МОДЕЛЬ ПРОГНОЗНОГО ОБЕСПЕЧЕНИЯ НАСЕЛЕНИЯ ОСНОВНЫМИ ВИДАМИ ПРОДОВОЛЬСТВИЯ В СООТВЕТСТВИИ С РАЦИОНАЛЬНЫМИ НОРМАМИ ЕГО ПОТРЕБЛЕНИЯ MODEL FOR PREDICTIVE PURPOSE OF POPULATION BY MAJOR...

“…Providing the population with affordable safe food is becoming increasingly important due to the growing population of the planet, the aggravation of socio-economic relations between states, the increase in the number of environmental problems and the replacement of natural organic food with snacks, products containing artificial components and GMOs, and functional foods.The article discusses the planning of measures taken by the regional authorities to provide the population with basic types of food, the calculation of the needs of which is compiled in accordance with rational norms for the consumption of food products that meet modern requirements for healthy nutrition.On the basis of linear programming, a model of predictive provision of the population with basic types of food products for the period 2018-2020 was compiled. …”
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Serum vitamin D levels in patients with Bell’s palsy: a systematic review and meta-analysis by Elaheh Foroughi, Mehrdad Mozafar, Shayesteh Haghighi, Maryam Moghbel Baerz, Kosar Salehi Torabi, Aref Hafezi Bafti, Fatemeh Asadi, Mani Khorsand Askari, Erfan Shahabinejad

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Development of an <i>in vitro</i> model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ova... by V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova

“…Isolation and purification of transmembrane proteins, including NaPi2b, for structural and functional studies is difficult, therefore it is necessary to develop an in vitro model to study the formation of disulfide bonds in the ECD region of the NaPi2b transporter and their role in ensuring the availability of the cryptic MX35 epitope and transporter activity in living cells.Aim. …”
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ANATOMICAL AND GENETIC PREDISPOSITION FOR CARIES IN PERMANENT DENTITION. REVIEW by K.A. Udaltsova, E.O. Pisarenko

“…They identified 23 modules comprising of 53 genes. Functional analyses of these 53 genes revealed three major clusters: cytokine network relevant genes, matrix metalloproteinases (MMPs) family, and transforming growth factor-beta (TGF-β) family, all of which have been previously implicated to play important roles in tooth development and carious lesions. …”
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Formation of tight junction-like structures of zonula occludens 2 in platelet–platelet interaction by Magdolna Nagy, Markus Bender, Natalie S. Poulter, Jeremy A. Pike, Albert Sickmann, Sonja Vondenhoff, Natalia Bielicka, Marc A.M.J. van Zandvoort, Rory R. Koenen, Hugo ten Cate, Xavier Stéphenne, Johan W.M. Heemskerk, Constance C.F.M.J. Baaten

“…Background: In tissues, cell–cell adhesion, barrier formation, and communication are regulated by gap, adherens, and tight junction (TJ) proteins. Platelets express several of these proteins. Platelets express key building blocks of gap junctions, the connexins, with known functions in integrin αIIbβ3 regulation. …”
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Selectively targeting BCL6 using a small-molecule inhibitor is a potential therapeutic strategy for glioblastoma by Min Wu, Lin Zhang, Weikai Guo, Shiyi Lv, Wangrui Jin, Shuangshuang Zhu, Huang Chen, Shuyi Jian, Layang Liu, Yajing Xing, Shihong Peng, Mingyao Liu, Yihua Chen, Zhengfang Yi

“…B-cell lymphoma 6 (BCL6) is a transcription factor that functions to suppress the transcription of DNA damage response genes, halting cell death in response to DNA damage. …”
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Methionine regulates maternal-fetal immune tolerance and endometrial receptivity by enhancing embryonic IL-5 secretion by Shuang Cai, Bangxin Xue, Siyu Li, Xinyu Wang, Xiangzhou Zeng, Zhekun Zhu, Xinyin Fan, Yijin Zou, Haitao Yu, Shiyan Qiao, Xiangfang Zeng

“…This study reveals the crucial functions of methionine and IL-5 and offers a potential nutritional strategy for successful pregnancy.…”
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Integrative Transcriptome and Metabolome Analysis Identifies Potential Pathways Associated with Cadmium Tolerance in Two Maize Inbred Lines by Pingxi Wang, Min Li, Xingye Ma, Bin Zhao, Xining Jin, Huaisheng Zhang, Shilin Chen, Xiangyuan Wu, Xiaoxiang Zhang

“…Functional annotation revealed that the unique DEGs in C7_2 were mainly enriched in plant hormone signal transduction, plant–pathogen interactions, and the MAPK signaling pathway, while the unique DEGs in Z58 were mainly enriched in ribosome-related functions, plant hormone signal transduction, and phenylpropanoid biosynthesis. …”
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Identification of autoantibodies targeting citrullinated CLEC12A in rheumatoid arthritis patients by Lillian Barra, Sheri Saunders, Mathias Mangion, Guillaume Paré, Halim Maaroufi, Alain Garnier, Ewa Cairns, Maria J. Fernandes

“…Citrullination may be a mechanism through which CLEC12A's inhibitory function is altered to exacerbate inflammation in RA. …”
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Erythropoietin delivery through kidney organoids engineered with an episomal DNA vector by Z. Du, A. Bas-Cristóbal Menéndez, M. Urban, A. Hartley, D. Ratsma, M. Koedam, T. P.P. van den Bosch, M. Clahsen-van Groningen, J. Gribnau, J. Mulder, M. E.J. Reinders, C. C. Baan, B. van der Eerden, R. P. Harbottle, Martin J. Hoogduijn

