Advanced Nanomaterials Functionalized with Metal Complexes for Cancer Therapy: From Drug Loading to Targeted Cellular Response by Bojana B. Zmejkovski, Nebojša Đ. Pantelić, Goran N. Kaluđerović

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Risk assessment in sociotechnical systems based on functional resonance analysis method and hierarchical fuzzy inference tree by Ashish Kumar, Sudhir Kumar Singh, Biswajit Samanta, Ashis Bhattcherjee

“…Additionally, the concept of degree centrality was utilized to identify functions that are impacted by multiple upstream functions and those that exert influence on several downstream functions. …”
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Acquisition and functional validation of transgenic AM79-EPSPS glyphosate-resistant soybean (Glycine max L.) by WENG Jiahui, LOU Yiyuan, XU Jing, HE Junguang, ZHANG Xiaoli, LIU Yongli

“…In order to introduce a new gene AM79-EPSPS with independent intellectual property rights into soybean and verify its function in transgenic soybean, an efficient transformation system of AM79-EPSPS gene was established through Agrobacterium-mediated genetic transformation from disinfection time, acetosyringone (AS) concentration, glyphosate concentration and indole-3-butyric acid (IBA) immersion time at the rooting stage with the receptor material of Tianlong No. 1 soybean. …”
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AAMP and MTSS1 Are Novel Negative Regulators of Endothelial Barrier Function Identified in a Proteomics Screen by Fabienne Podieh, Max C. Overboom, Jaco C. Knol, Sander R. Piersma, Richard Goeij-de Haas, Thang V. Pham, Connie R. Jimenez, Peter L. Hordijk

“…Following short-term inhibition of ubiquitination with E1 ligase inhibitor MLN7243 or Cullin E3 ligase inhibitor MLN4924 in primary human endothelial cells, we identified sixty significantly differentially expressed proteins. Intriguingly, our data showed that AAMP and MTSS1 are novel negative regulators of endothelial barrier function and that their turnover is tightly controlled by ubiquitination. …”
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Comprehensive analysis of YABBY gene family in foxtail millet (Setaria italica) and functional characterization of SiDL by Jie GUO, Xu-tao ZHOU, Ke-li DAI, Xiang-yang YUAN, Ping-yi GUO, Wei-ping SHI, Mei-xue ZHOU

“…SiYAB genes were highly expressed in reproductive tissues. SiDL, one of the SiYABs, was selected to be overexpressed in Arabidopsis thaliana to check the functions of the YABBY genes. …”
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Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes by Heiko Meyer, Judith Bossen, Maren Janz, Xenia Müller, Sven Künzel, Thomas Roeder, Achim Paululat

“…Abstract Drosophila nephrocytes are specialised cells that share critical functional, morphological, and molecular features with mammalian podocytes. …”
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Ornamentation and Islamic Identity in Contemporary European Mosques: An Analysis of Cultural, Aesthetic, and Functional Dimensions and Modern Influences by Haifa Ebrahim Al Khalifa, May Walid Lafi

“…These challenges impact mosque design’s cultural, esthetic, and functional dimensions, essential for sustaining Islamic identity. …”
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Characterization of a Novel Tc-Carbonyl Complex as a Functional Probe of P-Glycoprotein Transport Activity by Mary Dyszlewski, Helen M. Blake, Julie L. Dahlheimer, Christina M. Pica, David Piwnica-Worms

“…Furthermore, the protective function of Pgp-mediated efflux of xenobiotics in various organs has a profound effect on the bioavailability of drugs in general. …”
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Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. by Pablo J Fernandez-Marcos, Cristina Pantoja, Agueda Gonzalez-Rodriguez, Agueda Gonzalez-Rodriguez, Nicholas Martin, Juana M Flores, Angela M Valverde, Eiji Hara, Manuel Serrano

“…We conclude that Sei1 plays an important role in pancreatic beta-cells, which supports a functional link between Sei1 and the core cell cycle regulators specifically in the context of the pancreas.…”
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Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases by Yinan Zhao, Yanguo Xin, Zhiyi He, Wenyu Hu

“…In the neuro-glia-vascular unit, connexins are expressed in the capillary endothelial cells and prominent in astrocyte endfeet around and associated with maturation and function of the blood-brain barrier through a unique signaling pathway and an interaction with tight junction proteins. …”
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Flow transport and not ejection fraction determines blood stasis in patients with impaired left ventricular systolic function by Pablo Martinez‐Legazpi, Javier Bermejo, Juan C. delAlamo

