Heterozygous pathogenic STT3A variation leads to dominant congenital glycosylation disorders and functional validation in zebrafish by Linxue Meng, Zhixu Fang, Li Jiang, Yinglan Zheng, Siqi Hong, Yu Deng, Lingling Xie

“…We constructed wild-type and variant plasmids, transfected them into HEK293T cells and detected the expression levels of the STT3A protein. We performed CRISPR-Cas9 to establish heterozygous knockdown zebrafish to validate the functional implications of autosomal dominant inheritance of STT3A in pathogenesis. …”
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Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function. by Camilla Halvarsson, Pernilla Eliasson, Jan-Ingvar Jönsson

“…<h4>Principle findings</h4>Here we demonstrate that PDK1 activity is crucial for transplantable HSC function. Whereas Pdkl, Pdk2, and Pdk3 transcripts were expressed at higher levels in different subtypes of HSCs compared to differentiated cells, we could not detect any major differences in expression between LT-HSCs and more short-term HSCs and multipotent progenitors. …”
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SENP1 Senses Oxidative Stress to Regulate the SUMOylation Modification of ZIP8 and Maintain Zinc Transport Functions by Tao Liu, Chang-Chun Song, Fu-Xuan Duan, Chong-Chao Zhong, Sheng-Zan Liu, Jia-Cheng Guo, An-Gen Yu, Zhi Luo

“…Zinc (Zn) is a crucial trace element in vertebrates, fulfilling a range of physiological functions, whose metabolism and homeostasis are manipulated by Zn transporter proteins. …”
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Omics Multi-Layers Networks Provide Novel Mechanistic and Functional Insights Into Fat Storage and Lipid Metabolism in Poultry by Farzad Ghafouri, Abolfazl Bahrami, Abolfazl Bahrami, Mostafa Sadeghi, Seyed Reza Miraei-Ashtiani, Maryam Bakherad, Herman W. Barkema, Samantha Larose

“…Module finding revealed three important and functional modules, which were involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway, biosynthesis of unsaturated fatty acids, Alzheimer’s disease metabolic pathway, adipocytokine, insulin, PI3K–Akt, mTOR, and AMPK signaling pathway. …”
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Development of functional markers for peroxidase activity genes TaPod-7AS and TaPod-4AL in wheat by Xinyuan Liu, Yukun Cheng, Hongwei Geng, Yi Ren, Junmei Cao, Bin Bai, Yating Xue

“…The POD genes TaPod-7AS and TaPod-4AL have high effects on POD activity in wheat. Function marker for POD genes can be used to improve flour color attributes accurately and efficiently in wheat molecular breeding. …”
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Circulating endothelial progenitor cells as a marker of left ventricular pump function in ischemic chronic heart failure by A. A. Kremzer

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Screening of functional genes affecting the quality of translucent eggshell membranes based on RNA-seq analysis and DIA proteomics by Chun-Hao Han, Xiao-Yu Zhao, Chuan-Wen Wang, Li-Jun Xu, Hua-Ge Liu, Hui Chen, Rong-Yan Zhou, De-He Wang

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Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations. by Chisom Soremekun, Oyesola Ojewunmi, Amarachukwu Nwagbata, Homa Bazireh, Sapna Sharma, Daudi Jjingo, David Patrick Kateete, Oyekanmi Nash, Harald Grallert, Chiara Batini, Annette Peters, Segun Fatumo

“…Single nucleotide polymorphisms (SNPs) were prioritized using the SNP2GENE function, while the gene expression patterns and shared molecular functions were explored in the GENE2FUNC.…”
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Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems by Kosuke Sakaguchi, Chiemi Kimura-Nakajima, Akihiko Inaba, Yoshiko Hatano, Hanako Ogawa, Yuichi Koshiishi, Keisuke Tanaka, Tatsuya Kometani, Makoto Ohmoto, Koji Sato, Hiroo Imai, Ken Iwatsuki

