Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer by Bo Yin, Wei Wang, Ang Li, Mengjie Li, Huijuan Zhou, Haoran Hu, Jianyi Ding, Yashi Zhu, Xinxin Xu, Meiqin Yang, Tiefeng Huang, Yifan Kou, Zilale Rahim, Baoyou Huang, Lingfei Han

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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

“…Methods We conducted a multi-omics analysis—encompassing DNA methylation, total RNA sequencing, and microRNAs (miRNAs; N = 800) profiling on primary CICs and differentiated tumor cell lines, including autologous pairs. Functional immunological assays were performed to assess the impact of miRNA modulation. …”
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SOME OBSERVATIONS ON THE USE OF NEGATIVE FUTURE FORMS IN THE CONTEMPORARY BULGARIAN LANGUAGE by Krassimira Chakarova

“…The focus of the academic analysis is on the issue of the functional competition between the negative future forms, formed with the negating formants не and няма (нямаше, нямало), in the contemporary stage of the development of the Bulgarian language. …”
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Modality in President Jokowi’s Speech at the Arab Islamic American Summit in Riyadh by Majid Ariyoga

“…This study aimed to reveal President Jokowi's attitude on terrorism and radicalism issues expressed by modality in his speech. It was conducted by applying the Systemic Functional Linguistics approach. …”
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Multi-Omics Reveal the Improvements of Nutrient Digestion, Absorption, and Metabolism and Intestinal Function via GABA Supplementation in Weanling Piglets by Yan Zeng, Hong Hu, Yiwen He, Zhiying Deng, Yiting Guo, Xihong Zhou

“…Furthermore, increased lipase and trypsin activity, along with the elevated expression of tight junction proteins confirmed the beneficial effects of GABA on intestinal nutrient metabolism and barrier function. …”
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Huaier Cream Protects against Adriamycin-Induced Nephropathy by Restoring Mitochondrial Function via PGC-1α Upregulation by Ruochen Che, Chunhua Zhu, Guixia Ding, Min Zhao, Mi Bai, Zhanjun Jia, Aihua Zhang, Songming Huang

“…We designed the present study to examine whether mitochondrial function restored by PGC-1α serves as the major target of Huaier cream in protecting ADR nephropathy. …”
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A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor. by Jeremy D Volkening, Stephen J Spatz, Maricarmen Garcia, Teresa A Ross, Daniel A Maekawa, Kenneth S Rosenthal, Ana C Zamora, April Skipper, Julia R Blakey, Rashan Paudel

“…These results represent the first report of a previously unknown virokine encoded in the ILTV genome expressing a functional IL-4 homolog and virulence factor.…”
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Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. by Sherylanne Newton, Fanbo Kong, Adam J Carlton, Carlos Aguilar, Andrew Parker, Gemma F Codner, Lydia Teboul, Sara Wells, Steve D M Brown, Walter Marcotti, Michael R Bowl

“…Finally, we show that continued expression of Neuroplastin in OHCs of adult mice is required for membrane localisation of Plasma Membrane Ca2+ ATPase 2 (PMCA2), which is essential for hearing function. …”
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The effects of two polymorphisms on p21cip1 function and their association with Alzheimer's disease in a population of European descent. by Sharon C Yates, Amen Zafar, Erzsebet M Rabai, James B Foxall, Sheila Nagy, Karen E Morrison, Carl Clarke, Margaret M Esiri, Sharon Christie, A David Smith, Zsuzsanna Nagy

“…The aim of this study was to confirm this association and to elucidate the effects of the variant on protein function and Alzheimer-type pathology. We examined the association of the p21cip1 variant with Alzheimer's disease and Parkinson's disease with dementia. …”
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Identification and functional analysis of the S-layer protein SplA of Paenibacillus larvae, the causative agent of American Foulbrood of honey bees. by Lena Poppinga, Bettina Janesch, Anne Fünfhaus, Gerhard Sekot, Eva Garcia-Gonzalez, Gillian Hertlein, Kati Hedtke, Christina Schäffer, Elke Genersch

“…For elucidating the biological function of P. larvae SplA, a genetic system for disruption of gene expression in this important honey bee pathogen was developed. …”
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Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus by Sergey A. Afanasiev, Dina S. Kondratieva, Margarita V. Egorova, Shamil D. Akhmedov, Olesya V. Budnikova, Sergey V. Popov

