Opposite sex housing enhances reproductive function and induces transcriptional changes in the preoptic area of GnRH-deficient mice by Tyler N. Akonom, Mary A. Allen, Pei-San Tsai

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Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis by Chuanchuan Wang, Chuanchuan Wang, Yafei Chen, Jinyan Zhao, Jinyan Zhao, Xiaofang Feng, Xiaofang Feng, Ruoshuang Ma, Ruoshuang Ma, Hua Wang, Hua Wang, Lin Xue, Lin Xue, Jinli Tian, Jinli Tian, Lijuan Yang, Lijuan Yang, Yaling Gu, Yaling Gu, Juan Zhang, Juan Zhang

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Effect of Acupuncture Combined with Enriched Rehabilitation Training on Neural Function, Nogo Protein and Its Receptor in Cerebral Ischemia Rats by Mengxing LI, Zhaohui CHEN, Qi LIU, Fang LIU, Wei TANG

“…The expression of Nogo-A and NgR proteins in the model group, the acupuncture group, the enriched rehabilitation training group and the acupuncture combined with enriched rehabilitation training group were higher respectively than those of the sham operation group (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05), the proteins expression in the acupuncture group, the enriched rehabilitation training group and the acupuncture combined with enriched rehabilitation training group were lower respectively than those of the model group (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05), and the proteins expression in the acupuncture combined with enriched rehabilitation training group were lower respectively than those of the acupuncture group and the enriched rehabilitation training group (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05).Conclusion:Acupuncture combined with enriched rehabilitation training can improve hippocampal pathological damage induced by cerebral ischemia, and promote the recovery of sensory and motor functions. …”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation. by Arne W Mould, Marc A J Morgan, Andrew C Nelson, Elizabeth K Bikoff, Elizabeth J Robertson

“…Recent studies demonstrate that the zinc finger transcriptional repressor Blimp1/Prdm1 plays an essential role governing postnatal reprogramming of intestinal enterocytes during this period. Functional loss results in global changes in gene expression patterns, particularly in genes associated with metabolic function. …”
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Simvastatin regulating DAC-PKC and MAPK signaling pathway to improve the renal function in type 2 diabetic nephropathy patients by TIAN Lu, LUO Peng-cheng, WANG Gang, LI Yi

“…Objective To investigate the effect of simvastatin on the DAG/PKC and MAPK signaling pathways in type 2 diabetic nephropathy patients.Methods 16 patients with diabetic nephropathy were treated from June 2010 to December 2014 in Huangshi Central Hospital.These patients given simvastatin.After treatment for 3 months,15 mL blood was collected from each patient.Automatic biochemical analyzer was used to determine renal function parameters,and a kit was used to detected serum lipids,IL-1α,IL-6,IL-1β and TNF-a.The expression of DAG/PKC and MAPK signaling pathway-related enzyme proteins was compared before and after treatment.Results After treatment,blood urea nitrogen,serum creatinine and serum uric acid were reduced significantly in patients after treatment as compared with in patients before treatment(P<0.05).The endogenous creinine clearance rate in patients after treatment was significantly higher than in patients before treatment(P<0.05).CHOL,TG and LDL-C levels in patients after treatment was significantly lower than in patients before treatment(P<0.05).The HDL-C level in patients after treatment was significantly higher than in patients before treatment The levels of inflammatory cytokines(IL-1α,IL-1β,IL-6and TNF-a) were significantly lower in patients after treatment than in patients before treatment(P<0.05).The expression of PKC-η and PKC-ζ protein and mRNA was significantly lower in patients after treatment than in patients before treatment The expression levels of MAPK,MKK,and MAKK protein and mRNA in patients after treatment was significantly lower than in patients before treatment(P<0.05).Conclusions Simvastatin can improve renal function in type 2 diabetic nephropathy patients by regulating DAG-PKC and MAPK signaling pathway.…”
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The impact of combined exposure to triphenyltin and microplastics on the oxidative stress, energy metabolism, and digestive function of common carp (Cyprinus carpio) by Ping Li, Yiqun Wu, Siqi Zhang, Tengzhou Li, Chang Liu, Ling Liu, Zhi-Hua Li

“…This study investigated the individual and combined toxic effects of triphenyltin (TPT, 1 μg/L) and microplastics (MP, 0.5 mg/L) on oxidative stress, energy metabolism, and digestive function in Cyprinus carpio over a 42-day exposure period. …”
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Functional Characterization of <i>TNFα</i> in the Starry Flounder (<i>Platichthys stellatus</i>) and Its Potential as an Immunostimulant by Min-Young Sohn, Gyoungsik Kang, Kyung-Ho Kim, Ha-Jeong Son, Chan-Il Park

