Developing and validation of religious education curriculum in preschool by Zeinab Ashrafi Soltan-Ahmadi, Sadegh Maleki Avarsin, Javad Keyhan, jahangir yari

“…In addition to the role and function of the family as an effective and important factor in children's issues and problems (Abbass Ghorbani & Naghdi, 2020), today the role of educational systems, especially education, is not limited only in learning science, developing skills, cognitive abilities, and preparing children and teenagers to entering higher education degrees, but its cultural and educational function is very important in the progress and development of societies (Nasiri et al, 2022). …”
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Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells by Wenbo Wu, Mengying Bai, Wenli Hong, Shuyi Ling, Yuan Li, Yuqing Dai, Ruoxin Weng, Haifeng Wu, Chongyang Ren, Liujuan Zhang, Ziqiong Zhou, Zhisheng Zhong, Xinxin Fu, Yuehui Zheng

“…Therefore, activating FGSCs is critical in reshaping and safeguarding ovarian function. Methods In this study, we investigated the biological activity of proanthocyanidins (PACs), natural antioxidants that exhibit anti-aging and anti-inflammatory properties beneficial for both male and female reproduction. …”
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Metabolomics and transcriptomics analyses revealed overexpression of TaMGD enhances wheat plant heat stress resistance through multiple responses by Dongyun Ma, Haizhou Hu, Jianchao Feng, Beiming Xu, Chenyang Du, Yang Yang, Yingxin Xie, Chenyang Wang

“…The current study employed two transgenic wheat lines (MG1516 and MG1314) overexpressing the MGDG synthase gene (TaMGD) and wild-type cv ''JW1'' to explore the function of TaMGD in response to high temperature stress during the anthesis stage of wheat. …”
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Targeting HLA‐E in Lung Cancer: The Therapeutic Potential of IRF5‐Engineered M1‐Macrophage‐Derived Exosomes by Xuqin Feng, Xiangyu Lai, Mingming Zhou, Jun Bie, Tingting Li, Dan Wang, Silin Chen, Xin Hu, Chunyu Wang, Peng Xu

“…Notably, the mechanism by which IRF5 exerts its antitumor function through HLA‐E regulation in lung cancer has not been fully elucidated. …”
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Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling by Cheng Huang, Xi Huang, Xiaoyi Qiu, Xiangzhan Kong, Chunmiao Wu, Xue Jiang, Mingkang Yao, Minghui Wang, Liangping Su, Cui Lv, Ping‐Pui Wong

“…In animal studies, co‐injection of cancer cells with PCs compromises TKI effectiveness, independently of blood vessel functions, while inhibition of β5‐integrin restores tumor cell sensitivity. …”
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Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation by Yaheng Wu, Guo An, Jia Tong, Wenlong Zhang, Zhihua Tian, Bin Dong, Xijuan Liu, Lin Zhao, Chunxiang Ye, Jingtao Liu, Wei Zhao, Huachong Ma

“…Particularly, mitochondrial oxidative phosphorylation was functionally arrested in Gal-3-high tumor cells, as demonstrated by a lower oxygen consumption rate and mitochondrial ATP production through abnormal mitochondrial morphology. …”
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In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands by Christian A. Di Buduo, Francesca Careddu, Samuele Metti, Marco Lunghi, Santo Diprima, Virginia Camilotto, Giovanna Bruni, Umberto Gianelli, Delfina Tosi, Cesare Perotti, Claudia Del Fante, Mario Cazzola, Paola Braghetta, David L. Kaplan, Giampaolo Minetti, Luca Malcovati, Alessandra Balduini

“…This scaffold facilitates critical macrophage-RBC interactions and incorporates fibronectin functionalization to support the formation of erythroblastic island (EBI)–like niches. …”
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Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy by Juan Guo, Xueting Pan, Qingyuan Wu, Ping Li, Chaohui Wang, Shuang Liu, Haoyuan Zhang, Zezhong Huang, Xiaozhou Mou, Huiyu Liu, Jiajia Xue

