HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages by Parker S. Woods, Rengül Cetin-Atalay, Angelo Y. Meliton, Kaitlyn A. Sun, Obada R. Shamaa, Kun Woo D. Shin, Yufeng Tian, Benjamin Haugen, Robert B. Hamanaka, Gökhan M. Mutlu

“…We conclude that HIF-1α regulates mitochondrial function in BMDMs but not in TR-AMs. The findings highlight the heterogeneity of HIF-1α function in distinct macrophage populations and provide new insight into how HIF-1α regulates gene expression, inflammation, and metabolism in different types of macrophages.…”
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The potential of volatile oil farnesol as a new treatment for hypertension and improvement of vascular function in hypertensive rats by Roma Ehsan, Luciane Barbosa Pessoa, Waqas Younis, Wajiha Manzoor, Muhammad Nasir Hayat Malik, Muhammad Naveed Mushtaq, Tariq G. Alsahli, Muryam Abdul Razzaq, Francislaine Aparecida dos Reis Lívero, Arquimedes Gasparotto Junior

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Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy by Chen Y, Yue S, Yu L, Cao J, Liu Y, Deng A, Lu Y, Yang J, Li H, Du J, Xia J, Li Y, Xia Y

“…These modifications are interconnected and collectively influence pathway functionality. We summarize the functions of cGAS-STING and its PTMs in immune and non-immune cells across various diseases, and explore potential clinical applications.Keywords: cGAS, STING, immunity, immunotherapy, post-transcriptional regulation…”
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Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction by Valeria Vincenza Alvino, Sadie Slater, Yan Qiu, Monica Cattaneo, Khaled Abdelsattar Kassem Mohammed, Seamus Gate, Vealmurugan Sekar, Annibale Alessandro Puca, Paolo Madeddu

“…In male diabetic mice, LAV-BPIFB4 therapy improved systolic function, microvascular density, and senescence, whereas the benefit was limited to systolic function in females. …”
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New Applications of Elliptic Functions and Integrals in GPS Inter-Satellite Communications with Account of General Relativity Theory by Bogdan Dimitrov

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Regulatory Function of Polyamine Oxidase-Generated Hydrogen Peroxide in Ethylene-Induced Stomatal Closure in Arabidopsis thaliana by Zhi-hui HOU, Guo-hua LIU, Li-xia HOU, Lan-xiang WANG, Xin LIU

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Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology by Chen Zheng, Ting Liu, An Qi Wang, Xing An Chen, Rong Zhe Zhang, Xuan Chao Wang, Chao Yue Lv, Ru Lu Pan, Ou Chen Wang, Xin-Cheng Lu

“…PTPRK is widely recognized for its tumor-suppressive properties across various cancers, including colorectal, lung, ovarian, and melanoma. Despite its function as a tumor suppressor, the expression and activity of PTPRK exhibit considerable variability across different cancer types and stages. …”
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Characterization of the heat shock factor RcHsfA6 in Rosa chinensis and function in the thermotolerance of Arabidopsis by Yanhui Kang, Yuan Yang, Pei Sun, Maofu Li, Hua Wang, Xiangyi Sun, Wanmei Jin

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Bacteriophage-driven DNA inversions shape bacterial functionality and long-term co-existence in Bacteroides fragilis by Shaqed Carasso, Roni Keshet-David, Jia Zhang, Haitham Hajjo, Dana Kadosh-Kariti, Tal Gefen, Naama Geva-Zatorsky

“…Bacterial genomic DNA inversions, which govern molecular phase-variations, provide the bacteria with functional plasticity and phenotypic diversity. These targeted rearrangements enable bacteria to respond to environmental challenges, such as bacteriophage predation, evading immune detection or gut colonization. …”
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Unraveling the Molecular Mechanisms of Blueberry Root Drought Tolerance Through Yeast Functional Screening and Metabolomic Profiling by Xinyu Fan, Beijia Lin, Yahong Yin, Yu Zong, Yongqiang Li, Youyin Zhu, Weidong Guo

“…Hence, we established a yeast expression library comprising blueberry genes associated with root responses to drought stress. …”
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Lactiplantibacillus plantarum LZU-J-Q21 enhanced the functional metabolic profile and bioactivity of Cistanche deserticola by Kangkang Liu, Junxiang Li, Wenting Hao, Jingjing Li, Israr Khan, Yibo Liang, Haijuan Wang, Xiaofeng Li, Chunjiang Zhang

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Identification and functional analyses of drought stress resistance genes by transcriptomics of the Mongolian grassland plant Chloris virgata by Ganbayar Namuunaa, Baldorj Bujin, Ayumi Yamagami, Byambajav Bolortuya, Shintaro Kawabata, Hirotaka Ogawa, Asaka Kanatani, Minami Shimizu, Anzu Minami, Keiichi Mochida, Takuya Miyakawa, Bekh-Ochir Davaapurev, Tadao Asami, Javzan Batkhuu, Takeshi Nakano

