Interatrial conduction time is early marker of disturbed impulse propagation in adults with slightly elevated blood pressure by Đikić Dijana, Mujović Nebojša, Giga Vojislav, Marinković Milan, Trajković Goran, Lazić Snežana, Pavlović Vedrana, Perić Vladan, Simić Dragan

“…We studied P wave dispersion, reservoir function of the left atrium (LA), total emptying volume of the LA and total emptying fraction of the LA (LATEF). …”
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Interpretable and generalizable deep learning model for preoperative assessment of microvascular invasion and outcome in hepatocellular carcinoma based on MRI: a multicenter study by Xue Dong, Xibin Jia, Wei Zhang, Jingxuan Zhang, Hui Xu, Lixue Xu, Caili Ma, Hongjie Hu, Jiawen Luo, Jingfeng Zhang, Zhenchang Wang, Wenbin Ji, Dawei Yang, Zhenghan Yang

“…The adversarial network-based model's performance surpassed clinical radiology and squeeze-and-excitation network-based models. Biological function analysis was employed to enhance the interpretability and clinical translatability of the adversarial network-based model. …”
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A gene signature related to programmed cell death to predict immunotherapy response and prognosis in colon adenocarcinoma by Lei Zheng, Jia Lu, Dalu Kong, Yang Zhan

“…A RiskScore model was established with independent prognostic PCD-related genes filtered by Cox regression analysis. The mafCompare function was used to compare the differences in mutation rates of somatic genes. …”
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The effect of Polybrominated diphenyl ethers at the fetal blood-brain-barrier: evaluation using a microphysiological system by Sourabh Sharma, Manuel Vidal, Manuel Vidal, Souvik Paul, Arum Han, Ramkumar Menon, Lauren S. Richardson

“…Dextran propagation over 72 h confirmed FB barrier function. The activation status of microglia was determined using immunocytochemistry for CD11 b and Iba1, respectively. …”
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Effects of kinesiology taping timing on recovery in the lower limbs by Chia-Yu Tang, Ying-Che Huang, Ying-Che Huang, Fu-Shun Hsu, Fu-Shun Hsu, Fu-Shun Hsu, Chia-Hsien Yu, Chang-Chi Lai, Szu-Kai Fu

“…BackgroundKinesiology taping (KT) is widely used to support muscle function and recovery, but its optimal application timing remains unclear. …”
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Factors promoting development of renal tubulointerstitial lesions in patients with diabetes mellitus by Minara Shamkhalovna Shamkhalova, Kseniya Olegovna Kurumova, Inna Igorevna Klefortova, Ivan Ivanovich Sitkin, Alexander Viktorovich Il'in, Margarita Ivanovna Arbuzova, Nikolay Petrovich Goncharov, Gul'nara Viktorovna Katsiya, Andrey Alexeevich Aleksandrov, Svetlana Semenovna Kukharenko, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov

“…Hyperuricemia,TGF-1b, ADMA, and MCP-1 are considered to be the risk factors of impaired renal filtration function. Conclusion. The level of profibrogenic cytokines and ndothelial dysfunction factors in DM patients with different renal lesions reflects severity of tubulointerstitialfibrosis. …”
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STUDY OF THE STATE OF ENT-ORGANS IN CHILDREN WITH ANOMALIES AND DEFORMATIONS OF DENTOALVEOLAR APPARATUS AND SPEECH DISORDERS by P.S. Flis, N.V. Raschenko, A.O. Melnyk, V.V. Filonenko, O.I. Kotov

“…Adenoids (nasopharyngeal tonsil) of the 1st and 2nd degree were established in 86 children (69.35%), 28 children (22.58%) - second degree and 10 (8.06%) - II-III degree, but in all children of the main and comparison groups, nasal breathing function was not noted. In 124 subjects (100%), there was no adenoid type of facial skeleton. …”
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Рroblem of miscarriage in multiple pregnancies by A. V. Zharkikh, E. S. Lyubomirskaya

