PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle by Chengfei Zhang, Yangchun Zhou, Minghua Hu, Yue Pan, Xin Chen, Qi Sun, Zhijie Ma, Cheng Wang, Yong Zha, Feng Zhu, Hongping Xia

“…Herein, we aimed to investigate the underlying biological functions and mechanisms of PLOD1 in HCC. Methods: The expression levels of PLOD1 in HCC were measured by qPCR, Western blot, and immunohistochemistry. …”
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Characteristics of the Respiratory System Status in Patients with Liver Cirrhosis and the Dependence of its Syntropic Lesions on the Severity of the Disease due to C. G. Child – R.... by Tolopko S. Ya.

“…Pugh – the heavier liver damage, the more severe dyspnea, lung ventilation function violations of restrictive type with hypoxemia and blood gas composition disorders, with reduced ability of hemoglobin to bind and also carry oxygen and more pronounced formation of arterio-venous shunts.…”
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Sleepiness, fatigue, anxiety and depression in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea - Overlap - Syndrome, before and after continuous positive airways... by Nicholas-Tiberio Economou, Ioannis Ilias, Lemonia Velentza, Yiannis Papachatzakis, Paul Zarogoulidis, Anastasios Kallianos, Georgia Trakada

“…All patients underwent pulmonary function tests (PFTs), oximetry and overnight polysomnography and completed the questionnaires, before and after 3 months of CPAP therapy. …”
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Identifying the determinants of health–related quality of life in children after heart transplant by Jonathan B. Edelson, Jing Huang, Zi Wang, Vicky Tam, Debra Lefktowitz, Matthew J. O’Connor, Rachel White, Lynne Ha, Carol A. Wittlieb-Weber, Joseph W. Rossano, Kimberly Lin, Melissa K. Cousino, Meghan Lane-Fall, Michael L. O’Byrne

“…Conclusions: HRQOL in children after heart transplant is reduced and determined not only by traditional measures of cardiovascular function, but also by patient psychology and their household environment, highlighting the utility of using an adapted ecological systems framework to understand HRQOL.…”
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The cold immunological landscape of ATM-deficient cancers by Fresia Pareja, Stephen Morris, Sonali Sinha, Lorenzo Galluzzi, Fatemeh Derakhshan, Jennifer Ma, Jorge Reis-Filho, Nadeem Riaz, Shu Yazaki, Victor Ng, Ardijana Novaj, Yingjei Zhu, Xin Pei, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Kevin Ma, Anne Roulston, Maria Koehler, Simon Powell, Ezra Rosen, Atif Khan

“…Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. …”
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Somatic hypermutation shapes the viral escape profile of SARS-CoV-2 neutralising antibodiesResearch in context by Matthias Bruhn, Maureen Obara, Mariana Gonzalez-Hernandez, Wencke Reineking, Abdus Salam, Monica Mirolo, Imke Hinrichs, AhmedElmontaser Mergani, Yannic Bartsch, Axel Schambach, Gert Zimmer, Wolfgang Baumgärtner, Albert D.M.E. Osterhaus, Ulrich Kalinke

“…Fc-mediated effector functions of neutralising and non-neutralising mAb combinations were determined via multiple in vitro assays. …”
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Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways by Liya Liu, Liya Liu, Liya Liu, Ying Cheng, Ying Cheng, Guosheng Lin, Guosheng Lin, Huifang Zheng, Huifang Zheng, Xinran Zhang, Xinran Zhang, Peilin Zhao, Peilin Zhao, Meixuan Guo, Meixuan Guo, Qihong Liu, Qihong Liu, Wenyi Fang, Wenyi Fang, Wenrong Wang, Wenrong Wang, Anjum Jafri, Aling Shen, Aling Shen, Xiao Ke, Xiao Ke, Youqin Chen

“…Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used for functional exploration. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to validate RNA-seq analysis results. …”
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Promoting the Integration of Public Perspective into Urban Design Decision-Making Based on Crowdsourced Visual Perception Method by Lu HUANG, Takuya (JPN) OKI

“…Thus, understanding and integrating public urban perception not only enhances design responsiveness to user needs but also fosters a harmonious balance of functional efficiency and humanistic care. Crowdsourced visual perception data and analysis methods, with their advantages of efficiency, broad representativeness, and low cost, have become key methodological tools in urban built environment research. …”
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Ricci Semi-Symmetric Robertson–Walker Spacetime in <i>f</i>(<i>R</i>)-Gravity by H. Aruna Kumara, Abdul Haseeb, V. Venkatesha, Mohd Bilal

“…To further develop our understanding, we explored various energy conditions to constrain the functional form of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>f</mi><mo stretchy="false">(</mo><mi mathvariant="script">R</mi><mo stretchy="false">)</mo></mrow></semantics></math></inline-formula>. …”
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Handwritten Words Image Character Extraction Adaptive Algorithm Based on the Multi-branch Structure by GUO Xiaojing, ZHAO Xiaoyuan, ZOU Songlin

“…The improved model comprises four functional components. The innovation of this study lies in several aspects. …”
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Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression by Ludivine Obry, Raissa Medina-Santos, Myriam Rahmouni, Josselin Noirel, Toufik Labib, Pilar Galan, Jean-Louis Spadoni, Gaëlle Gendronneau, Randa Jdid, Sandra Courrèges, Julie Latreille, Nada André, Jean-François Zagury, Sigrid Le Clerc