“…Abstract Background The kidney’s endocrine function is essential for maintaining body homeostasis. …”
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Transient pharmacological inhibition of SUMOylation during pregnancy induces craniofacial malformations in offspring mice by Jorge Mata-Garrido, Isabella Zafferri, Alice Nordlinger, Yann Loe-Mie, Anne Dejean, Jack-Christophe Cossec

“…Transcriptomic analysis revealed the repression of genes involved in neural crest differentiation in the TAK981-treated embryos as well as the overexpression of the Fgfr gene family in the adult TAK981 progeny. These genes, expressed in neural crest derivatives, are known for their gain-of-function mutations linked to human craniosynostosis syndromes, suggesting that potential overactivation of the FGF signaling pathway may contribute to the malformations observed in TAK981 progeny. …”
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p54-Fc-Labeled Gold Nanoparticle-Based Lateral Flow Strip-Assisted Portable Devices for Rapid and Quantitative Point-of-Care Detection of ASFV Antibodies by Yang Yang, Yuhao Li, Ziyang Wang, Minglong Tong, Pengcheng Zhu, Juanxian Deng, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Zhongren Zhou, Yafeng Qiu, Zhiyong Ma, Jianchao Wei

“…The dilution of the serum sample can be determined by substituting the absorbance (T-line) interpreted by portable devices into the calibration curve function formula of an African swine fever virus standard serum. …”
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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model by Emily G. Thompson, Olivia Spead, Suleyman C. Akerman, Carrie Curcio, Benjamin L. Zaepfel, Erica R. Kent, Thomas Philips, Balaji G. Vijayakumar, Anna Zacco, Weibo Zhou, Guhan Nagappan, Jeffrey D. Rothstein

“…Human C9orf72 is typically associated with altered TAR DNA-binding protein (TDP-43) function, yet studies of this rodent model revealed no significant evidence of TDP-43 dysfunction. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…</em></p><p><em>2)     </em><em>Unconstrained decision problems that consist of minimizing or maximizing a function. The main concern is the finding of the solution value that corresponds to the global optimum. …”
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Identification of 2 novel noncoding variants in patients with Diamond-Blackfan anemia syndrome by whole genome sequencing by Ting Wen, Steven E. Boyden, Caleb M. Hocutt, Robert G. Lewis, Erin E. Baldwin, Jennie Vagher, Ashley Andrews, Thomas J. Nicholas, Alexander Chapin, Elaine M. Fan, Lorenzo D. Botto, Pinar Bayrak-Toydemir, Rong Mao, Jessica A. Meznarich

“…RNA sequencing analysis demonstrated deleterious functional consequences for both noncoding variants. …”
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Dap10 co-stimulation enhances the anti-HCC efficacy of NKp30 chimeric antigen receptor T cells by JieYu Li, LiMei Chen, MingShui Chen, Miao Lin, Zineng Xie, HuiLing Wu, ZhiFeng Zhou, WanSong Lin

“…These findings suggest that B7H6 is an attractive therapeutic target and DAP10 signaling is involved in the functional regulation of CAR-T cells in hepatocellular carcinoma, which may induce preferential cytokine profiling and differentiation for cancer therapy, and that NKp30-Dap10 CAR-T cell therapy offers a potential option for the treatment of hepatocellular carcinoma.…”
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Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa by Jillian Eisenhauer, Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R. Trachtman, Jacqueline D. Chu, David Custodio-Zegarra, Suman Bharti, Bhavya Bhardwaj, Shuangyi Bai, William T. Witt, Maria de la Paz Gutierrez, Sarah J. Miller, Kaitlyn Flowers, Trevor R. F. Smith, Bronwyn M. Gunn, Mariette Barbier, Elizabeth M. Parzych, David B. Weiner, Ami Patel

“…We previously described both protection and long-term expression of synthetic DNA-encoded MAb (DMAb) expressing the anti-PcrV MAb V2L2-MD. …”
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Insights into the Biological Activity and Bio‐Interaction Properties of Nanoscale Imine‐Based 2D and 3D Covalent Organic Frameworks by Hao Ye, Carlos Franco, Mostafa A. Aboouf, Markus Thiersch, Semih Sevim, Joaquin Llacer‐Wintle, Andrea Veciana, Gemma Llauradó‐Capdevila, Kaiyuan Wang, Xiang‐Zhong Chen, Qiao Tang, Roc Matheu, Pedro D. Wendel‐Garcia, Pedro A. Sánchez‐Murcia, Bradley J. Nelson, Cong Luo, Josep Puigmartí‐Luis, Salvador Pané

“…Their customizable functionalities and tunable pore structures make them valuable for various biomedical applications such as biosensing, bioimaging, antimicrobial activity, and targeted drug delivery. …”
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FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…Mouse orthotopic HCC models and a coculture system were constructed, and cytometry by time-of-flight analysis was performed to investigate the functions and mechanisms of specific CAFs in the immune context of HCC.Results We identified a distinct flavin-containing monooxygenase 2 (FMO2)+ CAF subset associated with a favorable response to anti-PD-1 therapy and better clinical outcomes. …”
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Effects of different dietary zinc sources on growth performance, muscle texture, and intestinal immunity in Mandarin Fish (Siniperca chuatsi) by Xiaolu Yan, Lingcheng Pan, Zhigang Deng, Yabin Wu, Dianchao Gu, Lei Yan, Yushuang Chen, Da Zhou, Fubao Wang, Min Zhao, Li Luo

“…Overall, amino acid-chelated zinc outperforms zinc sulfate in promoting growth, improving muscle quality, antioxidant and immune functions, and enhancing intestinal health, with Zn-Met (2:1) having the best effects.…”
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