Functional Analysis of <i>CsHsf10</i> in Drought Stress Response in <i>Camellia sinensis</i> by Yuqi Luo, Chenyu Shao, Rong Xu, Shuqi Qiu, Qiulong Hu, Jiayi Guo, Yun Peng, Han Tang, Yueling Zhao, Jianan Huang, Zhonghua Liu, Chengwen Shen

“…However, studies exploring the specific functions and mechanisms of action of the Hsf family in tea plants (<i>Camellia sinensis</i> L.) remain limited. …”
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Curcumin Mitigates Gut Dysbiosis and Enhances Gut Barrier Function to Alleviate Metabolic Dysfunction in Obese, Aged Mice by Gopal Lamichhane, Femi Olawale, Jing Liu, Da-Yeon Lee, Su-Jeong Lee, Nathan Chaffin, Sanmi Alake, Edralin A. Lucas, Guolong Zhang, Josephine M. Egan, Yoo Kim

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Polyphenol-rich extracts enhance growth, immune function, and antioxidant defense in juvenile rainbow trout (Oncorhynchus mykiss) by Aghil Mansoori, Hamid Allaf Noveirian, Seyed Hossein Hoseinifar, Mirmasoud Sajjadi, Ghasem Ashouri, Ghasem Ashouri, Roberta Imperatore, Marina Paolucci

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Study on individual differences in visual working memory tasks based on spatiotemporal brain functional metrics and biological perspectives by Ronglong Xiong, Qiuzhu Zhang, Junjun Zhang, Zhenlan Jin, Ling Li

“…This study investigates individual differences in VWM performance across four types of visual stimuli (Body, Face, Place, Tool) under 0-back and 2-back conditions by integrating gene expression data and spatiotemporal brain function metrics. …”
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Beyond ingredients: Supramolecular structure of lipid droplets in infant formula affects metabolic and brain function in mouse models. by Annemarie Oosting, Louise Harvey, Silvia Ringler, Gertjan van Dijk, Lidewij Schipper

“…In Study 2 and 3 adult (Western-style diet-induced) body fat accumulation and cognitive function were evaluated. Animals exposed to STR compared to ING showed improved omega-3 fatty acid accumulation in liver and brain, and higher expression of brain myelin-associated glycoprotein. …”
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Molecular function validation and prognostic value analysis of the cuproptosis-related gene ferredoxin 1 in papillary thyroid carcinoma by Shiyue He, Wenzhong Peng, Xinyue Hu, Yong Chen

“…In this study, comprehensive bioinformatics analyses with six independent cohorts and in vitro experiments were performed to explore the expression, prognostic significance, and molecular function of the cuproptosis key regulator FDX1 in papillary thyroid carcinoma (PTC). …”
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Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function. by Xin Jiang, Zeyu Wang, Longyun Wang, Yuqi Wang, Lijing Zhao, Hongyu Jiang

“…Serum creatinine (CREA), urea nitrogen (BUN), uric acid (UA), carbon dioxide combining power (CO2-CP), renal tissue apoptosis, oxidative stress and mitochondrial function indicators were assessed.<h4>Results</h4>Compared with those in the DOX group, the concentrations of CREA, BUN and UA decreased, the number of TUNEL-positive cells in kidney tissue decreased, the expression of antiapoptotic proteins increased, and the expression of proapoptotic proteins decreased in the COM group. …”
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Non-canonical nuclear function of glutaminase cooperates with Wnt signaling to drive EMT during neural crest development by Nioosha Nekooie Marnany, Alwyn Dady, Isabelle Duband-Goulet, Frédéric Relaix, Roberto Motterlini, Roberta Foresti, Sylvie Dufour, Jean-Loup Duband

“…Namely, glutamine is required for nuclear accumulation of glutaminase, which interacts and cooperates with Wnt signaling to regulate EMT gene expression and cell cycle during delamination. Our data indicate that similarly to cancer cells, embryonic cells engage metabolic enzymes for non-canonical signaling functions to connect metabolism with EMT.…”
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SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment of SAF-B2 by Xiangjun Wang, Chuanxin Yang, Yangming Liu, Jian Wang

“…SUMOylation, a reversible post-translational modification, plays a critical role in tumor progression, yet its prognostic significance in PDAC remains unclear.MethodsWe assessed SUMOylation expression patterns and function in PDAC using Western blot and the SUMOylation inhibitor TAK-981. …”
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High intensity interval training and selenium nanoparticles protect hippocampal neurons and enhance cognitive function in diabetic rats by Kimia Aliakbari, Payam Saidie

