Phosphorus-32 microspheres: A dual-modality transarterial radioembolization approach for hepatocellular carcinoma therapy and Anti-PD1 immunotherapy potentiation by Shipeng Dai, Xunzheng Su, Zhuozheng Li, Hongyu Wang, Li Liu, Yuchen Xie, Yue Chai, Yueran Chen, Zhaoyang Zhao, Bo Luo, Jie Kong, Yanshu He, Hengsong Cao, Maiqi Xin, Guoqiang Shao, Yadong Shi, Fei Xiong, Weiwei Tang, Jinhua Song

“…Genetic ablation of FABP1 or pharmacological inhibition with Orlistat reversed PD-L1 expression and augmented anti-tumor efficacy. Combining 32P-MS with anti-PD1 therapy synergistically suppressed tumor growth, reduced MDSC infiltration, and reinvigorated CD8+ T cell activity, significantly improving treatment sensitivity. 32P-MS is a promising HCC therapeutic with dual anti-tumor and immune-modulatory functions, providing a compelling rationale for integrating radioembolization with immune checkpoint blockade to counteract immunosuppressive resistance in HCC.…”
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Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy by Meng Guan, Xiao‐Ting Xie, Dong Zhou, Kai Cheng, Bin Zhang, Xin‐Yue Xu, Yong Li, Yi‐Tong Zhou, Wei Peng, Li‐Li Chen, Peng‐Shuo Dong, Si Chen, Jia‐Hua Zou, Bo Liu, Yuan‐Di Zhao, Jin‐Xuan Fan

“…In vitro and in vivo experiments demonstrate that OC47‐Ce6 enhances TAM phagocytic function through TAM polarization and CD47 blockade. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…While epilepsy and psychiatric behaviors increase in severity with age, communication abilities and motor function tend to improve. iPSCs, which were differentiated into GABAergic neurons, represent the first in vitro neuronal model of SSADHD and express the neuronal marker microtubule-associated protein 2 (MAP2), as well as GABA. …”
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Opinion of the Italian Association of Myology on Ataluren for the Treatment of Nonsense Mutation Duchenne Muscular Dystrophy by Luca Bello, Pietro Riguzzi, Emilio Albamonte, Guja Astrea, Roberta Battini, Andrea Barp, Angela L. Berardinelli, Enrico S. Bertini, Noemi Brolatti, Claudio Bruno, Stefania Corti, Adele D’Amico, Maria Grazia D’Angelo, Gianfranco Dallavalle, Rocco Liguori, Lorenzo Maggi, Francesca Magri, Michelangelo Mancuso, Riccardo Masson, Eugenio Mercuri, Carlo Minetti, Sonia Messina, Tiziana Mongini, Olimpia Musumeci, Vincenzo Nigro, Marika Pane, Chiara Panicucci, Marina Pedemonte, Antonella Pini, Luisa Politano, Stefano Previtali, Federica Ricci, Giulia Ricci, Lucia Ruggiero, Valeria Sansone, Gabriele Siciliano, Antonio Trabacca, Federica Trucco, Daniele Velardo, Elena Pegoraro, Giacomo P. Comi

“…Abstract The Italian Duchenne muscular dystrophy expert clinicians, gathered in the Italian Association of Myology (AIM), intend to express a position against the suspension of the Marketing Authorization of ataluren (Translarna®) for the treatment of nonsense mutation Duchenne muscular dystrophy. …”
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Advantages, disadvantages and optimization of organ-sparing methods for uterine fibroids treatment by A. L. Tikhomirov, V. V. Kazenashev, O. V. Maksimova, M. V. Maminova, N. L. Davydenko, N. V. Rurua, T. A. Sonina

“…In both groups, after assessing liver function tests in accordance with the instructions, a treatment course with SPRM group drug (ulipristal acetate) was used at a daily dose of 5 mg for 84 days (one course) with an interval until the onset of second menstruation after drug withdrawal. …”
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大型可展开网状天线反枕效应研究进展 by 贺乃馨, 宋燕平, 李团结, 张大羽, 黄鹏飞, 李怡晨, 曾家琛

“…It will make the antenna deviate from the ideal paraboloid, affect the far-field characteristics of the antenna, and then affect the communication function of the satellite.ProgressThe anti-pillow effect can be expressed by the negative Gauss curvature surface in mathematics. …”
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Evaluation and Comparison of Resource sustainability of Two Forest Reserves in Hamadan Province by Mohsen Akbari, Alireza Ildoromi, Farhad Ghasemi Aghbash, Iman Pajohan

