Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation by Thi Thom Mac, Teddy Fauquier, Nicolas Jullien, Pauline Romanet, Heather Etchevers, Anne Barlier, Frederic Castinetti, Thierry Brue

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QTL mapping by GWAS and functional analysis of OsbZIP72 for cold tolerance at rice seedling stage by Yunsong Gu, Haifeng Guo, Huahui Li, Runbin Su, Najeeb Ullah Khan, Jin Li, Shichen Han, Weitong Zhao, Wei Ye, Shilei Gao, Andong Zou, Meng Zhang, Xingming Sun, Zhanying Zhang, Hongliang Zhang, Pingrong Yuan, Jinjie Li, Zichao Li

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Neuroplastin 65 deficiency leads to the impairment of visual function through affecting ribbon synapse in retina of mice by Jiu-jiang Zeng, Jiu-jiang Zeng, Ling Chen, Ling Chen, Li-fen Liu, Li-fen Liu, Jia-lu Wang, Jie Cheng, Jie Cheng, Ya-ni Zheng, Ya-ni Zheng, Lei Zhang, Lei Zhang, Xiao-ming Zhang, Xiao-ming Zhang, Qiong-lan Yuan, Qiong-lan Yuan

“…Together, our findings reveal that NP65 deficiency leads to visual function impairment by affecting ribbon synapses in the OPL of mice, suggesting that NP65 is critical for visual function in mammals and a potential target for degenerative retinopathy.…”
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MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation by Yingying Lin, Yuqi Wang, Yuning Zhang, Yao Lu, Juan Chen, Yongting Luo, Jian He, Qingfeng Luo, Heng Quan, Weiru Yu, Yujia Luo, Peng Xue, Yi Xue, Xiaoya Lin, Rui Ding, Lining Chen, Yiran Wang, Zenghui Xia, Liang Zhao, Hao Zhang, Ran Wang, Qingyu Wang, Xifan Wang, Jiaqi Su, Fazheng Ren, Cong Lv, Yixuan Li, Huiyuan Guo

“…Similarly, the posttranscriptional regulation of the highly heterogenic CD8+ T cell populations and their effector function in IBD also remains poorly understood. Here, we find that miR‐29a and ‐29b (miR‐29a/b) regulate T cell fate, and their expression is higher near damaged colon tissue in patients with IBD compared to controls. …”
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Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions by Irma Saulle, Irma Saulle, Fiona Limanaqi, Micaela Garziano, Micaela Garziano, Maria Luisa Murno, Valentina Artusa, Valentina Artusa, Sergio Strizzi, Matteo Giovarelli, Carsten Schulte, Jacopo Aiello, Mario Clerici, Mario Clerici, Claudia Vanetti, Mara Biasin

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CD73 promotes the immunoregulatory functions of hepatic Tregs through enzymatic and nonenzymatic pathways in MASLD development by Hua Jin, Xinjie Zhong, Chunpan Zhang, Yongle Wu, Jie Sun, Xiyu Wang, Zeyu Wang, Jingjing Zhu, Yuan Jiang, Xiaonan Du, Zihan Zhang, Dong Zhang, Guangyong Sun

“…Regulatory T cells (Tregs) highly express CD73 and play a critical role in modulating the immune response. …”
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Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia by Yunyun Yuan, Ya Zhao, Lingqiang Meng, Shuyun Zheng, Hui Li, Jiabao Ren, Beibei Li, Chenyun Dou, Yan Hou, Wenjing Chen, Jing Zhang, Jing Zhang, Yulin Ding, Yulin Ding, Wenjing Shen

“…Herein we aimed to identify novel LRP6 variants in patients with non-syndromic oligodontia (NSO) and perform functional analyses of these variants.Methods:Whole-exome sequencing (WES) was conducted on probands and their first-degree relatives to identify potential pathogenic variants. …”
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Incretin-responsive human pancreatic adipose tissue organoids: A functional model for fatty pancreas research by E. Lorza-Gil, O.D. Strauss, E. Ziegler, K. Kansy, M.-T. Katschke, G. Rahimi, D. Neuscheler, L. Sandforth, A. Sandforth, G. Sancar, B. Kaufmann, D. Hartmann, S. Singer, A.L. Mihaljevic, R. Jumpertz-von Schwartzenberg, J. Sbierski-Kind, T.D. Müller, A.L. Birkenfeld, F. Gerst

“…Methods: Here, we developed a novel 3D model of functionally mature human pancreatic adipose tissue organoids by aggregating human pancreatic adipose tissue-derived stromal vascular fraction (SVF) cells into organoids and differentiating them over 19 days. …”
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Functional analysis of StWRKY75 gene in response to heat stress in potato (Solanum tuberosum L.) by Xi Zhu, Xi Zhu, Xi Zhu, Xiaoqin Duan, Xiaoqin Duan, Yasir Majeed, Yasir Majeed, Junfu Luo, Junfu Luo, Junfu Luo, Nengkang Guan, Nengkang Guan, Nengkang Guan, Haifei Zheng, Haifei Zheng, Haifei Zheng, Huafen Zou, Huafen Zou, Hui Jin, Hui Jin, Zhuo Chen, Zhuo Chen, Yu Zhang, Yu Zhang, Yu Zhang

