Overexpression of MMP Family Members Functions as Prognostic Biomarker for Breast Cancer Patients: A Systematic Review and Meta-Analysis. by Fanghui Ren, Ruixue Tang, Xin Zhang, Wickramaarachchi Mihiranganee Madushi, Dianzhong Luo, Yiwu Dang, Zuyun Li, Kanglai Wei, Gang Chen

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Pan-cancer analysis of the prognosis and immune infiltration of NSUN7 and its potential function in renal clear cell carcinoma by Jinwei Cui, Shiye Ruan, Zhongyan Zhang, Hailiang Wang, Qian Yan, Yubin Chen, Jiayu Yang, Jike Fang, Qianlong Wu, Sheng Chen, Shanzhou Huang, Chuanzhao Zhang, Baohua Hou

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Tianqi pingchan granule promotes recovery of glymphatic system function in a rat model of l-DOPA-induced dyskinesia by Zhihua Liu, Shuyuan Yang, Lu Song, Yu Zhang, Ying Wan, Jing Gan, Na Wu, Zhenguo Liu

“…Three doses of TPG were administered once a day for 3 weeks to investigate the role of TPG in behavioural characteristics of LID rats. The glymphatic function was evaluated by utilizing intracisternal infusion of a fluorescenttracer. …”
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High-intensity intermittent exercise regulates oxidative stress and improves endothelial progenitor cell function in patients with essential hypertension by Jixin ZHI, Tiantian WANG, Shuang REN, Chenyu WANG

“…Before and after intervention, brachial artery flow-mediated vasodilation (FMD) was used to evaluate vascular endothelial function; venous blood was sampled to perfrom circulating endothelial progenitor cell counts; endothelial progenitor cells were cultured in vitro, and the modified Boyden chamber assay and Matrigel lumen formation assay were used to detect their migration and tube formation ability, superoxide fluorescent anion probe method to detect reactive oxygen species levels, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining method to detect cell apoptosis, Western blotting to determine protein expression of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, NADPH oxidase 4, and superoxide dismutase. …”
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Exploring the functional role of POU5F1 using CRISPR RNP electroporation of zygote (CRISPR-EZ) in buffaloes by Meeti Punetha, Dharmendra Kumar, Suman Choudhary, Sheetal Saini, Kamlesh Kumari Bajwa, Surabhi Sharma, Manu Mangal, P. S. Yadav, T. K. Datta

“…We developed an easy and straightforward protocol for gene editing, which could serve as a valuable method for studying the functional genomics of the buffalo embryos. …”
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PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation

“… Background and Aims: Platelet activation leads to the release of various molecules with immunoregulatory functions. While these factors play a limited role in thrombosis, they have a significant impact on modulating host immune responses. …”
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Gold complex QB1561 suppresses drug-resistant cancer cells by inhibiting TrxR and mitochondrial respiratory function by Hai-Ling Gao, Wenwen Ding, Zhi-Xin Shen, Qingbin Cui, Qingbin Cui

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Aqueous extract of Solanum americanum Mill. relieves functional constipation by modulating the enteric nervous system and gut micro-ecosystems by Xiaoyu Gao, Xiaoyu Gao, Xiaoyu Gao, Yanan Li, Yifan Hu, Yifan Hu, Weixing Yang, Lei Peng, Jun Sheng, Yang Tian, Lu Yao, Yan Zhao

“…The present study evaluated the laxative activity of Solanum americanum Mill. aqueous extract (SAAE) using loperamide-induced functional constipation (FC) mouse model. The results demonstrated that SAAE is abundant in nucleotides and polysaccharides. …”
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Efficacy of 0.05% cyclosporine A on tear inflammatory cytokines and goblet cell function after corneal refractive surgery by Wenzhe Qian, Yue Wu, Xin Liu, Yuying Liu, Min Li, Ting Zhao, Na Chen, Bilian Ke

“…Conclusions For patients undergoing refractive surgery, the application of 0.05% CsA suppressed the expression of inflammatory cytokines such as IFN-γ and TNF-α, and preserved goblet cell function. …”
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Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit by Jing Liu, Xijun Liang, Danxia Zhou, Ling Lai, Liwei Xiao, Lin Liu, Tingting Fu, Yan Kong, Qian Zhou, Rick B Vega, Min‐Sheng Zhu, Daniel P Kelly, Xiang Gao, Zhenji Gan

