Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. by Tomoyuki Oshio, Rei Kawashima, Yuki I Kawamura, Teruki Hagiwara, Noriko Mizutani, Toshihiko Okada, Takeshi Otsubo, Kyoko Inagaki-Ohara, Akihiro Matsukawa, Tatsuya Haga, Shigeru Kakuta, Yoichiro Iwakura, Seijiro Hosokawa, Taeko Dohi

“…However, the role of CCR8 in inflammatory responses is not fully elucidated. To investigate the function of CCR8 in macrophages, we compared cytokine secretion from mouse PMφ or bone marrow-derived macrophages (BMMφ) stimulated with various Toll-like receptor (TLR) ligands in CCR8 deficient (CCR8-/-) and wild-type (WT) mice. …”
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Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage by Sandra Rayego-Mateos, Raul Rodrigues-Diez, Jose Luis Morgado-Pascual, Floris Valentijn, Jose M. Valdivielso, Roel Goldschmeding, Marta Ruiz-Ortega

“…Although many studies have investigated the factors involved in the progressive deterioration of renal function, current therapeutic strategies only delay disease progression, leaving an unmet need for effective therapeutic interventions that target the cause behind the inflammatory process and could slow down or reverse the development and progression of CKD. …”
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Factorizations in Geometric Lattices by Alex Aguila, Elvis Cabrera, Jyrko Correa-Morris

“…As part of the study, we first examine the main characteristics of the function <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="fraktur">N</mi><mo lspace="0pt">:</mo><mi mathvariant="normal">Π</mi><mo>(</mo><mi>X</mi><mo>)</mo><mo>→</mo><mi mathvariant="double-struck">N</mi></mrow></semantics></math></inline-formula>, which assigns to each partition <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>π</mi></semantics></math></inline-formula> the number of minimal atomic decompositions of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>π</mi></semantics></math></inline-formula>. …”
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Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma by Ruopeng Liang, Xiaoxue Zhang, Shitao Wu, Jing Liu, Yunpeng Zhai, Chaojie Lin, Zhenya Wang, Yi Zhang, Hao Chen, Rongtao Zhu

“…The cell-derived xenograft and liver metastasis tumor models were established to validate the function of DNM1L in vivo. The metabolomics data from transcriptomics/metabolomics were analyzed to identify the differentially expressed genes/metabolites of DNM1L in GBC. …”
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Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala by Todd J. Sahagian, Scott W. Harden, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Charles J. Frazier, Charles J. Frazier

“…Improved understanding of these effectors will provide potentially valuable new insights on the wide range of mechanisms through which cholinergic system dysfunction can lead to impaired executive function.…”
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POSTMODERN IRONY AND LAUGH: SPECIFIC FEATURES AND SCIENTIFIC RECEPTION by Iryna V. Kropyvko

“…Postmodern irony is presented as the textual function like the one that relates to various conventional lines that are in the space of the literary text and intertextual connections. …”
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Electromyographic Characteristics of a Single Motion Shoulder Exercise: A Pilot Study Investigating a Novel Shoulder Exercise by Michael J Henehan, Tamar Brand-Perez, Jeffrey C Peng, Masaaki Tsuruike

“…# Background Shoulder exercises focused on strengthening the rotator cuff and scapular stabilizing muscles as well as addressing scapular dyskinesis and motor control have been shown to improve rotator cuff function and decrease shoulder pain. A single motion shoulder exercise that effectively activates the rotator cuff and scapular stabilizing muscles, engages the scapulohumeral rhythm, and includes eccentric contractions may be more effective and easier for patients to consistently perform as compared to multiple standard shoulder exercises…”
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Quality of life after idiopathic multicentric Castleman disease in China: a cross-sectional, multi-center survey of patient reported outcome and caregiver reported outcome by Jia Chen, Miao-yan Zhang, Yu-han Gao, Lu Zhang, Jian Li

“…However, the impact of iMCD on life quality, mental and psychological status, social function, and caregiving burden is poorly understood. …”
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Optimization of mathematical processing of calibration curves when determining molecular mass of biologicals by SDS-polyacrylamide gel electrophoresis by V. A. Tomilin, N. L. Ivanyutina, E. V. Elbert, R. A. Volkova

“…A third-order polynomial regression equation was used to optimize mathematical processing methods used during calculation of the calibration function. This made it possible to reduce the MM relative deviation down to 2.3 - 3.5 % when using sets ranging from 10 to 100 kDa, and to 3.7 - 4.0 % when using the extended range sets, which is important for assessing similarity of different products.…”
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Managing Friends and Foes: Sanctioning Mutualists in Mixed‐Infection Nodules Trades off With Defense Against Antagonists by Camille E. Wendlandt, Saumik Basu, Angeliqua P. Montoya, Paige Roberts, Justin D. Stewart, Allison B. Coffin, David W. Crowder, E. Toby Kiers, Stephanie S. Porter

