Coat Proteins of the Novel Victoriviruses FaVV1 and FaVV2 Suppress Sexual Reproduction and Virulence in the Pathogen of Fusarium Head Blight by Shulin Cao, Xiaoyue Yang, Lele Xia, Xing Zhang, Haiyan Sun, Yuanyu Deng, Yan Shu, Aixiang Zhang, Huaigu Chen, Wei Li

“…This study unveiled the discovery of the victorivirus FgVV2 from the <i>F. asiaticum</i> strain F16176 and comprehensively characterized the function of the two victoriviruses FaVV1 and FaVV2 in virulence. …”
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The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality by David A. Salamanca-Díaz, Helen R. Horkan, Helena García-Castro, Elena Emili, Miguel Salinas-Saavedra, Alberto Pérez-Posada, Maria Eleonora Rossi, Marta Álvarez-Presas, Rowan Mac Gabhann, Paula Hillenbrand, Febrimarsa, Camille Curantz, Paris K. Weavers, Yasmine Lund-Ricard, Tassilo Förg, Manuel H. Michaca, Steven M. Sanders, Nathan J. Kenny, Jordi Paps, Uri Frank, Jordi Solana

“…Abstract Coloniality is a widespread growth form in cnidarians, tunicates, and bryozoans, among others. Colonies function as single physiological units despite their modular structure of zooids and supporting tissues. …”
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Genetic insights into MIS-C Post-COVID-19 in Kuwaiti children: investigating monogenic factors by Mohammed Dashti, Hessa AlKandari, Hessa AlKandari, Md Zubbair Malik, Rasheeba Nizam, Sumi Elsa John, Sindhu Jacob, Arshad Channanath, Fouzeyah Othman, Safa Al-Sayed, Osama Al-Hindi, Mona Al-Mutari, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

“…The findings highlight the critical role of genetic predispositions in MIS-C and suggest that further functional genomics work is necessary to explore the mechanistic contributions of these genes, facilitating the development of targeted diagnostic strategies.…”
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Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers. by Huiqing Li, Jin Xu, Yue-Hong Bian, Pep Rotllant, Tiansheng Shen, Wuying Chu, Jianshe Zhang, Martin Schneider, Shao Jun Du

“…<h4>Methodology/principal findings</h4>To better understand Smyd1b function in myofibrillogenesis, we analyzed the subcellular localization of Smyd1b_tv1 and Smyd1b_tv2 in transgenic zebrafish expressing a myc-tagged Smyd1b_tv1 or Smyd1b_tv2. …”
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Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation by Yifeng Gao, Qing Yin, Yaser Gamallat, Michael G. Grant, Aidan H. Snell, Xingxing Shi, Lara N. Ulstad, Arshita Singh, Tingan Chen, Joseph O. Johnson, Dorina Avram, Lixin Wan

“…Thus HOIP positively  regulates p31comet function. Consistent with this notion, HOIP-deficient cells exhibit prolonged mitotic duration similar to p31comet knockout. …”
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Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease by Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu

“…Although FGF13 is highly expressed in neurons, it functions by preventing glia‐dependent inflammatory processes. …”
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The role of universal stress protein Usp1413 in meropenem adaptive resistance and environmental stress responses in Acinetobacter baumannii by Sirui Zhang, Jingdan Wang, Rong Yu, Haiping Liu, Shuyan Liu, Kai Luo, Jin'e Lei, Bei Han, Yanjiong Chen, Shaoshan Han, E Yang, Meng Xun, Lei Han

“…These effects of Usp1413 were achieved by regulating its interaction proteins, within the functions of YigZ family protein, acetyltransferase, and SulP family inorganic anion transporter. …”
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PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma by Wei‐Ting Wang, Zi‐Wen Duan, Tong‐Yao Xing, Wei Hua, Kai‐Xing Du, Chun‐Yu Shang, Yi‐Fan Wu, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…The process functions independently of ferroptosis. Interestingly, TFRC is directly regulated by the transcription factor hypoxia‐inducible factor 1 alpha (HIF1A) in its promoter. …”
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The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren’s Syndrome by Linbo Li, Jing He, Lei Zhu, Yuqin Yang, Yuebo Jin, Rulin Jia, Xu Liu, Yanying Liu, Xiaolin Sun, Zhanguo Li

“…A significant elevation of the CD4+CD25+CD161+ T cell subpopulation was observed in the peripheral blood of pSS patients compared to HCs and this subset showed decreased regulatory functions compared with the CD4+CD25+CD161− population. …”
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Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling by Wenqi Song, Yanchuan Li, Hongtao Xu, Yaqun Zhang, Liu Liu, Yihao Li, Xinran Wang, Yueming Du, Yining Chen, Jianjun Lyu, Lingjing Jin, Chao Zhang, Yuchen Xiao

“…Additionally, MRAP2 suppressed the membrane trafficking of MTNR1A, but promoted the surface trafficking of MTNR1B.DiscussionThese findings highlighted the complex regulatory role of MRAP2, and shed light on its diverse functions in GPCR biology and its potential implications in regulating physiological processes governed by melatonin signaling.…”
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Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling by Xia Yang, Lu Liu, Zhongjian Yu, Yuanlin Chen, Shiting Xu, Meiyuan Liu, Meng Wang, Huili Guo, Zhiwu Zhang, Bingjie Shan, Silin Cai, Mengting Pan, Jiangyu Zhang, Fengpin Wang, Yanfang Zheng

