Towards developing new private sector maternity care models in South Africa: results from a deliberative stakeholder dialogue by Tanya Doherty, Sue Fawcus, Vishal Brijlal, Geetesh Solanki

“…Stakeholders at the dialogue expressed support for legislative reforms to allow for the creation of multi-disciplinary birthing units. …”
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Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel. by Aziza El Harchi, Dario Melgari, Yi Hong Zhang, Henggui Zhang, Jules C Hancox

“…<h4>Background</h4>The familial Short QT Syndrome (SQTS) is associated with an increased risk of cardiac arrhythmia and sudden death. Gain-of-function mutations in the hERG K(+) channel protein have been linked to variant 1 of the SQTS. …”
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Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency by Matthew Moll, Brian D. Hobbs, Katherine A. Pratte, Chengyue Zhang, Auyon J. Ghosh, Russell P. Bowler, David A. Lomas, Edwin K. Silverman, Dawn L. DeMeo

“…Results Among 4,446 Pi*MM and 352 Pi*ZZ individuals, sixteen blood proteins were associated with airflow obstruction, fourteen of which were highly expressed in lung. PPI networks implicated regulation of immune system function, cytokine and interleukin signaling, and matrix metalloproteinases. …”
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Alteração no diâmetro e na perda de carga em tubos de polietileno submetidos a diferentes pressões Variations in diameter and head loss in polyethylene tubes submitted to different... by Luís A. A. Vilela, Olívio J. Soccol, Eliézer S. Gervásio, José A. Frizzone, Tarlei A. Botrel

“…Thus, other equations in which the head loss was expressed as a function of flow and diameter or flow and pressure were adjusted for each of the diameters.…”
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Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation by Sara Kirmani, Tianxiao Huan, Joseph C. Van Amburg, Roby Joehanes, Md Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, David A. Ong, Fabio Puddu, James S. Floyd, Christie M. Ballantyne, Bruce M. Psaty, Laura M. Raffield, Pradeep Natarajan, Karen N. Conneely, Joshua S. Weinstock, April P. Carson, Leslie A. Lange, Kendra Ferrier, Nancy L. Heard-Costa, Joanne Murabito, Alexander G. Bick, Daniel Levy

“…We conduct a multiracial meta-analysis of EWAS of CHIP in the Framingham Heart Study, Jackson Heart Study, Cardiovascular Health Study, and Atherosclerosis Risk in Communities cohorts (N = 8196) to elucidate the molecular mechanisms underlying CHIP and illuminate how these changes influence cardiovascular disease risk. We functionally validate the EWAS findings using human hematopoietic stem cell models of CHIP. …”
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Perivascular Lymphocyte Clusters Induced by Gastric Subserous Layer Vaccination Mediate Optimal Immunity against Helicobacter through Facilitating Immune Cell Infiltration and Loca... by Chupeng Hu, Wei Liu, Ningyin Xu, An Huang, Zhiqin Zeng, Shuanghui Luo, Zhenxing Zhang, Menghui Fan, Feng Ye, Tao Xi, Yingying Xing

“…At 28 days post vaccination, a parabiosis mouse model along with depletion of anti-CD90.2 antibody was employed to explore the function of perivascular lymphocyte clusters in recall responses. …”
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Reference-guided detection of the transcriptome reveals circular RNA-related competing endogenous RNA networks in response to three respiration pathogens in pig lungs by Qian Wu, Kun Du, Mao-qing Gu, Yu Xia, Miao Yin, Xian Li, Shu-ting Zhang, Hong Zhao, Zhang-lin Li, Xi-wen Chen

“…The functional annotation showed that ceRNA networks of the circRNAs that were specifically up-regulated in response to Mhp and ASFV were significantly enriched in humoral immunity-related functions and reactive oxygen species-related signal pathways, respectively. …”
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Ethyl acetate extract of Ruta graveolens: a specific and potent inhibitor against the drug-resistant EGFR_T790M mutant in NSCLC by Vikas Kumar, Leena Chauhan, Deepa Singh, Akash Kumar, Rajkumar Kulandaisamy, Tushar Kushwaha, Kamal Baswal, Rajan Singh, Saroj Kumar, Shivajirao L. Gholap, P. Hariprasad, S. Babu Dadinaboyina, Jagadeshwar R. Thota, Deepak Sehgal, Mohan B. Appaiahgari, Krishna K. Inampudi

