The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction by Nestor Ruiz, Jiawei Xing, Igor B. Zhulin, Chad A. Brautigam, David R. Hendrixson

“…The Campylobacter jejuni BumSR TCS is unusual in that the BumS sensor exclusively functions as a phosphatase rather than a kinase to control phosphorylated levels of its cognate BumR response regulator (P-BumR). …”
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Non-invasive urinary proteomic biomarkers for prognostic assessment in sepsis by Qingbo Zeng, Nianqing Zhang, Junjie Zeng, Lincui Zhong, Qingwei Lin, Longping He, Xiaomin Song, Jingchun Song

“…KEGG and GO analyses were conducted to investigate the possible functions of these proteins. Feature variables were selected from the differentially expressed proteins using the Least Absolute Shrinkage and Selection Operator (LASSO) and the random forest algorithms and by determining whether their proteins had an area under the curve (AUC) greater than 0.8. …”
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Stunning and terrifying ascent of the american Superhuman in the superhero genre / Блистательное и ужасающее восхождение американского Сверхчеловека в жанре супергероики... by Dmitrii Losev / Дмитрий Вячеславович Лосев

“…The status of the Superhero as a demigod and superman is substantiated, his corresponding qualities and cultural functions are analyzed. Violence is interpreted as a deep component of superheroics, and comics as a wide and diverse cultural phenomenon, as well as a significant tool of "soft power". …”
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LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1 by Shuaihui Wu, Qian Cheng, Yang Shi, Kunlei Wang, Zhinan Chen, Xinyin Li, Ping Jiang, Zhixiang Cheng, Zhiyong Yang, Bo Liao

“…Results The data revealed that TGF-β1 upregulates PVT1, while Smad3 functions as a transcription factor to modulate PVT1. …”
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Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism by Yujie Huang, Weiqi Xu, Wei Dong, Guijie Chen, Yi Sun, Xiaoxiong Zeng

“…Additionally, analysis of gut microbiota structure and functions was conducted concurrently with the examination of DiCQAs’ impact on gut microbiota carrying the bile salt hydrolase (BSH) gene, as well as on the enterohepatic circulation of BAs and related signaling pathways. …”
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The effects of elastic band resistance training on serum levels of growth differentiation factor 11, myostatin, and insulin resistance in overweight elderly women by Akbar Azamian Jazi, Elias Abdellah

“…Even though these two factors have similar structural and signaling pathways, they can have different functions, and the available information about their effects on the regeneration of degenerated muscles during old age is contradictory. …”
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A Universal Framework for Near-Real-Time Detection of Vegetation Anomalies from Landsat Data by Yixuan Xie, Zhiqiang Xiao, Juan Li, Jinling Song, Hua Yang, Kexin Lv

“…Vegetation anomalies are frequently occurring and may greatly affect ecological functions. Many near-real-time (NRT) detection methods have been developed to detect these anomalies in a timely manner whenever a new satellite observation is available. …”
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394 Inclusion of cytomegalovirus viral Fc gamma receptors in a glycoprotein B protein subunit vaccine improves Fc-mediated effector responses by Claire Otero, Mackensie Gross, Savannah Herbek, Megan Connors, Philipp Kolb, Sallie Permar

“…Objectives/Goals: We hypothesized that adding cytomegalovirus (CMV) viral Fc gamma receptors (vFcγRs) to a glycoprotein B (gB) protein subunit vaccine would improve vaccine-elicited Fc mediated effector functions such as antibody dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC), over gB subunit alone. …”
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Transcriptional and Physiological Responses of <i>Saccharomyces cerevisiae</i> CZ to Octanoic Acid Stress by Zhi-Hai Yu, Ming-Zhi Shi, Wen-Xuan Dong, Xiao-Zhu Liu, Wei-Yuan Tang, Ming-Zheng Huang

“…Transcriptomic profiling of 5665 genes highlighted the predominant downregulation of ribosomal functions (translation, ribosome biogenesis) and amino acid metabolism pathways (e.g., <i>ARO10</i>, <i>ARO9</i>). …”
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Giant transposons promote strain heterogeneity in a major fungal pathogen by Emile Gluck-Thaler, Adrian Forsythe, Charles Puerner, Cecilia Gutierrez-Perez, Jason E. Stajich, Daniel Croll, Robert A. Cramer, Aaron A. Vogan

