PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation by Li He, Jiayu Wen, Qi Dai

“…When Prdm16 is lost, the SMAD complex relocates to nearby genomic regions, leading to abnormal upregulation of BMP target genes. This function of PRDM16 is also required for the specification of choroid plexus (ChP) epithelial cells. …”
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GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy by Xiaoli Yang, Yong Li, Min Min, Nan Jiang, Lijuan Sun, Dandan Zhang, Yuan Cao, Yanhong Zhang, Yufei Wang, Hui Zhong, Xueping Ma, Qi Gao, Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Xufeng Hou, Muyi Liu, Xuemiao Zhang, Congwen Wei

“…Further analysis revealed that the effector function of CD8+T cells in tumors relies on glycolysis regulated by HIF-1α rather than immune checkpoints. …”
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Construction of a multimodal esophageal cancer prognostic model with screening of key genes and investigation of their biological functions by Zhengsong Chang, Yiru Li, Mengyao Wang, Xin Zhang, Qiang Bai, Huan Luo, Pengyun Deng, Liping Yang, Xiaomei Li

“…Functional assays confirmed that CASQ2 overexpression enhanced esophageal cancer cell proliferation and invasion. …”
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Evaluation of the Effect of Dietary Manganese on the Intestinal Digestive Function, Antioxidant Response, and Muscle Quality in Coho Salmon by Dongwu Liu, Wenshuo Xie, Zhiling Xia, Ya Wang, Xinran Zhang, Qiuxiang Pang

“…Manganese (Mn) is a nutritional element required for fish growth and physiology functions. In this study, we examined the effect of Mn on the intestinal digestive function, antioxidant response, and muscle quality in coho salmon (Oncorhynchus kisutch). …”
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Multilayer Membranes of Glycosaminoglycans and Collagen I Biomaterials Modulate the Function and Microvesicle Release of Endothelial Progenitor Cells by Bingyan Dai, Qunwen Pan, Zhanghua Li, Mingyan Zhao, Xiaorong Liao, Keng Wu, Xiaotang Ma

“…Multilayer composite membrane of biomaterials can increase the function of adipose stem cells or osteoprogenitor cells. …”
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Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse? by Marcos R Chiaratti, Sajida Malik, Alan Diot, Elizabeth Rapa, Lorna Macleod, Karl Morten, Manu Vatish, Richard Boyd, Joanna Poulton

“…Placental mitochondrial function might link maternal food intake to fetal growth since impaired placental ATP production, in response to poor maternal nutrition, could be a pathway linking maternal food intake to reduced fetal growth.…”
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The Effect of the AQP1 Gene Knockout on the Diversity, Composition and Function of Gut Microbiota in Mice with Heart Failure by Haotian Li, Yubo Li, Jianqin Yang, Yanjun Liu

“…Introduction: This study aims to elucidate the impact of AQP1 on cardiac function and the intestinal microbiota in mice with chronic heart failure and to further investigate the broad effects of AQP1 on the gut microbiota composition in these mice. …”
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Functional Characteristics and Cellulose Degradation Genes of the Microbial Community in Soils with Different Initial pH Values by Li Jiang, Boyan Xu, Qi Wang

“…These findings underscore pH as a pivotal regulator of microbial community structure and functional gene expression, with soil-specific responses highlighting the need for tailored strategies to optimize carbon cycling and sequestration in agricultural ecosystems.…”
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Functional characterization of TMEM86A and TMEM86B mutants by a novel lysoplasmalogenase assay by Denise Kummer, Ilaria Dorigatti, Theresia Dunzendorfer-Matt, Georg Golderer, Ernst R. Werner, Katrin Watschinger

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A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming by Yang Zhou, Sahar Alimohamadi, Li Wang, Ziqing Liu, Joseph B. Wall, Chaoying Yin, Jiandong Liu, Li Qian

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49 Perinatal opioid exposure compromises placental structure and alters immune function at the maternal–fetal interface by Heather True, Brianna Doratt, Delphine Malherbe, Sheridan Wagner, Cynthia Cockerham, John O’Brien, Ilhem Messaoudi

