Blood Pressure and Late Pregnancy Circulating miRNAs in the MADRES Study by Elizabeth C. Anderson, Meghan E. Muse, Zhongzheng Niu, Helen B. Foley, Joshua J. Levy, Megan E. Romano, Jiang Gui, Jessica L. Bentz, Shohreh F. Farzan, Theresa M. Bastain, Carmen J. Marsit, Carrie V. Breton, Caitlin G. Howe

“…Target genes of BP‐associated EVP miRNAs were overrepresented in pathways involved in vascular inflammation, oxidative stress, endothelial dysfunction, and placental function. Conclusions Circulating levels of placenta‐expressed EVP miRNAs previously implicated in adverse birth and cardiovascular outcomes are sensitive to elevated maternal BP during pregnancy, including in the subclinical range.…”
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Targeting metabolic vulnerability by combining NAMPT inhibitors and disulfiram for treatment of recurrent ovarian cancer by Kei Kudo, Yoshimi Endo Greer, Daniel R. Crooks, Ye Yang, Jeffrey R. Brender, Teruhiko Yoshida, Brittney S. Harrington, Rahul Kamdar, Soumya Korrapati, Yusuke Shibuya, Leah Henegar, Jeffrey Kopp, Takeo Fujii, Stanley Lipkowitz, Christina M. Annunziata

“…Moreover, we identified a previously unrecognized anti-tumor mechanism whereby disulfiram, an aldehyde dehydrogenase (ALDH) inhibitor, synergistically inhibited mitochondrial function when combined with NAMPT inhibitors - leading to cell cycle arrest in G2/M. …”
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Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments by Kunle Odunsi, Hans Minderman, Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Raymond J Kelleher Jr, Beatriz M Carreno, Gerald Linette, Leonard D Shultz, Sathy V Balu-Iyer, Koon Yan Pak, Richard B Bankert

“…We have previously shown that phosphatidylserine (PS) expressed on the surface of exosomes isolated from human TMEs is causally linked to T-cell immunosuppression, representing a potential immunotherapeutic target. …”
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Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics by Yuanfeng Huang, Mingjie Liang, Yiwen Liao, Zirui Ji, Wanfen Lin, Xiangjin Pu, Lexun Wang, Weixuan Wang

“…Studies have demonstrated that SW033291 benefits tissue repair, organ function, and muscle mass in elderly mice. Our recent investigation initially reported the beneficial effect of SW033291 on T2DM progression. …”
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CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype by Binle Tian, Zhilong Wang, Mei Cao, Na Wang, Xuebing Jia, Yuanyuan Zhang, Jingyi Zhou, Sijia Liu, Wen Zhang, Xiao Dong, Zheng Li, Junli Xue, JianFei Wang, Guo-Huang Fan, Qi Li

“…Conclusions IPG0521m inhibited liver cancer growth via reducing the immunosuppressive function of Tregs, thereby boosting anti-cancer immunity. …”
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OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development by Ali Oghabian, Per Harald Jonson, Swethaa Natraj Gayathri, Mridul Johari, Ella Nippala, David Gomez Andres, Francina Munell, Jessica Camacho Soriano, Maria Angeles Sanchez Duran, Juha Sinisalo, Heli Tolppanen, Johanna Tolva, Peter Hackman, Marco Savarese, Bjarne Udd

“…Abstract Background Highly expressed in skeletal muscles, the gene Obscurin (i.e. …”
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Consumers acceptability of using screen capture methods to capture marketing strategies on online food delivery platforms: a qualitative study by Adyya Gupta, Kathryn Backholer, Catherine E Huggins, Gloria KW Leung, Rebecca Bennett, Anna Peeters

“…Over half used OFD service two to five times per week. Participants expressed that both smartphone’s in-built screen recording function and third-party screen recording application are easy-to-use and time-efficient with high levels of user satisfaction. …”
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Analysis of the Critical Discourse of the Mediatization of Religion in Murals from the Constitutional Era by Samaneh Seraj, Khashayar Ghazizadeh

“…Beyond their representational function, these murals symbolized ideological shifts and facilitated new modes of religious engagement. …”
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Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whol... by Jing Zeng, Jing Zeng, Qingli Li, Qingli Li, Kemin Li, Kemin Li, Lu Yang, Lu Yang, Lian Xu, Lian Xu, Wei Wang, Wei Wang, Kaixuan Yang, Kaixuan Yang, Qingbo Wei, Jin Wang, Changbin Zhu, Rutie Yin, Rutie Yin

“…The biological differences between MLAs and epithelial-initiated gynecologic tumors reported in The Cancer Genome Atlas database were also analyzed.ResultsKRAS mutations (82.4%) were considered the driving mechanism and were co-mutated with PIK3CA (47.1%) and SPOP (23.5%), but their functions were mutually exclusive. In addition, pathways and genes associated with kidney development were upregulated in MLA patients. …”
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Mutations in the WUSCHEL-related homeobox1 gene cause an increased leaflet number in soybean by Yawei Li, Li Chu, Peiyun Lyu, Wenhuan Lyu, Ping Xie, Chunting Zhang, Haoxian Feng, Bin Liu, Tuanjie Zhao

“…WUSCHEL-related homeobox (WOX) transcription factors play a crucial role in lateral organ development in several plant species; however, their precise functions in soybean (Glycine max [L.] Merr.) were unclear. …”
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SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation by Rosa Nicole Freiberger, Cynthia Alicia Marcela López, Patricio Jarmoluk, María Belén Palma, Cintia Cevallos, Franco Agustin Sviercz, Tomás Martín Grosso, Marcela Nilda García, Jorge Quarleri, M. Victoria Delpino