“…To this end, we evaluated the functional and therapeutic potential of a panel of polar and non-polar solvent extracts using various in vitro assay systems. …”
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Single-nucleus RNA sequencing defines adipose tissue subpopulations that contribute to Tibetan pig cold adaptation by Jiali Liu, Yao Jiang, Tianxia Liu, Chuanhe Chen, Linya Chui, Along Cui, Xueping Zhang, Xiao Wang, Yu Wang, Chunhuai Yang, Ying Zhang, Tianwen Wu, Shulin Yang, Jiaojiao Huang, Cong Tao, Jianguo Zhao, Yanfang Wang

“…Abstract Background Thermogenic beige adipocyte displays a remarkable ability in mammals to adapt to cold environments, but the underlying cellular mechanisms remain unclear, especially in pigs that lack functional UCP1. Results Multilocular beige adipocytes were observed in both Tibetan pigs (cold-tolerant) and Bama pigs (cold-sensitive) after short-term cold exposure (4 ℃ for 3 days). …”
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A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL by Melanie Märklin, Gundram Jung, Jonas S Heitmann, Joseph Kauer, Helmut R Salih, Stefanie Mueller, Bochong Li, Latifa Zekri, Naveen K Mehta, Martin Pfluegler, Kristan Meetze, Isabelle Sindel, Fabian Vogt, Lukas Osburg, Hans-Jörg Bühring, Sebastian Hörner, Patrick A Baeuerle, Jennifer S Michaelson

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Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways by Mohamed El-Sherbiny, Hany A. Elkattawy, Shimaa Hadhoud, Ahmed N. Nasr, Ateya M. Ibrahim, Ateya M. Ibrahim, Omar Z. Ameer, Noorhan Alsaleebi, Joud Asfari, Madaniah O. Zakari, Moaz A. Mojaddidi, Ehab K. Ali, Hailah M. Almohaimeed, Ahmed Abdeen, Sahar K. Ali, Mamdouh Eldesoqui, Mamdouh Eldesoqui

“…Recent research indicates that oxytocin (OXY), a neuropeptide typically linked to social bonding and reproductive functions, may influence inflammatory processes. This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.MethodsEighteen male albino rats were divided into three groups; the control group received no treatment; the LPS group received 0.5 mL of saline solution containing 5 mg/kg LPS intraperitoneally (orchitis model); and the LPS + OXY group received LPS and OXY (0.1 mg/kg) intraperitoneally every 12 h for 72 h.Results and discussionAnimals subjected to LPS were found to have severe orchitis, as evidenced by increased oxidative stress and surging inflammatory mediators (TNF-α, IL-1β, and IL-6), with declined IL-10 levels. …”
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M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7 by Lu Zhao, Xuejia Li, Min Gao, Lin Liu, Binyun Ma, Xun Liu, Jiachen Zhang, Ruoxuan Liu, Bei Du, Ruihua Wei, Hong Nian

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Identification of core noncoding RNA-associated competing endogenous RNA networks in renal fibrosis via whole-transcriptome sequencing by Yizhen Chen, Meng Cheng, Rong Dai, Weili Wang, Yonghao Sang, Liuting Wei, Yilin Gao, Wei Zhang, Yiping Wang, Lei Zhang

“…Enrichment analysis was performed to explore potential functions.Results Sequencing analysis revealed significant dysregulation of ncRNAs in all models compared to the normal group. …”
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Main circulating CD8⁺ T cell subsets in patients with systemic lupus erythematosus by S. S. Benevolenskaya, I. V. Kudriavtsev, M. K. Serebriakova, A. A. Rubinstein, E. S. Kuvardin, I. N. Grigor’yeva, D. B. Aliev, D. B. Zammoeva, D. B. Motorin, A. S. Golovkin, O. V. Kalinina, S. V. Lapin, I. Z. Gaydukova, A. L. Maslyanskiy, E. K. Gaydukova

