A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis by Wen Zhang, Rui Xiang, Wang Gu, Qiang Zhang, Lei Liu, Chenglin Wang, Muhu Chen, Yingchun Hu, Guihong Chen

“…Enrichment analysis demonstrated the molecular functions, biological processes involved, and related pathways of the intersection targets. …”
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Transcriptome analysis reveals the mechanism of mixed oligosaccharides in the response of rice seedlings to abiotic stresses by Yanan Xu, Yanan Xu, Yigang Yang, Yeran Bai, Makoto Saito, Wei Han, Yuanpei Zhang, Guohua Lv, Jiqing Song, Wenbo Bai

“…This coordinated gene expression was functionally associated with enhanced leaf photosynthesis capacity and mitigated oxidative damage through improved electron transport and reactive oxygen species scavenging mechanisms. …”
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Protocol for an economic evaluation alongside a natural experiment to evaluate the impact of later trading hours for bars and clubs in the night-time economy in Scotland: The ELEPH... by Colin Angus, Emma McIntosh, Nurnabi Sheikh, Jim Lewsey, Niamh Fitzgerald, Carol Emslie, Houra Haghpanahan

“…Furthermore, the night-time economy provides spaces for leisure activities, cultural expression and social interaction. On-trade alcohol premises (places where consumers can buy and consume alcohol such as bars, pubs, clubs and restaurants) are a significant component of this night-time economy, functioning as focal points for socialising, entertainment and cultural events. …”
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Effects of Yeast β-Glucan Supplementation on Calf Intestinal and Respiratory Health by Jiamin Wang, Fang Yan, Meng Xiong, Jieru Dong, Wenqian Yang, Xiurong Xu

“…The physiological functions of newborn calves are undeveloped, especially the immune system, making them susceptible to infections. …”
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S100A9 as a promising therapeutic target for diabetic foot ulcers by Renhui Wan, Shuo Fang, Xingxing Zhang, Weiyi Zhou, Xiaoyan Bi, Le Yuan, Qian Lv, Yan Song, Wei Tang, Yongquan Shi, Tuo Li, Sihan Zhou, Xiuyuan Hao

“…Datasets related to diabetic foot and diabetic skin were retrieved from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified using R software. …”
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أثر الدين في التوجهات الجيوبوليتيكية للولايات المتحدة الأمريكية تجاه إسرائيل by عيسى السيد عيسى دسوقي, حسن قطب حسن قطب

“…It focuses on the role of evangelical and Christian Zionist movements in shaping U.S. foreign policy, highlighting how religion functions both as an ideological force and a tool for political mobilization within executive and legislative institutions. …”
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Subtractive proteomics and reverse-vaccinology approaches for novel drug targets and designing a chimeric vaccine against Ruminococcus gnavus strain RJX1120 by Hou Dingding, Hou Dingding, Sher Muhammad, Irfan Manzoor, Sana Abdul Ghaffar, Hissah Abdulrahman Alodaini, Nadine MS. Moubayed, Ashraf Atef Hatamleh, Xu Songxiao

“…On one side it supports nutrient metabolism essential for bodily functions and on the other it contributes to the development of Inflammatory Bowel Disease (IBD) and other gastrointestinal disorders. …”
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Apoptotic vesicles of mesenchymal stem cells promote M2 polarization and alleviate early-onset preeclampsia via miR-191-5p by Ling Li, Xu Lu, Qinghai Lian, Xiaoyun Wang, Changchang Jia, Chengfang Xu

“…Mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) have anti-inflammatory, tissue repair, and immunomodulatory functions. MSC-apoVs may ameliorate EOPE by regulating macrophage polarization, but the underlying mechanisms remain to be clarified. …”
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Macrophage Membrane Coated Manganese Dioxide Nanoparticles Loaded with Rapamycin Alleviate Intestinal Ischemia-Reperfusion Injury by Reducing Oxidative Stress and Enhancing Autopha... by Sheng R, Wang W, Zeng W, Li B, Yu H, Li X, Liang Y, Wang Y, Liao Y, Liu D

“…RAPA released from the Ma@(MnO₂+RAPA), enhanced the expression of autophagy-regulated proteins p62, Beclin-1, and LC3II. …”
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LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration by Lei Yi, Kaiming Wang, Sui Liufu, Wenwu Chen, Bohe Chen, Xiaolin Liu, Caihong Liu, Jingwen Liu, Xin Xu, Haiming Ma

