Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis‐Related Glycoprotein in Lung Cancer by Lu Zhang, Yan Wu, Suntao Li, Miao Guo, Jiaqi Zhao, Chengxi Cao, Yan Zhang, Hua Xiao

“…Glycosylation site mutagenesis identified N339 and N386 as critical functional determinants of CDCP1. Collectively, our data demonstrate that glycoprotein CDCP1 was selectively packed into EVs and potentially contributed to cancer metastasis, which is a critical target for anti‐metastasis research and cancer therapy.…”
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Oral immunization of grouper with recombinant Chlamydomonas to prevent viral nervous necrosis and the effect of which on intestinal microbiota by Xiaodong Deng, Dequan Guo, Xiansong Cheng, Peng Hong, Zhijie Li, Sihang Liu, Xiaowen Fei

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PSYCHOLOGICAL CHARACTERISTICS IN PATIENTS WITH CHRONIC HEART FAILURE WAITING FOR HEART TRANSPLANTATION by R. Yu. Shindrikov, A. A. Velikanov, E. A. Demchenko, V. M. Tishkova, O. Yu. Shchelkova

“…Absence of violations of cognitive functions was revealed in 23 % of respondents, mild degree of cognitive deficiency – in 60 %, average degree – in 17 %. …”
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CXCL4 deficiency limits M4 macrophage infiltration and attenuates hyperoxia-induced lung injury by Bingrui Yu, Siyuan Jia, Yu Chen, Rong Guan, Shuyu Chen, Wanwen Tang, Tianping Bao, Zhaofang Tian

“…Macrophages, as key components of the innate immune system, play a role in lung tissue inflammation and injury, exhibiting diverse and dynamic functionalities. The M4 macrophage, a distinctive subtype primarily triggered by chemokine (C-X-C motif) ligand 4 (CXCL4), has been implicated in pulmonary inflammatory and fibrotic processes. …”
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INTERGENERATIONAL DIALOGUE IN THE NOVEL “BONJOUR TRISTESSE” BY FRANҪOISE SAGAN by Olga A. Bigun, Nataliia Ya. Yatskiv

“…First of all, in the variation “patronage as a maternal function”, the Mother archetype is characteristic of Anne. …”
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Creative Design as Research The Application of Practice Base Research in Designing the Logo of Didar Gallery of Isfahan by Rasool Kamali Dolat Abadi

“…In this research design, the author has used four cognitive fields: "Graphics and Sign Design", "Process Design and Triz's Theory of Creativity" (The four basic pillars of Triz: “Contrast”, “Ideality”, “Function” and “Resources”; The eight principles of Triz: “Consolidation”, “Nesting”, “Prior Action”, “Periodic Action”, “Mediator”, “Replacement of Mechanical Systems”, “Homogeneity” & “Phase Transition”), "Contemporary Art and Galleries" (Applying seven features of Contemporary Art: “innovation and experimentation” in the unconventional design process, “using Multimedia as a new tool” in logo design, “conceptual-critical and questioning approach” which has deconstructive features, “process oriented design”, “Multiplicity of meaning”, “Multidisciplinary approach in sound engineering and image engineering” and “Social action and interactivity” through collaboration with different people for sign design) and "Structuralist & Post-Structuralist Philosophy" (Concepts such as “the metaphysics of presence”, “the priority of speech (parole) over writing (language)”, “endless chain of significations” ,“the trace of meaning”, “the Play of presence and absence”, “deferral of meaning”, “difference”).In designing the final logo of Didar Gallery, the designer paid attention to the histogram of the recorded sound of saying the word Didar, instead of a purely written or visual approach, taking into account selected theoretical principles in the four cognitive fields and while visualizing the sound, he redesigned the letters with deformation in its geometry.As a result, in the final design, the designer has increased the creative and thoughtful aspect of the logo by making changes in the design tools and design approach, and by deepening the design -by finding ideas from philosophical propositions (especially Derrida's deconstruction)- to the extent that the gallery logo, in addition to the status of its functionality can be considered as an artwork.…”
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CRISPR/Cas9-Mediated <i>BocPDSs</i> Gene Editing in Chinese Kale Using the Endogenous tRNA-Processing System by Yudan Wang, Rahat Sharif, Guangguang Li, Guoju Chen, Changming Chen

“…Its low genetic transformation and gene editing efficiency hinder gene function research and molecular biology in Chinese kale. …”
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CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells by Jiang Guoyun, Qin Yuefeng, Huang Zhenglan, Yuan Zuowei, Zhou Hongyan, Yuan Ying, Feng Wenli

“…Chimeric antigen receptor macrophages (CAR-M) not only perform phagocytosis on target cells but also function as antigen-presenting cells, thereby activating the anti-tumor immune response.CD26 (dipeptidyl peptidase 4, DPP IV) is abundantly expressed in CML-LSCs and functions as a tumor-specific antigen (TSA) in CAR-M treatment. …”
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Delivering a Group-Based Quality of Life Intervention to Young Adult Cancer Survivors via a Web Platform: Feasibility Trial by Rina S Fox, Tara K Torres, Terry A Badger, Emmanuel Katsanis, DerShung Yang, Stacy D Sanford, David E Victorson, Betina Yanez, Frank J Penedo, Michael H Antoni, Laura B Oswald