“…The VANGL1 gene contributes to the structural organization of the plasma membrane and has been identified as a key gene for cutaneous function and was expressed during keratinization.DiscussionThis study revealed four relevant genetic associations with skin aging and one significant G × E interaction. …”
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Comparison of the Effect of Different Percentages of Sesame Oil and Soybean Oil on Growth Performance, the Weight of Internal Organs, and Serum Biochemical Parameters in Japanese q... by Maryam Karimi-Dehkordi, Forogh Mohammadi, Majid Gholami-Ahangaran

“…Sesame oil contains compounds called lignans, such as sisamin, sisamulin, and small amounts of sisamol, and has many different physiological functions, such as reducing blood fat, reducing the level of arachidonic acid, increasing antioxidant capacity, increasing the bioavailability of gamma-tocopherol, and anti-inflammatory functions. …”
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Analysis of differences in physicochemical properties and bacterial community characteristics of rhizosphere soil in apple orchards under different cover treatments by HU Zhifang, CHENG Lijun, LI Yunguo, HUANG Guoyan, CAI Rongjing, MA Miandi, MA Jing, CHEN Chen, YANG Yanqun, LU Xingkai, QUAN Yong

“…Specifically, the bacterial community associated with RSM exhibited a significant positive association with AK levels, while that associated with GC correlated positively with AN expression. This research would provide a theoretical basis for optimizing cultivation practices and enhancing soil quality and microbial functionality in apple orchards located in the cool highland regions of Southwestern China.…”
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miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthmaResearch in context by Rinku Sharma, Kevin Mendez, Sofina Begum, Su Chu, Nicole Prince, Julian Hecker, Rachel S. Kelly, Qingwen Chen, Craig E. Wheelock, Juan C. Celedón, Clary Clish, Robert Gertszen, Kelan G. Tantisira, Scott T. Weiss, Jessica Lasky-Su, Michael McGeachie

“…These findings imply that the indirect regulation of metabolism and cellular functions by miRNA influences Th2 inflammation, AHR, and airflow obstruction in childhood asthma. …”
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Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways by Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted to elucidate the functions of pivotal targets within the protein–protein interaction network. …”
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The brainstem BBSome regulates glucose homeostasis and lean mass in a state-dependent manner by Connor Laule, Deng-Fu Guo, Yuying Zhao, Paul A. Williams, Donald A. Morgan, Younes Rouabhi, Miriam McDonough, Trevor Butler, Jon Resch, Kamal Rahmouni

“…Objective: Obesity disrupts metabolic homeostasis through changes in brain function. Hypothalamic cilia and associated proteins, such as the BBSome, a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins, have been implicated in metabolic regulation and disorders. …”
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Examining the cultuling of Iranians’ concerns for others: From apathy to metapathy by Reza Pishghadam, Shima Ebrahimi

“…When seeing other people’s problems and issues, individuals use various verbal and functional approaches in accordance with their own perception and understanding of the situation, as well as the mental and emotional state of others. …”
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Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration by Macsue Jacques, Shanie Landen, Adam P. Sharples, Andrew Garnham, Ralf Schittenhelm, Joel Steele, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, James Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekström, Olof Asplund, Séverine Lamon, Sarah E. Alexander, Cassandra Smith, Carlie Bauer, Mary N. Woessner, Itamar Levinger, Andrew E. Teschendorff, Linn Gillberg, Ida Blom, Jørn Wulff Helge, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Atul S. Deshmukh, Kirsi H. Pietiläinen, Päivi Piirilä, Robert A.E. Seaborne, Marie Klevjer, Anja Bye, Ulrik Wisløff, Bernadette Jones-Freeman, Nir Eynon

“…We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene expression. …”
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Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-&amp;kappa;B Pathway by Xie Y, Ran L, Yue C, Wang C, Chen F, Su Y, Qin Y, Zhang Q, Liu J, Du N, Zhang L, Jiang Y, Liu G

“…Yu Xie,1,2,&amp;ast; Liuyi Ran,2,&amp;ast; Ciquan Yue,1,2,&amp;ast; Chenxing Wang,1,2 Fengming Chen,3 Yadong Su,1,2 Yin Qin,1,2 Qiuhong Zhang,1,2 Jie Liu,1,2 Ning Du,2 Li Zhang,4 Yu Jiang,5 Gang Liu1,2 1Department of Emergency and Critical Care Medicine, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, People’s Republic of China; 2Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, People’s Republic of China; 3Hubei University of Traditional Chinese Medicine Affiliated Shiyan Hospital, Shiyan, 442000, People’s Republic of China; 4Basic Research Laboratory of Traditional Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400011, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yu Jiang, Email jiangyu@cqmu.edu.cn Gang Liu, Email lg@cqmu.edu.cnBackground: Acute respiratory distress syndrome (ARDS) is characterized by diffuse lung injury and high mortality rates due to severe inflammation. Adipose tissue, functioning as both an endocrine and immune organ, plays a crucial role in immune regulation by secreting a variety of adipokines. …”
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Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism by Qianjiao Zhao, Qianjiao Zhao, Qianjiao Zhao, Yueting Zhong, Yueting Zhong, Yueting Zhong, Zheng Li, Zheng Li, Zheng Li, Jia Tang, Jia Tang, Jia Tang, Chao Pi, Chao Pi, Wenwu Zheng, Peng Shi, Ying Zuo, Jun Jiang, Yan Yang, Shifeng Chu, Yumeng Wei, Ling Zhao, Ling Zhao, Ling Zhao

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