RNA splicing: Novel star in pulmonary diseases with a treatment perspective by Zhihui Niu, Bingqian Xu, Wei Li, Jian Sun, Haihai Liang

“…This review offers an exhaustive analysis of the biological functions and underlying molecular mechanisms associated with various AS-induced splice variants, RNA-binding proteins, and cis-elements, highlighting their significance as clinical biomarkers. …”
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GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration by Dan Pascal Jean Albers, Sofya Novikova, Julio Vieyto-Nuñez, Yasser Almeida-Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, Christian Buske, Ulrich Stifel, Julia Zinngrebe, Pamela Fischer-Posovszky, Andy Chevigné, Frank Kirchhoff, Elsa Sanchez-Garcia, Jan Münch, Mirja Harms

“…Methods We investigated the effects of GPR15LG on CXCR4 signaling and downstream functions. Binding assays and computational modeling were performed to assess the interaction between GPR15LG and CXCR4. …”
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Brain-Derived Neurotrophic Factor in Chronic Periodontitis by Jôice Dias Corrêa, Daniele Sirineu Pereira, Mila Fernandes Moreira Madeira, Celso Martins Queiroz-Junior, Danielle Glória Souza, Mauro Martins Teixeira, José Eustáquio Costa, Antônio Lúcio Teixeira, Tarcília Aparecida da Silva

“…Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. …”
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Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling by Aseervatham Anusha Amali, Douglas Jie Wen Tay, Douglas Jie Wen Tay, Yiqi Seow, Marie Loh, Marie Loh, Marie Loh, Sharada Ravikumar, Jocelyn Jin Yu, Shaun Seh Ern Loong, Siew Wai Fong, Chang Jie Mick Lee, Jonathan Jordon Cailu Lim, Louis Hanqiang Gan, Winston Lian Chye Koh, Ying Ding, Qi Hui Sam, Zhaohong Tan, Rachel Ying Min Tan, Chong Boon Lua, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Amit Singhal, Shyam Prabhakar, Wee Joo Chng, Wee Joo Chng, Laurent Renia, Laurent Renia, David Chien Boon Lye, David Chien Boon Lye, Lisa F. P. Ng, Lisa F. P. Ng, Kai Sen Tan, Kai Sen Tan, Roger Foo, Roger Foo, Chang Chuan Melvin Lee, Chang Chuan Melvin Lee, Barnaby Young, Barnaby Young, Louis Yi Ann Chai, Louis Yi Ann Chai

“…To date, these studies have yielded loci mostly in non-functional domains of unknown biological significance and invariably require large sample sizes, potentially missing lower frequency variants, especially in under-represented or minority populations.MethodsTo identify unique genetic traits predisposing to severe COVID-19 in Asians, we employed an alternative strategy using whole exome sequencing of representative cohort of severe versus mild COVID-19 patients. …”
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Multidisciplinary Clinical Study on Retinal, Circulatory, and Respiratory Damage in Smoking-Dependent Subjects by Marcella Nebbioso, Annarita Vestri, Magda Gharbiya, Mattia D’Andrea, Matteo Calbucci, Federico Pasqualotto, Serena Esposito, Alessandra D’Amico, Valentina Castellani, Sandra Cinzia Carlesimo, Paolo Giuseppe Limoli, Alessandro Lambiase

“…Spirometric evaluation and blood sampling were also performed on both groups to study pulmonary functional capacity, as well as T-TAS. <i>Results</i>: An analysis of the obtained data confirmed the systemic impact of smoking, evidenced by an increase in T-TAS and a decrease in forced expiratory volume in 1 s expressed in liters (FEV1 L) in SMs compared to the non-SMs group. …”
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Pangenome analysis of transposable element insertion polymorphisms reveals features underlying cold tolerance in rice by Yongqing Qian, Zuwen Zhou, Tianmin Ouyang, Dongao Li, Ru Li, Ping Gan, Renfei Qiao, Yingying Tan, Mingchao Qian, Liezhao Liu, Jiana Li, Kun Lu, Jijing Luo, Ling-Ling Chen, Jia-Ming Song

“…Our TIP-GWAS analysis reveal two cold tolerance genes OsCACT and OsPTR. The biological functions of these genes are confirmed using knockout and overexpression lines. …”
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PSMD14-mediated deubiquitination of CARM1 facilitates the proliferation and metastasis of hepatocellular carcinoma by inducing the transcriptional activation of FERMT1 by Jing Lu, Huita Wu, Ping Zhan, Yuyan Lu, Qinliang Fang, Changhong Luo, Fuqiang Wang, Jing Wen, Chengrong Xie, Zhenyu Yin

“…The enzyme coactivator-associated arginine methyltransferase 1 (CARM1) is highly expressed in different types of cancer. However, the precise levels of expression, clinical significance, biological functions, and molecular mechanisms of CARM1 in HCC, particularly related to the downstream genes regulated by CARM1 through histone arginine methylation, remain unclear. …”
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Preliminary study of the mechanism of isolinderalactone inhibiting the malignant behavior of bladder cancer by Qun Wang, Wenkai Xu, Lu Ying, Hongjin Shi, Yuxin Sun, Wei Feng, Haole Xu, Jun Xie, Hairong Wei, Zhao Yang, Haifeng Wang