“…Non-targeted LC-MS/MS metabolomics analysis showed significant differences in the structure of metabolites in these 3 stages. (1) In the inflammatory stage, a total of 198 DEMs were identified, which were mainly enriched in the pathways regulating the inflammatory response. (2) in the repair stage, 264 DEMs were identified, which were mainly enriched in pathways that inhibit inflammatory response and promote protein synthesis. (3) During the remodeling stage, 102 DEMs were identified, which were mainly enriched in the pathways that inhibit protein depletion and promote protein deposition. Temporal expression analysis revealed metabolites consistent with changes in the skeletal muscle regeneration process and found that these metabolite functions were mainly enriched in inhibiting inflammatory responses, alleviating myofibrillar lysis, and promoting muscle growth. …”
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ETHIOPATHOGENETIC PARALLELS OF MORPHOLOGICAL CHANGES IN CHRONIC DENTAL CARIES AND ITS COMPLICATIONS by B.M. Fylenko

“…Dental plaque (biofilm) is resulted from structurally and functionally ordered colonization of microorganisms on the tooth surface. …”
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Naimat Khana: The Narrative of Human's Mythological and Surreal Structure by Suryya Siddique

“…What makes <em>Nimatkhana</em> remarkable is its dualistic nature - it functions simultaneously as mythological allegory and psychological mirror, reflecting both our transcendental history and primal human truths. …”
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Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway by Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang

“…This study elucidates the cascade of biological processes by which heterogeneous electrical signals at the micro‐ and nanoscale modulate macrophage functions to promote vascularization and bone regeneration. …”
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Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development by Zixian Huang, Junyue Fang, Li Lin, Nvlue Cai, Siyu Chen, Gui He, Yuan Cao, Guo Wu, Yuepeng Wang, Wende Li, Zhiquan Huang, Phei Er Saw

“…In this study, we utilized bioactive phospholipids (dipalmitoyl phosphatidic acid, DPPA) with antiangiogenic functions to encapsulate a small-molecule ERK inhibitor (called NP-AE) and constructed an intrinsically biotherapeutically active nanomedicine delivery platform with dual therapeutic efficacy. …”
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Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology by Luce Perie, Selina Stippa, Christoph Saffer, Christoph Saffer, Andrea Hartmann, Mathias Mörgelin, Svante L. H. Zipfel, Marc Thilo Figge, Marc Thilo Figge, Thorsten Wiech, Christine Skerka, Peter F. Zipfel, Peter F. Zipfel

“…The action profiles of FHR1 and Factor H were calculated and compared.ResultsFunctional data revealed that residues YVQ vs HLE in SCR3 and LA vs SV in SCR5 altered ligand binding and surface interaction, influenced target recognition and complement control. …”
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Effects of Sacubitril/Valsartan on Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction and the Role of Percentage of Delayed Enhancement Measured by Car... by Cinzia Nugara, Francesco Giallauria, Giuseppe Vitale, Silvia Sarullo, Giovanni Gentile, Francesco Clemenza, Annamaria Lo Voi, Antonino Zarcone, Elio Venturini, Gabriella Iannuzzo, Andrew JS Coats, Filippo M Sarullo

“…Conclusion: Sacubitril/valsartan improves cardiopulmonary functional capacity in HFrEF patients. The presence of myocardial fibrosis on cardiac magnetic resonance is a predictor of response to therapy.…”
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Equine Adipose-Derived Mesenchymal Stromal Cells Release Extracellular Vesicles Enclosing Different Subsets of Small RNAs by Stefano Capomaccio, Katia Cappelli, Cinzia Bazzucchi, Mauro Coletti, Rodolfo Gialletti, Franco Moriconi, Fabrizio Passamonti, Marco Pepe, Stefano Petrini, Samanta Mecocci, Maurizio Silvestrelli, Luisa Pascucci

“…Enrichment analyses were performed to infer involved pathways and functional categories. Results. Electron microscopy showed the presence of vesicles ranging in size from 30 to 300 nm and expressing typical markers. …”
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MtDNA copy number enrichment is associated with poor prognosis and eosinophilic morphology in clear cell renal cell carcinoma by Sarah Bellal, Sarah Bellal, Cyrielle Rolley, Jeremy Richard, Nolwenn Bounaix, Vincent Le Corre, Marie-Christine Copin, Odile Blanchet, Pierre Bigot, Pierre Bigot, Vincent Procaccio, Vincent Procaccio, Céline Bris, Céline Bris

“…Furthermore, these results underline the importance of the role of mitochondria in ccRCC and the need for further functional studies to understand the pathophysiological mechanisms better and consider therapies targeting mitochondrial metabolism.…”
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Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Abstract Background Higher embryonic mortality, especially in aged breeding hens, is associated with insufficient hepatic functionality in maintaining redox homeostasis. Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
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EXPLORING DISCOURSE MARKERS IN COMPLAINTS: A COMPARATIVE ANALYSIS OF NATIVE AND NON-NATIVE ITALIAN SPEAKERS by Anna De Marco, Emanuela Paone

“…At the B1-B2 level, a broader range of DMs was observed, fulfilling functions such as mitigating or reinforcing the complaint, modulating certainty, and managing the expressive tone of the interaction. …”
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