“…Cognitive function was assessed using the Morris water maze test. …”
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Effect of enhanced early life nutrition on the molecular regulation of anterior pituitary function in Holstein Friesian bull calves by K. Keogh, S. Coen, P. Lonergan, S. Fair, D. A. Kenny

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Functional Elucidation of <i>Vitellogenin receptor</i> Activity in <i>Apis mellifera</i> in Response to Abiotic Stress by Li Lei, Hongyu Song, Zhenguo Liu, Ge Zhang, Ying Wang, Baohua Xu

“…Here, we identified the <i>AmVgR</i> gene, which encodes a member of the low-density lipoprotein receptor family, and examined its function in the response of <i>Apis mellifera</i> to adverse abiotic stress. …”
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Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host by Ayinuer Aierken, Aili Aierken, Kalibixiati Aimulajiang, Abuduaini Abulizi, Zhongdian Yuan, Chang Liu, Dalong Zhu, Hanyue Zhao, Tuerganaili Aji

“…Similar changes in NKG2A expression and NK cell quality were observed in a mice model of splenic NK cells, as well as the functional recovery of NK cells after blocking NKG2A. …”
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Effect of dapagliflozin on the structural and functional properties of arterial vessels in patients with type 2 diabetes mellitus in combination with obesity by О. А. Soloviuk, R. L. Kulynych

“…However, the possible significance of dapagliflozin in the reversal of structural and functional changes in the arteries in patients with type 2 DM and obesity has not been studied enough. …”
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Chondroprotective functions of neutrophil-derived extracellular vesicles by promoting the production of secreted frizzled-related protein 5 in cartilage by Keita Kitahara, Taku Ebata, Chen Liyile, Yoshio Nishida, Yuki Ogawa, Taiki Tokuhiro, Junki Shiota, Tatsuya Nagano, Taichi E. Takasuka, Tsutomu Endo, Tomohiro Shimizu, Hend Alhasan, Tsuyoshi Asano, Daisuke Takahashi, Kentaro Homan, Tomohiro Onodera, Ken Kadoya, M. Alaa Terkawi, Norimasa Iwasaki

“…However, this homeostatic function is dependent on the activation state of neutrophils and the surrounding environment/tissues. …”
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Biochemical and functional characterization of the interaction between liprin-α1 and GIT1: implications for the regulation of cell motility. by Claudia Asperti, Veronica Astro, Emanuela Pettinato, Simona Paris, Angela Bachi, Ivan de Curtis

“…Liprin-α1 may interact with different proteins, and the functional significance of these interactions in the regulation of cell motility is poorly known. …”
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<i>Bifidobacterium animalis</i> Supplementation Improves Intestinal Barrier Function and Alleviates Antibiotic-Associated Diarrhea in Mice by Xiaoyu Du, Mingkun Liu, Jingyu Li, Yue Liu, Shaoyang Ge, Haina Gao, Ming Zhang

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Tendomodulin in pan-cancer analysis: exploring its impact on immune modulation and uncovering functional insights in colorectal cancer by Jingfeng Chen, Qin Hu, Cong Zhang, Aiqi Zhao, Bihua Guan, Yifan Wang, Min Zhang, Xia Li, Biao Chen, Lulu Zeng, Minjiang Chen, Bing Wu, Jianping Wang, Yang Yang, Jiansong Ji

“…However, its comprehensive impact across cancers, particularly its immunomodulatory function in CRC, remains underexplored. This study explored the role of TNMD in CRC by focusing on its immunomodulatory functions through comprehensive molecular and clinical analyses. …”
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Legume lectin phytohemagglutinin reduces transepithelial electrical resistance by counteracting the chaperone function of heat shock protein-70 by Karol Dokladny, Prashanth Setty, Pope L. Moseley, Henry C. Lin

“…Since the relationship between lectin toxicity and the cellular chaperone machinery remains unknown, the study aimed to determine the effects of heat-denatured PHA on epithelial barrier function and heat shock protein 70 (HSP70) expression and its function as a molecular chaperone in PHA-treated Caco-2 cells and animals. …”
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Identification of a potentially functional MKS2/ALT homolog gene in the genome of the cultivated potato Solanum tuberosum by Huong Thi Diem Tran, Thuong Thi Hong Nguye

“…A combined in silico approach including sequence alignment, phylogenetic assessment, 3D structural modeling and RNA-sequencing data analysis was performed to exploit the functional properties of this gene. The encoded protein possesses the conserved Aspartate and functional domain characteristic of single Hotdog-fold thioesterases, and it shares high similarity in sequence and structure with SlMKS2a of the cultivated tomato (S. lycopersicum). …”
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