Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction. by Zongjin Li, Kitchener D Wilson, Bryan Smith, Daniel L Kraft, Fangjun Jia, Mei Huang, Xiaoyan Xie, Robert C Robbins, Sanjiv S Gambhir, Irving L Weissman, Joseph C Wu

“…<h4>Conclusion</h4>Taken together, we report a more efficient method for derivation of hESC-ECs that express appropriate patterns of endothelial genes, form functional vessels in vivo, and improve cardiac function. …”
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Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients by Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal

“…They were viable and functional after sorting, as confirmed by single‐cell collagen‐I secretion after 48 h of culturing. …”
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Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions by Michelle L. McKeague, Jason Lohmueller, Matthew T. Dracz, Najla Saadallah, Eric D. Ricci, Donella M. Beckwith, Ramya Ayyalasomayajula, Maré Cudic, Olivera J. Finn

“…Twelve of these fully human monoclonal antibodies (mAb) were tested for binding to MUC1+ target cells, and three with the highest binding were further evaluated for various effector functions important for tumor rejection. Methods: Immune cells were incubated together with target cells expressing variations in the number, distance, and membrane anchoring properties of the MUC1 epitope in the presence of each mAb. …”
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Mono‐Ethyl‐Phosphonates: Functional Group Masking Strategy to Stabilize and Optimize the Pharmacokinetics of Rare Earth Radiochelates by Jennifer N. Whetter, Axia Marlin, Edith K. Amason, Eduardo Aluicio‐Sarduy, Angus J. Koller, Phuong Nguyen Tran, Kaelyn V. Becker, Jonathan W. Engle, Eszter Boros

“…Previously, the chelator m‐phospatcn (H4L2) is identified as suitable for radiolabeling with 44Sc and 177Lu at room temperature. However, functionalizing H4L2 for targeting vector conjugation destabilizes the 44Sc chelates, leading to increased blood retention, liver accumulation, and bone deposition. …”
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Cloning and function analysis of ZmICE1a, a contributor to the melioration of maize kernel traits by Yifei Xiao, Liang Tu, Yulin Jiang, Pengfei Liu, Xiangyang Guo, Angui Wang, Yunfang Zhu, Xuefeng Lu, Zehui Chen, Xun Wu

“…Gene mining and clarification of relevant gene functions associated with kernel traits is beneficial for breeding high-yield maize varieties. …”
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CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models by Ilaria Musante, Davide Cangelosi, Lorenzo Muzzi, Fanny Jaudon, Marco Di Duca, Sara Guerrisi, Francesca Antonini, Yeraldin Chiquinquira Castillo De Spelorzi, Lorenzo A. Cingolani, Federico Zara, Paolo Scudieri

“…Abstract CACNA1A encodes the pore-forming α1A subunit of the CaV2.1 calcium channel, whose altered function is associated with various neurological disorders, including forms of ataxia, epilepsy, and migraine. …”
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Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis by Laura Heydemann, Małgorzata Ciurkiewicz, Theresa Störk, Isabel Zdora, Kirsten Hülskötter, Katharina Manuela Gregor, Lukas Mathias Michaely, Wencke Reineking, Tom Schreiner, Georg Beythien, Asisa Volz, Tamara Tuchel, Christian Meyer zu Natrup, Lisa-Marie Schünemann, Sabrina Clever, Timo Henneck, Maren von Köckritz-Blickwede, Dirk Schaudien, Karl Rohn, Klaus Schughart, Robert Geffers, Mika K. Kaneko, Yukinari Kato, Carina Gross, Georgios Amanakis, Andreas Pavlou, Wolfgang Baumgärtner, Federico Armando

“…This study aimed to characterize the trajectory of lung regeneration over 112 days in the male hamster model by combining morphological, transcriptomic and functional readouts. We demonstrate that in the acute phase, SARS-CoV-2 Delta-infected, male, aged hamsters show a severe impairment of lung function at rest. …”
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Effect of transcutaneous electrical spinal cord stimulation on the functional activity of reciprocal and presynaptic inhibition in healthy subjects by Denis A. Gladchenko, Lyudmila V. Roshchina, Sergey M. Bogdanov, Andrey A. Chelnokov

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IMPACT OF THE SECOND GENERATION ANTIHISTAMINES ON COGNITIVE FUNCTION IN CHILDREN WITH POLLEN ALLERGY RECEIVING SPECIFIC ALLERGEN IMMUNOTHERAPY by O. I. Muradova, L. S. Namazova-Baranova, G. A. Karkashadze, O. I. Maslova, R. M. Torkhshoeva, A. Yu. Tomilova, A. A. Alekseeva, E. А. Vishneva, K. S. Volkov, T. A. Konstantinidi

“…Allergic pathology in particular, a hay fever, can lead to decrease in cognitive functions at children. Earlier it was established that antihistamine preparations of I generation influence cognitive functions of patients. …”
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CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions by Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

“…Pharmacological inhibition of Casein kinase II by Silmitasertib or genetic depletion of the catalytic subunit of Casein kinase II (CK2α) markedly destabilizes YAP1 and consequently suppresses its oncogenic functions in vitro and in vivo. Moreover, we reveal that DUB3 as a bona fide deubiquitinase of YAP1, which functionally links CK2 and YAP1 stability in a variety of human cancers. …”
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SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function by Mihyun Bae, Junyeop Daniel Roh, Youjoung Kim, Seong Soon Kim, Hye Min Han, Esther Yang, Hyojin Kang, Suho Lee, Jin Yong Kim, Ryeonghwa Kang, Hwajin Jung, Taesun Yoo, Hyosang Kim, Doyoun Kim, Heejeong Oh, Sungwook Han, Dayeon Kim, Jinju Han, Yong Chul Bae, Hyun Kim, Sunjoo Ahn, Andrew M Chan, Daeyoup Lee, Jin Woo Kim, Eunjoon Kim

