Retinal Pigment Epithelial Cells Express a Functional Receptor for Glucagon-Like Peptide-1 (GLP-1) by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio L. Viviani

“…Since the retinal pigment epithelium (RPE), that forms the outer retinal barrier, has a key role in protecting from diabetic retinopathy (DR), we investigated the potential expression and function of GLP-1R in a RPE cell line. …”
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Development of an efficient expression system for human chaperone BiP in Pichia pastoris: production optimization and functional validation by Eimantas Žitkus, Evaldas Čiplys, Mantas Žiaunys, Andrius Sakalauskas, Rimantas Slibinskas

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Nutrigenomic evidence of phytogenic cytoprotective functions in the ovary and liver provides mechanistic support for improved laying hen performance by Ioannis Brouklogiannis, Konstantinos C. Mountzouris

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The Function of Heat Shock Transcription Factors in Sex Differentiation in <i>Cynoglossus semilaevis</i> by Zhijie Li, Xuexue Sun, Haipeng Yan, Lijun Wang, Xihong Li, Na Wang, Min Wei, Wenteng Xu

“…The heat shock transcription factor (<i>hsf</i>) is known as an important component of temperature sensing and mediates the heat shock response in fish such as <i>Danio rerio</i>; however, its function in <i>C. semilaevis</i> is unclear. In this study, five <i>hsf</i> genes (<i>hsf1</i>, <i>hsf2</i>, <i>hsf4</i>, <i>hsf5a</i>, and <i>hsf5b</i>) were identified in tongue sole and found to be expressed in the gonads at different developmental stages, peaking from 7M to 1Y. …”
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Exercise and aging: relationships between functional fitness, body mass index and psychosocial variables by Philipe de Souto Barreto, Enguerran Macia, Nicole Chapuis-Lucciani, Anne-Marie Ferrandez

“…Although the results indicated high levels of FF, self-esteem, and aesthetic body care for Es, further research, especially exercise-controlled trials, is needed to confirm the impact of bodily expression on physical function and well-being in the elderly.…”
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Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes by Neeraja Balasubrahmaniam, Jon C. King, Bridget Hegarty, Karen C. Dannemiller

“…A de novo metatranscriptomic analysis was performed using house dust from across the US, incubated at 50%, 85%, or 100% equilibrium relative humidity (ERH) for 1 week. Results Gene expression was a function of moisture (adonis2 p < 0.001), with fungal metabolic activity increasing with an increase in moisture condition (Kruskal–Wallis p = 0.003). …”
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Functional metabolomics as a tool to analyze Mediator function and structure in plants. by Celine Davoine, Ilka N Abreu, Khalil Khajeh, Jeanette Blomberg, Brendan N Kidd, Kemal Kazan, Peer M Schenk, Lorenz Gerber, Ove Nilsson, Thomas Moritz, Stefan Björklund

“…We describe subunit localization and activities of Mediator in Arabidopsis through metabolome and transcriptome analyses from a set of Mediator mutants. Functional metabolomic analysis based on the metabolite profiles of Mediator mutants using multivariate statistical analysis and heat-map visualization shows that different subunit mutants display distinct metabolite profiles, which cluster according to the reported localization of the corresponding subunits in yeast. …”
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Functional and transcriptomic insights into plant response to arginine-functionalized nanohydroxyapatite treatment by Chinenye L. Izuegbunam, Beate Wone, Bernard W.M. Wone

“…This study reports the bioactivity of nHA on two model plants, including a crop species, and examines the global gene expression alterations in Arabidopsis thaliana. Treatment of seeds and seedlings with arginine-functionalized nHA (R-nHA) at concentrations at 50, 200 and 500 µg/ml led to accelerated germination in Arabidopsis, an effect not observed in Nicotiana benthamiana. …”
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Polystyrene Microplastics‐Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes by Md. Sadequl Islam, Md. Kamruzzaman, Umme Kulsum Rima

“…Objectives This study investigates the effects of PS‐MPs on thyroid function in mice, offering insights relevant to veterinary care by examining changes in gene expression and biochemical markers. …”
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Genome-wide identification and function analysis of the sucrose phosphate synthase MdSPS gene family in apple by Li-hua ZHANG, Ling-cheng ZHU, Yu XU, Long LÜ, Xing-guo LI, Wen-hui LI, Wan-da LIU, Feng-wang MA, Ming-jun LI, De-guo HAN