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NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS by E. V. Kaigorodova, M. V. Bogatyuk, M. V. Zavyalova, N. A. Tarabanovskaya, E. I. Simolina, E. M. Slonimskaya, E. L. Choynzonov, V. M. Perelmuter

“…These coefficients are more clearly reflect the functional state of Hsp27, than classical evaluation of chaperone expression only in the cytoplasm. …”
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The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus by Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin, Ivan Ivanovich Dedov

“…A tendency toward a rise in Cd25+ and CD4+25+ T-lymphocytes and a decrease in FoxP3 expression was documented in the risk group compared with control (p0.05) but their functional activity was lower (p…”
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Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila. by Miriam Merenciano, Anna Ullastres, M A R de Cara, Maite G Barrón, Josefa González

“…We analyzed the sequence of the nine roo insertions and we investigated whether the different insertions were functionally equivalent by performing 5'-RACE, gene expression, and cold-stress survival experiments. …”
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Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence by Lexin Qin, Tingting Liang, Hailong Zhang, Xian Gong, Meidan Wei, Xiangrong Song, Yaoyu Hu, Xinyu Zhu, Wentao Hu, Jianxiang Li, Jin Wang

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NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway by Xiyao Zhao, Mengrui He, Lina He, Ruijie Han, Yanan Liu

“…We therefore hypothesized that upregulation of SIRT1 expression could improve cardiac function in SIRT3 knockout mice through its interactive compensatory effect. …”
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Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading by Lan Cheng, Hui Chen, R. Nfornah Maboh, Huan Wang

“…Renal function and renal histopathology did not significantly differ among the three groups. …”
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Functional and molecular characterization of rod-like cells from retinal stem cells derived from the adult ciliary epithelium. by Gian Carlo Demontis, Claudia Aruta, Antonella Comitato, Anna De Marzo, Valeria Marigo

“…Rod maturation was evaluated at two levels: gene expression and electrophysiological functionality. Here we present a strong correlation between phototransduction protein expression and functionality of the cells in vitro. …”
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Mesenchymal stem cells improve ovarian function by suppressing fibrosis through CTGF/FAK signalling in systemic lupus erythematosus by Min Xu, Hui Yang, Lingyun Sun, Hongwei Chen, Yueyang Zhang, Haiwei Zhang, Yingyi Wu, Yirui Shi

“…This study investigated the therapeutic efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in ameliorating ovarian impairment and restoring ovarian function through the inhibition of fibrosis in a lupus mouse model.Methods Serum levels of sex hormones were quantified via ELISA. …”
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Disulfidptosis-related gene in acute myocardial infarction and its diagnostic value and functions based on bioinformatics analysis and machine learning by Liwen Chen, Jinru Wei, Jinru Wei, Guoxiong Deng, Guoxiong Deng, Guien Xu

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Identification and functional analysis of six DNAJ genes from Myzus persicae (Hemiptera: Aphididae) in response to UV-B stress by Long-Chun HE, Jian-Yu MENG, Guy SMAGGHE, Chang-Li YANG, Xue TANG, Chang-Yu ZHANG

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Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells by Sasi Kumar Jagadeesan, Ahmad Galuta, Ryan Vimukthi Sandarage, Eve Chung Tsai

“…RNA sequencing analysis revealed distinct transcriptomic profiles and functional disparities among NSPC types. iPSC-Br NSPCs exhibited a close resemblance to bona fide spinal cord NSPCs, characterized by enriched expression of neurogenesis, axon guidance, synaptic signaling, and voltage-gated calcium channel activity pathways. …”
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Functional T cell response to COVID-19 vaccination with or without natural infection with SARS-CoV-2 in adults and children by Evana Akhtar, Rakib Ullah Kuddusi, Md. Tanvir Talukder, Md. Jakarea, Md. Ahsanul Haq, Md. Shamim Hossain, Maya Vandenent, Mohammad Zahirul Islam, Rashid U. Zaman, Abdur Razzaque, Protim Sarker, Rubhana Raqib

“…In vaccinated individuals, prior infection induced perforin expression in both adults and children. Children showed slightly different functional T cell response than adults in response to COVID-19 vaccination and infection. mRNA vaccination provided higher IFN-γ response in both adults and children, but induced cytotoxic T lymphocyte (CTL) response in adults only. …”
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Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…These findings indicated that rTsCTL vaccination impeded larval invasion and improved gut epithelial integrity and barrier function, reduced worm burdens, and relieved gut and muscle inflammation.…”
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