“…Biodiversity, with the lowest score in both reserves including legal measures and organizational structure, economic and social functions, forest production functions, forest resources, conservation functions with the lowest score have the greatest impact on the instability of two forest reserves respectively. …”
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Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer by Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong

“…Here, we aimed to examine whether IDO1 activity is correlated with OS in NSCLC patients with brain metastasis (Bramet) and has negative effect on modulating the anti-tumor functions of immune cells. Methods: This study was a part of a prospective clinical trial in circulating biomarkers. …”
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N6‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastasis by Song Li, Jianyuan Zhou, Shuang Wang, Qian Yang, Shulun Nie, Chunwang Ji, Xue Zhang, Shuhan Li, Xuanyu Zhou, Jiahui Chu, Xuehui Wu, Jianqiao Jiao, Ruitao Xu, Qian Xu, Miao Huang, Qiushi Wang, Liliang Dou, Qinqin Hu, Fan Jiang, Xin Dai, Zhaodi Nan, Xinyu Song, Di Zhang, Lian Liu

“…Macrophage and T‐cell functions were assessed using enzyme‐linked immunosorbent assay, flow cytometry, and cytotoxicity assays. …”
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Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury by Lingyan Li, Xingjie Wu, Qianqian Guo, Yu'e Wang, Zhiyong He, Guangqiong Zhang, Shaobo Liu, Liping Shu, Babu Gajendran, Ying Chen, Xiangchun Shen, Ling Tao

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Optimized lipid nanoparticles enable effective CRISPR/Cas9-mediated gene editing in dendritic cells for enhanced immunotherapy by Kuirong Mao, Huizhu Tan, Xiuxiu Cong, Ji Liu, Yanbao Xin, Jialiang Wang, Meng Guan, Jiaxuan Li, Ge Zhu, Xiandi Meng, Guojiao Lin, Haorui Wang, Jing Han, Ming Wang, Yong-Guang Yang, Tianmeng Sun

“…Modulation of gene expression in DCs using genome editing techniques, such as the CRISPR-Cas system, is important for regulating DC functions. …”
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Comparative effectiveness of epilepsy surgery versus additional anti-seizure medications for Lennox–Gastaut syndrome: study protocol for a multicenter, mixed-methods study by Sandi Lam, Sandi Lam, Marc Rosenman, Marc Rosenman, Tracy Dixon-Salazar, Kelly G. Knupp, Liu Lin Thio, Taylor J. Abel, Taylor J. Abel, William P. Welch, William P. Welch, Laurel Reed, Laurel Reed, Stephanie C. Randle, Stephanie C. Randle, Rebecca Garcia-Sosa, Rebecca Garcia-Sosa, Jason S. Hauptman, Carolyn C. Foster, Carolyn C. Foster, Elizabeth R. Alpern, Elizabeth R. Alpern, Lu Zhang, Lu Zhang, Nicole Villalba, Nicole Villalba, Maura Carroll, Anup D. Patel

“…The outcomes are those that families identify as important: emergency medical care for seizures and patients’ functional outcomes. The results of this study may help guide decisions regarding the treatment of LGS and development of computable phenotypes for this rare disease. …”
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Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications by Dian Hu, Zerui Zhang, Yijun Wang, Siwen Li, Jiaqian Zhang, Zhangfan Wu, Mengyu Sun, Junqing Jiang, Danfei Liu, Xiaoyu Ji, Shuai Wang, Yufei Wang, Xiangyuan Luo, Wenjie Huang, Limin Xia

“…It also exerts a critical impact on the development of the immune system. However, its function is dysregulated through posttranslational modifications, gene fusions, and complex signaling crosstalk under pathological conditions. …”
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The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm by Erlei Zhi, Haowei Bai, Chuan Ren, Yue Dong, Jintao Zhang, Yanzhi Xu, Chen Tan, Yun Pan, Lunni Zhou, Peng Li, Yueqiu Tan, Yihong Zhou, Lanlan Meng, Junwei Xu, Yuxiang Zhang, Shuai Xu, Zhiyong Ji, Liangyu Zhao, Min Jiang, Zheng Li, Chencheng Yao, Yuchuan Zhou, Jianping Wu, Xiaoyu Yang, Siyu Liu, Mingxi Liu