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Novel insights into the crosstalk between non-coding RNA and apoptosis in rheumatoid arthritis: diagnostic functions and therapeutic applications by Jianting Wen, Jianting Wen, Jianting Wen, Jian Liu, Jian Liu, Jian Liu, Lei Wan, Lei Wan, Lei Wan, Fanfan Wang, Fanfan Wang

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Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue by Sangmin Lee, Jeongbok Lee, Hyunseok Kwon, Heungsoo Shin

“…Current efforts to engineer 3D vascularized adipose tissue in vitro typically involve co-culturing adipocytes and endothelial cells, but adipogenic differentiation often suppresses endothelial function. In this study, we propose a novel approach to reconstruct vascularized adipose tissues in vitro by effectively coupling adipogenesis and vasculogenesis. …”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

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Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume‐loading by John D. Dauz, Kana Yazaki, Yohei Akazawa, Theo A. Meister, Golam Kabir, Sachiko Kadowaki, Osami Honjo, Scott P. Heximer, Rachel M. Wald, Kim A. Connelly, Mark K. Friedberg

“…TRN reduced TGFβ canonical signaling in PAB rats associated with improved RV fibrosis, hypertrophy, and RV function. In response to PR, TRN reduced PDGFRβ expression and normalized ERK1/2 activity, which were associated with reduced RV hypertrophy and improved diastolic relaxation. …”
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Real meat shows good performance in maintaining colonic barrier function at a recommended amount of intake in mice by Yunting Xie, Linlin Cai, Isaiah Henry Ibeogu, Guanghong Zhou, Chunbao Li

“…In contrast, the intake of real meat for 68 days performed better in maintaining colonic barrier function by reducing cell apoptosis, increasing the number of goblet cells and mucin secretion, and upregulating the expression of tight junction proteins. …”
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Fecal carriage of vanB antibiotic resistance gene affects adipose tissue function under vancomycin use by Lars M. M. Vliex, Giang N. Le, Marina Fassarella, Dorien Reijnders, Gijs H. Goossens, Erwin G. Zoetendal, John Penders, Ellen E. Blaak

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Integrated metabolomic and transcriptomic analysis revealed the transition of functional components in edible flower buds of Hemerocallis citrina Baroni by Congrong Jiang, Wenwen Zhang, Yating Zhang, Guanghui Yang, Dongmei Cao, Wei Li

“…The edible flower buds of Hemerocallis citrina Baroni are used both as a vegetable and functional food. It has various health benefits due to the diversity of natural products. …”
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Protective Effects of Low‐Intensity Pulsed Ultrasound on Cardiac Electrophysiological Function in a Rat Model of Ischemic Cardiomyopathy by Zhong‐Hao Lin, Qiu‐Lu Yu, Bing‐Hua Yi, Wen‐Cai Xu, Hua‐Ling He, Kai‐Yu Huang, Cheng Zheng, Shu‐Jie Wu, Jia‐Feng Lin

“…Results The results showed that LIPUS alleviated ventricular remodeling, improved cardiac electrophysiological function, and reduced the cardiac expression of collagens and inflammatory cytokines. …”
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Neurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology by Takamasa Mizoguchi, Ayumi Maki, Yuno Nakase, Mayu Okita, Yuina Minami, Misa Fukunaga, Motoyuki Itoh

“…We induced photothrombosis in the telencephalon utilizing rose bengal and conducted a temporal investigation of changes in cerebral vascular function and learning ability. Our findings revealed that blood flow in young zebrafish was restored approximately 7 days post-IS induction (dpi), with brain function recuperating by 14 dpi. …”
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Functional characterization of a novel plant growth-promoting rhizobacterium enhancing root growth and salt stress tolerance by Sanghee Lee, Young Kook Kim, Haulin Nie, Jongmin Ahn, Nayoung Kim, Seo-Rin Ko, Ah-Hyeon Choi, Hayoung Kwon, Yuxin Peng, Suk-Yoon Kwon, Ah-Young Shin

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Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma by Huihui Hu, Liangmiao Wu, Xiaodie Hu, Minghua Wang, Yewei Sun, Gaoxiao Zhang, Yuqiang Wang, Peng Yi, Zaijun Zhang

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