“…These models yield closed‐form expressions for the average RT of blood in the LV as a function of (1) EF, (2) direct flow (DF), and (3) residual volume (RV). …”
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The Exercising Brain: Changes in Functional Connectivity Induced by an Integrated Multimodal Cognitive and Whole-Body Coordination Training by Traute Demirakca, Vita Cardinale, Sven Dehn, Matthias Ruf, Gabriele Ende

“…This study investigated the impact of “life kinetik” training on brain plasticity in terms of an increased functional connectivity during resting-state functional magnetic resonance imaging (rs-fMRI). …”
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Identification of the principal neuropeptide FxFa and its function in larval settlement of the echiuran worm Urechis unicinctus by Wenyuan Lai, Long Zhang, Zhi Yang, Wei Zhang, Zhifeng Zhang, Zhengrui Zhang

“…The results of our work indicate FxFa5 triggers the U.unicinctus early-segmentation larval settlement by inhibiting the function of the ciliary gene FLNB, and this study contributes important data for elucidating a complete understanding of neuropeptides regulation in larval settlement of marine benthic invertebrates.…”
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Beyond basic characterization and omics: Immunomodulatory roles of platelet‐derived extracellular vesicles unveiled by functional testing by Mari Palviainen, Johanna Puutio, Rikke Halse Østergaard, Johannes A. Eble, Katariina Maaninka, Umar Butt, Joseph Ndika, Otto K. Kari, Masood Kamali‐Moghaddam, Kasper Kjaer‐Sorensen, Claus Oxvig, Ana M. Aransay, Juan M. Falcon‐Perez, Antonio Federico, Dario Greco, Saara Laitinen, Yuya Hayashi, Pia R.‐M. Siljander

“…Abstract Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases. Platelets express a wide range of receptors, which allows them to reach a variety of activation endpoints and grants them immunomodulatory functions. …”
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Multi-omics integration analysis and association study reveal the potential of ADIPOQ function in gestational diabetes mellitus by Xiaoying Li, Tianshuang Jia, Yingnan Wu, Yanqing Peng, Yanan Feng, Liping Gong, Shuang Dong, Jiawei Tian, Litao Sun

“…Functional enrichment analysis showed ADIPOQ gene was associated with response to nutrient levels, fat cell differentiation. …”
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Specialization of the brain for language in children with Fragile X Syndrome: a functional Near Infrared Spectroscopy study by Elizabeth Smith, Kelli C. Dominick, Lauren M. Schmitt, Ernest V. Pedapati, Craig A. Erickson

“…We report results of a functional Near Infrared Spectroscopy (fNIRS) study of responses to speech and nonspeech sounds in the auditory cortex in a sample of 2- to 10-year-old children with FXS and typically developing controls (FXS n = 23, TDC n = 15, mean age = 6.44 and 7.07 years, respectively). …”
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A role for transcription factor GTF2IRD2 in executive function in Williams-Beuren syndrome. by Melanie A Porter, Carol Dobson-Stone, John B J Kwok, Peter R Schofield, William Beckett, May Tassabehji

“…Executive functions are amongst the most heritable cognitive traits with twin studies indicating a strong genetic origin. …”
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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function by Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass

“…Abstract Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and innate immunity in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. …”
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Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogaster. by Leslie M Stevens, Goheun Kim, Theodora Koromila, John W Steele, James McGehee, Angelike Stathopoulos, David S Stein

“…Here we describe the development and characterization of the photo-N-degron, a peptide tag that can be used in optogenetic studies of protein function in vivo. The photo-N-degron can be expressed as a genetic fusion to the amino termini of other proteins, where it undergoes a blue light-dependent conformational change that exposes a signal for the class of ubiquitin ligases, the N-recognins, which mediate the N-end rule mechanism of proteasomal degradation. …”
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Analysis of the prevalence, secretion and function of a cell cycle-inhibiting factor in the melioidosis pathogen Burkholderia pseudomallei. by Pornpan Pumirat, Charles Vander Broek, Niramol Juntawieng, Veerachat Muangsombut, Pattarachai Kiratisin, Kovit Pattanapanyasat, Joanne M Stevens, Mark P Stevens, Sunee Korbsrisate

“…A homologue of Cif has been identified in Burkholderia pseudomallei (CHBP; Cif homologue in B. pseudomallei; BPSS1385), which shares catalytic activity, but its prevalence, secretion and function are ill-defined. Among 43 available B. pseudomallei genome sequences, 33 genomes (76.7%) harbor the gene encoding CHBP. …”
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