“…Isolinderalactone (ILL), extracted from the dried tubers of Linderae aggregate, has multiple functions, such as antioxidation, antitumor, and anti-infection effects. …”
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Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…Among these, the expression levels of 9 proteins were upregulated and 13 proteins were downregulated in the SAE group. …”
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Transcriptomic Differences by RNA Sequencing for Evaluation of New Method for Long-Time In Vitro Culture of Cryopreserved Testicular Tissue for Oncologic Patients by Cheng Pei, Plamen Todorov, Qingduo Kong, Mengyang Cao, Evgenia Isachenko, Gohar Rahimi, Frank Nawroth, Nina Mallmann-Gottschalk, Wensheng Liu, Volodimir Isachenko

“…Background: Earlier studies have established that culturing human ovarian tissue in a 3D system with a small amount of soluble Matrigel (a basement membrane protein) for 7 days in vitro increased gene fusion and alternative splicing events, cellular functions, and potentially impacted gene expression. …”
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RETRACTED ARTICLE: Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer by Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos, Francisco Eduardo Martinez

“…Abstract Background Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. …”
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Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancer by Hou Wang, Hou Wang, Kai Zhang, Guang Ning, Guang Ning

“…Core mitochondrial metabolism-related gene, TMEM86B was identified and its functions validated through cell-based assays and in vivo mouse models.ResultsFifteen mitochondrial metabolism-related genes were identified, including HSD3B7, ORC1, GPSM2, NDUFA4L2, CHDH, LARS2, TMEM86B, FABP4, TNFAIP8L3, HMGCL, GDE1, ACOX1, ARV1, HDC, and GSR. …”
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Placental Mesenchymal Stromal Cells (PMSCs) and PMSC-Derived Extracellular Vesicles (PMSC-EVs) Attenuated Renal Fibrosis in Rats with Unilateral Ureteral Obstruction (UUO) by Regul... by Zhu Zhu, Chaonan Han, Shuli Xian, Feng Zhuang, Feng Ding, Wei Zhang, Yingli Liu

“…Such functions may be mediated by the paracrine activity of PMSC-EVs.…”
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Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model by Minyue Qiu, Lixin Zhao, Xiaojia Li, Yipei Fan, Minchi Liu, Dong Hua, Yunkai Zhu, Yinyin Liang, Yu Zhang, Wen Xiao, Xiaofeng Xu, Jintao Li

“…Finally, motor and sensory functions of mice were detected by open field test and hot plate test, respectively. …”
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DKK1 promotes migration and invasion of non–small cell lung cancer via β-catenin signaling pathway by Jing Zhang, Xintong Zhang, Xiaoting Zhao, Mei Jiang, Meng Gu, Ziyu Wang, Wentao Yue

“…Disregulation of dickkopf-related protein 1 (DKK1) has been reported in a variety of human cancers. However, how DKK1 functions in Non-small cell lung cancer has not been revealed. …”
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The intersection between circulatory microRNAs and biomarkers of neurodegeneration by Amber Yaqub, Rima Mustafa, M. Arfan Ikram, Mohsen Ghanbari

“…Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs with a vast array of biological functions, including the regulation of gene expression. …”
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Electronic Educational Resource as a Source and Means of Developing Digital Education by Magomed Abdurazakov, Tatiana Litvinova, Georgy Tokmazov, Nadezhda Salangina

“…It is concluded that educational information and knowledge receive digital expression in an electronic educational resource (EER), which is at the same time a form, a means, and the content of education. …”
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Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for imm... by Hongwei Wang, Yu-nan Zhu, Sifan Zhang, Kexin Liu, Rong Huang, Zhigao Li, Lan Mei, Yingpu Li

“…However, the compositional patterns of ECM in breast cancer and their underlying biological functions remain elusive. Methods Transcriptome and genome data of breast cancer patients from TCGA database was downloaded. …”
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The HIF-1α/miR-145b/Angpt2 axis attenuates renal fibrosis induced by unilateral renal ischemia–reperfusion by Bingyou Cheng, Shang Huang, Lin Zhou, Pei Zhu, Zhongpu Li, Liang Hu, Jingsong Liu, Kejian Zhu

“…Further, our study also found miR-145b in vivo transfection suppressed the expression of angiopoietin-2 (Angpt2) in mice after uIR operation. …”
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Maternal loss of mouse Nlrp2 alters the transcriptome and DNA methylome in GV oocytes and impairs zygotic genome activation in embryos by Zahra Anvar, Michael D. Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K. To, Daniel C. Kraushaar, Ying-Wooi Wan, Michael C. Mari, Simon Andrews, Gavin Kelsey, Ignatia B. Van den Veyver

“…Maternal inactivation of genes encoding SCMC proteins has been linked to infertility and subfertility in mice and humans, but the underlying molecular mechanisms for the diverse functions of SCMC proteins, and specifically the role of NLRP2, are incompletely understood. …”
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