“…This study underscores the capacity of ancestral and Omicron SARS-CoV-2 variants to disrupt osteoblast differentiation, a process essential for preserving the homeostasis and functionality of bone tissue.…”
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ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by Recruiting SMYD3 in Breast Cancer by Wenwen Geng, Junhua An, Ke Dong, Hailu Zhang, Xiuyuan Zhang, Yuchen Liu, Rong Xu, Yifan Liu, Xiaofen Huang, Haiyun Song, Wei Yan, Aihua Sun, Fuchu He, Jian Wang, Haidong Gao, Chunyan Tian

“…The transforming growth factor‐β (TGF‐β) pathway plays a vital role in breast cancer metastasis, in which Smad3 is the key mediator and performs specific functions by binding with different cofactors. However, Smad3 cofactors involved in lung metastasis have not yet been identified. …”
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Lung‐Targeted Lipid Nanoparticle‐Delivered siUSP33 Attenuates SARS‐CoV‐2 Replication and Virulence by Promoting Envelope Degradation by Yuzheng Zhou, Yujie Liao, Lujie Fan, Xiafei Wei, Qiang Huang, Chuwei Yang, Wei Feng, Yezi Wu, Xiang Gao, Xiaotong Shen, Jian Zhou, Zanxian Xia, Zheng Zhang

“…Abstract As a structural protein of SARS‐CoV‐2, the envelope (E) protein not only plays a key role in the formation of viral particles, but also forms ion channels and has pathogenic functions, including triggering cell death and inflammatory responses. …”
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Cell Wall Invertase 4 Governs Sucrose–Hexose Homeostasis in the Apoplast to Regulate Wood Development in Poplar by Jing Lu, Qiao Ren, Qilin Wang, Yaqi Wen, Yanhong Wang, Ruiqi Liang, Dingxin Ran, Yifeng Jia, Xinyu Zhuo, Jiangtao Luo, Xianqiang Wang, Keming Luo

“…In perennial trees, wood development is a carbon-demanding process, pivotal for secondary cell wall (SCW) formation and xylem development. Sugars, functioning both as carbon substrates and signaling molecules, orchestrate cambial proliferation and xylem differentiation. …”
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Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses by Rita Turpin, Karita Peltonen, Jenna H. Rannikko, Ruixian Liu, Anita N. Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Petrus Järvinen, Kanerva Lahdensuo, Riikka Järvinen, Sara Tornberg, Tuomas Mirtti, Pia Boström, Ilkka Koskivuo, Anil Thotakura, Jeroen Pouwels, Maija Hollmén, Satu Mustjoki, Juha Klefström

“…Tumor-resident immune cells play a crucial role in eliciting anti-tumor immunity and immunomodulatory drug responses, yet these functions have been difficult to study without tractable models of the tumor immune microenvironment (TIME). …”
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Improving recombinant protein secretion in Aspergillus nidulans by targeting the N-glycosylation machinery by Jaqueline Aline Gerhardt, Marcelo Ventura Rubio, Cesar Rafael Fanchini Terrasan, Natalia Sayuri Wassano, Aryadne Rodrigues, Fernanda Lopes de Figueiredo, Everton Paschoal Antoniel, Fabiano Jares Contesini, Artur Hermano Sampaio Dias, Uffe Hasbro Mortensen, Munir Salomão Skaf, André Damasio

“…N-glycosylation can significantly affect protein stability, production yield, and functionality. This study investigated the isolated and combined deletion of genes involved in N-glycan assembly on protein production in Aspergillus nidulans. …”
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Identification of a novel aminoglycoside nucleotidyltransferase gene in Morganella morganii from farm sewage by Junwan Lu, Jing Wang, Mengdi Gao, Kexin Zhou, Jialei Liang, Chunhan Song, Xuying He, Chaoqun Liu, Huiyue Feng, Wei Pan, Qiyu Bao, Chunxia Yan, Dawei Huang

“…Cloning of the predicted resistance gene was conducted, and its resistance function was assessed through MIC testing. The protein was expressed in E. coli, and the kinetic parameters were quantified. …”
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Transcriptomic Analysis Provides New Insights into Oocyte Growth and Maturation in Greater Amberjack (<i>Seriola dumerili</i>) by Jiahui Yang, Xiaoying Ru, Yang Huang, Jinhui Wu, Tonglin Yang, Peipei Chen, Jin Li, Kunfeng Zhu, Chunhua Zhu

“…A total of 6597, and 1061 differentially expressed genes (DEGs) were detected in FII vs. FIII, FIII vs. …”
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Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach by Guanwei Ma, Xi Yan, Chao Wang, Xiaoqian Ran, Zhiyuan Liang, Xiaolu Chen, Ting Hu, Xiaoxiao Tang, Hongbin Zhuang, Yuhan Huang, Peng Luo, Liming Shen

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Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer’s disease patients by Matthew Paul Lennol, Irene Sánchez-Domínguez, Inmaculada Cuchillo-Ibañez, Elena Camporesi, Gunnar Brinkmalm, Daniel Alcolea, Juan Fortea, Alberto Lleó, Guadalupe Soria, Fernando Aguado, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero

“…Conclusion These results indicate that despite the increase in total apoE content the apoE protein is altered in AD CSF, suggesting that function may be compromised.…”
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