Peritoneal cavity-derived small extracellular vesicles from aged tumor-naïve hosts promote ovarian cancer adhesion and invasion by Reihaneh Safavi-Sohi, Jeff Johnson, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Christopher Barile, Josh Mijares, Ceming Wang, Hsueh-Chia Chang, Rebecca J. Whelan, M. Sharon Stack

“…This was confirmed using meso-mimetic adhesion assays with function blocking antibodies or small molecule inhibitors, supporting a potential role for several proteins in promoting intra-peritoneal dissemination in the aged host. …”
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An in-depth study of the association of breast arterial calcification with cardiovascular disease, its risk factors, and other chronic noncommunicable diseases: rationale and study... by I. V. Kim, E. V. Bochkareva, E. K. Butina, O. V. Molchanova, N. Kh. Bayramkulova, E. M. Filichkina, E. B. Yarovaya, O. M. Drapkina

“…To assess association between breast artery calcification (BAC) with ultrasound and biochemical markers of cardiovascular risk, asymptomatic and clinically expressed forms of cardiovascular diseases, as well as other chronic non-communicable diseases.Material and methods. …”
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CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling by Yuxi Lin, Zhixing Liang, Zhiyan Weng, Xiaofang Liu, Feng Zhang, Yutian Chong

“…Methods In-silico/house dataset analysis, lipid droplets (LDs) formation, HCC mouse models and targeted lipidomic analysis were performed to determine the function of CRSP8 on regulating lipid metabolism in HCC. …”
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Understanding The Concept of Zuhud in Fashion Trends in The Young Generation of Muslim Women by Mulyana Abdullah

“…This is closely tied to their understanding of the function, purpose, and meaning behind their clothing choices. …”
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Electrical modelling of a grid-connected battery energy storage system via EMS and BMS data by Mirko Ledro, Jan Martin Zepter, Morten Paludan, Mattia Marinelli

“…Finally, the energy capacity and PCS efficiency are reported as a function of the power of the PCS. The usable energy capacity per rack is approx. 59.7kWh, which is 91.5% of the rated DC energy capacity, and it is independent of the power at which the BESS is discharged. …”
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FOUNDING THE SENSE FOR MUSICAL FORM IN THE CASE OF PUPILS IN PUBLIC EDUCATION by Miklós–Csaba GYÖRGYJAKAB

“…. [2] Structural function [3] Even songs consisting of G-E sounds can be formally analysed…”
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THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“…., 1975–1977, "The DNA (RNA) Nucleotide Sequence–The Function." One can notice that a change of levels occurs at almost every 30-year period. …”
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iTRAQ-based quantitative proteomic analysis of herbicide stress in Avena ludoviciana Durieu by Hossein Adim, Leila Fahmideh, Barat Ali Fakheri, Hamid Najafi Zarrini, Hamidreza Sasanfar

“…Furthermore, enrichment pathway analysis using Kyoto Encyclopedia of Genes and Genomes (KEGG) showed that the most important pathways included metabolic pathways, carbohydrate metabolism, secondary metabolites, amino acid synthesis, and photosynthesis. The function of DEPs indicated that some proteins, such as cytochrome P450, play a direct role in herbicide detoxification. …”
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IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential by Feiya Sheng, Mi Li, Jia-Mei Yu, Si-Yu Yang, Liang Zou, Guan-Jun Yang, Le-Le Zhang, Le-Le Zhang

“…Interleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form the IL-33/Suppression of tumorigenicity 2 (ST2) signaling pathway. …”
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Rituximab induced lung injury by Rohit Chari, Youmna Abdelghany, Madeleine Purcell, Blaine Kenaa

“…Given curative effect of R-CHOP, careful changes in management plan and co-treatment with steroids could help preserve lung function while allowing for full continuation of the chemotherapy regimen.…”
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Parallel Jacobian Computation Based on Distance-2 Algorithm and Its Application in Coupling Problems by LIU Lixun, ZHANG Han, PENG Xinru, DOU Qinrong, WU Yingjie, GUO Jiong, LI Fu

“…By exploiting the sparsity of the Jacobian matrix, all structurally orthogonal columns can be computed simultaneously through one function evaluation. Thus, the Jacobian computational cost can be reduced by one order of magnitude. …”

Does Incretin Agonism Have Sustainable Efficacy? by Sok-Ja Janket, Miyo K. Chatanaka, Dorsa Sohaei, Faleh Tamimi, Jukka H. Meurman, Eleftherios P. Diamandis

“…We will briefly review other molecules involved in glucose homeostasis such as amylin and glucagon. Amylin is co-expressed with insulin from the pancreas β-cells but does not have insulinotropic function. …”
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Clinical significance of ICAM-1,VCAM-1 and PECAM-1 in vascular endothelial injury of end-stage renal disease patients by Wang Lan-min, Sun Dong

