THE EFFICACY OF THERAPEUTIC MEASURES FOR PATIENTS WITH GENERALIZED PERIODONTITIS IN CONTEXT OF TYPE 1 DIABETES MELLITUS WITH CARDIOMYOPATHY ON SEPARATE PARAMETERS OF THE ORAL LIQUI... by T. D. Zabolotnyj, O. I. Kordiyak, R. Y. Shkrebnyuk

“…The performed study proved the adequacy of the proposed treatment and preventive scheme in patients of the main group, which is confirmed by the improvement of endothelial function of the vessels of the periodontium, which is expressed by increasing in the concentrations of nitrogen metabolites in context of decrease of endothelin-1 in the oral liquid in this group of patients, in the absence of positive dynamics in the control group, where treatment was performed according to standard methods. …”
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Geometric Characterization of Atmospheric Islands Formed by Two Point Vortices by Gil Marques, Sílvio Gama

“…In order to characterize the geometry of these atmospheres, we compute their perimeter and area as a function of <inline-formula><math display="inline"><semantics><mrow><mi>γ</mi><mo>=</mo><mstyle scriptlevel="0" displaystyle="true"><mfrac><msub><mi mathvariant="normal">Γ</mi><mn>1</mn></msub><mrow><msub><mi mathvariant="normal">Γ</mi><mn>1</mn></msub><mo>+</mo><msub><mi mathvariant="normal">Γ</mi><mn>2</mn></msub></mrow></mfrac></mstyle><mspace width="0.166667em"/><mo>,</mo></mrow></semantics></math></inline-formula> if <inline-formula><math display="inline"><semantics><mrow><msub><mi mathvariant="normal">Γ</mi><mn>1</mn></msub><mo>+</mo><msub><mi mathvariant="normal">Γ</mi><mn>2</mn></msub><mo>≠</mo><mn>0</mn><mspace width="0.166667em"/><mo>.…”
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Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals by Qi Zhang, Chengxiang Xia, Qitong Weng, Leqiang Zhang, Yao Wang, Yanhong Liu, Xiujuan Zheng, Yunqing Lin, Yi Chen, Yiyuan Shen, Hanmeng Qi, Lijuan Liu, Yanping Zhu, Min Zhang, Dehao Huang, Fangxiao Hu, Mengyun Zhang, Mengyun Zhang, Hui Zeng, Jinyong Wang, Jinyong Wang, Tongjie Wang, Tongjie Wang

“…BackgroundChimeric antigen receptor (CAR) engineered natural killer (NK) cells exhibit advantages such as MHC-independent recognition and strong anti-tumor functions. However, allogeneic CAR-NK cells derived from human tissues are heterogeneous and susceptible to clearance by hosts.MethodsWe generated a B2M knockout, HLA-E and CD19 CAR ectopic expressing embryonic stem cell (ESC) line, which differentiated normally and gave rise to homogeneous CD19 CAR-NK (CD19 CAR-UiNK) cells using an organoid aggregate induction method. …”
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MCM9 deficiency impairs DNA damage repair during spermatogenesis, leading to Sertoli cell-only syndrome in humans by Xuan Sha, Xin Zhang, Hao Geng, Yuqian Li, Xun Xia, Guotong Li, Rong Hua, Kuokuo Li, Yang Gao, Qunshan Shen, Rui Guo, Yuping Xu, Xiaojin He, Yunxia Cao, Mingxi Liu, Huan Wu

“…Our study identified two novel homozygous loss-of-function (LoF) mutations in MCM9 in two unrelated NOA patients presenting with Sertoli cell-only syndrome (SCOS). …”
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Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease by Benjamin Siciliano, Nicholas D. Henkel, William G. Ryan V, Ali Sajid Imami, John M. Vergis, Chongchong Xu, Taylen O. Arvay, Smita Sahay, Priyanka Pulvender, Abdul-rizaq Hamoud, Chadwick Hales, Robert E. McCullumsmith, Zhexing Wen

“…Our transcriptomic analysis identified 1249 significantly differentially expressed genes, highlighting a pronounced upregulation of inflammatory genes (SERPINA3, IL6R, IL1RAP, TNFRSF11A) and a concomitant downregulation of genes essential for synaptic support and ion channel function (STMN2, NMNAT2, SCN2A, GRIN1). …”
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Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer by Yongzhi Wu, Chengen Deng, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Weizhong Tang, Xiaoliang Huang