“…Here, we aimed to uncover the impact of maternal OUD on placental structure, function, and inflammatory responses and further stratified our findings by maternal hepatitis C (HCV) infection. …”
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Evaluation of Peri-Implant Bone Repair in Ovariectomized Rats Submitted to the Implant Placement Functionalized with Anti-Sclerostin by Pedro Henrique Silva Gomes-Ferreira, Paula Buzo Frigério, Nathália Dantas Duarte, Juliana de Moura, Naara Gabriela Monteiro, André Luis da Silva Fabris, Roberta Okamoto

“…The right tibia was used for removal torque and RT-PCR, while the left tibia was collected for micro-CT and laser confocal microscopy. (3) Results: Functionalization with Scl-Ab significantly increased the gene expression of bone markers, especially ALP, in the SHAM Scl-Ab group compared to the other groups (<i>p</i> < 0.05). (4) Conclusions: Some parameters of this study indicate that implants functionalized with anti-sclerostin bone anabolic drug enhance peri-implant bone repair, especially in healthy rats. …”
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Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice by Lauren J. Tracey, Mahmoud El-Maklizi, Dustin J. Sokolowski, Miki S. Gams, Travis Brooke-Bisschop, Julie Ruston, Christine Taylor, Alexandra Khozin, Sujeetha A. Rajakumar, Michael D. Wilson, Cynthia J. Guidos, Monica J. Justice

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Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8) by Angela K. Nietz, Laurentiu S. Popa, Russell E. Carter, Morgan L. Gerhart, Keerthi Manikonda, Laura P.W. Ranum, Timothy J. Ebner

“…It is difficult to elucidate how the disease alters brain function in areas with little or no degeneration producing both motor and cognitive symptoms. …”
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Broccoli sprouts as an underrated functional food: a rich source of bioactive compounds with prominent anticancer properties by Kamila Smala, Julia Głowacz, Michał Popiel, Dominik Stanibuła, Kamil Dziekoński, Jakub Rybowski, Maksymilian Wiśniowski, Klaudia Kulig

“…Conclusions: Broccoli sprouts offer strong potential as a functional food in cancer prevention, thanks to their SFN content and multifaceted biological effects. …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. …”
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Preparing the functional biomaterial with osteogenic bioactivities by incorporating annealing pretreated silk fiber and iron oxide nanoparticles by Peng Wang, Hengda Wang, Xucai Wang, Jiayu Gu, Caoxing Huang, Jianfei Sun

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Metabolomic and Molecular Mechanisms of Glycerol Supplementation in Regulating the Reproductive Function of Kazakh Ewes in the Non-Breeding Season by Ying Nan, Baihui Jiang, Xingdong Qi, Cuifang Ye, Mengting Xie, Zongsheng Zhao

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Digitoflavone Ameliorates Acute Lung Injury via Disturbing the Formation of Functional Stimulator of Interferon Genes Signalosome by Jun-Jie Li, Qing Yao, Ming Dong, Yan Wang, Ye Xiu, Zhi-Xin Wu, Xiao-Mei Zhao, Yin-Kang Wang, Xian-Ling Wang, Yu-Xuan Tian, Xiao-He Xiao, Zhao-Fang Bai

“…Next, we examined the effect of DG on STING downstream signaling events, such as STING oligomerization and functional STING signalosome formation. Using in vivo experiments, the 5,6-dimethylxanthenone-4-acetic acid (DMXAA)-induced agonist and lipopolysaccharide-induced acute lung injury models were used to assay the therapeutic effects of DG. …”
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Vestibulo-Oculomotor Reflex Dysfunction in Children with Cerebral Palsy Correlates with Gross Motor Function Classification System by Laura Casagrande Conti, Nicola Ferri, Leonardo Manzari, Tommaso Lelli, Maria Mangeruga, Margherita Dal Piaz, Andrea Manzotti, Luca Verrecchia, Marco Tramontano

“…Methods: This cross-sectional study included children diagnosed with CP who attempted a vestibular function assessment with the vHIT. Descriptive statistics and a subgroup analysis based on clinical expression were performed. …”
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