“…Abstract Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its role in sperm function has remained unclear. Through whole-exome sequencing (WES) of 800 patients with asthenozoospermia, we identified biallelic Testis-Expressed Protein 44 (TEX44) variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. …”
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ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment by Xinyue Dong, Hao Wang, Jinxuan Cai, Yichun Wang, Dezhi Chai, Zichen Sun, Jie Chen, Mengxia Li, Tianxia Xiao, Chunhua Shan, Jian V. Zhang, Ming Yu

“…Siglec-G in murine embryos was analyzed by immunofluorescence staining. The function of Siglec-G is evidenced by uterine horn injection and protein interaction assay. …”
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Study on Zinc-binding Capacity of Featherback (<i>Chitala ornata</i>) Skin Hydrolysate by Tam Dinh Le Vo, Thinh Ngoc Tran, Bao Chi Vo, Hieu Trung Ma, Hoa Gia Tran, Son Manh Nguyen, Quyen Phuong Hoang, Van Thi Tuyet Nguyen, Mai Thi Ngoc Nguyen, Thao Huynh Ngoc Nguyen, Vy Thuy Pham, Khang Tran Gia Cao, Cuong Viet Pham

“…These findings indicate that hydrolysate and/or its peptide fractions derived from featherback skin could be a natural supplement, especially when producing functional food or nutraceuticals.…”
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Real-world validation study of the LSC17 score for risk prediction in patients with newly diagnosed acute myeloid leukemia by Tracy Murphy, Boyang Zhang, Tong Zhang, Ian King, Jose-Mario Capo-Chichi, Vikas Gupta, Dawn Maze, Caroline J. McNamara, Mark D. Minden, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen W.L. Yee, Andrea Arruda, Zhibin Lu, Dina Khalaf, Chantal Rockwell, Brian Leber, Mitchell Sabloff, Anne Tierens, Tracy L. Stockley, Steven M. Chan, Stanley W.K. Ng, Jean C.Y. Wang

“… Acute myeloid leukemia (AML) patients exhibit diverse molecular and cytogenetic changes with heterogeneous outcomes. The functionally-derived LSC17 gene expression score has demonstrated strong prognostic significance in retrospective analyses of adult and pediatric AML cohorts, where above-median scores are associated with worse outcomes compared to below-median scores in intensively-treated patients. …”
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A MODEL OF THE ENGLISH-UKRAINIAN SUB-CORPUS OF TEXTS OF NATO, UN AND WTO OFFICIAL AND BUSINESS DOCUMENTS by Yuliya I. Demyanchuk

“…Compilation of terminological nominations glossary, their functional and stylistic labeling and assimilation into the commonly used vocabulary of the EUS and later on in the UNC are currently at the stage of formation and approval. …”
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Optimized GMP-grade production of non-viral Sleeping Beauty-generated CARCIK cells for enhanced fitness and clinical scalability by Ilaria Pisani, Giusi Melita, Patricia Borges de Souza, Stefania Galimberti, Angela Maria Savino, Jolanda Sarno, Beatrice Landoni, Stefano Crippa, Elisa Gotti, Carolina Cuofano, Olga Pedrini, Chiara Capelli, Giada Matera, Daniela Belotti, Stefania Cesana, Benedetta Cabiati, Michele Quaroni, Valentina Colombo, Massimiliano Mazza, Barbara Vergani, Anna Gaimari, Fabio Nicolini, Marcella Tazzari, Martine Bocchini, Marta Serafini, Alessandro Rambaldi, Benedetta Rambaldi, Giuseppe Dastoli, Andrea Biondi, Giuseppe Gaipa, Martino Introna, Josée Golay, Sarah Tettamanti

“…Recent evidence also suggests that ex vivo culture conditions can significantly impact CAR T cell functionality. Methods We present our optimized methodology for expanding Sleeping Beauty transposon-engineered Chimeric Antigen Receptor-Cytokine-Induced Killer (CARCIK) cells using G-Rex devices and evaluate its impact on CARCIK cell phenotype and T cell fitness. …”
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Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus studyResearch in context by Sarah E. Hughes, Foram Khatsuria, Christel McMullan, Karen L. Shaw, Anita Walker, Francesca Kinsella, David Burns, Olalekan L. Aiyegbusi, Elin Haf Davies, John Ansell, Evelyn Chakera, Charles Craddock, Alastair Denniston, Rebecca Lloyd, Paul Ferguson, Ronjon Chakraverty, Melanie Calvert

“…These measures, EQ5D-5L, measuring HRQoL, and Functional Assessment of Chronic Illness Therapy–Item GP5 (FACT-GP5), single-item global indicator of cancer treatment tolerability, will be included in the ePRO system. …”
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