Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies by Xinyi Zhang, Xinyi Zhang, Zhongge Zhu, Peijie Zhai, Peijie Zhai, Peng Lv, You Yang, Chuanhang Cheng, Busen Wang, Ting Fang, Guanying Zhang, Xiangyang Chi, Jianmin Li, Wei Chen, Yunzhu Dong

“…Subsequently, we predicted key functional residues through structural modeling of antigen-antibody complexes and validated their roles via mutagenesis studies. …”
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Case report: A rare case of catastrophic Takayasu arteritis: acute ischemic stroke and anterior ischemic optic neuropathy by Oladotun V. Olalusi, Oladotun V. Olalusi, Joseph Yaria, Akintomiwa Makanjuola, Rufus Akinyemi, Rufus Akinyemi, Rufus Akinyemi, Mayowa Owolabi, Mayowa Owolabi, Mayowa Owolabi, Mayowa Owolabi, Mayowa Owolabi, Adesola Ogunniyi, Adesola Ogunniyi

“…Her vision improved to the ability to count fingers, with good functional outcomes and reduced disease activity. This case highlights the challenging diagnostic trajectory of TAK in a Nigerian female patient, featuring a unique multi-vessel affectation. …”
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The Effects of Acute Temperature Changes on Transcriptomic Responses in the Liver of Leopard Coral Groupers (<i>Plectropomus leopardus</i>) by Yilan Guo, Chaofan Jin, Cun Wei, Kangning Zhong, Yurui Gao, Peiyu Li, Zhe Qu, Zhenmin Bao, Bo Wang, Jingjie Hu

“…Functional enrichment analysis revealed that these DEGs were significantly associated with biological processes such as lipid metabolism and antioxidant defense, as well as pathways related to metabolism, fatty acid biosynthesis, and ferroptosis. …”
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GWAS and RNA-seq reveal novel loci and genes of low-nitrogen tolerance in cucumber (Cucumis sativus L.) by Huaxiang Wu, Huiming Yan, Bowen Li, Yike Han, Yike Han, Nan Liu, Mengyu Fan, Yahan Liu, Mingjie Lyu, Shengli Du, Shengli Du, Shengli Du, Aimin Wei, Aimin Wei

“…Through GWAS, we identified 29 QTNs harboring 196 candidate genes, while RNA sequencing (RNA-seq) revealed 3,765 differentially expressed genes (DEGs). 24 were identified by both methods. …”
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The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles by Zhiqiang Li, Zhiqiang Li, Zhiqiang Li, Xiaoyuan Kuang, Dashuang Mo, Magnus Åbrink, Ge Shan, Jin-ping Li, Can Yang, Yuexi Wang, Tao Shen, Weiwei Yu

“…In mice, mast cell protease-4 (MCP-4) is considered as the functional homolog of human chymase, sharing similar enzymatic activity and biological roles.MethodsTo investigate the role of MCP-4 in UC, we induced colitis in Mcpt-4-deficient (Mcpt-4∆Cre) and littermate control (Mcpt-4fl/fl) mice using 2% dextran sulfate sodium salt (DSS) for 8 days followed by 2 days of water. …”
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Surface Display of Type 1 Fimbriae on <i>Shigella flexneri</i> Induces Antigen-Specific Immune Response via Oral Route by Shuli Sang, Rui Yu, Yunyun Mao, Yanfang Zhai, Chen Cao, Kai Li, Yiyan Guan, Haoxia Tao, Chunjie Liu, Yanchun Wang

“…Additionally, we used pBAD-Fim/FWL01 to deliver the neutrophil–activating protein A subunit (NapA) to assess immunogenicity. Results: Functional type 1 fimbriae on pBAD-Fim/FWL01 were confirmed using TEM and mannose–sensitive agglutination assays. …”
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Exosomal delivery of IL-10: Biodistribution, pharmacokinetics, and preterm birth prevention strategies by Brinley Harrington, Tilu Jain Thomas, Madhuri Tatiparthy, Awanit Kumar, Lauren Richardson, Ramkumar Menon, Ananth Kumar Kammala

“…Characterization of tIL-10 includes size, shape, and molecular markers. Functional assays demonstrate tIL-10's ability to reduce pro-inflammatory cytokine production and extend half-life, with biodistribution in maternal and fetal tissues. …”
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Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease by Judy Cheng, Ellen T. Koch, Daniel Ramandi, James P. Mackay, Timothy P. O’Leary, William Rees-Jones, Lynn A. Raymond

“…While degeneration of striatal D2-type dopamine receptor (D2)-expressing indirect pathway medium spiny neurons (iMSNs) occurs prior to that of D1-type dopamine receptor (D1)-expressing direct pathway neurons, altered corticostriatal synaptic function precedes degeneration. …”
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Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection by Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinkang Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…Overall, this study has identified numerous ARV-induced differentially expressed mRNAs and lncRNAs, including the functional lncRNA linc000889 that inhibits ARV replication. …”
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Marine sponge‐derived smenospongine preferentially eliminates breast cancer stem‐like cells via p38/AMPKα pathways by Jie Tang, Wei Wu, Fan Yang, Liyun Liu, Zhen Yang, Li Liu, Weizhuo Tang, Fan Sun, Houwen Lin

