Joint risk assessment of drought and heat stroke in rainfed maize in Córdoba, Argentina by Antonio de la Casa, Gustavo Ovando, Guillermo Díaz, Pablo Díaz, Fernando Soler, Juan Clemente, Karina Torterolo, Lorenzo Gabba

“…According to the bivariate normal probability function, the joint risk of both factors occurs in approximately 7–10 % of the years in both December and January, corresponding to roughly half of the drought and heat stroke episodes considered independently.…”
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Overexpression of the apple expansin-like gene MdEXLB1 accelerates the softening of fruit texture in tomato by Yan-hui CHEN, Bin XIE, Xiu-hong AN, Ren-peng MA, De-ying ZHAO, Cun-gang CHENG, En-mao LI, Jiang-tao ZHOU, Guo-dong KANG, Yan-zhen ZHANG

“…Semi-quantitative RT-PCR revealed that most of the expansins were expressed at the ripening stage before harvest. The biological function of the EXLB subfamily gene, MdEXLB1, was further identified, and its subcellular localization on the cell wall was confirmed by transient transformation experiments. …”
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Children’s Headache Through Drawings: A Narrative Review and a Portrait Gallery by Floriana Ferro, Caterina Gaspari, Giulia Manfrè, Federica Cernigliaro, Daniela D’Agnano, Ruben Panzica, Edvige Correnti, Maria Rosita Ruta, Francesca Marchese, Renata Pitino, Mariarita Capizzi, Giuseppe Santangelo, Antonella Versace, Vittorio Sciruicchio, Vincenzo Raieli

“…Headache represents one of the most prevalent and disabling conditions in the pediatric population, with significant repercussions on mental and psychological well-being, as well as on academic achievement and social functioning, ultimately leading to a marked reduction in quality of life. …”
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Effect of areca nut extracts on growth performance, slaughtering performance, and meat quality of broiler chickens by Juan Xu, Mengyao Li, Rong Li, Zhen Zhang, Ying Ma, Ran Tao, Lirui Zou, Ji Wang, Lixin Wen, Lixin Wen, Rongfang Li, Rongfang Li

“…Areca catechu L (AN), known as the leader among the four southern medicinal herbs, possesses functions such as insecticidal, antibacterial, antiinflammatory, promoting gastrointestinal motility and preventing Alzheimer's disease. …”
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Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy by Jianghui Zhang, Hongfeng Jiang, Sa Liu, Zhong Xian, Limin Zhao, Yue Li, Wenxiu Lu, Changrong Shao, Sanbao Chai

“…TNTs mediate the transmission of multiple signaling molecules, enabling cells to exert different biological functions. In the present study, we investigated the role of TNTs in MSC-based therapy for myocardial hypertrophy. …”
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Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways by Qingshan Tang, Jiachen Dong, Feng Zhang, Dan Zhao, Qi Yang, Jiayu Wen, Yuhao Sun, Jifu Wei, Zhixian Liu

“…Next, transcriptome sequencing technology was performed to identify differentially expressed genes (DEGs). Gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) analysis and gene set enrichment analysis (GSEA) were applied to predict the potential functions of DEGs. …”
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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…Furthermore, MEVs were able to traverse the intestinal barriers and reach distal organs, including the brain, thereby potentially influencing brain functionality and contributing to mental and behavior.…”
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A small molecule cryptotanshinone induces non-enzymatic NQO1-dependent necrosis in cancer cells through the JNK1/2/Iron/PARP/calcium pathway by Ying Hou, Bingling Zhong, Lin Zhao, Heng Wang, Yanyan Zhu, Xianzhe Wang, Haoyi Zheng, Jie Yu, Guokai Liu, Xin Wang, Jose M. Martin-Garcia, Xiuping Chen

“…Human NAD(P)H: quinone oxidoreductase 1 (NQO1) is a flavoenzyme expressed at high levels in multiple solid tumors, making it an attractive target for anticancer drugs. …”
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Lactobacillus reuteri alleviates diquat induced hepatic impairment and mitochondrial dysfunction via activation of the Nrf2 antioxidant system and suppression of NF-κB inflammatory... by Shenao Zhan, Lianchi Wu, Yujie Lv, Weichen Huang, Chaoyue Ge, Zhaoying Hu, Xinyu Shen, Gang Lin, Dongyou Yu, Bing Liu

“…In addition, L. reuteri curtailed reactive oxygen species (ROS) production and mitigated the depletion of membrane potential and thus recovering mitochondrial function disturbed by DQ challenge. Moreover, L. reuteri inhibited hepatic toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway activation, downregulated the pro-inflammatory-response-related gene expressions (IL-1β, TNF-α, and IL-6) and the phosphorylation levels of IκBα, and p65 in liver and thus reducing hepatic inflammatory response and apoptosis. …”
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Temporal dynamics of the multi-omic response reveals the modulation of macrophage subsets post-myocardial infarction by Yuan Wu, Panting Wei, Bin Li, Jiaqi He, Ting Zhou, Qingbin Hou, Yunhao Yu, Jingjin Hou, Chenghui Yan, Yaling Han

