Inhibition of IL-6 trans-signaling promotes post-stroke functional recovery in a sex and dose-dependent manner by Cassandra Hall, Dustin T. Nguyen, Kate Mendoza, Chunfeng Tan, Anjali Chauhan

“…Flow cytometry was performed on days 3 (blood) and 7 (spleen and brain) to assess IL-6, mIL-6R, and phosphorylated STAT3 expression. Results Improved long-term functional outcomes were observed in male, but not female mice. …”
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Effects of albumin-bound paclitaxel combined with Sophora subprostrate polysaccharide on inflammatory factors and immune function in breast cancer rats by Changli Ding, Zhuolin Li, Ying Zheng, Kaichun Li, Wenyan Yu, Lingzhijie Kong, Zhiyong Zhang

“…Reducing the level of inflammation in tumor-bearing body to relieve immune suppression and enhance anti-tumor immune function has become an important strategy for tumor treatment. …”
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Impact of Chronic Intermittent Hypoxia on Cognitive Function and Hippocampal Neurons in Mice: A Study of Inflammatory and Oxidative Stress Pathways by Zhang K, Ma D, Wu Y, Xu Z

“…Specifically, downregulated LepR, SIRT1, and Nrf2 genes were found to exacerbate oxidative stress and neuroinflammation, impairing neuronal integrity and cognitive function. Further validation showed increased oxidative stress levels in hippocampal tissue and downregulation of key gene expression. …”
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway by Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

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3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

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Intraovarian injection of 3D-MSC-EVs-ECM gel significantly improved rat ovarian function after chemotherapy by Yaping Zhang, Dong Li, Yi Han, Min Wu, Shule Zhang, Huixian Ma, Linghong Liu, Xiuli Ju

“…Abstract Background Restoring the function of the ovary is important for chemotherapy-induced ovarian failure (COF) patients. …”
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The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity by Douglas A. Gaskarth, Shujun Fan, Andrew J. Highton, Roslyn A. Kemp

“…Consequently, butyrate treatment may have strong application in T cell-based immunotherapies to improve protective cell functions and patient outcomes.…”
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Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism by Yuge Chen, Xuejia Zhang, Xuejia Zhang, Shengbin Huang, Shengbin Huang, Maria Febbraio

“…Macrophage CD36 is a key functional player in metabolic expression profiles that determine phenotype. …”
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Identification and Functional Characterization of a Novel Variant in the SEMA3A Gene in a Chinese Family with Kallmann Syndrome by Meng Shu, Huixiao Wu, Shuoshuo Wei, Yingzhou Shi, Zongyue Li, Yiping Cheng, Li Fang, Chao Xu

“…The present study aimed to identify the variant causing KS in a Chinese family and evaluate the functional consequences and phenotypes associated with the novel variant. …”
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Pyrroloquinoline quinone promotes porcine oocyte maturation and subsequent embryo development by enhancing lipid metabolism and improving mitochondrial function by Zehua Zhang, Zhigang Gao, Zhenwei Jia

“…Then, we assessed oocyte mitochondrial function, oxidative stress levels, lipid metabolism and subsequent embryonic development. …”
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Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer’s disease using circMeta2 by Fengdi Zhao, Yangping Li, Li Chen, Bing Yao

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CD25bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression by Ziqing Chen, Le Tong, Shi Yong Neo, Shuijie Li, Jiwei Gao, Susanne Schlisio, Andreas Lundqvist

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Investigating the associations between personality functioning, cognitive biases, and (non-)perceptive clinical high-risk symptoms of psychosis in the community by Giulia Rinaldi, Stefan Lerch, Frauke Schultze-Lutter, Stefanie Julia Schmidt, Marialuisa Cavelti, Michael Kaess, Chantal Michel

“…Findings suggest intricate associations between personality functioning impairments and cognitive biases with CHR-P-symptom expression in non-help-seeking populations, possibly contributing to different per-CHR-P- and nonper-CHR-P-symptom expression patterns. …”
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Astragalin improved mitochondrial function through AMPK/PGC-1α pathway and alleviated renal injury in diabetic nephropathy by Yi Luo, Meng-jing Wang, Shu-fen Liu, Shuang Yuan, Hao Huang

“…Conclusion AG improves mitochondrial function and alleviates kidney injury through AMPK/PGC-1α pathway, thereby delaying the progression of DKD.…”
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Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation by Li Z, Chen J, Zhang J, Li N, Yi Y, Lu H, Li M, Liu R, Chen Y, Liu X

“…Anthrahydroquinone-2,6-disulfonate (AH2QDS) has potent antioxidant properties, but its ability to alleviate persistent airway oxidative damage and normalize lung function in COPD patients is not fully elucidated. …”
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The effect of high intensity interval and continues training on cardiac stem cells function and myocardial regeneration capacity in male rats by AREZOO ESKANDARI SHAHRABI, rahman sori, siroos chobineh, zohre mazaheri tirani

“…The aim of this study was the effect of high intensity interval and continues training on cardiac stem cells function and myocardial regeneration capacity in male rats.Methods: Twenty-four Vistar male rats (365.6±13.3 g, 6-8 month) were divided into three groups HIIT (high intensity) continuous and control. …”
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Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence by Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu

“…We examined the roles of MAD2L1 in ROS production, mitochondrial function, cell senescence, and the establishment of a profibrotic microenvironment. …”
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Monocytes Undergo Functional Reprogramming to Generate Immunosuppression through HIF-1α Signaling Pathway in the Late Phase of Sepsis by Li-Li Li, Bing Dai, Yu-Han Sun, Ting-Ting Zhang

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Function and Potential ceRNA Identification of Circ_009773 in Neodymium Oxide Nanoparticle-Induced Lung Epithelial Mesenchymal Transition by Lei Gao, Juan Juan, Zimeng Zheng, Lihua Huang

“…The previous experiments revealed that circ_009773 was localised in the cytoplasm and functioned at the post-transcriptional level. With the EMT-related pathway used as the basis for circ_009773-related competing endogenous (ce)RNA mechanisms, our observations indicate that circ_009773 is capable of binding to and regulating the expression of miR-135b-5p. …”
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Correlation study of BDNF/TrkB/CREB, violence, and cognitive function in first-episode drug-naive schizophrenia patients by Tiankai Jiang, Zhipeng Li, Tao Yu, Xudong Zhou, Tiantian Jiang, Yuhang Liang, Chen Yu, Min Zhu, Wenyu Wu

“…IntroductionSchizophrenia (SCZ) is a complex mental disorder affecting thought processes, perceptions, and emotional regulation.MethodsThis study investigated the relationship between brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), and cAMP response element-binding protein (CREB) expression with violence risk and cognitive function in first-episode, drug-naive SCZ patients. …”
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