“…While Tc1, Tc17, Tc17.1, Tfc subsets probably have regulatory functions…”
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Evaluating the anticancer efficacy of Chara vulgaris ethanolic extract and selenium nanoformulation in Ehrlich carcinoma mice: role of autophagy and apoptosis by Maha Alsunbul, Thanaa A. El-Masry, Maisra M. El-Bouseary, Enas I. El Zahaby, Mostafa M. El-Sheekh, Mohamed M. S. Gaballa, Eman Wahsh, Heba Kamel Badawy, Jawaher Abdullah Alamoudi, Reem ALQahtani, Naifa Alenazi, Maysa M. F. El-Nagar

“…Abstract Background Bioactive compounds with a wide range of chemical compositions and biological functions are found in the Chlorophyceae family. The present work investigated the anticancer effect of ethanolic extract from Chara vulgaris (C. vulgaris) and its selenium nanoformulation (CvSeNPs) against solid Ehrlich carcinoma (SEC). …”
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Genome-wide association study reveals the genetic basis of vitamin C content in rapeseed (Brassica napus L.) seedlings by Chao Wang, Lieqiong Kuang, Ze Tian, Xinfa Wang, Xinfa Wang, Hanzhong Wang, Hanzhong Wang, Xiaoling Dun

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses of the 2365 annotated genes near associated SNPs revealed significant involvement in diverse metabolic pathways including peroxisome, ascorbate, secondary metabolites, and terpenoid biosynthesis, as well as biological processes such as hydrogen peroxide/lactate metabolism and ROS biosynthesis, along with associations with specific cellular components and molecular functions. Furthermore, we identified six candidate genes that exhibit significant differences in expression between low and high Vc accessions, which are potentially involved in Vc biosynthesis but require further experimental validation. …”
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Reading the Visual Aspects of the Grotesque Body in the Iranian Cinema and Theater Posters (1390s) by Amir Hossein Pormehr Yabandeh, Mohsen Marasy

“…The results of this research suggest that the idea of grotesque in modern Iranian cultural posters refers to the illustration of a human being in connection with nature and an inverted life, expressing an ambiguous element. Also, it covers human disturbances, transformations, and phobias, which have found a critical and societal function. …”
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Effect of Seminal Plasma on the Freezability of Boar Sperm by Kuanfeng Zhu, Yukun Song, Zhi He, Peng Wang, Xuguang Wang, Guoshi Liu

“…Background: Seminal plasma is an important component of semen and has a significant effect on sperm function. However, the relationship between seminal plasma and sperm freezing capacity has not been fully studied. …”
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Impact of Makarasana on Cardiovascular Parameters: A Prospective Interventional Study by Meenu Dahiya, Deepti Dwivedi, Nimarpreet Kaur, Pushpa Lamba, Sunil Chamola

“…Introduction: Makarasana, a yogic posture also known as the crocodile pose on elbows, is a gentle backbend practised in yoga for its potential physiological benefits, including enhanced breathing, digestive function and purported effects on spiritual and emotional wellbeing. …”
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Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology by Ling Xie, Ryan N. Sheehy, Adil Muneer, Yan Xiong, John A. Wrobel, Feng Zhang, Kwang-Su Park, Julia Velez, Jing Liu, Yan-Jia Luo, Brent Asrican, Ping Dong, Ya-Dong Li, Corina Damian, Luis Quintanilla, Yongyi Li, Chongchong Xu, Mohanish Deshmukh, Leon G. Coleman, Guo-Li Ming, Hongjun Song, Zhexing Wen, Jian Jin, Juan Song, Xian Chen

“…Correspondingly, we developed a brain-penetrant inhibitor of G9a, MS1262, which restored both age-related learning & memory and noncognitive functions in multiple AD mouse models. Further, comparison of AD pathology-correlated mouse proteomes with those of AD patients found G9a regulates pathological pathways that promote Aβ and neurofibrillary tangles. …”
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