Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter by Yandan Ren, Ziyan Wang, Ziheng Wei, Ruijuan Zhuang, Yongtao Zhang, Xiaoxi Liu, Cong Jiang, Xuan Liu, Ye Yun, Yanfang Li, Wanjin Hong, Tuanlao Wang

“…Dysregulated Rab proteins are associated with neurological diseases through the regulation of receptor endocytosis, recycling, and/or degradation. Rab26 is highly expressed in the brain, but its physiological function remains poorly elucidated. …”
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Gordon Decomposition of the Magnetizability of a Dirac One-Electron Atom in an Arbitrary Discrete Energy State by Patrycja Stefańska

“…Using the Sturmian expansion of the generalized Dirac–Coulomb Green function proposed by Szmytkowski in 1997, we derive a closed-form expressions for the diamagnetic (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>χ</mi><mi>d</mi></msub></semantics></math></inline-formula>) and paramagnetic (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>χ</mi><mi>p</mi></msub></semantics></math></inline-formula>) contributions to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>χ</mi></semantics></math></inline-formula>. …”
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In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. by Alireza Naghizadeh, Wei-Chung Tsao, Jong Hyun Cho, Hongye Xu, Mohab Mohamed, Dali Li, Wei Xiong, Dimitri Metaxas, Carlos A Ramos, Dongfang Liu

“…Recognizing the inadequacy of conventional tools and the importance of IS in immune cell functions, we investigate a new strategy for assessing CAR-T efficacy by quantifying CAR IS quality using the glass-support planar lipid bilayer system combined with ML-based data analysis. …”
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Relevansi konsep pemikiran pendidikan dan kebudayaan George S. Counts dan Ki Hajar Dewantara dengan kompetensi peserta didik abad 21 by Sekar Purbarini Kawuryan

“…The research results show that the concepts of thought of the two figures are interrelated especially about the four main points, namely the purpose of education, the function of education, the educational process, and the role of educators. …”
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A bloom of a single bacterium shapes the microbiome during outdoor diatom cultivation collapse by Naomi E. Gilbert, Jeffrey A. Kimbrel, Ty J. Samo, Anthony J. Siccardi, Rhona K. Stuart, Xavier Mayali

“…We lack information on the identity and function of bacteria that specialize in consuming algal-derived dissolved organic matter in high algal density ecosystems such as outdoor algal ponds used for biofuel production. …”
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IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways by Ke Liu, Hongliang Dong, Kaiyue Zhang, Wanping Yan, Huanyu Wu, Jing fan, Wei Ye

“…Notably, IL-15 did not alter the mitochondrial function of these cells. The JAK/STAT5 and PI3K/mTOR pathways were found to play a critical role in IL-15-induced innate-like cytotoxicity. …”
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Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus by Dimitrios T Boumpas, Antonis Fanouriakis, George Bertsias, Dionysis Nikolopoulos, Aggelos Banos, Anastasia Filia, Antigone Pieta, Sofia Flouda, Katerina Chavatza, Panagiotis Garantziotis, Spyridon Katechis, Noemin Kapsala, George Sentis, Georgia Savina Moysidou, Nikos Malissovas

“…We identified differentially expressed genes and co-expressed transcript modules.Results Achieving response, irrespective of treatment, was accompanied by downregulation of B cell immunity-related and complement activation-related signatures. …”
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FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis by Hamza M Al‐Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti

“…Importantly, mice with global‐ (Foxo3−/−) or fibroblast‐specific (Foxo3f.b−/−) FoxO3 knockout displayed enhanced susceptibility to bleomycin challenge, with augmented fibrosis, loss of lung function, and increased mortality. Activation of FoxO3 with UCN‐01, a staurosporine derivative currently investigated in clinical cancer trials, reverted the IPF myofibroblast phenotype in vitro and blocked the bleomycin‐induced lung fibrosis in vivo. …”
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RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer by Qin Li, Ziteng Li, Bing Chen, Jingjing Zhao, Hongwu Yu, Jia Hu, Hongyan Lai, Hena Zhang, Yan Li, Zhiqiang Meng, Zhixiang Hu, Shenglin Huang