“…Furthermore, using transcriptome data from 23 CRC patients, we constructed an immune cell infiltration matrix to deeply explore the biological functions associated with LNM. Eventually, using the characteristics of the gut microbiota associated with LNM, we developed random forest (RF) and multilayer perceptron (MLP) machine learning models to predict the LNM status of CRC patients. …”
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An organotypic human melanoma-in-skin model as an in vitro tool for testing Vγ9Vδ2-T cell-based immunotherapy by E. Michielon, L.A. King, T. Waaijman, M. Veth, S.W. Spiekstra, H.J. van der Vliet, S. Gibbs, T.D. de Gruijl

“…Conclusions: This study highlights the viability and persistence of Vγ9Vδ2-T cells within the 3D microenvironment, their migratory and antitumor functionality, and the suitability of the model for testing T cell-based therapies, contributing both to the understanding of Vγ9Vδ2-T cell biology and their application in cancer immunotherapy.…”
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Quality management system in vocational education of the Republic of Belarus: Improvement strategy by V. N. Golubovsky

“…In the course of the research, the determinants of improving quality management system of vocational education were identified: established practice for ensuring the quality of vocational education, expressed exclusively by the functions of monitoring the implementation of state requirements of educational institutions and specialities inspected during accreditation every five years; lack of criteria and indicators absence in college development plans that would allow determining the effectiveness of educational activities taking into account the requirements of the state, as well as the future expectations of employers and students from various target groups (school graduates, adults, people with disabilities); diversity in the goal setting of participants in educational relations and ideas about the quality of education. …”
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An in vivo “turning model” reveals new RanBP9 interactions in lung macrophages by Yasuko Kajimura, Shuxin Dong, Anna Tessari, Arturo Orlacchio, Alexandra Thoms, Maria Concetta Cufaro, Federica Di Marco, Foued Amari, Min Chen, Shimaa H. A. Soliman, Lara Rizzotto, Liwen Zhang, Damu Sunilkumar, Joseph M. Amann, David P. Carbone, Amer Ahmed, Giuseppe Fiermonte, Mike A. Freitas, Alessia Lodi, Piero Del Boccio, Lino Tessarollo, Dario Palmieri, Vincenzo Coppola

“…Abstract The biological functions of the scaffold protein Ran Binding Protein 9 (RanBP9) remain elusive in macrophages or any other cell type where this protein is expressed together with its CTLH (C-terminal to LisH) complex partners. …”
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Genome-Wide Analysis of GLK Gene Family in Four Cotton Species Provides Insights into Their Involvement in Cotton Abiotic Stress Response by Rui Tang, Xin Zhou, Shuangshuang Weng, Fei Wang, Rong Li, Quanliang Xie, Zihan Li, Shuangquan Xie, Aiping Cao, Lu Zhuo, Manhong Wang, Hongbin Li

“…However, the specific functions and regulatory mechanisms of GLK members in cotton remain largely unexplored. …”
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MicroRNA-665 and its potential role in drug response and survival outcomes in multiple myeloma: a preliminary study by Rui Bergantim, Rui Bergantim, Rui Bergantim, Rui Bergantim, Sara Peixoto da Silva, Sara Peixoto da Silva, Sara Peixoto da Silva, Vanessa Pinto, Vanessa Pinto, Joana M. Pereira, Joana M. Pereira, Diana Sousa, Diana Sousa, Diana Sousa, Fernanda Trigo, Rune Matthiesen, José E. Guimarães, José E. Guimarães, José E. Guimarães, José E. Guimarães, José E. Guimarães, M. Helena Vasconcelos, M. Helena Vasconcelos, M. Helena Vasconcelos

“…In silico analysis for target-prediction and gene ontology (GO) enrichment was performed to explore the potential biological and functional role of the identified miRNAs.ResultsNGS profiling revealed several miRNAs differently expressed between treatment-refractory and sensitive patients, as well as between PB and BM. …”
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Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications by Mehrdad Hashemi, Asal Abolghasemi Fard, Bita Pakshad, Pezhman Shafiei Asheghabadi, Amineh Hosseinkhani, Atena Sadat Hosseini, Parham Moradi, Mohammadreza Mohammadbeygi Niye, Ghazal Najafi, Mohadeseh Farahzadi, Saloomeh Khoushab, Afshin Taheriazam, Najma Farahani, Mahya Mohammadi, Salman Daneshi, Noushin Nabavi, Maliheh Entezari

