzà, Reyes Benlloch

“…These results suggest that the flowering-suppressing function of <i>CcTFL1</i> is conserved in globe artichoke whereas conservation of the floral promoting function of <i>CcFT</i> remains uncertain.…”
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Lactobacillus johnsonii alleviates experimental colitis by restoring intestinal barrier function and reducing NET-mediated gut-liver inflammation by Hao-Yu Liu, Peng Yuan, Shicheng Li, Kennedy Jerry Ogamune, Xinyu Shi, Cuipeng Zhu, Wael Ennab, Ping Hu, Abdelkareem A. Ahmed, Yunzeng Zhang, In Ho Kim, Demin Cai

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Transcutaneous auricular vagus nerve stimulation enhances structural and functional remodeling in sensorimotor networks following intracerebral hemorrhage in rats by Jun Zhang, Zengyu Zhang, Lichao Wei, Dewen Ru, Meihua Wang, Pengfei Fu, Weijian Yang, Gang Wu, Lei Yang, Caihua Xi, Xiangru Ye, Yuwen Zhang, He Wang, Jin Hu, Qiang Yuan

“…Abstract Background Intracerebral hemorrhage (ICH) leads to severe neurological deficits by disrupting brain structure and function, particularly in the sensorimotor cortex. …”
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