Construction and validation of a necroptosis-related lncRNA signature for predicting the prognosis of gastrointestinal cancer patients by Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Chi Feng, Chi Feng, Chi Feng, Chi Feng, Jiehua Wu, Jiehua Wu, Jiehua Wu, Jiehua Wu, Xing Sun, Xing Sun, Xing Sun, Xing Sun, Pengfei Zhu, Pengfei Zhu, Pengfei Zhu, Pengfei Zhu, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…The robustness of the score was further supported by cluster analysis, and the biological functions of the selected lncRNAs were experimentally validated through phenotypic assays.ResultsWe constructed a prognostic signature comprising five necroptosis-related lncRNAs, referred to as the Necro-lnc score. …”
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Vaimse heaolu komponendid muusikuks kujunemise teel. Toimetulek esinemisärevuse ja vaimsete blokkidega Eesti Muusika- ja Teatriakadeemia viiuli-, vioola- ja klaveritudengite hulgas... by Jelizaveta Bukina, Janika Mesi, Marju Raju

“…In addition to performance anxiety, mental blocks caused by fear or past trauma can also affect musicians’ mental well-being. These blocks function as metaphorical walls (Baumeier 1984), where a musician, despite having no physical limitations, struggles to perform certain musical material due to self-doubt and negative thought patterns. …”
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Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes by Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman, Júlia Faura, Sara Alidadiani, Claudia Schrauwen, Billie J. Matchett, Bavo Heeman, Marleen Van den Broeck, Wouter De Coster, Thuy Nguyen, Julie S. Lau, Saurabh Baheti, Tim de Pooter, Peter De Rijk, Mojca Strazisar, Matt Baker, Mariely DeJesus-Hernandez, NiCole A. Finch, Cyril Pottier, Marka van Blitterswijk, Yan Asmann, Melissa E. Murray, Leonard Petrucelli, Andrew King, Claire Troakes, Safa Al-Sarraj, Robert A. Rissman, Annie Hiniker, Margaret Flanagan, Bret M. Evers, Charles L. White, Carlos Cruchaga, Rudolph Castellani, Jeroen G.J. van Rooij, Merel O. Mol, Harro Seelaar, John C. van Swieten, Björn Oskarsson, Robert Ross Reichard, Aivi T. Nguyen, Keith A. Josephs, Ronald C. Petersen, Nilüfer Ertekin-Taner, Bradley F. Boeve, Neill R. Graff-Radford, Sarah Weckhuysen, Dennis W. Dickson, Rosa Rademakers

“…Abstract Background In the last decade, the importance of DNA methylation in the functioning of the central nervous system has been highlighted through associations between methylation changes and differential expression of key genes involved in aging and neurodegenerative diseases. …”
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DON-Apt19S bioactive scaffold transplantation promotes in situ spinal cord repair in rats with transected spinal cord injury by effectively recruiting endogenous neural stem cells... by Bi-Qin Lai, Rong-Jie Wu, Chuang-Ran Wu, Hai-Yang Yu, Jing Xu, Shang-Bin Yang, Zheng-Hong Chen, Xing Li, Yi-Nan Guo, Yue Yang, Ming-Tian Che, Ting-Ting Wu, Guang-Tao Fu, Yu-Hui Yang, Zhen Chen, Nan Hua, Rui Liu, Qiu-Jian Zheng, Yuan-Feng Chen

“…Synaptic connections between corticospinal tracts and calcitonin gene-related peptide positive nerve fibers with newborn neurons confirmed the formation of endogenous neuronal relays at the injury site, which improved the rats' motor and sensory functions. This study offers a new strategy for recruiting both NSCs and MSCs to synergistically overcome low spinal cord self-repair ability, holding a high potential for clinical translation.…”
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Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development by Piotr Jaholkowski, Shahram Bahrami, Vera Fominykh, Guy F.L. Hindley, Markos Tesfaye, Pravesh Parekh, Nadine Parker, Tahir T. Filiz, Kaja Nordengen, Espen Hagen, Elise Koch, Nora R. Bakken, Evgeniia Frei, Viktoria Birkenæs, Zillur Rahman, Oleksandr Frei, Jan Haavik, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Alexey A. Shadrin, Ole A. Andreassen

“…The observation that the risk of developing Alzheimer's disease is reduced in individuals with high premorbid cognitive functioning, higher educational attainment, and occupational status has led to the ‘cognitive reserve’ hypothesis. …”
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In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China by Weilun Zuo, Weilun Zuo, Chen Wei, Meiyan He, Mengyao Zhang, Jiangli Liang, Xiao Ma, Na Gao, Qin Gu, Yan Ma, Jingyan Li, Shuyuan Liu, Yan Huang, Mingbo Sun, Li Shi

“…In vivo RNA-seq results revealed that BP-L2 significantly upregulated relA (log2FC = 2.1, FDR P-value = 0.019) and sodA (log2FC =2.4, FDR P-value = 8.61E-06) compared to BP-L1, functionally linked to enhanced stringent response and oxidative stress defense. …”
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Addressing Disparities in access to expert physical therapy care and diagnosis for lumbar radiculopathy by Manum Tahir, Hammad Haider

“…INTRODUCTION: I am writing this letter to express my sincere concern regarding the disparities observed in the healthcare services of lumbar radiculopathy in Pakistan. …”
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GRAPHIC NOVEL TRANSLATION: SEMIOTIC AND MULTIMODAL PERSPECTIVE by Anna V. Khodorenko.

