Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells by Jerome Tan, Jiahui Chen, Daniel Roxby, Wai Hon Chooi, Tan Dai Nguyen, Shi Yan Ng, Jongyoon Han, Sing Yian Chew

“…On the other hand, cellular biophysical properties have demonstrated a strong correlation to cell state, quality and functionality and can be measured with ingenious label-free technologies in a rapid and non-destructive manner. …”
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Serum CD5L Responds Positively to Selenium and Coenzyme Q₁₀ Supplementation with Relation to Thyroid Hormones, Mortality, and Health-Related Quality-of-Life—A Sub-Analys... by Urban Alehagen, Jan O. Aaseth, Trine B. Opstad, Anders Larsson, Sabrina Asaad, Lutz Schomburg, Jan Alexander

“…It is an innate immune mediator protein with a multitude of functions, such as binding of invading microorganisms and oxidised LDL, and it is associated with clinical conditions, i.e., atherosclerosis and inflammation. …”
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Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and p... by Shrinjana Dhar, Pritha Bhattacharjee

“…It uses a comprehensive bioinformatics methodology to depict pathways and functionality enrichment, allowing for cost-effective risk prediction and management. …”
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The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism by Wilhelm Gottschall, Florent Ailloud, Christine Josenhans, Sebastian Suerbaum

“…Methylation has been associated with multiple functions in H. pylori, including the defense against foreign DNA and transcriptional regulation. …”
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Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma by Haikun Yang, Yuan Chen, Yuan Chen, Zheng Zhou, Yanjing Wang, Peng Li, Yang Li

“…Ubiquitination not only supports proliferation and anti-apoptotic functions within tumor cells but also promotes tumor progression by modulating the activity of immune and stromal cells. …”
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The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis by Yang S, Liu H, Zheng Y, Chu H, Lu Z, Yuan J, Xu S

“…In LUAD, clofibrate was identified as a potential inhibitor of PLIN3’s pro-oncogenic functions.Conclusion: PLIN3 may serve as a potential biomarker and oncogene, particularly in LUAD. …”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…Austeja Butkute,1,2,* Evelina Kazlauske,3,4,* Agata Mlynska,1,4 Emile Peciukaityte,3 Vitalijus Karabanovas,3,4 Ricardas Rotomskis,3,5 Simona Steponkiene3 1Laboratory of Immunology, National Cancer Institute, Vilnius, Lithuania; 2Life Science Center, Vilnius University, Vilnius, Lithuania; 3Biomedical Physics Laboratory of National Cancer Institute, Vilnius, Lithuania; 4Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Vilnius, Lithuania; 5Biophotonics Group of Laser Research Center, Vilnius University, Vilnius, Lithuania*These authors contributed equally to this workCorrespondence: Simona Steponkiene, Biomedical Physics Laboratory of National Cancer Institute Vilnius, Vilnius, Lithuania, Email simona.steponkiene@nvi.ltBackground: Photodynamic therapy (PDT) is a promising tool that utilizes photosensitizers (PS) for two functions: cancer imaging by fluorescence (diagnostics), and treatment by the generation of reactive oxygen species (therapy). …”
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“THE MIGHT-HAVE-BEENS” AS METAPLOT IN JULIAN BARNES’ STORYBOOK “THE LEMON TABLE” by Elena S. Annenkova

“…In the article “The Lemon Table” by Julian Barnes is analyzed from the point of view of “the mighthave-beens” plot functioning in this storybook. This plot is an essential part of the fundamental for this book plot of aging and associated with its physical and mental processes that heroes of these short stories are experienced. …”
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Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation by Li Chunxiao, Hou Xin, Liu Bowen, Sun Bingqing, Zhou Mengqi, Zhang Shuwen, Zhang Jingyuan, Lin Jiangtao

