IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells by Enrico Maggi, Alberto Mantovani, Lorenzo Moretta, Francesca Romana Mariotti, Andrea Pelosi, Irene Veneziani, Claudia Alicata, Nadine Landolina, Biancamaria Ricci, Tiziano Ingegnere, Bruno Giuseppe Azzarone, Cecilia Garlanda

“…The inhibitory receptor interleukin-1 receptor 8 (IL-1R8) has been recently recognized to be expressed also by human natural killer (NK) cells. …”
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The Therapeutic Potential of Low-Intensity Pulsed Ultrasound in Enhancing Gallbladder Function and Reducing Inflammation in Cholesterol Gallstone Disease by Fang Chen, Run Guo, Tian Chen, Liping Liu, Fan Ding, Gang Zhao, Bo Zhang

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Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. by Dadi Jiang, Catherine I Dumur, H Davis Massey, Viswanathan Ramakrishnan, Mark A Subler, Jolene J Windle

“…Some of these mutants appear to have acquired novel functions beyond merely losing wild-type functions. …”
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Lambda-cyhalothrin stress response and functional analysis of AiGSTe3 from the black cutworm Agrotis ipsilon by CAO Fu, YU Jiamin, ZHANG Jin, LI Bin, WANG Yong, JIANG Lianqiang, LI Shiguang, LI Maoye, LIU Su

“…This study aims to elucidate the lambda-cyhalothrin stress response and biological function of the glutathione-S-transferase (GST) gene AiGSTe3 from the black cutworm Agrotis ipsilon. …”
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Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases by Ti Yang, Yue Zhang, Zeen Cai, Ying Wang, Shengqiong Deng

“…Population-level analysis (NHANES, n = 1,127) confirmed higher serum C23:0 associated with better cognitive function.DiscussionThis study provides strong evidence for frontal cortex-specific reduced C23:0 in AD and highlights its potential as a serum cognitive marker.…”
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A gene‐centered C. elegans protein–DNA interaction network provides a framework for functional predictions by Juan I Fuxman Bass, Carles Pons, Lucie Kozlowski, John S Reece‐Hoyes, Shaleen Shrestha, Amy D Holdorf, Akihiro Mori, Chad L Myers, Albertha JM Walhout

“…We used this network as a backbone to predict TF binding sites for 77 TFs, two‐thirds of which are novel, as well as integrate gene expression, protein–protein interaction, and phenotypic data to predict regulatory and biological functions for multiple genes and TFs.…”
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Effects of folic acid on body folate status, ovarian function, and organ indexes of offspring during embryonic stage by Jianfei Zhao, Zhongqian Lu, Jialin Wu, Yufei Zhu, Yufei Zhu

“…This experiment aimed to investigate the effect of dietary folic acid supplementation on maternal folate status and ovarian function in female broiler breeders. Fifty 30-week-old Arbor Acres female broiler breeders were randomly divided into two groups (5 pens/group, 5 hens/pen) after 2 weeks of pre-feeding: the control group (Con, supplementation 0 mg/kg folic acid) and the folic acid group (FA, supplementation 4 mg/kg folic acid). …”
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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease by Yuan Zhao, Yidan Zhang, Xin Liu, Jian Zhang, Ya Gao, Shuyue Li, Cui Chang, Xiang Liu, Guofeng Yang

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Effects of maternal blood beta-hydroxybutyrate on brown adipose tissue functions and thermogenic and metabolic health in neonatal calves by Yang Gai, Guiling Ma, Shuyan Yang, Zhiyong Hu, Yulin Ma, Rui He, Yu Zhang, Shilong Huang, Hossam H. Azzaz, Zhaobing Gu, Shengyong Mao, Morteza H. Ghaffari, Yanting Chen

“…ABSTRACT: Maternal metabolic health, particularly during late pregnancy, plays a crucial role in fetal development and postnatal metabolic function. Elevated levels of BHB in dry cows, commonly observed in late gestation, may affect offspring development, but the effects on brown adipose tissue (BAT) and metabolic health remain unclear. …”
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miR-449, identified through antiandrogen exposure, mitigates functional biomarkers associated with ovarian cancer risk by Xia Wang, Ho-Hyung Woo, Michelle Wei, Steven Gibson, Mitzi Miranda, Demaretta Rush, Janiel Cragun, Wenxin Zheng, Guang Yao, Setsuko K. Chambers

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Ferrostatin-1 reduces the inflammatory response of rheumatoid arthritis by decreasing the antigen presenting function of fibroblast-like synoviocytes by Xiaoying Zhu, Hanya Lu, Haonan Jia, Xuemin Wei, Jiawei Xue, Wenjing Li, Juan Zhang, Yanli Wang, Jingyao Yan, Haoyuan Sun, Yanlei Ge, Zhiyi Zhang