“…To characterize its function, we generated transgenic lines overexpressing StWRKY75 (OE) or knockdown by RNA interference (RNAi). …”
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Precedent texts in the modern educational discourse (in terms of speech of cadets of a military institute) by O. P. Fesenko

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Methodology of determining of the transfer function of engagement kinematics of accelerations of an aircraft and its elliptic coordinates in alternative representation by V. V. Legkostup

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Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study. by Carolyn A Carr, Daniel J Stuckey, Jun Jie Tan, Suat Cheng Tan, Renata S M Gomes, Patrizia Camelliti, Elisa Messina, Alessandro Giacomello, Georgina M Ellison, Kieran Clarke

“…Here we used cine-magnetic resonance imaging (MRI) to track administered cardiosphere-derived cells (CDCs) and to measure changes in cardiac function over four months in the infarcted rat heart.…”
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Extending completeness of the eigenmodes of an open system beyond its boundary, for Green's function and scattering-matrix calculations by Z. Sztranyovszky, W. Langbein, E. A. Muljarov

“…We illustrate this by using the Mittag-Leffler series of the Green's function expressed in terms of the eigenmodes, which converges to the correct solution anywhere within the basis system, including the space outside the target system. …”
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Microwave exposure induced ferroptosis by inhibiting the Nrf2 pathway and affected reproductive function in male mice by Jingchao Gao, Xinyue Li, Yizhuo Hou, Yanyang Li, Yueyue Pang, Xiaoran Wu, Li Zhao, Jing Zhang, Haoyu Wang, Hui Wang, Ji Dong, Xinping Xu, Ruiyun Peng, Yu Wang, Binwei Yao

“…This study demonstrates that microwave exposure affects mouse reproductive function by enhancing oxidative stress, inducing ferroptosis by inhibiting the Nrf2 signalling pathway and reducing SLC7A11 and GPX4 protein expressions.…”
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Asgard Arf GTPases can act as membrane-associating molecular switches with the potential to function in organelle biogenesis by Jing Zhu, Ruize Xie, Qiaoying Ren, Jiaming Zhou, Chen Chen, Meng-Xi Xie, You Zhou, Yan Zhang, Ningjing Liu, Jinchao Wang, Zhengwei Zhang, Xipeng Liu, Wupeng Yan, Qingqiu Gong, Liang Dong, Jinwei Zhu, Fengping Wang, Zhiping Xie

“…These findings suggest certain AArfs are membrane-associating molecular switches with the functional potential to initiate organelle biogenesis, and the evolution of a functional coat could be the next critical step towards establishing eukaryotic cell architecture.…”
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A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms by Adrián Alacreu-Crespo, Emilie Olié, Maxime Manière, Jeremy Deverdun, Emmanuelle Lebars, Maithé Corbani, Gilles Guillon, Philippe Courtet

“…Three hV1B polymorphisms, rs35369693 (K65N), rs28632197 (R364H) and rs33990840 (G191R), have been related to psychiatric disorders with altered HPA axis function and social behavior. The aim of this study was to explore hV1B pharmacological properties as a function of the polymorphism in transfected cells and the brain functioning in an emotional task in volunteers harboring different AVP1BR polymorphisms. …”
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Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function. by Melody D Fulton, Danielle J Yama, Ella Dahl, Jill L Johnson

“…We examined the requirement for Hsp90 and cochaperones more closely and found that Hsp90 and cochaperones have two distinct roles in regulating eEF2 function. Yeast expressing one group of Hsp90 mutations or one group of cochaperone mutations had reduced steady-state levels of eEF2. …”
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BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis by Ross C. Gruber, Gregory S. Wirak, Anna S. Blazier, Lan Lee, Michael R. Dufault, Nellwyn Hagan, Nathalie Chretien, Michael LaMorte, Timothy R. Hammond, Agnes Cheong, Sean K. Ryan, Andrew Macklin, Mindy Zhang, Nilesh Pande, Evis Havari, Timothy J. Turner, Anthony Chomyk, Emilie Christie, Bruce D. Trapp, Dimitry Ofengeim

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Mean velocity and suspended sediment concentration profile model of turbulent shear flow with probability density function by Guanglin Wu, Liangsheng Zhu, Fangcheng Li

“…This work purposes a general mean velocity and a suspended sediment concentration (SSC) model to express distribution at every point of the cross section of turbulent shear flow by using a probability density function method. …”
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Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter. by Rugmani Padmanabhan Iyer, Sumin Gu, Bruce J Nicholson, Jean X Jiang

“…Mutation of residue Cys-232, and the two highly conserved residues Cys-249 and Cys-321, compromised the transport function of SNAT4. However, this reduction was not caused by the decrease of SNAT4 on the cell surface since the cysteine-null mutant generated by replacing all five cysteines with alanine was equally capable of being expressed on the cell surface as wild-type SNAT4. …”
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