PPM1J regulates meat quality feature and glycerophospholipids composition in broiler by modulating protein dephosphorylation by Manting Ma, Xin Yang, Yanan Zhang, Shuang Wang, Chenglong Jin, Weiguang Xia, Wei Chen, Bolin Cai, Chuntian Zheng

“…Gain- and loss-of-function analysis revealed that PPM1J induced muscular atrophy, improved meat quality and regulated the composition of glycerophospholipids. …”
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Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers with tertiary lymphoid structures by Richard H. Mebane, Teia Noel, Nathan Ing, Kenneth H. Gouin, III, Aagam Shah, David Zitser, Andrew Martinez, Gaorav Gupta, Sandra Demaria, Lorenzo Galluzzi, Alice Ho, Heather McArthur, Stephen L. Shiao, Simon.R.V. Knott

“…However, TLSs vary in their ability to elicit anticancer immune activity, so it is important to develop databases that allow study of variables that regulate their function. We applied single RNA molecule resolution imaging to longitudinal biopsies taken from women with TLS-enriched triple negative breast cancers prior to therapy, after pembrolizumab and after pembrolizumab plus radiation therapy. …”
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Metabolomics and proteomics insights into hepatic responses of weaned piglets to dietary Spirulina inclusion and lysozyme supplementation by Cátia Falcão Martins, Manolis Matzapetakis, David M. Ribeiro, Josipa Kuleš, Anita Horvatić, Nicholas Guillemin, Peter David Eckersall, João P. B. Freire, André M. Almeida, José A. M. Prates

“…Together, Spirulina and lysozyme demonstrate potential as functional dietary components, but further optimization is needed to fully realize their benefits without compromising growth performance.…”
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METTL3-mediated m6A modification is required for cerebellar development. by Chen-Xin Wang, Guan-Shen Cui, Xiuying Liu, Kai Xu, Meng Wang, Xin-Xin Zhang, Li-Yuan Jiang, Ang Li, Ying Yang, Wei-Yi Lai, Bao-Fa Sun, Gui-Bin Jiang, Hai-Lin Wang, Wei-Min Tong, Wei Li, Xiu-Jie Wang, Yun-Gui Yang, Qi Zhou

“…However, the in vivo functions of METTL3 and m6A modification in mammalian development remain unclear. …”
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Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis by Nelson García-Vázquez, Tania J González-Robles, Ethan Lane, Daria Spasskaya, Qingyue Zhang, Marc A Kerzhnerman, YeonTae Jeong, Marta Collu, Daniele Simoneschi, Kelly V Ruggles, Gergely Róna, Sharon Kaisari, Michele Pagano

“…In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. …”
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Recovery of Bacteroides thetaiotaomicron ameliorates hepatic steatosis in experimental alcohol-related liver disease by Moris Sangineto, Christoph Grander, Felix Grabherr, Lisa Mayr, Barbara Enrich, Julian Schwärzler, Marcello Dallio, Vidyasagar Naik Bukke, Archana Moola, Antonio Moschetta, Timon E. Adolph, Carlo Sabbà, Gaetano Serviddio, Herbert Tilg

“…Bacteroides thetaiotaomicron (Bt) is a prominent member of human and murine intestinal microbiota, and plays important functions in metabolism, gut immunity, and mucosal barrier. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…A protein-protein interaction (PPI) network was then constructed, and core targets were screened with the Cytoscape plug-in. Molecular functions and pathways were analyzed through GO and KEGG pathway enrichment analyses. …”
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Fluridone promotes the germination of Polygonatum cyrtonema seeds by modulating hormone signal transduction, phenylpropanoid biosynthesis, and energy metabolism by Xiaogang Jiang, Darong Li, Hua Wang, Yuying Yang, Kaidi Yu, Jinwen You, Haihua Liu, Xiaoliang Guo, Yinsheng He, Wuxian Zhou, Qingfang Wang

“…Abstract Polygonatum cyrtonema Hua functions as a highly valued medicinal herb. However, the seeds of P. cyrtonema exhibit morphophysiological dormancy. …”
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PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway by Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu

“…Platelet factor 4 (PF4), a chemokine with diverse biological functions, has an unclear role in ICH and its impact on neuronal ferroptosis. …”
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Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease by Han Gao, Mingming Sun, Ai Li, Qiaoyan Gu, Dengfeng Kang, Zhongsheng Feng, Xiaoyu Li, Xuehong Wang, Liang Chen, Hong Yang, Yingzi Cong, Zhanju Liu

“…The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on mucosal CD4+ T cell functions in inflammatory bowel disease (IBD) remain elusive. …”
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Sedimentary records from human-made talavs reveal climate risks in semi-arid watersheds of India by Atreyee Bhattacharya, S. Sarkar, J.S. Leonard-Pingel, A.V. Michelson, A Anoop, P.K. Mishra, S. Chakraborty, K Bajaj, U Singh, V Petryshyn, R. Ray, P.D. Sabale, A Bhattacharya, M. Kirby, A. Bazaz