“…Our study revealed that circLIMK1-005 was upregulated in LUAD and correlated with poor patient prognosis. Functionally, circLIMK1-005 significantly promoted LUAD cell proliferation and metastasis. …”
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Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024 by Yanhong Pei, Haijie Liang, Yu Guo, Boyang Wang, Han Wu, Zhijian Jin, Shanyi Lin, Fanwei Zeng, Yifan Wu, Qianyu Shi, Jiuhui Xu, Yi Huang, Tingting Ren, Jiarui Liu, Jiarui Liu, Wei Guo

“…BackgroundLiquid–liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling processes in cancer is still scarce. …”
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Exploring the Biological Activity of a Humanized Anti-CD99 ScFv and Antibody for Targeting T Cell Malignancies by Nuchjira Takheaw, Thanathat Pamonsupornwichit, Ratthakorn Chaiwut, Kamonporn Kotemul, Kanokporn Sornsuwan, On-anong Juntit, Umpa Yasamut, Passaworn Cheyasawan, Witida Laopajon, Watchara Kasinrerk, Chatchai Tayapiwatana

“…By targeting CD99, mAb MT99/3 suppresses antigen presentation and disrupts T cell functions, offering promise for addressing hyperresponsive T cell conditions. …”
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The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells by Nitika Gaurav, Ryan O’Hara, Usman Hyder, Weihua Qin, Cheenou Her, Hector Romero, Amarjeet Kumar, Maria J. Marcaida, Rohit K. Singh, Ruud Hovius, Karthik Selvam, Jiuyang Liu, Sara Martire, Yuhang Yao, Ashwini Challa, Matteo Dal Peraro, Beat Fierz, Hidetoshi Kono, M. Cristina Cardoso, Galia T. Debelouchina, Heinrich Leonhardt, Iván D’Orso, Laura A. Banaszynski, Tatiana G. Kutateladze

“…Our findings provide mechanistic and functional insights that further our understanding of how ERVs are silenced.…”
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Chitosan-based multimodal polymeric nanoparticles targeting pancreatic β-cells by Lorenzo Rossi, Cataldo Pignatelli, Krisztina Kerekes, Francesca Cadamuro, András Dinnyés, Felix Lindheimer, Jochen Seissler, Magdalena Lindner, Sibylle Ziegler, Peter Bartenstein, Yi Qiu, Judit Kovács-Kocsi, Zoltán Körhegyi, Magdolna Bodnár, Erika Fazekas, Eszter Prépost, Francesco Nicotra, Laura Russo

“…The NPs, composed of chitosan (CH) and γ-poly-glutamic-acid (γ-PGA) with different “clickable” functional groups were chemoselectively decorated at the surface with Exendin-4 (Ex4), a ligand of glucagon-like peptide 1 (GLP-1) β-cell receptors, and with a DOTA containing linker, to chelate diagnostic radioisotopes. …”
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Identification of a novel linear B-cell epitope recognized by a monoclonal antibody against the capsid protein of goose astrovirus genotypes 2 by Haiqin Li, Haoyu Huang, Cui Lin, Fanfan Zhang, Jia Tan, Na Li, Chengcheng Wu, Jiangnan Huang, Qipeng Wei, Siyi Wang, Yujun Zhu, Yanbing Zeng

“…Conclusions These findings will be useful for the development of diagnostic kits for GoAstV-2 and will aid further research on the structure and function of the capsid protein.…”
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Exploring human-nature relationships in academic literature on the nitrogen cycle by Bede West, Maximilian Bauer, Charis Chalkiadakis, Nicolas Dendoncker, Tanya M. González-Martínez, André Mascarenhas, Francesca Leucci, Benjamin B. Phillips, Konstantina Tania Ploumi, Carolina Rodriguez, Marie Vandewalle, Carla-Leanne Washbourne

“…This can obscure the idea that humanity is both a direct beneficiary of the nitrogen cycle (through food and resources) and an increasingly significant influence on its function. This study sought to understand how diverse Human-Nature relationships (HNR) are expressed in recent academic literature on the nitrogen cycle. …”
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OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation by Kexuan Zhang, Wenqing Zhang, Lin Zhang, Xiaorong Hou, Runyi Tian, Zhengmao Hu, Lili Yin, Zhonghua Hu

“…Conclusions This study highlights the domain-specific impacts of OPA1 mutations on mitochondrial function and ADOA pathology, revealing unique roles of the BSE domain in apoptosis regulation and mitochondrial integrity. …”
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Corrosion behavior of Q235 under dynamic simulated seawater and online monitoring using resistance probes by Hao Zhang, Xiaowen Song, Hao Miao, Yao Tan, Hao Yu, Junhang Chen, Chenghui Yin, Feixiong Mao, Kui Xiao

“…The accumulation of corrosion products caused the relative deviation between resistance probe measurements and corrosion coupon results to increase from 23.19 % in the initial stages to 148.09 % in later stages, prompting the proposal of a logarithmic function-based data correction model, with the correction model expressed as: dc=dm1.069·lnt−3.732. …”
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Multi-Scale Long- and Short-Range Structure Aggregation Learning for Low-Illumination Remote Sensing Imagery Enhancement by Yu Cao, Yuyuan Tian, Xiuqin Su, Meilin Xie, Wei Hao, Haitao Wang, Fan Wang

“…The key lies in sufficiently exploiting both the specific long-range (e.g., non-local similarity) and short-range (e.g., local continuity) structures distributed across different scales of each input LI image to build an appropriate deep mapping function from the LI images to their corresponding high-quality counterparts. …”
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