“…This design conferred dual functionality: (1) enhanced tumor accumulation and immune evasion by exploiting homologous cell-cell interactions and mimicking “self” markers, thereby effectively bypassing macrophage clearance and surpassing the limitations of traditional targeted drug delivery; and (2) amplified ultrasound (US)-mediated intratumoral penetration. …”
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Integrated Single-Cell Analysis Revealed Novel Subpopulations of Foamy Macrophages in Human Atherosclerotic Plaques by Yunrui Lu, Shuang Wu, Shiyu Zhu, Jian Shen, Chang Liu, Chaoyue Zhao, Sheng’an Su, Hong Ma, Meixiang Xiang, Yao Xie

“…We further re-clustered the foamy macrophages into five unique subsets with distinct potential functions: (i) pro-foamy macrophages, exhibiting relatively high inflammatory and adhesive properties; (ii) phagocytic foamy macrophages, specialized in efferocytosis; (iii) high-efflux foamy macrophages marked by high <i>NR1H3</i> expression; (iv) mature foamy macrophages prone to programmed cell death; and (v) synthetic subset. …”
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THE BIBLE IN THE WORLD OF JENA ROMANTICISM by Galina V. Sinilo

“…The purpose of this paper is to determine the significance of The Bible for the religious and mystical philosophy of romantics and to establish the functions of biblical archetextuality in their poetry. …”
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Machine learning–guided single-cell multiomics uncovers GDF15-driven immunosuppressive niches in NSCLC: A translational framework for overcoming anti-PD-1 resistance by Xianfei Zhang, Zhengxin Yin, Xueyu Chen, Nengchong Zhang, Shengjia Yu, Congcong Zhu, Lianggang Zhu, Liulan Shao, Bin Li, Runsen Jin, Hecheng Li

“…External validation using melanoma cohorts (GSE91061) confirmed the pan-cancer predictive relevance of GDF15 and its associated tumor cluster. Functional studies utilizing GDF15-knockdown Lewis lung carcinoma cells showed no significant effect on intrinsic tumor proliferation or growth under immune stress (both p>0.05). …”
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Comprehensive analysis of phagocytosis regulatory genes in bladder cancer: implications for prognosis and immunotherapy by Xueming Ma, Xueming Ma, Xueming Ma, Dongnuan Yao, Dongnuan Yao, Dongnuan Yao, Weitao Yu, Weitao Yu, Weitao Yu, Gongping Wu, Gongping Wu, Gongping Wu, Chengwei Fan, Chengwei Fan, Chengwei Fan, Junqiang Tian, Junqiang Tian, Junqiang Tian

“…A variety of algorithms and analysis techniques, such as Kaplan-Meier analysis, Cox regression analysis, and ConsensusClusterPlus clustering analysis, were used to identify PRGs related to the prognosis of bladder cancer patients, and functional analysis and clustering analysis were conducted in depth. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

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KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation by Maximiliano Arce, Iza Erzar, Fan Yang, Neeharika Senthilkumar, Favour C. Onyeogaziri, Dario Ronchi, Frida C. Ahlstrand, Nora Noll, Roberta Lugano, Mark Richards, Elisa Scola, Monica Corada, Francesca Lazzaroni, Linda Meggiolaro, Jens Schuster, Niklas Dahl, Mika Niemelä, Behnam Rezai Jahromi, Anna Dimberg, Silvia Lanfraconi, Roberto Latini, Peetra U. Magnusson

“…KRIT1 bi-allelic loss-of-function mutations in endothelial cells are known to trigger brain cavernomas; however, human preclinical models are needed to unveil the importance of germline KRIT1 heterozygous mutations in CCM pathogenesis. …”
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LIF Promotes Sec15b‐Mediated STAT3 Exosome Secretion to Maintain Stem Cell Pluripotency in Mouse Embryonic Development by Li Xu, Jinjun Ji, Lingbo Wang, Jieli Pan, Mingzhe Xiao, Chenxi Zhang, Yihong Gan, Guanqun Xie, Mingdian Tan, Xinchang Wang, Chengping Wen, Yongsheng Fan, Y. Eugene Chin