“…However, these outcomes may be difficult to achieve simultaneously, since plant defenses activated in response to antagonists can compromise mutualism function, and plant resources allocated to defense may trade off with resources allocated to managing mutualists. …”
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Transcriptomic and physiological insights into auxin-mediated root growth and potassium uptake in tobacco under low-potassium stress by Kunhao Guan, Yingying Li, Yuyin Zhang, Jie Yang, Zixuan Ge, Xiaoyan Dai

“…This study highlights the regulatory function of auxin in enhancing root growth and potassium absorption under low potassium conditions, offering insights into the molecular mechanisms of potassium stress response. …”
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Genetic analysis and gene mapping of a rice spikelet degradation mutant (spd-hp73) by REN Sanjuan, SUN Chu, TONG Chuan, ZHAO Fei, SHU Qingyao, SHEN Shengquan

“…The traits of mutant were expressed stably in different growth environments. …”
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Novel Compound Heterozygous Variants in ZNF526 Causing Dentici‐Novelli Neurodevelopmental Syndrome: A Case Report and Literature Review by Shaoxin Li, Hui Fang, Hong Li, Min Peng, Jinsong Bao, Yunfei Cai, Jing Chen, Zhige Li

“…ABSTRACT Background The ZNF526 gene encodes a ubiquitously expressed Kruppel‐type zinc finger protein crucial in transcriptional regulation. …”
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Efficacy of Shenkang Injection combined with renin-angiotensin-aldosterone system blockers in diabetic nephropathy: a systematic review and meta-analysis of randomized controlled t... by Xinyue Zhang, Xuyuan Lao, Shengchun Liao, Chaoyang Ye, Chen Wang

“…No publication bias was detected for TER, SCr, BUN, 24h-UTP, TG, and adverse reactions, though UPER and TC showed potential bias.Conclusion SKI combined with RAAS blockers may enhance renal function and metabolic profiles in DN patients. Further high-quality RCTs are needed to validate these findings and assess long-term safety.…”
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Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages by Mengjiao Zhou, Bing Pei, Peipei Cai, Chengxue Yi, Francis Atim Akanyibah, Changkun Lyu, Fei Mao

“…Abnormal macrophage function is implicated in the pathophysiology of IBD. …”
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Oxidative/Nitrosative Stress and Brain Involvement in Sepsis: A Relationship Supported by Immunohistochemistry by Giuseppe Bertozzi, Michela Ferrara, Mariagrazia Calvano, Natascha Pascale, Aldo Di Fazio

“…This evidence, together with that of the previous study, can only support the introduction of substances with an antioxidant function in the guidelines for the treatment of sepsis.…”
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THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“…., 1975–1977, "The DNA (RNA) Nucleotide Sequence–The Function." One can notice that a change of levels occurs at almost every 30-year period. …”
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Role of adiponectin and its receptors AdipoR1/2 in inflammatory bowel disease by Qiuyan Zhu, Xiaoli Jia, Shupeng Li, Jinxing Feng

“…Abstract Intake of nutrients and water from diet to maintain life, a typical physiological function of gut, is highly dependent on the extensive immune network, whose imbalance is easy to induce inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). …”
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Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction by Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo

“…Some important findings have been reported: (1) Using urine chemokines CXCL-1 and interleukin-8 (IL-8), we may discriminate overactive bladder (OAB) symptoms in women between DO and urinary tract infection. (2) Urinary levels of oxidative stress biomarkers such as 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane have a potential being used as a tool to identify women with mixed DO and stress urinary incontinence. (3) Urine levels of total antioxidant capacity (TAC), and prostaglandin E2 (PGE2) are positively correlated with voiding detrusor pressure in patients with DU. (4) Urine levels of brain-derived neurotrophic factor (BDNF) and PGE2 were significantly higher in the DU patients with detrusor function recovery. (5) Women with DV had higher urinary levels of tumor necrosis factor-alpha (TNF-α) and 8-OHdG, and urinary IL-2 level was significantly lower. (6) Urine level of 8-isoprostane was higher in the patients with idiopathic DO and neurogenic DO. (7) Higher urine cytokine levels of monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted (RANTES), CXCL-10, IL-7, and eotaxin-1 in patients with IC/BPS than controls. (8) The urine levels of IL-8, CXCL-10, BDNF, IL-6, and RANTES were significantly higher in patients with Hunner's IC than non-Hunner's IC. (9) Male patients with IC/BPS had a significantly higher level of eotaxin, MCP-1, TNF-α, 8-OHdG, and TAC. …”
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THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“…., 1975–1977, "The DNA (RNA) Nucleotide Sequence–The Function." One can notice that a change of levels occurs at almost every 30-year period. …”
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