“…The gene structures and their promoter cis-elements, protein conserved motifs, subcellular localizations, physiological functions and biochemical properties were analyzed. …”
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Editorial: Expanding insights into structure, function, and disorder of genome by the power of artificial intelligence in bioinformatics by Hongqiang Lyu, Yao Li, Sijia Wu, Laiyi Fu, Xiaoping Liang, Erhu Liu

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The Potential of Pequi Oil as a Modulator of Chaperone Expression to Minimize Heat Stress in Laying Hens by Paola Aparecida Damázio Rodrigues, Joyce Andrade da Silva, José Cavalcante Souza Vieira, Gabrieli Andressa de Lima, Laís Garcia Cordeiro, Elis Omar Figueroa Castillo, Júlia de Lima Lopes, Marília Afonso Rabelo Buzalaf, Pedro de Magalhães Padilha, José Roberto Sartori

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An alternating breathing pattern significantly affects the brain functional connectivity and mood states by Yulin Duan, Yulin Duan, Xun Guo, Bingnan Ren, Fang Liu, Yuhang Li, Fangfang Liu, Fan Xu, Min Huang

Subjects: “…functional connectivity…”
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Comparative analysis of electrical signals in facial expression muscles by Luna Adamov, Bojan Petrović, Lazar Milić, Vojin Štrbac, Sanja Kojić, Karunan Joseph, Goran M. Stojanović

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The anti-apoptotic function of HSV-1 LAT in neuronal cell cultures but not its function during reactivation correlates with expression of two small non-coding RNAs, sncRNA1&amp;2. by Jay J Oh, Ujjaldeep Jaggi, Kati Tormanen, Shaohui Wang, Satoshi Hirose, Homayon Ghiasi

“…Our results suggest that the antiapoptotic function of LAT resides within the two sncRNAs, which works independently of its latency-reactivation function and it has suppressive effect on LAT expression in vivo and in vitro.…”
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Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes by Junfei Gu, Jiajia Jin, Xiaoyu Ren, Xinjie Zhang, Jiaxuan Li, Xiaowei Wang, Shucui Zhang, Xianlun Yin, Qunye Zhang, Zhe Wang

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Eicosapentaenoic Acid Improves Endothelial Nitric Oxide Bioavailability Via Changes in Protein Expression During Inflammation by Samuel C. R. Sherratt, Peter Libby, Hazem Dawoud, Deepak L. Bhatt, R. Preston Mason

“…Loss of endothelial function and NO bioavailability are associated with inflammation, including leukocyte activation. …”
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Postnatal expression of Cat-315-positive perineuronal nets in the SAMP10 mouse primary somatosensory cortex by Hiroshi Ueno, Yu Takahashi, Sachiko Mori, Eriko Kitano, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

“…However, it is not clear which molecules in PNNs have these functions. We have previously reported that Cat-315-positive molecules were not expressed in the PNNs of the senescence-accelerated model (SAM)P10 strain model mice at 12 months of age. …”
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A Genome-Wide Characterization of the Xyloglucan Endotransglucosylase/Hydrolase Family Genes and Their Functions in the Shell Formation of Pecan by Mengyun Wen, Zekun Zhou, Jing Sun, Fanqing Meng, Xueliang Xi, Aizhong Liu, Anmin Yu

“…Structural analyses of the deduced proteins revealed conserved catalytic residues alongside divergent loop regions, suggesting functional diversification. Expression profiling across various tissues and among pecan cultivars with contrasting shell phenotypes indicated that specific <i>XTH</i> genes may play critical roles in shell structure formation. …”
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Identification and functional characterization of the RPP13 gene family in potato (Solanum tuberosum L.) for disease resistance by Baoqi Yuan, Chuang Li, Qingfeng Wang, Qi Yao, Xiaowei Guo, Yuhang Zhang, Zhongwei Wang

“…The RPP13 gene family is known to play a pivotal role in plant disease resistance responses; however, its specific functions in potato remain unclear. In this study, we conducted the first comprehensive identification and analysis of 28 RPP13 gene family members in potato, examining their gene structures, chromosomal locations, expression patterns, and functional characteristics. …”
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