“…Starship-mobilized genes encode diverse functions, including known biofilm-related virulence factors and biosynthetic gene clusters, and many are differentially expressed during infection and antifungal exposure in a strain-specific manner. …”
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Compensatory mechanisms in γδ T cell-deficient chickens following Salmonella infection by Felix Tetzlaff, Felix Tetzlaff, Ulrich Methner, Theresa von Heyl, Christian Menge, Benjamin Schusser, Benjamin Schusser, Angela Berndt

“…In later stages of the infection, the γδ T cells and their functions appear to be replaced by other cells.…”
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Transcriptome and Physiological Analysis Reveals the Mechanism of Abscisic Acid in Regulating Cadmium Uptake and Accumulation in the Hyperaccumulator <i>Phytolacca acinosa</i> Roxb... by Qin Xie, Wenting Xu, Qing Wang, Feihong Yao, Yachao Jiang, Haijia Cao, Wanhuang Lin

“…The results show that ABA treatment affected gene expression in <i>P. acinosa</i> roots under Cd stress. …”
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Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1 by Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y

“…Finally, drug docking was performed on INSIG1, and the expression levels of INSIG1 in psoriasis were verified through clinical and in vivo experiments, and further in vivo experiments established the efficacy of tetrandrine in the treatment of psoriasis.Results: T cells were initially categorized into seven states, with differentially expressed genes in T cells (TDEGs) identified and their functions and signaling pathways. …”
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Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype by Jun Wang, Hongliang Dong, Yueyao Yang, Chenhui Gao, Hehe Sun, Hongmin Wang, Chao Hong, Fangyuan Gong, Xiaoming Gao

“…TAMs after treatment with immunocomplex (IC) between human LTF and M860 (LTF-IC) were phenotypically and functionally characterized by flow cytometry (FACS), ELISA, Q-PCR and killing assays. …”
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Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway by Panyang Li, Linna Yu, Jinzhong Yao, Tingting Zhao, Sen Zhao

“…Additionally, PIK3CG and NLRP3 expression were manipulated (via overexpression or knockdown) to determine their roles in CPSP and their regulatory relationship. …”
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Virocell resource manipulation under nutrient limitation by Morgan M. Lindback, Cristina Howard-Varona, Jane Fudyma, Malak Tfaily, Matthew B. Sullivan, Melissa B. Duhaime

“…ABSTRACT Virus-infected cells, called virocells, impact host metabolic functions, resources, and ecosystem processes, but the effects of nutrient limitation remain less well understood. …”
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The developmental transcriptome dynamics of current-year shoot utilized as scion in Camellia chekiangoleosa by Yu Sheng, Haili Gao, Chunlian Yu, Guangyuan Huang, Kunxi Wang, Kailiang Wang, Leyan Lv, Wei Long

“…Results Analysis of temporal expression characteristics of genome-wide genes and differentially expressed genes (DEGs) revealed that genes differentially patterned between stem and apical bud were enriched in functions related to cell division and differentiation, hormone responses, and vascular or flower development. …”
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Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions by Olexandr Kuryata, Oleh Akimov, Mykola Riabushko, Heorhii Kostenko, Viktoriia Kostenko, Artur Mishchenko, Svetlana Nazarenko, Natalia Solovyova, Vitalii Kostenko

“…This review provides the thorough analysis of the latest research on the molecular mechanisms and potential therapeutic benefits of 5-ALA in managing metabolic disorders.The ability of 5-ALA to influence immune response and inflammation, oxidative/nitrosative stress, antioxidant system, mitochondrial functions, as well as carbohydrate and lipid metabolism, is mediated by molecular mechanisms associated with the suppression of the transcription factor NF-κB signaling pathway, activation of the transcription factor Nrf2/heme oxygenase-1 (HO-1) system leading to the formation of heme-derived reaction products (carbon monoxide, ferrous iron, biliverdin, and bilirubin), which may contribute to HO-1-dependent cytoprotection through antioxidant and immunomodulatory effects. …”
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Eksplorasi Bunyi Komposisi Harmonic in Ryoanji: Inovasi dalam Proses Kreatif by Agustinus Welly Hendratmoko, Johanes Kristianto Agung Nugroho

“…The musical work "Harmonic in Ryoanji" not only functions as a performance tool but also contributes to the development of experimental music composition. …”
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The polarity protein Par3 enhances renal cell carcinoma metastasis via YAP/TAZ activation by Soo Lee, Jonathan Balcazar, Karla Davis, Rey-Chen Pong, Jer-Tsong Hsieh, Payal Kapur, Xiaosong Meng

“…Interestingly, Par3’s functions vary among cancers: both Par3 elevation (in the prostate or liver) and loss (in the breast or lung) have been implicated in cancer metastasis. …”
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