“…Although single-cell RNA sequencing (scRNA-seq) shed light on the differentiation and function of macrophage subsets post-MI, it failed to capture protein-level changes, limiting comprehensive assessment. …”
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Targeting the pregnane X receptor using microbial metabolite mimicry by Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani

“…Based on prior work that established microbial (indole) metabolites as PXR ligands, we proposed microbial metabolite mimicry as a novel strategy for drug discovery that allows exploiting previously unexplored parts of chemical space. Here, we report functionalized indole derivatives as first‐in‐class non‐cytotoxic PXR agonists as a proof of concept for microbial metabolite mimicry. …”
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TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors by Tanja Bhuiyan, Niccolò Arecco, Paulina Karen Mendoza Sanchez, Juhyeong Kim, Carsten Schwan, Sophie Weyrauch, Sheikh Nizamuddin, Andrea Prunotto, Mehmet Tekman, Martin L. Biniossek, Bettina Knapp, Stefanie Koidl, Friedel Drepper, Pitter F. Huesgen, Robert Grosse, Thorsten Hugel, Sebastian J. Arnold

“…The TFIID complex consists of the TATA binding protein (TBP) and 13 TBP-associated factors (TAFs) that contain intrinsically disordered regions (IDRs) with currently unknown functions. Here, we show that a conserved IDR drives TAF2 to nuclear speckle condensates independently of other TFIID subunits. …”
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Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma by Linlin Zhang, Chuanying Zhu, Shuo Huang, Miaomiao Xu, Chao Li, Hongliang Fu, Yafu Yin, Sheng Liang, Hui Wang, Zhilei Cui, Lei Huang

“…Epidermal growth factor receptor (EGFR) and mutant P53 expressions were positive in 80% and 60% of patients with ATC, respectively. …”
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Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy by Zhihe Chen, Zhongying Yang, Lifen Rao, Changgen Li, Na Zang, Enmei Liu

“…Results GSEA analysis showed significant enrichment of gene sets related to endothelial functions (barrier, defense, and regeneration) and ALI in the HAdV-7-infected group. …”
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Melatonin Alleviates Photosynthetic Injury in Tomato Seedlings Subjected to Salt Stress via OJIP Chlorophyll Fluorescence Kinetics by Xianjun Chen, Xiaofeng Liu, Yundan Cong, Yao Jiang, Jianwei Zhang, Qin Yang, Huiying Liu

“…The findings suggest that exogenous MT mitigates salt stress-induced photoinhibition by (1) modulating endogenous MT concentrations, (2) augmenting PSII reaction center functionality, (3) safeguarding the oxygen-evolving complex (OEC), (4) reinstating PSI redox potential, (5) facilitating photosynthetic electron transport, and (6) optimizing energy absorption and dissipation. …”
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Proxêmica e cinésica como recursos comunicacionais entre o profissional de saúde e o idoso hospitalizado [Proxemics and kinetics as communication resources between health professio... by Teresa Cristina Prochet, Maria Julia Paes da Silva

“…Body posture and gestures deemed as favorable to interacting with the elderly were grouped as follows: functions and meanings (64.1%), situational applicability (43.6%), and expression of feelings (35.0%). …”
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Comparative effects of selenium-enriched lactobacilli and selenium-enriched yeast on performance, egg selenium enrichment, antioxidant capacity, and ileal microbiota in laying hens by Jianmin Zhou, Uchechukwu Edna Obianwuna, Longfei Zhang, Yongli Liu, Haijun Zhang, Kai Qiu, Jing Wang, Guanghai Qi, Shugeng Wu

“…However, high SeL level (6.0 mg Se/kg) compromised productivity and metabolic functions while enhancing Se deposition.…”
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The state of NOergic homeostasis in experimental autoimmune glomerulonephritis against the background of the use of cell-free cryopreserved biological agents by F.V. Hladkykh, T.I. Lіadova

“…NO is a vital molecule involved in a number of signaling functions in the kidney and can be released by a variety of kidney cells, including endothelial and mesangial cells as well as podocytes. …”
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Multiple Hub Genes as Diagnostic and Therapeutic Targets Inducing Inflammation and Angiogenesis in Retinopathy of Prematurity by Du C, Tian Y, Liu Y, Shi Y, Chen X, Chai H, Zhang Y, Shen H, Zhang L

“…WGCNA was utilized to obtain oxygen-induced retinopathy (OIR)-related modules, and then key genes were obtained in the intersection of DEGs and the above modules. Biological functions and pathways of key genes were enriched through DAVID, Metascape and Gene set enrichment analysis. …”
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Retroperitoneal fibrosis in presence of autoimmune coagulation factor XIII deficiency result in recurrent critical post-operative hemorrhage: a case report and molecular research w... by Tomonori Matsushita, Tomonori Matsushita, Mitsuhiro Tachibana, Hiromichi Nakagawa, Shuhei Goto, Koji Nishizawa, Takashi Kobayashi, Takashi Kobayashi, Shigeki Fukuzawa, Kunihiko Itoh

“…The purified IgG antibody samples containing IgG1 and IgG4 were shown to significantly reduce the function of coagulation Factor XIII derived from healthy individuals. …”
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