“…Objective To compare the serum levels of ICAM-1,VCAM-1 and PECAM-1 between maintenance dialysis and non-dialysis end-stage renal disease（ESRD）patients and explore the effect of dialysis versusnon-dialysis on vascular endothelial damage.Methods A total of 71 ESRD patients were selected and divided into two groups of MHD（n=35）and N-HD（n=36）.At the same time, 20 cases of normal control group（group C）were selected.And 5 mL of venous blood was harvested from normal control and non-dialysis groups in the morning under a fasting state.Also 5 mL of venous blood was collected from dialysis group on the day of dialysis from the side of internal fistula under a fasting state.The samples were submitted to the biochemical room for blood routine, parathyroid hormone（PTH）,hepato-renal function, blood glucose, blood lipid and electrolytes.Another 4 mL of venous blood was tested for the values of ICAM-1,VCAM-1 and PECAM-1 by double antibody sandwich enzyme-linked immunosorbent assay（ELISA）.Results Among three groups, no significant difference existed in gender, age or etiology（all P>0.05）.And significant differences existed in hemoglobin（Hb）,PTH,blood phosphorus, albumin（Alb）,triglyceride（TG）,total cholesterol（TC）,low-density lipoprotein（LDL）,blood urea nitrogen（BUN）,creatinine（Cr）and uric acid（UA）（all P<0.05）.Also significant differences existed between MHD and control groups（all P<0.05）;And significant differences existed in the above parameters between N-HD and control groups（all P<0.05）.PTH,BUN,Cr and UA in N-HD group were significantly higher than those in MHD group（all P<0.05）.No significant differences existed in Hb, serum calcium, phosphorus, ALB,TG,LDL and high-density lipoprotein（HDL）between MHD and N-HD groups（both P>0.05）.ICAM-1,VCAM-1 and PECAM-1 were higher in MHD group than those in control group（all P<0.05）.ICAM-1,VCAM-1 and PECAM-1 were higher in N-HD group than those in control group（all P<0.05）.ICAM-1,VCAM-1 and PECAM-1 were significantly higher in N-HD group than those in MHD group（all P<0.05）.Conclusion The serum expressions of ICAM-1,VCAM-1 and PECAM-1 in ESRD patients with MHD are lower than those in N-HD patients.It indicates that maintenance hemodialysis has a protective effect on vascular endothelial injury in ESRD patients.…”
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Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model by Markus Kraller, Julia Faßbender, Ammar Jabali, Joseph Kroeger, Barbara Fink, Bastian Popper, Martin Ungerer, Miriam A. Christlmeier

“…Behavior tests were carried out in 5 × familiar AD (5xFAD) mice of both genders, to test for brain function and cognition as well as hippocampus-dependent spatial memory using the Barnes maze. …”
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LncRNA MBNL1‐AS1 represses cell proliferation and enhances cell apoptosis via targeting miR‐135a‐5p/PHLPP2/FOXO1 axis in bladder cancer by Xiaosong Wei, Xiaoming Yang, Beibei Wang, Yang Yang, Zhiwei Fang, Chengzhi Yi, Lei Shi, Dongkui Song

“…Our microarrays of clinical samples firstly screened that lncRNA muscleblind‐like 1 antisense RNA 1 (MBNL1‐AS1) was poorly expressed in BC tissues. However, its biological function in BC remains not well understood. …”
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The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane by Piergiorgio La Rosa, Jessica Tiberi, Enrico Palermo, Roberta Stefanelli, Sofia Maria Luigia Tiano, Sonia Canterini, Mirko Cortese, John Hiscott, Maria Teresa Fiorenza

“…Abstract Background The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/Ly) that is involved in the mobilization of endocytosed cholesterol. Loss-of-function mutations in the NPC1 gene lead to the accumulation of cholesterol and sphingolipids in LE/Ly, resulting in severe fatal NPC1 disease. …”
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Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis by Adio J. Akamo, Adetutu O. Ojelabi, Oluwatobi T. Somade, Iyabode A. Kehinde, Adewale M. Taiwo, Boluwatife A. Olagunju, Mushafau A. Akinsanya, Adedayo A. Adebisi, Tobi S. Adekunbi, Abiola F. Adenowo, Florence Anifowose, Olufemi M. Ajagun-Ogunleye, Ofem E. Eteng, Jacob K. Akintunde, Regina N. Ugbaja

“…Conclusion: HESP chemotherapeutic interventions enhanced cerebral functions in DDVP-treated rats by abrogating oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspases-3 signaling.…”
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Notch Signaling Hydrogels Enable Rapid Vascularization and Promote Dental Pulp Tissue Regeneration by Siyuan Zhang, Mei Yu, Maojiao Li, Min He, Li Xie, Fangjun Huo, Weidong Tian

“…Cultivating dental pulp stem cells (DPSCs) and endothelial cells (ECs) on this hydrogel significantly upregulate Notch target genes and key proangiogenic markers expression. Three‐dimensional (3D) culture assays demonstrate Notch signaling hydrogels improve effectiveness by facilitating encapsulated cell differentiation, enhancing their paracrine functions, and promoting capillary lumen formation. …”
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Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development by Yaoyu Sun, Min Li, Chao Ning, Lei Gao, Zhenbo Liu, Suijuan Zhong, Junjie Lv, Yuwen Ke, Xinxin Wang, Qiang Ma, Zeyuan Liu, Shuaishuai Wu, Hao Yu, Fangqi Zhao, Jun Zhang, Qian Gong, Jiang Liu, Qian Wu, Xiaoqun Wang, Xuepeng Chen

“…However, the spatiotemporal organization of three-dimensional (3D) chromatin structure and its regulatory functions across different brain regions remain poorly understood. …”
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The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex by Karina S. Krings, Anastasia Ritchie, Laura Schmitt, Judith Hatzfeld, Gudrun Totzke, Thomas Lenz, María José Mendiburo, Björn Stork, Nicole Teusch, Peter Proksch, Kai Stühler, Lisa Müller, Sebastian Wesselborg

“…This apparently affected the functionality of the NPC, as evidenced by the bromoxib-mediated inhibition of the nuclear translocation and subsequent gene reporter activity of transcription factors such as nuclear factor of activated T cells (NFAT) and nuclear factor κB (NF-κB). …”
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