“…GO enrichment analysis identified 2,595 significant terms, associated with 2,402 biological processes, followed by 153 molecular functions and 40 cellular components. KEGG enrichment analysis identified 107 relevant pathways, including “apoptosis,” “TNF signaling pathway,” and “MAPK signaling pathway.” …”
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A Dirigent Gene, <i>ZmDIR11</i>, Positively Regulates Drought Tolerance in Maize by Zhixiong Zhao, Yuan Guan, Tao Qin, Hongjian Zheng, Hui Wang, Wen Xu, Wei Gu, Diansi Yu, Jihui Wei, Yinxiong Hu

“…The <i>DIR</i> gene family, which encodes Dirigent proteins, plays a crucial role in plant development and stress responses. However, the functions and mechanisms of this family in maize remained underexplored. …”
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Inhibition of GAPDH aggregation as a potential treatment for acute ischemic stroke by Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Masatoshi Nakatsuji, Naoki Harada, Ryoichi Yamaji, Takatoshi Hikida, Takashi Inui, Hidemitsu Nakajima

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Transcriptome-Wide Analysis of N6-Methyladenosine-Modified Long Noncoding RNAs in Particulate Matter-Induced Lung Injury by Yingying Zeng, Guiping Zhu, Wenjun Peng, Hui Cai, Chong Lu, Ling Ye, Meiling Jin, Jian Wang

“…We use bioinformatic tools to analyze the potential functions and pathways of these m⁶A-modified lncRNAs, revealing their involvement in regulating inflammation, immune response, and metabolism-related pathways. …”
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Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses by Bruna Gonçalves, Diana Priscila Pires, Liliana Fernandes, Miguel Pacheco, Tiago Ferreira, Hugo Osório, Ana Raquel Soares, Mariana Henriques, Sónia Silva

“…Accordingly, various genes and matrix proteins with predicted functions in the regulation of carbohydrate metabolism, sugar binding, sugar transport, and adhesion (including Epa family) were repressed by Zap1. …”
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The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism by Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng

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Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model by Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z

“…The results of RNA-seq and GSEA indicated that HDCA influenced the expression of genes related to primary bile acid synthesis and fatty acid degradation (p&lt; 0.05). …”
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TME-Activated MnO2/Pt Nanoplatform of Hydroxyl Radical and Oxygen Generation to Synergistically Promote Radiotherapy and MR Imaging of Glioblastoma by Chen L, Liu M, Wang Y, Wei W, Li Y, Bai Y, Yu X, Jiao L, Wang M

“…The nanoplatform exhibited excellent biocompatibility and performed multiple functions related to radiotherapy, with simpler components. …”
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GNNs and ensemble models enhance the prediction of new sRNA-mRNA interactions in unseen conditions by Shani Cohen, Lior Rokach, Isana Veksler-Lublinsky

“…Abstract Bacterial small RNAs (sRNAs) are pivotal in post-transcriptional regulation, affecting functions like virulence, metabolism, and gene expression by binding specific mRNA targets. …”
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Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus by Zhao JD, Fang ZH

“…STG can downregulate Plin2 and upregulate Fdps (p < 0.01).Conclusion: STG ameliorated hyperglycaemia by significantly altering the expression of different proteins, especially Fdps and Plin2, in the livers of GK rats. …”
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Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer by Geng Xu, Yaling Jiang, Chen Sun, Bernd W. Brandt, Kamran Nazmi, Luca Morelli, Giulia Lencioni, Elisa Giovannetti, Dongmei Deng

“…Expressing either CDD_L or CDD_S in CDD-deficient <i>E. coli</i> resulted in equivalent gemcitabine degradation and resistance, indicating that CDD function is independent of isoform length. …”
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Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling by Domitille Heitzler, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D Violin, Laurence Dupuy, Christophe Gauthier, Vincent Piketty, Pascale Crépieux, Anne Poupon, Frédérique Clément, François Fages, Robert J Lefkowitz, Eric Reiter

“…We demonstrate that, in addition to its well‐established function in the desensitization of G‐protein activation, GRK2 exerts a strong negative effect on β‐arrestin‐dependent signaling through its competition with GRK5 and 6 for receptor phosphorylation. …”
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