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Detection and functional assessment of structural variants using whole-genome re-sequencing data in Nellore cattle by Natalia A. Marín-Garzón, Lucio F. M. Mota, Giovana Vargas, Leonardo M. Arikawa, Larissa F. S. Fonseca, Gerardo A. Fernandes Júnior, Roberto Carvalheiro, Lucia G. Albuquerque

“…The identified genes were functionally classified for biological mechanisms and pathways (Gene Ontology - GO) using the panther database. …”
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Impacts of Early Weaning on Lamb Gut Health and Immune Function: Short-Term and Long-Term Effects by Chong Li, Yunfei Xu, Jiale Jia, Xiuxiu Weng, Yang Zhang, Jialin Peng, Xueming An, Guoxiu Wang

“…The transcriptome analysis revealed significant changes in gene expression related to immune function, fat digestion, and metabolism. …”
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The Anti-Inflammatory Mediator, Vasoactive Intestinal Peptide, Modulates the Differentiation and Function of Th Subsets in Rheumatoid Arthritis by Raúl Villanueva-Romero, Irene Gutiérrez-Cañas, Mar Carrión, Selene Pérez-García, Iria V. Seoane, Carmen Martínez, Rosa P. Gomariz, Yasmina Juarranz

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Lead Causes Lipid Droplet Accumulation by Impairing Lysosomal Function and Autophagic Flux in Testicular Sertoli Cells by Chengwei Guo, Lingqiao Wang, Ke Cui, Guowei Zhang, Yao Tan, Weiyan Chen, Yiqi Wang, Jijun Liu, Wenbin Liu, Guanghui Zhang, Ziyuan Zhou

“…Our findings indicate that the Pb hindered the autophagic clearance by impairing the lysosomes’ function and then obstructing the fusion of lysosomes and autophagosomes. …”
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Integrated bioinformatics and experimental analysis of mitochondrial-associated membrane function and mechanism in acute respiratory distress syndrome​​ by Yanqiong Zhou, Qiuying Chen, Xiaoxia Wang, Kaimin Lv, Hui Huang, Jifeng Feng, Bijun Luo

“…Publicly available RNA-sequencing data from ARDS and control samples were analyzed to identify differentially expressed genes (DEGs). Functional enrichment, gene set variation analysis (GSVA), and weighted gene co-expression network analysis (WGCNA) were performed to explore pathway alterations and hub gene interactions. …”
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DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function by Md Nur Ahad Shah, Harry Wilton-Clark, Farhia Haque, Brooklynn Powell, Laura Edellein Sutanto, Radha Maradiya, Pavel Zhabyeyev, Rohini Roy Roshmi, Saeed Anwar, Tejal Aslesh, Kenji Rowel Q. Lim, Rika Maruyama, Anne Bigot, Courtney S. Young, Scott Bittner, Melissa J. Spencer, Hong M. Moulton, Gavin Y. Oudit, Toshifumi Yokota

“…In a humanized DMD mouse model (hDMDdel45;mdx), DG9-PMO significantly increases exon skipping, restores dystrophin expression, and improves muscle function, particularly in the heart. …”
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Case Report: A heterozygous loss-of-function variant of the ERG gene in a family with vascular pathologies by Philipp Erhart, Nicola Dikow, Eva M. C. Schwaibold, Susanne Dihlmann, Caspar Grond-Ginsbach, Daniel Körfer, Christian P. Schaaf, Sabrina Oeser, Katrin Hinderhofer, Dittmar Böckler, Jiarna R. Zerella, Jiarna R. Zerella, Hamish S. Scott, Hamish S. Scott, Christopher N. Hahn, Christopher N. Hahn, Felix Marbach, Felix Marbach

“…Histological analysis of arterial aneurysm specimen showed comparable expression of ERG in endothelial cells of the vasa vasorum in samples from the patient and controls.ConclusionOur report discusses the possibility that loss-of-function variants in ERG may act as a risk factor for arterial disease.…”
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Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. by Ching-Ti Liu, Maija K Garnaas, Adrienne Tin, Anna Kottgen, Nora Franceschini, Carmen A Peralta, Ian H de Boer, Xiaoning Lu, Elizabeth Atkinson, Jingzhong Ding, Michael Nalls, Daniel Shriner, Josef Coresh, Abdullah Kutlar, Kirsten Bibbins-Domingo, David Siscovick, Ermeg Akylbekova, Sharon Wyatt, Brad Astor, Josef Mychaleckjy, Man Li, Muredach P Reilly, Raymond R Townsend, Adebowale Adeyemo, Alan B Zonderman, Mariza de Andrade, Stephen T Turner, Thomas H Mosley, Tamara B Harris, CKDGen Consortium, Charles N Rotimi, Yongmei Liu, Sharon L R Kardia, Michele K Evans, Michael G Shlipak, Holly Kramer, Michael F Flessner, Albert W Dreisbach, Wolfram Goessling, L Adrienne Cupples, W Linda Kao, Caroline S Fox

“…Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. …”
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