“…Qualitative feedback identified needed revisions to the aesthetics (eg, images), content (eg, session titles), function (eg, clarity of functionality), and structure (eg, expandable sections), which were implemented. …”
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Overexpression of the GmERF071 gene confers resistance to soybean cyst nematode in soybean by Erhui Xiong, Jiaqi Xu, Pingzhang Feng, Yun Lian, Xiaoling Zhi, Ke Li, Erhan Zhang, Bing Li, Shijie Zhao, Changzhong Liu, Chengyu Wei, Panpan Li, Yaping Zhao, Lipei Zhao, Mengwei Zheng, Heng Zhang, Yi Li, Shanshan Chu, Yongqing Jiao

“…The validation and functional characterization of SCN resistance genes are crucial to improving soybean yield worldwide. …”
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Observation on the clinical effectiveness of intermuscular suture combined with fullthickness advancement flap in the treatment of suprasphincteric anal fistula: a series of 33 cas... by Yang Xiaoyuan, Chen Wenping, Lin Wanlin, Ma Qiaoling, Zhang Lei, Zhu Jiandong, Zhao Shen, Yang Limin, Ma Zhiteng, Huang Shaoling, Yuan Yuewen

“…The treatment outcomes (cure or treatment failure), disease-related information, anal function, and patient’s satisfaction with surgical treatment were recorded. …”
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Quantifying the burden of hereditary hemorrhagic telangiectasia on quality of life and psychological health: a cross-sectional study by Anna J. Gong, Marisabel Linares Bolsegui, Emerson E. Lee, Matthew R. Tan, Yong Zeng, Jianqiao Ma, Prateek C. Gowda, Tushar Garg, Clifford R. Weiss

“…Participants expressed desire for improvement in a broad range of functional domains disturbed by HHT. …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…Traditional ancillary methods like immunohistochemistry (IHC) to assess TP53 functionality face pre- and post-analytical challenges. …”
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Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles by Aryana M. Razmara, Marshall Lammers, Sean J. Judge, William J. Murphy, Cameron E. Gaskill, William T.N. Culp, Alicia A. Gingrich, Zachary S. Morris, Robert B. Rebhun, C. Titus Brown, David M. Vail, Michael S. Kent, Robert J. Canter

“…IntroductionNatural killer (NK) cells in mice and humans are key effectors of the innate immune system with complex immunoregulatory functions, and diverse subsets have been identified with distinct characteristics and roles. …”
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Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells by Taha B. Hayal, Aman A. Mulla, David S.J. Allan, Brynn B. Duncan, Saanika Joshi, So Gun Hong, Rafet Basar, Katayoun Rezvani, Richard W. Childs, Chuanfeng Wu, Cynthia E. Dunbar

“…We found that P407 significantly improved transduction efficiency, achieving up to 60% in expanded RM NK cells, without compromising cell viability or functionality. Additionally, P407 facilitated the expression of anti-CD20 chimeric antigen receptors (CARs) with or without interleukin (IL)-15. …”
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Modern approaches to treating drug-resistant epilepsy - ketogenic diet, innovative drugs and neurosurgery by Robert Rzenno, Monika Brzozowska, Wiktoria Wardal, Natalia Furlepa, Karolina Wojciechowska, Marcelina Matuszewska, Katarzyna Wicha, Natalia Sidz, Magdalena Tomaszewska, Wiktoria Jedlikowska

“…This condition severely affects the quality of life of those impacted, often leading to difficulties in daily functioning and associated mental health issues such as anxiety and depression. …”
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SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling by Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang

“…Here, we reveal that the voltage‐gated calcium channel subunit α2δ1‐mediated calcium signaling can upregulate the expression of SIRT4, which is highly expressed in α2δ1‐positive pancreatic tumor‐initiating cells (TICs). …”
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KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism by Li Chen, Kaikai Shi, Nicholas Ditzel, Weimin Qiu, Michaela Tencerova, Louise Himmelstrup Dreyer Nielsen, Florence Figeac, Alexander Rauch, Yuhang Liu, Jiuyuan Tao, Veronika Sramkova, Lenka Rossmeislova, Greet Kerckhofs, Tatjana N. Parac-Vogt, Sébastien de Bournonville, Thomas Levin Andersen, Mikael Rydén, Moustapha Kassem

“…Abstract An increasing number of studies have characterized the bone as an endocrine organ, and that bone secreted factors may not only regulate local bone remodeling, but also other tissues and whole-body metabolic functions. The precise nature of these regulatory factors and their roles at bridging the bone, bone marrow adipose tissue, extramedullary body fat and whole-body energy homeostasis are being explored. …”
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Designing a Business Model in the Tourism Industry of Iran by Amirhossein Samadian, Saeid Ehdaie, kamyar Raissifar

“…The key resources component describes the most important assets required for the business model to function properly. Key activities describe the most important tasks required for the business model to function properly. …”
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Label-Free Quantitative Proteomics Analysis of Nasal Lavage Fluid in Chronic Rhinosinusitis with Nasal Polyposis by Musallam Kashoob, Afshan Masood, Assim A. Alfadda, Salini Scaria Joy, Wed Alluhaim, Shahid Nawaz, Mashal Abaalkhail, Omar Alotaibi, Saad Alsaleh, Hicham Benabdelkamel

“…Data from LC-MS/MS underwent univariate and multivariate analyses. (3) Results: The proteomic analyses revealed distinct differences in the abundances of nasal lavage fluid proteins between the CRSwNP and control groups: a total of 234 proteins, 151 up- and 83 down-regulated in CRSwNP. Functional Gene Ontology (GO) analysis showed that dysregulated proteins were involved in airway inflammatory reaction, immune response, and oxidative stress. …”
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