“…Abstract Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co‐agonist activity for NMDA receptors (NMDARs), have been considered to be important targets for the treatment of brain disorders with suppressed NMDAR function such as schizophrenia. However, it remains unclear whether other amino acid transporters expressed in the brain can also regulate brain glycine levels and NMDAR function. …”
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Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators by Ashutosh Sharma, Ashutosh Sharma, Nandini B. Kale, Priyanka Yadav, Priyanka Yadav, Shivani Yadav, Shivani Yadav, Madhavi Ranawat, Madhavi Ranawat, Valmik S. Shinde, Valmik S. Shinde, Aravind Singh Kshatri, Aravind Singh Kshatri

“…Thus, we characterized and validated the microglial Hv1 channel’s functions using the recently reported Hv1 inhibitor (YHV98-4) and a novel Hv1 activator (S-023-0515) in a model of lipopolysaccharide (LPS)-induced neuroinflammation. …”
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What is the influence of exacerbations on pulmonary function in pediatric and adolescent patients with severe asthma despite controller therapies? by A. Z. P. Brandão, L. M. L. B. F. Lasmar, L. M. A. S. Pertence, M. I. R. Vieira, G. B. Lasmar, V. O. Ganem, E. V. Mancuzo, M. V. N. P. de Queiroz

“…Methods This was a prospective study in which lung function parameters—forced vital capacity (forced vital capacity [FVC]), forced expiratory volume in 1 s (forced expiratory volume in 1 s [FEV1]), the FEV1/FVC ratio, and the forced expiratory flow between 25% and 75% of FVC (FEF25–75%), each expressed as a percentage of the predicted value—were measured at 3‐month intervals for three years in 64 patients (6–18 years of age) with severe asthma. …”
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Prediction of grey mould disease from greenhouse tomato based on radical basis function neural network by Zhang Zhi, Hu Xiaohui, Zou Zhirong

“…Input vectors had been pretreated with the normalization function “premnmx”. Mean temperature, minimum temperature and mean relative humidity were selected as input vectors. …”
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Functional Outcome of Epidural Steroid Injection in the Treatment of Chronic Low Backache due to Intervertebral Disc Prolapse by R Sahaya Jose, SL Binesh, N Kattu Bava, M Syed Moosa

“…The Chi-squared test will be used to determine the statistical significance of the relationship between the functional outcome of an ESI and qualitative indicators. …”
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Multi-omics insights into functional alterations of the liver in growth-retarded offspring: transcriptomic, epigenetic and metabolomic profiles by Qun Lan, Sui Liufu, Xin Xu, Bohe Chen, Wenwu Chen, Kaiming Wang, Caihong Liu, Lanlin Xiao, Xiaolin Liu, Lei Yi, Jingwen Liu, Qiuchun Deng, Haiming Ma, Meng Kang

“…The liver plays a crucial role in regulating nutrient metabolism and immune function and frequently communicates with other organs to maintain overall health. …”
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Arecoline regulates glycolipid and endoplasmic reticulum metabolisms in adult grass carp (Ctenopharyngodon idella) by Liangqin Wu, Na Yao, Weidan Jiang, Pei Wu, Yang Liu, Yaobin Ma, Hongmei Ren, Xiaowan Jin, Hequn Shi, Xiaoqiu Zhou, Lin Feng

“…Firstly, arecoline alleviated endoplasmic reticulum (ER) stress in grass carp muscle by suppressing the mRNA levels of ER stress-related genes atf4, chop, ire1, and xbp1 as well as the protein expression of p-PERK and p-IRE1 (P < 0.05). Secondly, arecoline protected mitochondrial function by promoting the mitochondrial respiratory chain complex I–V-related protein expression and triggering the mitochondrial unfolded protein response (UPRmt) (P < 0.05). …”
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Deciphering the proteome of Escherichia coli K-12: Integrating transcriptomics and machine learning to annotate hypothetical proteins by Sagarika Chakraborty, Zachary Ardern, Habibu Aliyu, Anne-Kristin Kaster

“…Omics technologies have led to the discovery of a vast number of proteins that are expressed but have no functional annotation - so called hypothetical proteins (HPs). …”
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Metabolomics of the interaction between PPAR‐α and age in the PPAR‐α‐null mouse by Helen J Atherton, Melanie K Gulston, Nigel J Bailey, Kian‐Kai Cheng, Wen Zhang, Kieran Clarke, Julian L Griffin

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The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner by Tomoko Okuyama, Takahiro Tsuno, Ryota Inoue, Setsuko Fukushima, Mayu Kyohara, Anzu Matsumura, Daisuke Miyashita, Kuniyuki Nishiyama, Yusuke Takano, Yu Togashi, Makiko Meguro-Horike, Shin-ichi Horike, Tatsuya Kin, A.M. James Shapiro, Hiromi Yanagisawa, Yasuo Terauchi, Jun Shirakawa

“…However, much uncertainty remains regarding the function of the ECM and its components in β-cells. …”
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