“…Importantly, Sme exhibited the ability to abrogate CSC‐like cells associated with a downregulation of stem cell markers including Nanog, Sox2, and Bmi1. Functionally, Sme inhibited the ability of MCF7‐Nanog cells to form tumor sphere in vitro and develop tumor in vivo. …”
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Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease by Md. Sohanur Rahman, Suvankar Ghorai, Kingshuk Panda, Maria J. Santiago, Saurabh Aggarwal, Ting Wang, Irfan Rahman, Srinivasan Chinnapaiyan, Hoshang J. Unwalla

“…Recent studies have revealed that miR-145-5p functions as a tumor suppressor in several cancers, including lung, liver, and breast cancers. …”
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The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression by Zhuoran Gu, Libin Zou, Xinjian Pan, Yang Yu, Yongqiang Liu, Zhijin Zhang, Ji Liu, Shiyu Mao, Junfeng Zhang, Changcheng Guo, Wei Li, Jiang Geng, Wentao Zhang, Xudong Yao, Bing Shen

“…Based on its molecular mechanism and biological functions, ac4C is a central factor in tumorigenesis, tumor progression, drug resistance, and tumor immune escape. …”
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Hirsutella sinensis polysaccharides and Parabacteroides goldsteinii reduce lupus severity in imiquimod-treated mice by Shih-Hsin Chang, Yun-Fei Ko, Jian-Ching Liau, Cheng-Yeu Wu, Tsong-Long Hwang, David M. Ojcius, John D. Young, Jan Martel

“…Moreover, the polysaccharides and P. goldsteinii improved markers of kidney and liver functions such as creatinine, blood urea nitrogen, glomerulus damage and fibrosis, and serum liver enzymes. …”
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Single‐Cell Analysis Reveals Fibroblast‐Derived Migrasomes as CXCL12 Carriers Promoting Skin Wound Repair by Haoyu Zhou, Zhen Zhang, Zhan Liu, Guodong Sa, Mingjing Jiang, Zhongyang Zou, Yingliang Shi, Liwu Zheng, Xuewen Yang, Guoliang Sa

“…ABSTRACT Migrasomes are newly discovered organelles with demonstrated functions in organ morphogenesis and angiogenesis. …”
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EspH interacts with the host active Bcr related (ABR) protein to suppress RhoGTPases by Rachana Pattani Ramachandran, Ipsita Nandi, Nir Haritan, Efrat Zlotkin-Rivkin, Yael Keren, Tsafi Danieli, Mario Lebendiker, Naomi Melamed-Book, William Breuer, Dana Reichmann, Benjamin Aroeti

“…These effectors manipulate diverse host cell organelles and functions for the pathogen’s benefit. However, the precise mechanisms underlying their activities are not fully understood despite intensive research. …”
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Multifunctional vitamin D-incorporated PLGA scaffold with BMP/VEGF-overexpressed tonsil-derived MSC via CRISPR/Cas9 for bone tissue regeneration by So-Yeon Park, Jun-Kyu Lee, Sang-Hyeok Lee, Da-Seul Kim, Ji-Won Jung, Jun Hyuk Kim, Seung-Woon Baek, Seungkwon You, Dong-Youn Hwang, Dong Keun Han

“…The optimized seeding ratio of engineered ToMSCs on the scaffold demonstrated favorable immunomodulatory function, angiogenesis, and osteogenic activity in vitro. …”
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Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent by Dinendra L. Abeyawardhane, Spiridon E. Sevdalis, Kaylin A. Adipietro, Raquel Godoy-Ruiz, Kristen M. Varney, Izza F. Nawaz, Alejandro X. Spittel, Daniel Hunter, Richard R. Rustandi, Vitalii I. Silin, Amedee des Georges, Mary E. Cook, Edwin Pozharski, David J. Weber

“…These and structure/function studies of a Ca2+-binding double mutant targeting RBD1 (i.e., D623A/D734A) support a model in which dissociation of Ca2+ from RBD1 induces dynamic properties in CDTb that enable it to bind and form pores in lipid bilayers.…”
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Characterization of microRNA and Metabolite Profiles of Seminal Extracellular Vesicles in Boars by Jianfeng Ma, Shuang Liang, Siyu Chen, Yuqian Shi, Yu Zou, Lei Chen, Lili Niu, Ye Zhao, Yan Wang, Linyuan Shen, Li Zhu, Mailin Gan

“…Extracellular vesicles (EVs) contain bioactive substances and mediate a multitude of physiological functions. EVs can be found in most body fluids and are particularly abundant in semen. …”
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Immuno-transcriptomic analysis based on machine learning identifies immunity signature genes of chronic rhinosinusitis with nasal polyps by Zhaonan Xu, Qing Hao, Bingrui Yan, Qiuying Li, Xuan Kan, Qin Wu, Hongtian Yi, Xianji Shen, Lingmei Qu, Peng Wang, Yanan Sun

“…Functional enrichment analysis revealed that the DIRGs were primarily associated with cell chemotaxis and leukocyte migration, and cytokine-cytokine receptor interaction. …”
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Design, Synthesis, and Biological Evaluation of a Novel [¹⁸F]AlF-H₃RESCA-FAPI Radiotracer Targeting Fibroblast Activation Protein by Qingyu Zhang, Zhoumi Hu, Haitao Zhao, Fuqiang Du, Chun Lv, Tukang Peng, Yukai Zhang, Bowu Zhang, Jianjun Liu, Cheng Wang

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