“…It’s extremely important to use modern uninvasive and safe methods of fetus state function analysis for early diagnostics, prevention of multiple pregnancy miscarriage.…”
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Association of Omega-3 Index and Blood Cell Count-Derived Systemic Inflammatory Indexes among Testicular Germ Cell Tumor Survivors by Milica Zeković, Marko Živković, Marija Takić, Sanja Stanković, Nebojša Bojanić, Aleksandar Janičić, Uroš Bumbaširević

“…Background and objectives: Although testicular cancer is considered the paradigm of highly curable malignancy, treatment-induced adverse effects and potential impairment of gonadal function may cause non-negligible long-term health repercussions, including metabolic disturbances and cardiovascular sequelae. …”
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Comparative effect of dietary fortification of raw and roasted seeds of pumpkin (Cucurbita pepo L) on fertility biomolecules in cisplatin-induced spermatotoxic rats by Seun Funmilola Akomolafe, Mary Aderonke Bola Ogundare, Ibikunle Akinlua, Oluwadamilare Oluwaseun Ajayi, Elijah Olalekan Odesanmi, Olusola Bolaji Adewale

“…Therefore, this study sought to evaluate how raw and roasted pumpkin seed enriched diets affect reproductive function biomarkers in adult male Wistar rats that had been exposed to a single dose (7 mgkg-1 i.p) of cisplatin-induced testicular damage. …”
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Evaluation of Drought Tolerance and Trehalose Response in <i>Auricularia heimuer</i> by Jian Sun, Fangjie Yao, Lixin Lu, Youmin Zhang, Ming Fang, Xiaoxu Ma, Kaisheng Shao, Xu Sun

“…The tested strains were classified into the following four categories according to their membership function values: the first category consisted of the highly drought-tolerant strain A; the second consisted of the drought-tolerant strains A127 and C; the third consisted of the moderately drought-tolerant strains A124, A14, A386, A462, A184, A496, A125, and B; and the fourth consisted of the drought-sensitive strains A356 and A508. …”
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Comparative effectiveness of different transarterial embolization therapies alone or in combination with local ablative or adjuvant systemic treatments for unresectable hepatocellu... by Konstantinos Katsanos, Panagiotis Kitrou, Stavros Spiliopoulos, Ioannis Maroulis, Theodore Petsas, Dimitris Karnabatidis

“…<h4>Findings</h4>The network of evidence included 55 RCTs (12 direct comparisons) with 5,763 patients with preserved liver function and unresectable HCC (intermediate to advanced stage). …”
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The Effect of the Enteral Correction Program on Oxidative Stress Parameters in Patients with Poisoning with Psychopharmacological Agents or Corrosive Substances by M. B. Belova, E. V. Klychnikova, M. M. Potskhverya, A. S. Bogdanova, A. Yu. Simonova, E. V. Tazina

“…Among modern methods of treatment of acute poisoning, the attention is drawn to approaches aimed at normalizing homeostatic indicators by cleansing the enteric environment, restoration of its barrier function.PURPOSE OF THE STUDY Assess the impact of the enteral correction program (ECP) on the parameters of lipid peroxidation (LPO) and antioxidant systems in acute exogenous poisoning.MATERIAL AND METHODS 119 patients who underwent treatment at the N.V. …”
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Realismo y antirrealismo en la concepción semántica de las teorías científicas by León Olivé

“…I go on to argue that the confusion at issue is also present in Pérez Ransanz’s conception of scientific theories, according to what she expressed in her debate with van Fraassen. I stress the idea that there are at least three ways in which the notion of “model” can be used, which are relevant in philosophy of science for the analysis of the structure and function of scientific theories: 1) model in the sense of a structure that satisfies a set of conditions of definition; I refer to this type as logical models; 2) sentential models; and 3) iconic models. …”
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S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation by Fiona K. Sailer, Megan A. Palmer, Blerina Aliraj, Jan Heering, Jan Heering, Andreas Brockmann, Mohammed A. F. Elewa, Mohammed A. F. Elewa, Aissa Röhrig, Aissa Röhrig, Ewgenij Proschak, Ewgenij Proschak, Ewgenij Proschak, Dariusz T. Stepniak, Simeon Ramsey, Bernhard Brüne, Bernhard Brüne, Andreas Weigert