“…Our reconstructions show that land erosion and subsequent sediment deposition in talavs are tied to the regional expressions of the Indian summer monsoon (ISM). We also find that while run-off is sensitive to divisional expressions of hydroclimate variability (associated with the ISM), the intensity of run-off and resultant erosion is not a simple function of rainfall intensity; in fact, we find that land-surface erodibility is impacted by land-use patterns and incidence of prior climate events (e.g. flooding) and that these compunded effects are more prominent in drier catchments (which also experience more extreme climate events) than in the wetter parts of the watersheds. …”
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Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel by Geoanna M. Bautista, Yingjie Du, Michael J. Matthews, Allison M. Flores, Nicole R. Kushnir, Nicolle K. Sweeney, Nam Phuong N. Nguyen, Elmira Tokhtaeva, R. S. Solorzano-Vargas, Michael Lewis, Matthias Stelzner, Ximin He, James C. Y. Dunn, Martin G. Martin

“…Here, we investigate the effects of SMC-specific Piezo1 deletion on small bowel function. Piezo1 depletion results in weight loss, delayed GI transit, muscularis thinning, and decreased SMCs. …”
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Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. by Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari

“…The GRADE evidence quality was noted to be very low for dizziness and fatigue, low for difficulties with mentation, and moderate for visual disturbances. Functional and emotional improvements were reported by few studies and showed no significant improvements.…”
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Stroke in a young patient? Consider reversible cerebral vasoconstriction syndrome (RCVS) by Muhammad Khairul Fadli Abd Ghaffar, Mohamed Hassan, Shawn Halpin

“…With no stroke risk factors or relevant family history, she made a full functional recovery. She was discharged on antiplatelets and a statin but struggled emotionally with the diagnosis and was referred for psychological support. …”
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LOCAL APPLICATION OF RECOMBINANT INTERFERON-ALFA2 FOR TREATMENT OF RECURRENT RESPIRATORY PAPILLOMATOSIS by M. Plouzhnikov, E. Katinas, M. Ryabova, S. Karpishenko, K. Syssoev, A. Chukhlovin, A. Totolian

“…In all cases, we revealed an initially decreased functional activity of Т-lymphocytes, as well as low contents of Т-killer and NK-cells. …”
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DETECTION AND SYSTEMATIZATION OF SIGNS AND MARKERS OF MODIFICATIONS IN MEDIA CONTENT FOR THE DEVELOPMENT OF A METHODOLOGY TO ENHANCING CRITICAL THINKING IN THE ERA OF DEEPFAKES by Ганна Чемерис

“…A comprehensive approach was employed, combining general (systemic, instrumental, and functional approaches, dialectical and comparative analysis, synthesis, and systematization for the study of pedagogical, scientific-technical, and methodological literature), specific (observation and analysis of educational practices), and general-logical methods (extrapolation, induction, and deduction for formulating conclusions) in scientific research to solve the tasks set in the study. …”
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Beyond access: assessing WASH service delivery models in healthcare facilities of North Mecha, Dera, and Farta, Ethiopia by Abireham Misganaw Ayalew

“…Hygiene services were made accessible through both fixed and mobile handwashing devices; however, many of these devices were non-functional during our visit. All HCFs implemented a three-bin waste collection system, with disposal methods involving incinerators and secured dump pits. …”
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Large-scale integration of meta-QTL and genome-wide association study identifies genomic regions and candidate genes for photosynthetic efficiency traits in bread wheat by Ming Chen, Tao Chen, Letong Yun, Zhuo Che, Jingfu Ma, Binxue Kong, Jiangying Long, Chunhua Cheng, Kaiqi Guo, Peipei Zhang, Lijian Guo, Delong Yang

“…For the key CG TaGGR-6A (TraesCS6A02G307700) involved in the porphyrin metabolism pathway, a functional kompetitive allele-specific PCR (KASP) marker was developed at 2464 bp (A/G) position within the 3′ untranslated region, successfully distinguishing two haplotypes: TaGGR-6A-Hap I (type AA) and TaGGR-6A-Hap II (type GG). …”
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El paisatge : patrimoni en mutació i recurs didàctic formatiu en l'àmbit europeu by Jaume Busquets i Fàbregas

“…From a notion linked with the ideas of «past» and «preservation» we have moved towards a more dynamic and functional approach, more linked to the present and the idea of use. …”
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Identifying Patients’ Preference During Their Hospital Experience. A Sentiment and Topic Analysis of Patient-Experience Comments via Natural Language Techniques by Yuan J, Chen X, Yang C, Chen J, Han P, Zhang Y, Zhang Y

“…The regression analysis showed that the occurrence of negative comments about “humanity of care”, “information, communication, and education”, “sense of responsibility of staff”, “technical competence”, “responding to requests”, and “continuity of care” was significantly associated with a worse patient satisfaction and loyalty, while the occurrence of negative comments about other aspects of healthcare services had no impact on patient satisfaction and loyalty.Conclusion: The results of this study highlight the interpersonal and functional aspects of care, especially the interpersonal aspects, which are often the “moment of truth” during a service encounter when patients critically evaluate hospital services.Keywords: patient experience, natural language processing, sentiment analysis, topic modelling, free-text comments…”
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