“…Aims: To study the features of functional remodeling of the heart muscle in coronary heart disease with and without type 2 diabetes mellitus (DM2) depend on the level of Ca2+-ATPase and the activity of enzymes involved in energy metabolism. …”
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Regulatory T Cell Function Is Not Affected by Antisense Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer (PPMO)-Mediated TMPRSS2 Truncation by Sandra Gunne, Fiona K. Sailer, Lucas Keutmann, Marie Schwerdtner, Hong M. Moulton, Eva Böttcher-Friebertshäuser, Susanne Schiffmann

“…<b>Methods:</b> TMPRSS2 was truncated in human Tregs using a splice-modulating PPMO. Effects on Treg function were analyzed by evaluation of surface marker and transcription factor expression, cytokine secretion, and effector cell suppression capability. …”
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Allogenic mitochondria transfer improves cardiac function in iPS-cell-differentiated cardiomyocytes of a patient with Barth syndrome by Ye Seul Kim, Sukdong Yoo, Yoon Ji Jung, Jung Won Yoon, Yong Seong Kwon, Nayeon Lee, Chong Kun Cheon, Jae Ho Kim

“…In addition, mitochondrial morphology and function were impaired and mitophagy was decreased in BTHS CMs compared with normal CMs. …”
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The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep. by Kirsten Hogg, Charlotte Wood, Alan S McNeilly, W Colin Duncan

“…We examined the effect of prenatal androgens on liver function and metabolism of adult sheep. As non-alcoholic fatty liver disease is increased in PCOS we hypothesized that this, and other important liver pathways including metabolic function, insulin-like growth factor (IGF) and steroid receptivity, would be affected. …”
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FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells by Lydia Barré, Irfan Shaukat, Mohamed Ouzzine

“…Here, we demonstrated that <i>FAM20B</i> gain-of-function decreased, in a dose dependent manner, the synthesis of both CS- and HS-attached PGs. …”
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High-Quality Assembly of the Apple Fungal Pathogen <i>Marssonina coronaria</i> Genome and Functional Analysis of Candidate Effectors by Huiting Guo, Yicong Fu, Lichi Zhong, Qiang Cheng

“…Based on genome annotation, 97 candidate effector proteins (CEPs) were identified, and 61 CEPs were successfully cloned for functional analysis. Transient expression assays in <i>Nicotiana benthamiana</i> revealed that eight CEPs significantly suppressed BAX-induced cell death, with McCEP12, McCEP23, McCEP24, and McCEP52 concurrently inhibiting flg22-triggered reactive oxygen species bursts. …”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…Transcriptome analysis of RTS osteoblasts validated decreased bone morphogenesis while revealing aberrantly upregulated mitochondrial respiratory complex I gene expression. RTS osteoblast metabolic assays demonstrated elevated mitochondrial respiratory complex I function, increased oxidative phosphorylation (OXPHOS), and increased ATP production. …”
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Notch2 improves granulosa cell functions in premature ovarian failure by activating the Wnt2/β-catenin pathway by Xia Liang, Nina Li, Senyan Wu

“…Abstract Background Notch2 and Wnt2/β-catenin pathway improve granulosa cell (GC) functions, and there are interactions between Notch and Wnt/β-catenin in some cells. …”
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Interplay between circulating von Willebrand factor and neutrophils: implications for inflammation, neutrophil function, and von Willebrand factor clearance by Alua Kuanyshbek, Hamideh Yadegari, Jens Müller, Nasim Shahidi Hamedani, Samhitha Urs Ramaraje, Johannes Oldenburg

“…Moreover, stimulated neutrophils exposed to purified plasma-derived VWF exhibited elevated expression of neutrophil surface markers CD45 and CD66b, indicative of altered neutrophil function related to cell adhesion, migration, and phagocytosis. …”
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Optimization of Protoplast Preparation Conditions in <i>Lyophyllum decastes</i> and Transcriptomic Analysis Throughout the Process by Xiaobin Li, Ying Qin, Yufei Kong, Samantha Chandranath Karunarathna, Yunjiang Liang, Jize Xu

“…Protoplasts are essential tools for genetic manipulation and functional genomics research in fungi. This study systematically optimized protoplast preparation conditions and examined transcriptional changes throughout the preparation and regeneration processes to elucidate the molecular mechanisms underlying the formation and regeneration of protoplasts in <i>Lyophyllum decastes</i>. …”
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