“…Regarding receptor dynamics, we show that Etrasimod induces internalization of S1PR4.ConclusionTaken together, our data show that S1PR4 takes on an essential role in the regulation of various immunological functions, and that Etrasimod can act as a superagonist/functional antagonist of S1PR4.…”
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Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay by Hang Liu, Qiyu Ren, Meihan Gong, Feifei Zuo, Qian Li, Dawei Huo, Ye Yuan, Yutong Zhang, Yu Kong, Xiaozhi Liu, Cailing Lu, Xudong Wu

“…During the peri-implantation stage, coinciding with the transition from naive to primed pluripotency, the long isoform of KDM2B (KDM2BLF) underlies the de novo establishment of polycomb repressive complex (PRC) functions at promoters after fertilization. However, it remains unclear whether and how ethanol exposure affects this spatiotemporal chromatin setting. …”
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CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium by Zhixuan Chen, Huayi Qu, Jian Sun, Tao Wang, Yan Yuan, Yan Yuan, Yan Yuan, Jianhong Gu, Jianhong Gu, Jianhong Gu, Jianchun Bian, Jianchun Bian, Jianchun Bian, Zongping Liu, Zongping Liu, Zongping Liu, Hui Zou, Hui Zou, Hui Zou

“…Key unanswered questions include specific effects on liver function and potential mechanisms.MethodsIn this study, C57BL/6 mice and AML12 cells were used to establish in vivo and in vitro models to elucidate the effects of combined exposure to PS-MPs and Cd on the liver and their mechanisms.ResultsThe results showed that the combined effects of PS-MPs and Cd caused significantly more liver damage than exposure alone. …”
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Maternal phthalates exposure promotes neural stem cell differentiation into phagocytic astrocytes and synapse engulfment via IRE1α/XBP1s pathway by Fengzhen Cui, Shiyu Deng, Yan Fu, Tongtong Xu, Shuangshuang Bao, Siyi Wang, Yahang Lin, Xianghui Wang, Faming Zhao, Tingting Zhang, Shunqing Xu, Zhijun Zhang, Wanlu Li, Guo-Yuan Yang, Huanwen Tang, Jixian Wang, Xia Sheng, Yaohui Tang

“…Conditional knockout or pharmacological inhibition of IRE1α markedly inhibits NSC differentiation into astrocytes and astrocyte reactivity, attenuates synapse phagocytosis, and improves cognitive function. This phenotype is further recapitulated in a human brain organoid model. …”
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Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events by Juncal Fernandez-Orth, Cansu Koyunlar, Julia M. Weiss, Emanuele Gioacchino, Hans de Looper, Geoffroy Andrieux, Mariëtte ter Borg, Joke Zink, Irene Gonzalez-Menendez, Remco Hoogenboezem, Baris Yigit, Kirsten J. Gussinklo, Roger Mulet-Lazaro, Charlotte Wantzen, Sophie Pfeiffer, Christian Molnar, Eric Bindels, Sheila Bohler, Mathijs Sanders, Leticia Quintanilla-Martinez, Marcin Wlodarski, Melanie Boerries, Ivo P. Touw, Charlotte Niemeyer, Miriam Erlacher, Emma de Pater

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Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells by Kyungwha Lee, Jung-Yun Lee, Ji-Hyun Kim, Min Park, Junsik Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Jongil Kim, Suyoun Park, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Kook Hwan Kim

“…Background Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) in various immune cell types. …”
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