“…Here, we show that the expression of the genes encoding type I myosins, Myh7/Myh7b and their intronic miR‐208b/miR‐499, parallels mitochondrial function during fiber type transitions. …”
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Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle-Atrophy-Associated Ubiquitin Ligase Cbl-b by Tomoki Abe, Shohei Kohno, Tomonari Yama, Arisa Ochi, Takuro Suto, Katsuya Hirasaka, Ayako Ohno, Shigetada Teshima-Kondo, Yuushi Okumura, Motoko Oarada, Inho Choi, Rie Mukai, Junji Terao, Takeshi Nikawa

“…Soy glycinin contains a functional inhibitory sequence against muscle-atrophy-associated ubiquitin ligase Cbl-b. …”
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The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. by Brett A McKinney, Caleb Lareau, Ann L Oberg, Richard B Kennedy, Inna G Ovsyannikova, Gregory A Poland

“…We test this method for augmenting variant-based network analyses with functional interactions by applying it to a smallpox vaccine immune response GWAS. …”
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A multi-omics dataset of C57 BL/6J mice regulated function by feed with ε-polylysine by Xuelei Zhang, Zhenping Hou, Yuxin Cao, Songshan Wang, Yong Zhang, Jinrong Wang, Duanqin Wu

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Nov/Ccn3, a novel transcriptional target of FoxO1, impairs pancreatic β-cell function. by Renée Paradis, Noureddine Lazar, Peter Antinozzi, Bernard Perbal, Jean Buteau

“…Type 2 diabetes is characterized by both insulin resistance and progressive deterioration of β-cell function. The forkhead transcription factor FoxO1 is a prominent mediator of insulin signaling in β-cells. …”
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Clinical and functional characterization of a novel TNFRSF9 variant causing immune dysregulation with predisposition to EBV-driven lymphomagenesis by Peiwei Zhao, Peiwei Zhao, Kailan Chen, Li Yang, Chunhui Wan, Lei Zhang, Sukun Luo, Xuelian He, Xuelian He

“…Functional analysis in vitro demonstrated that this variant decreased the expression of TNFRSF9 both mRNA and protein levels. …”
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Human Leucocyte Antigen-G (HLA-G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection by Fabrício C. Dias, Celso T. Mendes-Junior, Maria C. Silva, Fabrine S. M. Tristão, Renata Dellalibera-Joviliano, Philippe Moreau, Edson G. Soares, Jean G. Menezes, André Schmidt, Roberto O. Dantas, José A. Marin-Neto, João S. Silva, Eduardo A. Donadi

“…HLA-G and its murine functional homolog Qa2 have well-recognized immunomodulatory properties. …”
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Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer by Meng Zhang, Guiling Li, Jing Peng, Keqin Hua, Yumeng Wang, Congwen Wang, Junjun Qiu, Xinyu Qu, Chong Lu, Mingxing Zhang, Xingling Qi

“…Treatment with the CD96 blockade significantly enhanced the PD-1 blockade to blunt tumor growth and improve the function of CD8+ TILs in both mouse and CC specimen models.Conclusions Our findings showed that CD96 and PD-1 cooperatively and negatively regulate the function of CD8+ TILs, and CD96 blockade has promise for use in combination with PD-1 blockade for the treatment of CC.…”
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Two possible candidate enzymes from Ulva lactuca-associated epiphytic bacteria obtained through PCR and functional evaluation by Ruiz-Toquica Jordan Steven, Comba-González Natalia Beatriz, Montoya-Castaño Dolly

“…The resulting PCR products were sequence-analyzed and used for expression and functional evaluation with the Escherichia coli pBAD-TOPO system. …”
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Identification and functional study of a novel FOXC1 missense mutation in a Chinese family with Axenfeld–Rieger syndrome by Xue Gong, Xinlan Lei, Zhaohui Li, Yiqiao Xing

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Neurobiology of Recovery of Motor Function after Stroke: The Central Nervous System Biomarker Effects of Constraint-Induced Movement Therapy by Auwal Abdullahi, Steven Truijen, Wim Saeys

“…Recovery of motor function after stroke involves many biomarkers. This review attempts to identify the biomarker effects responsible for recovery of motor function following the use of Constraint-Induced Movement Therapy (CIMT) and discuss their implications for research and practice. …”
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