“…Additionally, TSTs display mutual exclusivity with somatic mutations and are overrepresented in transposable-element-derived transcripts possessing oncogenic functions. Importantly, TSTs can generate putative neoantigens for immunotherapy. …”
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Cell-free regenerative medicine: identifying the best source of mesenchymal stem cells for skin therapy in Systemic Sclerosis by Filomena Napolitano, Valentina Giudice, Valentina Giudice, Vittoria D’Esposito, Nella Prevete, Pasqualina Scala, Amato de Paulis, Amato de Paulis, Carmine Selleri, Carmine Selleri, Pietro Formisano, Pietro Formisano, Francesca Wanda Rossi, Francesca Wanda Rossi, Nunzia Montuori, Nunzia Montuori

“…Understanding of the secretion profile of different MSCs is necessary to identify the most efficient and useful source for SSc treatment.MethodsWe analyzed the content of MSC-conditioned media (MSC-CM) obtained from MSCs isolated from adipose tissue (AT), bone marrow (BM), Wharton’s jelly (WJ), and cord blood (CB) by ELISA method, and their effects on the wound healing process by fibroblast proliferation, migration, and ECM deposition assays, to compare regenerative potential of different MSC populations.ResultsWJ-MSC-conditioned medium (CM) and BM-MSC-CM show a greater regenerative profile, compared to CB-MSC-CM and AT-MSC-CM, due to the abundance of growth factors and immunomodulatory cytokines and the effects on fibroblast functions. In SSc fibroblasts, WJ-MSC-CM significantly promotes fibroblast-mediated wound healing processes and VEGF expression, compared to BM-MSC-CM.DiscussionOur data indicate that WJ-MSC-CM could be considered an appealing strategy to both topical and systemic administrations in SSc patients.…”
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ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression by Fangyuan Zhong, Hengyuan Zhang, Xinning Guo, Yichao Zhao, Yufei Wang, Wenli Li, Yuyan Lyu, Heng Ge, Xiyuan Lu, Jun Pu

“…Although CD147 is highly expressed in VSMCs and upregulated in aneurysmal tissue, the precise role of VSMC-derived CD147 in phenotypic switching and AAA pathogenesis remains elusive. …”
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Genetic deletion of the sodium phosphate cotransporter NaPi2a ameliorates heart failure in mice by Hiroko Yamauchi-Sawada, Tomoharu Ida, Masashi Nakamura, Minato Umehara, Natsuko Okuno-Ozeki, Itaru Nakamura, Yayoi Matoba, Atsushi Minamida, Yasuto Sunahara, Tomohiro Nakata, Kunihiro Nakai, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Noriyuki Yamashita, Yuhei Kirita, Keiichi Tamagaki, Benjamin D. Humphreys, Satoaki Matoba, Tetsuro Kusaba

“…Sodium-phosphate co-transporter 2a (NaPi2a) is predominantly expressed in the apical membrane of proximal tubular epithelia and functions to reabsorb filtered phosphate and sodium. …”
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MicroRNA signature of lymphoblasts from amyotrophic lateral sclerosis patients as potential clinical biomarkers by Eva P. Cuevas, Enrique Madruga, Ignacio Valenzuela-Martínez, David Ramírez, Carmen Gil, Siranjeevi Nagaraj, Angeles Martin-Requero, Ana Martinez

“…MicroRNAs (miRNAs) are a class of small, non-coding RNAs involved in different cellular functions that have emerged as key regulators of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). …”
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A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination by Canghai Guan, Jianjun Gao, Xinlei Zou, Wujiang Shi, Yunhe Hao, Yifei Ge, Zhaoqiang Xu, Chengru Yang, Shaowu Bi, Xingming Jiang, Pengcheng Kang, Xiaoxue Xu, Xiangyu Zhong