“…In STAT3mut/mut embryos, gene expressions related to hematological system function changed significantly and those living ones carry a series of abnormalities in the hematopoietic system. …”
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VISUAL LANGUAGE OF MULTIMODAL TEXT: PRAGMATICS OF COLOR (The Russian-Ukrainian War in the Covers of World Publications) by Maryna M. Zhovnir, Tetyana O. Leshchenko

“…The purpose of the article is to clarify and describe the pragmatic potential of color as a key component of the visual-graphic text for expressing the information encoded in it. To achieve the goal, it was necessary to find out the essence, specificity and functions of the cover as a multimodal text consisting of heterogeneous components; to identify the potential of color for symbolization of information and the process of decoding meanings presented on the cover with the usage of color; to analyze the peculiarity of the embodiment of the main realities within Russian-Ukrainian war on the cover by means of color and their connection with pragmatic tasks. …”
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Pseudovibriamides from Pseudovibrio marine sponge bacteria promote flagellar motility via transcriptional modulation by Yitao Dai, Vitor Lourenzon, Laura P. Ióca, Dua Al-Smadi, Lydia Arnold, Ian McIntire, Roberto G. S. Berlinck, Alessandra S. Eustáquio

“…Here, we first assign functions to pseudovibriamide biosynthetic genes using reverse genetics. …”
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“Pink power”—the importance of coralline algal beds in the oceanic carbon cycle by Nadine Schubert, Fernando Tuya, Viviana Peña, Paulo A. Horta, Vinícius W. Salazar, Pedro Neves, Cláudia Ribeiro, Francisco Otero-Ferrer, Fernando Espino, Kathryn Schoenrock, Federica Ragazzola, Irene Olivé, Thalassia Giaccone, Matteo Nannini, M. Cristina Mangano, Gianluca Sará, Francesco Paolo Mancuso, Mario Francesco Tantillo, Mar Bosch-Belmar, Sophie Martin, Line Le Gall, Rui Santos, João Silva

“…Here, our data, covering large bathymetrical (2–51 m) and geographical ranges (53°N–27°S), show that coralline algal beds are highly productive habitats that can express substantial carbon uptake rates (28–1347 g C m−2), which vary in function of light availability and species composition and exceed reported estimates for other major macroalgal habitats. …”
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Sucrose synthase gene family in common bean during pod filling subjected to moisture restriction by Norma Cecilia Morales-Elias, Eleazar Martínez-Barajas, Lilia Angélica Bernal-Gracida, Monserrat Vázquez-Sánchez, Iris Grisel Galván-Escobedo, Jose Salud Rodriguez-Zavala, Amelia López-Herrera, Cecilia Beatriz Peña-Valdivia, Antonio García-Esteva, Carlos Alberto Cruz-Cruz, María Teresa González-Arnao, José Cruz Jiménez-Galindo, Daniel Padilla-Chacón

“…The results provide a systematic overview of the PvSUS gene family in P. vulgaris, offering a framework for further research and the potential functional application of PvSUS genes.…”
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Effectiveness and Safety of Pharmacopuncture Therapy Compared to Standard Physical Therapy in Patients with Chronic Knee Pain: A Pilot Study for a Pragmatic Randomized Controlled T... by Myung In Jeong, Jun Kyu Lim, Yong Jun Kim, Yu Sun Jeon, Suna Kim, Chang Youn Kim, Yeon-Cheol Park, Eun-Jung Kim, Yejin Hong, Dongwoo Nam, Yoon Jae Lee, Doori Kim, In-Hyuk Ha

“…<i>Conclusions</i>: PPT demonstrated excellent effectiveness in pain relief and functional improvement in these patients.…”
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