“…As a result, we investigated the expression and role of PI3K/AKT-related ncRNAs in clinical characteristics of lung cancer, as well as their functions as potential biomarkers in lung cancer diagnosis, prognosis, and treatment.…”
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Depletion of conventional CD4+ T cells is required for robust priming and dissemination of tumor antigen-specific CD8+ T cells in the setting of anti-CD4 therapy by Keisuke Shirai, Tiffany Chen, Mary Jo Turk, Delaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Joseph D Phillips, Pamela C Rosato, Yina H Huang

“…However, the underlying basis for treatment efficacy, more specifically the implications of codepleting other CD4-expressing cell compartments in tumor-bearing hosts, is not well understood.Methods Tumor-bearing mice were treated with anti-CD4 versus other therapies that preserve helper T cell function, and the priming, tissue distribution, and maintenance of tumor antigen-specific CD8 T cells were assessed. …”
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Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24 by Yu Liu, Xiaoli Zhang, Kun Chen, Hongying Wang, Junhu Yuan, Yiming Ma, Jianhui Ma, Fanyu Zhang, Bing-zhi Wang, Yinong Wang, Xinhua Zhao

“…Mechanistic studies indicated that inhibiting PAR2 expression upregulated miR-34a and miR-146a and downregulated CD24 in cancer cells. …”
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Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice by Yan Gong, Yuzhuo Zhang, Xingda Chen, Zelin Zhou, Weicheng Qin, Yanchi Gan, Jiahui He, Jizhi Ma, Guifeng Chen, Qi Shang, Kai Tang, Honglin Chen, Yu Liu, De Liang, De Liang, Gengyang Shen, Xiaobing Jiang, Zhaojun Cheng, Zhaojun Cheng, Zhaojun Cheng

“…However, the precise mechanism by which MA functions in relation to IDD remains unclear.MethodsIn vivo, a naturally aged animal model was used. …”
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Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…TPL can enter RhoA, Rock1, and Rock2 target protein binding domains with stable binding activities, and may cause conformational changes of Rock1 related to molecular functions.ConclusionTPL inhibits RA-FLS in motility by regulating actin cytoskeleton remodeling through action on the RhoA/Rho-associated kinase signaling pathway.…”
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LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity by D Gareth Rees, Robert W Wilkinson, Mark Cobbold, Georgina Bowyer, Kathy Mulgrew, Simon J Dovedi, Fernanda Arnaldez, Des C Jones, Lorraine Irving, Marcin Wolny, Seraina Blümli, Stacy Pryts, Michael Kierny, Sonja Hess, Rebecca Dudley, Elisavet I Chatzopoulou, Shreya Ahuja, Alan M Sandercock, Saravanan Rajan, Reena Varkey, Andrew Kayserian, Saly Songvilay, Kamila Bienkowska, Matthew S Glover

“…Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2), expressed on myeloid cells, including TAMs, is an inhibitory receptor, which contributes to macrophage-mediated immunosuppression. …”
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POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons by Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia Leon, Elizabeth A McCarthy, Oline K Rønnekleiv, Martin J Kelly, Victor M Navarro

“…Here, we show that Mc4r expressed in Kiss1 neurons regulates fertility in females. …”
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Sex shapes phenotype-linked metabolic signatures of stress exposure in the mouse hypothalamus and pituitary by Lili Wang, Bingtao Jiang, Xunan Ji, Jiaxin Tu, Fengmei Lu, Chen Yang, Xianhui Zhong, Lu Wang, Xiao Cai, Faping Yi, Zongling He, Liang Xie, Jian Zhou

“…These differences facilitated phenotypic differentiation and underscored the relevance of sex-specific metabolic changes and their functional associations to behavioral phenotypes. Moreover, diverging and converging pathways were identified to elucidate the molecular and physiological bases of stress susceptibility in both sexes. …”
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Alterations in neutrophil mRNA profiles in multiple sclerosis and identification of candidate genes for further investigation by Huining Zhang, Huining Zhang, Huining Zhang, Ruoyi Guo, Ruoyi Guo, Ruoyi Guo, Yusen Han, Yusen Han, Yusen Han, Zhichao Yao, Zhichao Yao, Zhichao Yao, Moyuan Quan, Moyuan Quan, Moyuan Quan, Bin Li, Bin Li, Bin Li, Li Guo, Li Guo, Li Guo

“…These results lay the groundwork for future studies exploring therapeutic strategies targeting neutrophil functions in MS.…”
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