“…Functionally, this study elucidates the regulatory effect of circPCSK6‐167aa on IκBα ubiquitination within the NF‐κB pathway, which is mediated by its competitive binding to the E3 ligase RBBP6. …”
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Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep by Zhaohua He, Fangfang Zhao, Hongxian Sun, Jiang Hu, Jiqing Wang, Xiu Liu, Mingna Li, Zhiyun Hao, Zhidong Zhao, Bingang Shi, Feiyan Liu, Shaobin Li

“…Utilizing functional enrichment analysis on the target genes, we successfully identified a number of target genes might be associated with the improvement of wool fineness, such as FOXN1, LIPK, LOC101116068, LOC101106296, KRTAP5.4, KRT71, KRT82, DNASE1L2, which are related to hair follicle development, histidine metabolism, epidermal cell differentiation, oxidative phosphorylation and hair cycle process. …”
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Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.) by Prashanth Babu, Manjunath Prasad, R. Nirmalaruban, Sudhir Kumar, Rajbir Yadav, Manjeet Kumar, Kiran B. Gaikwad, Naresh Kumar Bainsla, S. Bhaskar Reddy, Nasreen Saifi, Amit Kumar Mazumder, Meda Alekya, Gaurav Kaushik, Palaparthi Dharamteja, Meghashri S. Patil, Shiv Kumar Singh, Dunna Vijay, Ranjeet Ranjan Kumar

“…Notably, eight novel Si-responsive QTLs were detected under Si+-three associated with leaf rust resistance (qLr7AS.1_Si+, qLr6DS.1_Si+, and qLr7BL.1_Si+). Functional annotation of candidate genes revealed the involvement of key pathways, including cation transport, isomerase and, ethylene-responsive transcription factors reflecting Si’s multifaceted role in enhancing mineral uptake, stress tolerance, and overall plant growth. …”
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Shared and specific competing endogenous RNAs network mining in four digestive system tumors by Yulai Tang, Aamir Fahira, Siying Lin, Yiming Shao, Zunnan Huang

“…Functional enrichment analysis and prognostic RNA screening were performed with ConsensusPathDB and univariate Cox regression analysis. …”
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Natural microbial exposure populates the maternal fetal interface with diverse T cells by Amy Whillock, Perianne Smith, Perianne Smith, Sarah Burger, Sarah Burger, Adhvaith Sridhar, Alex Lindgren, James Berg, Sayaka Tsuda, Sayaka Tsuda, Shweta Mahajan, Shweta Mahajan, Tamara Tilburgs, Tamara Tilburgs, Tamara Tilburgs, Nathaniel J. Schuldt, Nathaniel J. Schuldt, Nathaniel J. Schuldt, Nathaniel J. Schuldt

“…Yet, the dynamics of T cell influx and function at the MFI remain poorly defined. Conventional specific pathogen free (SPF) murine models fail to replicate the number and diversity of T cells in the human MFI, hindering mechanistic study of MFI T cells. …”
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Integrated cytomembrane proteomics identifies EpCAM/MGST1 as therapeutic targets in metastatic laryngeal carcinoma by Suling Zhuang, Xiaobo Wu, Xiaobo Wu, Xiaobo Wu, Xiaohuang Lin, Zhihan Li, Di Gan, Shixin Wang, Xue Lin, Gongbiao Lin, Gongbiao Lin, Gongbiao Lin, Miao Gao, Miao Gao, Miao Gao

“…Functional siRNA knockdown confirmed their critical roles in driving in vitro proliferation, invasion, and migration. …”
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Integrative QTL Mapping and Transcriptomic Profiling to Identify Growth-Associated QTL and Candidate Genes in Hong Kong Catfish (<i>Clarias fuscus</i>) by Yian Zhu, Dayan Zhou, Yijun Shen, Chuanhao Pan, Yu Chen, Yulei Zhang, Binlan Yang, Guangli Li, Huapu Chen, Changxu Tian

“…Seventeen growth-related QTL were identified across eight linkage groups, explaining phenotypic variance ranging from 8.00% to 11.90%. A total of 162 functional genes were annotated within these QTL intervals. …”
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