“…Characters may have their own characteristic expressions and circumstances that explain the choice of phrase translations. …”
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Interest groups in Lithuania: dynamics of development and characteristics of institutionalization by Alvidas Lukošaitis

“…On the other - it implies functional inclusion of the interest groups into the decision-making process. …”
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Molecular heterogeneity of CD30+ peripheral T-cell lymphoma with prognostic significance and therapeutic implications: a retrospective multi-centre studyResearch in context by Yu-Jia Huo, Shu Cheng, Hong-Mei Yi, Ting Niu, Lei Fan, Guo-Hui Cui, Fu-Ling Zhou, Xian-Min Song, Fei Li, Ou Bai, Xiao-Jing Yan, Jun Shi, Ming-Ci Cai, Yao-Hui Huang, Lei Dong, Jie Xiong, Song Hu, Yu-Ran Qiu, Yan Zhao, Peng-Peng Xu, Li Wang, Min Lu, Hong-Mei Jing, Wei-Li Zhao

“…CD30 serves as a pivotal surface antigen in PTCL, however, its biological functions and therapeutic potential warrant further investigation. …”
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Discourse Structure Analysis of Hasanak-e-Vazir’s Hanging Tale: A Study based on Van Dijk’s (2007) Socio-Cognitive Approach by Nader Abyar, Mousa Ghonchepour, Zahra Iranmanesh

“…This descriptive-analytical study investigates the hanging tale of Hasanak-e-Vazir based on Van Dijk’s (2007) socio-cognitive approach to clarify the functional relation between language, ideology, power and dominance in social and political context of Bayhaqi's period. …”
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The Effectiveness of Using the Reggio Emilia Approach on the Experimental Science Lesson for Third-Grade Elementary Students by Batool Sabzeh, Farangis Ghalavand, Seyedamir Ghasemtabar

“…Data collection was done using a researcher-made test of the science lesson and functional checklist. Teachers and professors confirmed the validity of the tool and its reliability was obtained through Cronbach's alpha test of 0.865. …”
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Double accusative cases in old Persian constructions by Sahar Vahdati Hosseinian, Ehsan Changizi, Jaleh Amouzgar Yeghaneh, Ameneh Zaheri Abdvand

“…Depending on the meaning and context of a sentence, it can perform different functions and express various semantic roles. In transitive constructions, the accusative case marks the semantic role of the theme or patient.   1) adam auramazdām ayadaiy nom.1sg. …”
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In-depth analysis of the safety of CAR-T cell therapy for solid tumors by Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiexiong Wu, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Ting Su, Ting Su, Ting Su, Ting Su, Ting Su, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Size Chen, Size Chen, Size Chen, Size Chen, Size Chen

“…The complex TME includes dense stroma that obstructs T cell infiltration, abnormal blood vessel structures leading to hypoxia, and an acidic pH, all of which hinder CAR-T cell function. Additionally, the presence of immunosuppressive factors in the TME reduces the efficacy of CAR-T cells, making successful targeting of tumors more difficult. …”
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Against Futility Judgments for Patients with Prolonged Disorders of Consciousness by William Choi

“…Despite such uncertainty, clinicians often end patients’ lives based on empirically tenuous beliefs regarding the patient’s inability to recover.[6] The grounds for futility judgments are further undermined by emerging data about the likelihood of long-term functional recovery in many patients with prolonged disorders of consciousness. …”
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The Figure of the Migrant and Multilingual Practices in Selected Lithuanian Novels and Their English Translations: Antanas Škėma’s Balta drobulė and Gabija Grušaitė’s Stasys Šaltok... by Rūta Eidukevičienė, Kristina Aurylaitė

“…The texts are analysed addressing both their cultural and socio-historical contexts and their aesthetic form and expression, in which multilingualism plays an important role. …”
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Criminal Law Challenged by Crossing into Virtual Reality by Mahdi Karimi

“…This social revolution could challenge the function of criminal law and have fundamental impacts and consequences on it. …”
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Villa d’époque romaine et habitat médiéval à Mont-Saint-Jean (Sarthe) : bilan des recherches 2008-2020 by Florian Sarreste, Paul-André Besombes, Phaedra Bouvet, Chloé Genies, Étienne Jaffrot, Florian Jedrusiak, Thomas Jubeau, Anthony Ledauphin, Annaïg Le Martret, Christophe Loiseau, Hugo Meunier, Aurore Noël, Sandrine Paradis-Grenouillet, Boris Robin

“…A round fibula and a back plate from a belt buckle, both discovered out of context, point to the presence of burials within which the deceased would have been dressed.Concurrent with this funerary reoccupation was a change of function for the ancient agricultural annexes. Several hundred shards of culinary ceramics testify to the presence of a population living within the buildings belonging to the former agricultural courtyard. …”
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Anti-leishmanial activity of Carthamus tinctorius and Matricaria chamomilla extracts on the survival of promastigotes of Leishmania major by S Hamoonnavard, H Rezvan, M Maleki, H Heydarianpour, B Bazargani-Gilani, F Behdarvand

“…Safflower extracts functionally regulate monoamine transporters. Journal of Ethnopharmacology 2009; 124(1): 116-24. ## 8.Shirwaikar A, Khan S, Kamariya YH, Patel BD, Gajera FP. …”
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Дискурс как контекст функционирования реалий в русском языке by Hala Jabor, Hisham Hussein

“… This article is devoted to the study of the problem of the functioning of realities in Russian discourse. This question refers to the functions of realities representing words or expressions unique to a particular language and culture in the context of communication. …”
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