“…Ferroptosis can increase the expression of citrullinated histone H3 (cit-h3) by promoting the production of peptidyl arginine deiminase 4 (PAD4), which further promotes the expression of MHC-I molecules. …”
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Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation by Mi-Mi Li, Ying-Xia Yang, Ya-Li Huang, Shu-Juan Wu, Wan-Li Huang, Li-Chao Ye, Ying-Ying Xu

“…Furthermore, S100A4 knockdown mitigated oxidative stress, restoring mitochondrial function and decreasing ROS levels.ConclusionThis study developed a robust PCDS model for AD prediction and identified S100A4 as a potential therapeutic target. …”
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A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. by Lingjun Zuo, Clarence K Zhang, Fei Wang, Chiang-Shan R Li, Hongyu Zhao, Lingeng Lu, Xiang-Yang Zhang, Lin Lu, Heping Zhang, Fengyu Zhang, John H Krystal, Xingguang Luo

“…The replicable associations were then subjected to secondary replication in a sample of 6,438 Australian family subjects. A functional expression quantitative trait locus (eQTL) analysis of these replicable risk SNPs was followed-up in order to explore their cis-acting regulatory effects on gene expression. …”
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SIRT6-dependent functional switch via K494 modifications of RE-1 silencing transcription factor by Adam Zaretsky, Alfredo Garcia Venzor, Ekaterina Eremenko, Daniel Stein, Dmitrii Smirnov, Yuval Rabuah, Rebecca Dryer, Dmitrii Kriukov, Shai Kaluski-Kopatch, Monica Einav, Ekaterina Khrameeva, Debra Toiber

“…SIRT6 reintroduction or REST methyl-mimic K494M expression rescues this phenotype, while an acetyl-mimic mutant loses its function even in WT cells. …”
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Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture in vitro intestinal model by Christoph Benkstein, Laurin Mosig, Daniel Vondran, Heidi Schlichting, Lea Kissing, Bente Wohlert, Ida Gensmer, Larissa Nogueira de Almeida, Peter König, Peter König, Kerstin Fibelkorn, Anna Kordowski, Stefanie Derer-Petersen, Christian Sina, Christian Sina, Yves Laumonnier, Yves Laumonnier

“…In order to get additional insights in possible changes of specific epithelial functions, we assessed the expression profile of different genes that are critical for various functions of the epithelia. …”
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Activation of cannabinoid CB1 receptors suppresses HCN channels function in dorsal root ganglion neurons of rats by Xiaolu Lei, Meiyun Chen, Xingfeng Liu, Yan Yan, Xupeng Li, Fei Gong, Deqian Yu, Xiaohong Liu

“…In this study, we investigated the effect of ACEA, a selective agonist for CB1R, on HCN channel expression and function in the DRG of rats with chronic constriction injury (CCI) of the sciatic nerve. …”
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Novel Hybrid Function Operational Matrices of Fractional Integration: An Application for Solving Multi-Order Fractional Differential Equations by Seshu Kumar Damarla, Madhusree Kundu

“…In the present study, a novel numerical algorithm is proposed based on orthogonal hybrid functions (HFs), which were constructed as linear combinations of piecewise constant sample-and-hold functions and piecewise linear triangular functions. …”
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Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain. by George A Follows, Rita Ferreira, Mary E Janes, Dominik Spensberger, Francesco Cambuli, Amy F Chaney, Sarah J Kinston, Josette R Landry, Anthony R Green, Berthold Göttgens

“…Our data suggests that the +45 region functions as a boundary element that separates the Scl/Map17 and Cyp transcriptional domains, and raise the possibility that this element may be useful for improving tissue-specific expression of transgenic constructs.…”
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A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability by Amy K Schmid, David J Reiss, Min Pan, Tie Koide, Nitin S Baliga

“…Here, we demonstrate that a single TrmB family transcription factor in Halobacterium salinarum NRC‐1 globally coordinates functionally linked enzymes of diverse phylogeny in response to changes in carbon source availability. …”
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Mitochondrial carrier homolog 2 is important for mitochondrial functionality and non-small cell lung cancer cell growth by Yong Zhao, Siyang Wu, Guohong Cao, Peidong Song, Chang-gong Lan, Lin Zhang, Yong-hua Sang

“…This study examines MTCH2 expression and its functional role in NSCLC. Bioinformatic analysis showed that MTCH2 is overexpressed in NSCLC tissues, correlating with poor prognosis and other key clinical parameters of the patients. …”
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